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Histidine-containing phosphotransfer domain, HPT domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Four-helical up-and-down bundle [ 47161] (28)
Superfamily:   Histidine-containing phosphotransfer domain, HPT domain [ 47226] (6)
Families:   Aerobic respiration control sensor protein, ArcB [ 47227]
  Phosphorelay protein-like [ 47230] (3)
  Chemotaxis protein CheA P1 domain [ 63512]
  Sensor-like histidine kinase YojN, C-terminal domain [ 116868]
  Phosphorelay protein luxU [ 116871]
  SphA-like [ 158394]


Superfamily statistics
Genomes (1,901) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 8,944 55,170 13
Proteins 7,968 46,977 13


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)biological regulation0.00001120.001918Least InformativeInherited
Biological Process (BP)response to stimulus0.0016130.000000002172Least InformativeInherited
Biological Process (BP)cell communication0.0000000011960.000000000008489Moderately InformativeDirect
Biological Process (BP)single organism signaling0.00000000025320.0000000000009672Moderately InformativeDirect
Biological Process (BP)response to organic substance0.00045691Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.12690.9888Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.00063030.441Moderately InformativeInherited
Biological Process (BP)cellular response to hormone stimulus0.000000006850.0004533InformativeDirect
Biological Process (BP)intracellular signal transduction0.000027950.00000000007158InformativeDirect
Biological Process (BP)hormone-mediated signaling pathway0.0000018690.0004926Highly InformativeDirect
Molecular Function (MF)transferase activity0.00000014260Least InformativeDirect
Molecular Function (MF)binding0.33551Least InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.000000000000022050Moderately InformativeDirect
Molecular Function (MF)signal transducer activity0.000000000000090120InformativeDirect
Molecular Function (MF)enzyme binding0.000012550.006205InformativeInherited
Molecular Function (MF)kinase activity0.24420.02179InformativeInherited
Molecular Function (MF)kinase binding0.0000000012290.00001919Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.000000002172 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.9878 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) biological regulation 0.001918 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.7664 Least Informative Inherited
Biological Process (BP) cell communication 0.000000000008489 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000000009672 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.1081 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.9888 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.441 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 0.4824 Moderately Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 0.0004533 Informative Direct
Biological Process (BP) intracellular signal transduction 0.00000000007158 Informative Direct
Biological Process (BP) locomotion 0.000002049 Informative Direct
Biological Process (BP) phosphorylation 0.02501 Informative Inherited
Biological Process (BP) hormone-mediated signaling pathway 0.0004926 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0.0001254 Informative Direct
Molecular Function (MF) enzyme binding 0.006205 Informative Inherited
Molecular Function (MF) kinase activity 0.02179 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 1 Informative Inherited
Molecular Function (MF) kinase binding 0.00001919 Highly Informative Direct
Molecular Function (MF) protein kinase activity 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processVirulence0.000001473Moderately InformativeDirect
Biological processChemotaxis0InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Cellular componentMembrane0.00571Least InformativeInherited
Cellular componentCell membrane0.00002567Moderately InformativeDirect
Cellular componentCell inner membrane0.0000005305InformativeDirect
DomainTransmembrane0.000003412Least InformativeDirect
Molecular functionNucleotide-binding0.00000001492Least InformativeDirect
Post-translational modificationTransferase0.0000000007071Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008207 SSF47226 Protein matches
Abstract This domain is present at the N terminus in proteins which undergo autophosphorylation. The group includes, the gliding motility regulatory protein from Myxococcus xanthus and a number of bacterial chemotaxis proteins.

InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Histidine-containing phosphotransfer domain, HPT domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Histidine-containing phosphotransfer domain, HPT domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]