SUPERFAMILY 1.75 HMM library and genome assignments server

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4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (68) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 2,880 6,515 79
Proteins 2,860 6,496 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.0000000025510.00007776Least InformativeDirect
Biological Process (BP)multicellular organismal process00Least InformativeDirect
Biological Process (BP)developmental process0.00000000000055430.0000000005041Least InformativeDirect
Biological Process (BP)single-organism cellular process0.0000000001820.00000000002227Least InformativeDirect
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)regulation of cellular process0.0012980.005879Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis11Least InformativeInherited
Biological Process (BP)cellular macromolecule metabolic process0.0079331Least InformativeInherited
Biological Process (BP)biosynthetic process0.026540.9482Least InformativeInherited
Biological Process (BP)single-organism metabolic process11Least InformativeInherited
Biological Process (BP)organic cyclic compound metabolic process11Least InformativeInherited
Biological Process (BP)localization11Least InformativeInherited
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance0.000000000000039210Moderately InformativeDirect
Biological Process (BP)cell differentiation00Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000032880.000000001862Moderately InformativeDirect
Biological Process (BP)organ development0.000000590.00000000001548Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.000000000040960.0000000001771Moderately InformativeDirect
Biological Process (BP)regulation of developmental process0.0000000000034660.0000000004968Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process00Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process00Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of signal transduction11Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound10.2889Moderately InformativeInherited
Biological Process (BP)tissue development0.93581Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.012780.1872Moderately InformativeInherited
Biological Process (BP)positive regulation of molecular function0.0023671Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.73251Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.0067231Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.73560.01832Moderately InformativeInherited
Biological Process (BP)nervous system development11Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process0.0018861Moderately InformativeInherited
Biological Process (BP)regulation of phosphate metabolic process10Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus10.2956Moderately InformativeInherited
Biological Process (BP)cellular response to stress11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.020890.002838Moderately InformativeInherited
Biological Process (BP)cellular localization11Moderately InformativeInherited
Biological Process (BP)signal transduction0.049090.1028Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.090040.01372Moderately InformativeInherited
Biological Process (BP)organic substance transport0.63680.1304Moderately InformativeInherited
Biological Process (BP)regulation of catalytic activity10.1782Moderately InformativeInherited
Biological Process (BP)positive regulation of response to stimulus0.023230.000000000000003755Moderately InformativeInherited
Biological Process (BP)lipid metabolic process0.66431Moderately InformativeInherited
Biological Process (BP)organic hydroxy compound metabolic process0.044330.5616Moderately InformativeInherited
Biological Process (BP)reproduction0.24610.1253Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process0.23581Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)negative regulation of immune system process00.0000000000001643InformativeDirect
Biological Process (BP)positive regulation of immune system process0.000017290.00000001298InformativeDirect
Biological Process (BP)regulation of immune effector process0.0000000000000048660.0000000008829InformativeDirect
Biological Process (BP)apoptotic process00InformativeDirect
Biological Process (BP)defense response00.000000000000001938InformativeDirect
Biological Process (BP)immune response0.00000020990InformativeDirect
Biological Process (BP)response to wounding0.0000000000043370.00000006477InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00025930.00001121InformativeDirect
Biological Process (BP)regulation of intracellular protein kinase cascade0.000000054690.00000000003562InformativeDirect
Biological Process (BP)regulation of defense response0.00018130.0000003364InformativeDirect
Biological Process (BP)response to nutrient levels0.0000000000013330InformativeDirect
Biological Process (BP)regulation of protein localization0.000000000000024560.00000000121InformativeDirect
Biological Process (BP)response to lipid0.00000021890.000000001002InformativeDirect
Biological Process (BP)response to cytokine stimulus0.00000015290.0000000001523InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)leukocyte activation0.00000011930InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.000000000004790InformativeDirect
Biological Process (BP)hematopoietic or lymphoid organ development00InformativeDirect
Biological Process (BP)regulation of immune response0.0000000032320.00000003126InformativeDirect
Biological Process (BP)regulation of cell activation00InformativeDirect
Biological Process (BP)regulation of body fluid levels0.000002580.0004186InformativeDirect
Biological Process (BP)regulation of secretion00InformativeDirect
Biological Process (BP)positive regulation of transport0.00000010240.000003288InformativeDirect
Biological Process (BP)negative regulation of transport0.000000010160.00000000001088InformativeDirect
Biological Process (BP)positive regulation of developmental process0.000020470.000000003958InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.000086340.00002212InformativeDirect
Biological Process (BP)positive regulation of protein metabolic process0.0000002420InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0016710.7626InformativeInherited
Biological Process (BP)negative regulation of cell communication11InformativeInherited
Biological Process (BP)negative regulation of signaling0.97921InformativeInherited
Biological Process (BP)regulation of apoptotic signaling pathway0.79140.716InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound0.3620.07177InformativeInherited
Biological Process (BP)cation homeostasis0.004030InformativeInherited
Biological Process (BP)response to organic cyclic compound0.00049980.01611InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.8020.7163InformativeInherited
Biological Process (BP)generation of neurons0.0000036780.0188InformativeInherited
Biological Process (BP)regulation of cell development11InformativeInherited
Biological Process (BP)response to hormone stimulus0.070830.008599InformativeInherited
Biological Process (BP)negative regulation of cell death0.019290.0008634InformativeInherited
Biological Process (BP)positive regulation of gene expression0.0000000037210.02042InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.000000013840.1206InformativeInherited
Biological Process (BP)regulation of cell cycle process0.33270.5066InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.00000000058970.02044InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.0000000000047490.01197InformativeInherited
Biological Process (BP)regulation of growth0.075730.01382InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.33520.1623InformativeInherited
Biological Process (BP)negative regulation of biosynthetic process11InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.011830.000000000009295InformativeInherited
Biological Process (BP)regulation of nervous system development11InformativeInherited
Biological Process (BP)regulation of system process11InformativeInherited
Biological Process (BP)regulation of cellular catabolic process0.0012310.0000000000009384InformativeInherited
Biological Process (BP)cellular component movement0.1291InformativeInherited
Biological Process (BP)locomotion0.00096690.4653InformativeInherited
Biological Process (BP)localization of cell0.000027920.007776InformativeInherited
Biological Process (BP)secretion by cell0.49620.3831InformativeInherited
Biological Process (BP)regulation of hormone levels10.7364InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.46950.000000001198InformativeInherited
Biological Process (BP)single-organism behavior0.24750.4256InformativeInherited
Biological Process (BP)alcohol metabolic process0.0035950.1822InformativeInherited
Biological Process (BP)single organism reproductive process0.21560.8543InformativeInherited
Biological Process (BP)multi-multicellular organism process0.2250.000006876InformativeInherited
Biological Process (BP)intracellular signal transduction10.9155InformativeInherited
Biological Process (BP)nitrogen compound transport0.45750.159InformativeInherited
Biological Process (BP)immune effector process0.001730.00000000001253InformativeInherited
Biological Process (BP)response to bacterium0.1360.04306InformativeInherited
Biological Process (BP)regulation of protein phosphorylation0.0066230.00000001399InformativeInherited
Biological Process (BP)embryo development ending in birth or egg hatching0.017760.4768InformativeInherited
Biological Process (BP)embryonic organ development0.010970.3028InformativeInherited
Biological Process (BP)negative regulation of leukocyte activation0.000000012250.00000002904Highly InformativeDirect
Biological Process (BP)regulation of production of molecular mediator of immune response0.0000000014840Highly InformativeDirect
Biological Process (BP)regulation of adaptive immune response based on somatic recombination of immune receptors built from00Highly InformativeDirect
Biological Process (BP)inflammatory response0.0000043630.000001832Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.00000000093520.000005116Highly InformativeDirect
Biological Process (BP)regulation of cell size0.000010350.00000001955Highly InformativeDirect
Biological Process (BP)response to virus0.0000000006950.00000009187Highly InformativeDirect
Biological Process (BP)hormone transport0.0003150.000001524Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway0.000000000078520.000000000000342Highly InformativeDirect
Biological Process (BP)negative regulation of cellular catabolic process00Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.00000028070.000007841Highly InformativeDirect
Biological Process (BP)response to lipopolysaccharide0.0000056690.0000000008635Highly InformativeDirect
Biological Process (BP)regulation of interleukin-1 beta production0.00000023850.000001829Highly InformativeDirect
Biological Process (BP)regulation of cytokine biosynthetic process0.00000008320.000000008465Highly InformativeDirect
Biological Process (BP)regulation of protein catabolic process0.00000043840.0002547Highly InformativeDirect
Biological Process (BP)amide transport0.00059290.00002316Highly InformativeDirect
Biological Process (BP)regulation of nitric oxide biosynthetic process0.000012870.0000000002687Highly InformativeDirect
Biological Process (BP)regulation of myeloid cell differentiation0.0000010180Highly InformativeDirect
Biological Process (BP)positive regulation of transcription, DNA-dependent0.0000000000000032610.00000000000679Highly InformativeDirect
Biological Process (BP)alpha-beta T cell activation0.00051540Highly InformativeDirect
Biological Process (BP)regulation of cytokine secretion0.0000041360.000003359Highly InformativeDirect
Biological Process (BP)positive regulation of protein secretion00Highly InformativeDirect
Biological Process (BP)regulation of peptidyl-tyrosine phosphorylation00.00000000000006884Highly InformativeDirect
Biological Process (BP)regulation of steroid biosynthetic process0.000010510.0000167Highly InformativeDirect
Biological Process (BP)coagulation0.000000035370.00000173Highly InformativeDirect
Biological Process (BP)positive regulation of cell activation00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion0.000000053020.0000000008658Highly InformativeDirect
Biological Process (BP)regulation of DNA metabolic process0.000000000074730.00000001584Highly InformativeDirect
Biological Process (BP)positive regulation of sequence-specific DNA binding transcription factor activity00.000000000002275Highly InformativeDirect
Biological Process (BP)negative regulation of protein transport0.000031380.0001769Highly InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.000000000000024560.0000000004233Highly InformativeDirect
Biological Process (BP)response to glucocorticoid stimulus00Highly InformativeDirect
Biological Process (BP)monovalent inorganic cation homeostasis0.00034380Highly InformativeDirect
Biological Process (BP)leukocyte proliferation0.000023630.0000008894Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.0000011120.00000000003148Highly InformativeDirect
Biological Process (BP)cellular response to biotic stimulus0.0000057550.0000002024Highly InformativeDirect
Biological Process (BP)extrinsic apoptotic signaling pathway0.000000000066040.000000000000007347Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.000000000014090Highly InformativeDirect
Biological Process (BP)negative regulation of apoptotic signaling pathway0.00071180.0001337Highly InformativeDirect
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)regulation of reactive oxygen species metabolic process0.019120Highly InformativeInherited
Biological Process (BP)connective tissue development0.011720.00000224Highly InformativeInherited
Biological Process (BP)regulation of innate immune response0.71671Highly InformativeInherited
Biological Process (BP)regulation of proteolysis0.00048210.001789Highly InformativeInherited
Biological Process (BP)regulation of multi-organism process0.0000016020.001185Highly InformativeInherited
Biological Process (BP)regulation of mononuclear cell proliferation0.98941Highly InformativeInherited
Biological Process (BP)positive regulation of neurogenesis0.23820.001295Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.54560.8719Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.1690.0000000002395Highly InformativeInherited
Biological Process (BP)negative regulation of carbohydrate metabolic process0.015620Highly InformativeInherited
Biological Process (BP)T cell differentiation0.18980.001806Highly InformativeInherited
Biological Process (BP)cell fate commitment0.17670.00000004526Highly InformativeInherited
Biological Process (BP)carbohydrate homeostasis0.019930.8111Highly InformativeInherited
Biological Process (BP)response to salt stress0.13030.00001282Highly InformativeInherited
Biological Process (BP)locomotory behavior0.84590.0002638Highly InformativeInherited
Biological Process (BP)response to topologically incorrect protein0.16880.6382Highly InformativeInherited
Biological Process (BP)innate immune response11Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.0028390.01005Highly InformativeInherited
Biological Process (BP)negative regulation of apoptotic process10.9964Highly InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.027570.0008584Highly InformativeInherited
Biological Process (BP)regulation of response to nutrient levels11Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis11Highly InformativeInherited
Biological Process (BP)ER-nucleus signaling pathway0.0082850.1254Highly InformativeInherited
Biological Process (BP)response to endoplasmic reticulum stress0.000086340.0149Highly InformativeInherited
Biological Process (BP)chemotaxis0.44881Highly InformativeInherited
Biological Process (BP)leukocyte migration0.2760.4092Highly InformativeInherited
Biological Process (BP)signal release0.0021820.0002634Highly InformativeInherited
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.0089720Highly InformativeInherited
Biological Process (BP)adult behavior0.00097520.08778Highly InformativeInherited
Biological Process (BP)sterol metabolic process0.00028420.007989Highly InformativeInherited
Biological Process (BP)hemostasis00.001028Highly InformativeInherited
Biological Process (BP)wound healing0.74821Highly InformativeInherited
Biological Process (BP)female pregnancy0.00000012010.004307Highly InformativeInherited
Biological Process (BP)cell-type specific apoptotic process0.026420.007536Highly InformativeInherited
Biological Process (BP)positive regulation of programmed cell death0.000037440.001276Highly InformativeInherited
Biological Process (BP)leukocyte activation involved in immune response0.041630.0000000001547Highly InformativeInherited
Biological Process (BP)multi-organism behavior0.54270.00000002561Highly InformativeInherited
Biological Process (BP)placenta development0.000021990.002543Highly InformativeInherited
Biological Process (BP)leukocyte homeostasis0.01470.02794Highly InformativeInherited
Molecular Function (MF)binding00.000000000000001562Least InformativeDirect
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)cytokine activity0.000000041550Highly InformativeDirect
Molecular Function (MF)cytokine receptor binding0.0000014710Highly InformativeDirect
Molecular Function (MF)growth factor receptor binding0.00018330.0001101Highly InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)plasma membrane0.31911Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cell surface0.0000000000082230.00002573InformativeDirect
Cellular Component (CC)external side of plasma membrane0.00000000018080.00000001618Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) regulation of metabolic process 0.00007776 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0.0000000005041 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.00000000002227 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) regulation of cellular process 0.005879 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) cellular macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) protein metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 0.9482 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 1 Least Informative Inherited
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cell differentiation 0 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000000001862 Moderately Informative Direct
Biological Process (BP) organ development 0.00000000001548 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0000000001771 Moderately Informative Direct
Biological Process (BP) positive regulation of response to stimulus 0.000000000000003755 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.0000000004968 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.2889 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.1253 Moderately Informative Inherited
Biological Process (BP) tissue development 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.1872 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.01832 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1028 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) phosphate-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.9419 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.002838 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.01372 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1304 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.1782 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organic hydroxy compound metabolic process 0.5616 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.2956 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) regulation of protein phosphorylation 0.00000001399 Informative Direct
Biological Process (BP) immune effector process 0.00000000001253 Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000000001643 Informative Direct
Biological Process (BP) positive regulation of immune system process 0.00000001298 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0000000008829 Informative Direct
Biological Process (BP) apoptotic process 0 Informative Direct
Biological Process (BP) defense response 0.000000000000001938 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to wounding 0.00000006477 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.00001121 Informative Direct
Biological Process (BP) regulation of intracellular protein kinase cascade 0.00000000003562 Informative Direct
Biological Process (BP) regulation of cellular catabolic process 0.0000000000009384 Informative Direct
Biological Process (BP) regulation of defense response 0.0000003364 Informative Direct
Biological Process (BP) response to nutrient levels 0 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.000000000009295 Informative Direct
Biological Process (BP) regulation of protein localization 0.00000000121 Informative Direct
Biological Process (BP) response to lipid 0.000000001002 Informative Direct
Biological Process (BP) response to cytokine stimulus 0.0000000001523 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) multi-multicellular organism process 0.000006876 Informative Direct
Biological Process (BP) leukocyte activation 0 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0 Informative Direct
Biological Process (BP) hematopoietic or lymphoid organ development 0 Informative Direct
Biological Process (BP) gland development 0.0006288 Informative Direct
Biological Process (BP) regulation of immune response 0.00000003126 Informative Direct
Biological Process (BP) regulation of cell activation 0 Informative Direct
Biological Process (BP) regulation of body fluid levels 0.0004186 Informative Direct
Biological Process (BP) regulation of secretion 0 Informative Direct
Biological Process (BP) positive regulation of transport 0.000003288 Informative Direct
Biological Process (BP) negative regulation of transport 0.00000000001088 Informative Direct
Biological Process (BP) positive regulation of developmental process 0.000000003958 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00002212 Informative Direct
Biological Process (BP) positive regulation of protein metabolic process 0 Informative Direct
Biological Process (BP) cation homeostasis 0 Informative Direct
Biological Process (BP) negative regulation of cell death 0.0008634 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.000000001198 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.7626 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) regulation of apoptotic signaling pathway 0.716 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.07177 Informative Inherited
Biological Process (BP) growth 0.8877 Informative Inherited
Biological Process (BP) multicellular organismal reproductive process 0.2131 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8986 Informative Inherited
Biological Process (BP) epithelium development 0.7072 Informative Inherited
Biological Process (BP) tube development 0.3793 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.01611 Informative Inherited
Biological Process (BP) cytoplasmic transport 0.06123 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.7163 Informative Inherited
Biological Process (BP) regulation of cell development 1 Informative Inherited
Biological Process (BP) generation of neurons 0.0188 Informative Inherited
Biological Process (BP) response to hormone stimulus 0.008599 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.02042 Informative Inherited
Biological Process (BP) regulation of cell cycle process 0.5066 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.02044 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1206 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.01197 Informative Inherited
Biological Process (BP) regulation of growth 0.01382 Informative Inherited
Biological Process (BP) regulation of locomotion 0.1264 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.1293 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.9155 Informative Inherited
Biological Process (BP) phosphorylation 0.9311 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.22 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.1623 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.01153 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) cellular component movement 1 Informative Inherited
Biological Process (BP) locomotion 0.4653 Informative Inherited
Biological Process (BP) localization of cell 0.007776 Informative Inherited
Biological Process (BP) secretion by cell 0.3831 Informative Inherited
Biological Process (BP) regulation of hormone levels 0.7364 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.1822 Informative Inherited
Biological Process (BP) single-organism behavior 0.4256 Informative Inherited
Biological Process (BP) single organism reproductive process 0.8543 Informative Inherited
Biological Process (BP) protein transport 0.3724 Informative Inherited
Biological Process (BP) nitrogen compound transport 0.159 Informative Inherited
Biological Process (BP) response to bacterium 0.04306 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.4768 Informative Inherited
Biological Process (BP) embryonic organ development 0.3028 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.0008584 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 0.0000000001547 Highly Informative Direct
Biological Process (BP) negative regulation of leukocyte activation 0.00000002904 Highly Informative Direct
Biological Process (BP) regulation of production of molecular mediator of immune response 0 Highly Informative Direct
Biological Process (BP) regulation of adaptive immune response based on somatic recombination of immune receptors built from 0 Highly Informative Direct
Biological Process (BP) inflammatory response 0.000001832 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.0002638 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.000005116 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000001955 Highly Informative Direct
Biological Process (BP) response to virus 0.00000009187 Highly Informative Direct
Biological Process (BP) response to salt stress 0.00001282 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0000000002395 Highly Informative Direct
Biological Process (BP) hormone transport 0.000001524 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) protein import 0.00001366 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0.000000000000342 Highly Informative Direct
Biological Process (BP) signal release 0.0002634 Highly Informative Direct
Biological Process (BP) negative regulation of cellular catabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000007841 Highly Informative Direct
Biological Process (BP) positive regulation of response to external stimulus 0.00000000006217 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 0.0000000008635 Highly Informative Direct
Biological Process (BP) regulation of interleukin-1 beta production 0.000001829 Highly Informative Direct
Biological Process (BP) protein localization to nucleus 0.0000063 Highly Informative Direct
Biological Process (BP) regulation of cytokine biosynthetic process 0.000000008465 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0002547 Highly Informative Direct
Biological Process (BP) amide transport 0.00002316 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.0000008474 Highly Informative Direct
Biological Process (BP) cell fate commitment 0.00000004526 Highly Informative Direct
Biological Process (BP) regulation of nitric oxide biosynthetic process 0.0000000002687 Highly Informative Direct
Biological Process (BP) regulation of myeloid cell differentiation 0 Highly Informative Direct
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.00000000000679 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0 Highly Informative Direct
Biological Process (BP) alpha-beta T cell activation 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.000003359 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0 Highly Informative Direct
Biological Process (BP) regulation of peptidyl-tyrosine phosphorylation 0.00000000000006884 Highly Informative Direct
Biological Process (BP) regulation of steroid biosynthetic process 0.0000167 Highly Informative Direct
Biological Process (BP) coagulation 0.00000173 Highly Informative Direct
Biological Process (BP) positive regulation of cell activation 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion 0.0000000008658 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000001584 Highly Informative Direct
Biological Process (BP) positive regulation of sequence-specific DNA binding transcription factor activity 0.000000000002275 Highly Informative Direct
Biological Process (BP) nuclear import 0.00000106 Highly Informative Direct
Biological Process (BP) negative regulation of protein transport 0.0001769 Highly Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.0000000004233 Highly Informative Direct
Biological Process (BP) response to glucocorticoid stimulus 0 Highly Informative Direct
Biological Process (BP) multi-organism behavior 0.00000002561 Highly Informative Direct
Biological Process (BP) monovalent inorganic cation homeostasis 0 Highly Informative Direct
Biological Process (BP) mammary gland epithelium development 0.00002958 Highly Informative Direct
Biological Process (BP) connective tissue development 0.00000224 Highly Informative Direct
Biological Process (BP) leukocyte proliferation 0.0000008894 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.00000000003148 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0000002024 Highly Informative Direct
Biological Process (BP) extrinsic apoptotic signaling pathway 0.000000000000007347 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of apoptotic signaling pathway 0.0001337 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) developmental growth 0.7378 Highly Informative Inherited
Biological Process (BP) branching morphogenesis of an epithelial tube 0.2747 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of proteolysis 0.001789 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.001185 Highly Informative Inherited
Biological Process (BP) regulation of mononuclear cell proliferation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of neurogenesis 0.001295 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.001035 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.8719 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle tissue development 1 Highly Informative Inherited
Biological Process (BP) regulation of striated muscle cell differentiation 0.005955 Highly Informative Inherited
Biological Process (BP) T cell differentiation 0.001806 Highly Informative Inherited
Biological Process (BP) carbohydrate homeostasis 0.8111 Highly Informative Inherited
Biological Process (BP) protein phosphorylation 0.6252 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.5125 Highly Informative Inherited
Biological Process (BP) response to topologically incorrect protein 0.6382 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.01005 Highly Informative Inherited
Biological Process (BP) negative regulation of apoptotic process 0.9964 Highly Informative Inherited
Biological Process (BP) regulation of response to nutrient levels 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 1 Highly Informative Inherited
Biological Process (BP) ER-nucleus signaling pathway 0.1254 Highly Informative Inherited
Biological Process (BP) response to endoplasmic reticulum stress 0.0149 Highly Informative Inherited
Biological Process (BP) chemotaxis 1 Highly Informative Inherited
Biological Process (BP) leukocyte migration 0.4092 Highly Informative Inherited
Biological Process (BP) adult behavior 0.08778 Highly Informative Inherited
Biological Process (BP) sterol metabolic process 0.007989 Highly Informative Inherited
Biological Process (BP) hemostasis 0.001028 Highly Informative Inherited
Biological Process (BP) wound healing 1 Highly Informative Inherited
Biological Process (BP) female pregnancy 0.004307 Highly Informative Inherited
Biological Process (BP) cell-type specific apoptotic process 0.007536 Highly Informative Inherited
Biological Process (BP) positive regulation of programmed cell death 0.001276 Highly Informative Inherited
Biological Process (BP) regulation of cell adhesion 0.2401 Highly Informative Inherited
Biological Process (BP) placenta development 0.002543 Highly Informative Inherited
Biological Process (BP) leukocyte homeostasis 0.02794 Highly Informative Inherited
Molecular Function (MF) binding 0.000000000000001562 Least Informative Direct
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) cytokine activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Molecular Function (MF) growth factor receptor binding 0.0001101 Highly Informative Direct
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0.6078 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cell surface 0.00002573 Informative Direct
Cellular Component (CC) secretory granule 0.0000009515 Informative Direct
Cellular Component (CC) external side of plasma membrane 0.00000001618 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)immune system disease0.0000007162Least InformativeDirect
Disease Ontology (DO)organ system cancer0.0002227Least InformativeDirect
Disease Ontology (DO)nervous system disease0.1689Least InformativeInherited
Disease Ontology (DO)skin disease0.00000003134Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.0000007863Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001887Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0005596Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0009962Moderately InformativeDirect
Disease Ontology (DO)mouth disease0.002157Moderately InformativeInherited
Disease Ontology (DO)bacterial infectious disease0.01931Moderately InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.03849Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.04241Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1846Moderately InformativeInherited
Disease Ontology (DO)muscular disease0.3418Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3884Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.5771Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8345Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.0000001998InformativeDirect
Disease Ontology (DO)multiple sclerosis0.0000002087InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0000003238InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000002168InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.000003395InformativeDirect
Disease Ontology (DO)myositis0.00009781InformativeDirect
Disease Ontology (DO)eye disease0.02891InformativeInherited
Disease Ontology (DO)schizophrenia0.0643InformativeInherited
Disease Ontology (DO)auditory system disease0.09212InformativeInherited
Disease Ontology (DO)lymphoma0.1227InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1238InformativeInherited
Disease Ontology (DO)kidney failure0.1261InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.1301InformativeInherited
Disease Ontology (DO)parasitic helminthiasis infectious disease0.137InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.3085InformativeInherited
Disease Ontology (DO)viral infectious disease0.3706InformativeInherited
Disease Ontology (DO)esophageal disease0.4464InformativeInherited
Disease Ontology (DO)arthritis0.8927InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis0.0000001358Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia0.00005441Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001181Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001291Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0004919Highly InformativeDirect
Disease Ontology (DO)pertussis0.0008542Highly InformativeDirect
Disease Ontology (DO)eating disorder0.004564Highly InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.226Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.00002051Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00008675Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.2341Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3793Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body phenotype0.4793Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.8558Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.00002239Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0001981Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.0002137Moderately InformativeDirect
Mammalian Phenotype (MP)tumorigenesis0.0005442Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.002747Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.005885Moderately InformativeInherited
Mammalian Phenotype (MP)digestive/alimentary phenotype0.007352Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.008084Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.008799Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.1108Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.1978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.2147Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.2526Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.2645Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.2925Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.3986Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.5257Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.7157Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal phagocyte morphology0.000000001437InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.000000001597InformativeDirect
Mammalian Phenotype (MP)autoimmune response0.0000002106InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.00004302InformativeDirect
Mammalian Phenotype (MP)abnormal female reproductive system physiology0.0006982InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.001098InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.001804InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.003219InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.02131InformativeInherited
Mammalian Phenotype (MP)abnormal hepatobiliary system physiology0.06887InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.07744InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.1164InformativeInherited
Mammalian Phenotype (MP)abnormal circulating amino acid level0.1508InformativeInherited
Mammalian Phenotype (MP)abnormal cranium morphology0.1694InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin secretion0.2247InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.233InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.4315InformativeInherited
Mammalian Phenotype (MP)abnormal respiration0.8697InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.00000001659Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0000005512Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-10 secretion0.000005266Highly InformativeDirect
Mammalian Phenotype (MP)abnormal alveolar process morphology0.00005196Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology0.00006585Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glial cell physiology0.00008362Highly InformativeDirect
Mammalian Phenotype (MP)abnormal airway responsiveness0.00009842Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0001548Highly InformativeDirect
Mammalian Phenotype (MP)colitis0.0008477Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesenteric lymph node morphology0.001392Highly InformativeInherited
Mammalian Phenotype (MP)respiratory system inflammation0.005447Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circulating interleukin-17 level0.03477Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ovulation cycle0.07742Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processHost-virus interaction0.6138Moderately InformativeInherited
Biological processInflammatory response0.0000002159InformativeDirect
Biological processCell adhesion0.000005317InformativeDirect
Biological processViral immunoevasion0.008857InformativeInherited
Biological processAcute phase0Highly InformativeDirect
Biological processAntiviral defense0Highly InformativeDirect
Biological processGrowth regulation0Highly InformativeDirect
Biological processAdaptive immunity0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Coding sequence diversityPolymorphism0.00007423Moderately InformativeDirect
DiseaseObesity0InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc0.0000003553Least InformativeDirect
Post-translational modificationGrowth factor0InformativeDirect
Post-translational modificationCytokine0Highly InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009079 SSF47266 Protein matches
Abstract

These domains display a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing such domains include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [PubMed14511776], the growth hormone somatotropin [PubMed14507421], interleukin-6 [PubMed9118960] and leptin [PubMed9144295]; short-chain cytokines, such as erythropoietin [PubMed9783743], stem cell factor (SCF) [PubMed10880433], macrophage colony-stimulating factor (M-CSF) and interleukin-2, -3, -4, -5 and -13; and interferons/interleukin-10.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 43 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a 4-helical cytokines domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 43 hidden Markov models representing the 4-helical cytokines superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Disease Ontology (DO) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · UniProtKB KeyWords (KW) · Internal database links ]