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4-helical cytokines superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   4-helical cytokines [ 47265]
Superfamily:   4-helical cytokines [ 47266] (3)
Families:   Long-chain cytokines [ 47267] (9)
  Short-chain cytokines [ 47286] (13)
  Interferons/interleukin-10 (IL-10) [ 47305] (8)


Superfamily statistics
Genomes (67) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 2,870 8,858 79
Proteins 2,850 8,820 77


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.038230.006511Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.54771Least InformativeInherited
Biological Process (BP)primary metabolic process11Least InformativeInherited
Biological Process (BP)organonitrogen compound metabolic process11Least InformativeInherited
Biological Process (BP)reproduction0.00071760.00002393Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)response to external stimulus00.00000000000275Moderately InformativeDirect
Biological Process (BP)response to biotic stimulus00Moderately InformativeDirect
Biological Process (BP)positive regulation of metabolic process00Moderately InformativeDirect
Biological Process (BP)response to organic substance00Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.000000000085410.000000005129Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000000000058760.000000003991Moderately InformativeDirect
Biological Process (BP)regulation of localization0.000000000022690Moderately InformativeDirect
Biological Process (BP)macromolecule localization0.0000000043860.000000000000007367Moderately InformativeDirect
Biological Process (BP)single organism signaling00Moderately InformativeDirect
Biological Process (BP)single-organism transport0.0000075730Moderately InformativeDirect
Biological Process (BP)positive regulation of cellular process00Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.00000000000072120.00000001091Moderately InformativeDirect
Biological Process (BP)system development0.0000000013060.0000000003749Moderately InformativeDirect
Biological Process (BP)cellular developmental process0.0000000000027790.0009366Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.0000000093680.00008579Moderately InformativeDirect
Biological Process (BP)regulation of protein metabolic process0.00000033790.00000000000003469Moderately InformativeDirect
Biological Process (BP)multi-organism process00Moderately InformativeDirect
Biological Process (BP)regulation of molecular function0.0007490.00000007887Moderately InformativeDirect
Biological Process (BP)organic substance transport0.00000013790Moderately InformativeDirect
Biological Process (BP)nitrogen compound transport0.00000000033810Moderately InformativeDirect
Biological Process (BP)response to oxygen-containing compound0.48130.1158Moderately InformativeInherited
Biological Process (BP)regulation of macromolecule biosynthetic process11Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process11Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.053350.001526Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.13570.0000001547Moderately InformativeInherited
Biological Process (BP)regulation of gene expression0.026530.8403Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization11Moderately InformativeInherited
Biological Process (BP)negative regulation of metabolic process0.2330.2448Moderately InformativeInherited
Biological Process (BP)regulation of nucleobase-containing compound metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process0.0090650.3516Moderately InformativeInherited
Biological Process (BP)cellular localization0.97491Moderately InformativeInherited
Biological Process (BP)cellular protein modification process0.58411Moderately InformativeInherited
Biological Process (BP)ion transport0.0012180.5231Moderately InformativeInherited
Biological Process (BP)response to abiotic stimulus0.81390.09322Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process0.001950.008065Moderately InformativeInherited
Biological Process (BP)cell activation00InformativeDirect
Biological Process (BP)regulation of cytokine production00InformativeDirect
Biological Process (BP)immune response0.0003390.000000000002536InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway00InformativeDirect
Biological Process (BP)cell-cell signaling0.000000059970InformativeDirect
Biological Process (BP)regulation of catabolic process0.00000000000020120.000000000000001945InformativeDirect
Biological Process (BP)positive regulation of signal transduction0.00000042390.0000000000516InformativeDirect
Biological Process (BP)positive regulation of gene expression00InformativeDirect
Biological Process (BP)organic acid transport0.0000042980.0002276InformativeDirect
Biological Process (BP)regulation of defense response0.0000064920.0000000000001856InformativeDirect
Biological Process (BP)regulation of protein modification process0.00000044330.00002551InformativeDirect
Biological Process (BP)positive regulation of cellular protein metabolic process0.000040520.0000002232InformativeDirect
Biological Process (BP)secretion by cell0.0000000000020850InformativeDirect
Biological Process (BP)response to cytokine00InformativeDirect
Biological Process (BP)regulation of cell proliferation00InformativeDirect
Biological Process (BP)regulation of phosphorylation00InformativeDirect
Biological Process (BP)positive regulation of phosphate metabolic process0.00000000019560.0000000000001514InformativeDirect
Biological Process (BP)ion homeostasis0.00015130.00000006434InformativeDirect
Biological Process (BP)regulation of secretion0.00000025410.000001032InformativeDirect
Biological Process (BP)positive regulation of transport0.0000000000014540InformativeDirect
Biological Process (BP)negative regulation of transport0.0000000000081530InformativeDirect
Biological Process (BP)positive regulation of multicellular organismal process0.0000000014080.00000006759InformativeDirect
Biological Process (BP)negative regulation of cell death0.00000068910InformativeDirect
Biological Process (BP)regulation of establishment of protein localization0.000026830.000001587InformativeDirect
Biological Process (BP)response to nitrogen compound0.0000000000080210.000000000226InformativeDirect
Biological Process (BP)regulation of intracellular signal transduction0.000001990.000000001692InformativeDirect
Biological Process (BP)regulation of system process0.23660.01596InformativeInherited
Biological Process (BP)regulation of hormone levels0.026540InformativeInherited
Biological Process (BP)positive regulation of cell death0.31340.8124InformativeInherited
Biological Process (BP)regulation of apoptotic process0.19430.01289InformativeInherited
Biological Process (BP)regulation of transferase activity0.00000011730.1378InformativeInherited
Biological Process (BP)regulation of ion transport10.9642InformativeInherited
Biological Process (BP)positive regulation of nucleobase-containing compound metabolic process0.44961InformativeInherited
Biological Process (BP)positive regulation of macromolecule biosynthetic process0.012991InformativeInherited
Biological Process (BP)regulation of hydrolase activity10.724InformativeInherited
Biological Process (BP)regulation of cell differentiation0.000078030.04138InformativeInherited
Biological Process (BP)negative regulation of protein metabolic process0.99720.8534InformativeInherited
Biological Process (BP)regulation of transmembrane transport10.02967InformativeInherited
Biological Process (BP)regulation of cellular localization11InformativeInherited
Biological Process (BP)intracellular signal transduction11InformativeInherited
Biological Process (BP)response to bacterium10.9832InformativeInherited
Biological Process (BP)cellular response to lipid11InformativeInherited
Biological Process (BP)cellular response to oxygen-containing compound11InformativeInherited
Biological Process (BP)metal ion transport0.2030.399InformativeInherited
Biological Process (BP)system process0.057160.6753InformativeInherited
Biological Process (BP)developmental process involved in reproduction0.96080.06136InformativeInherited
Biological Process (BP)reproductive system development0.78080.0007073InformativeInherited
Biological Process (BP)defense response to other organism0.023240.00006907InformativeInherited
Biological Process (BP)regulation of transcription, DNA-templated11InformativeInherited
Biological Process (BP)regulation of proteolysis11InformativeInherited
Biological Process (BP)positive regulation of cellular component organization0.75681InformativeInherited
Biological Process (BP)negative regulation of multicellular organismal process0.0000088690.02388InformativeInherited
Biological Process (BP)positive regulation of developmental process0.033020.111InformativeInherited
Biological Process (BP)positive regulation of immune response11InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis11InformativeInherited
Biological Process (BP)positive regulation of cellular biosynthetic process0.0099261InformativeInherited
Biological Process (BP)response to acid chemical0.71070.3529InformativeInherited
Biological Process (BP)regulation of lipid metabolic process0.021790.0000000002411InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process11InformativeInherited
Biological Process (BP)negative regulation of macromolecule biosynthetic process11InformativeInherited
Biological Process (BP)cellular response to hormone stimulus11InformativeInherited
Biological Process (BP)response to extracellular stimulus0.014010.002283InformativeInherited
Biological Process (BP)tissue development11InformativeInherited
Biological Process (BP)growth0.0023420.1924InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.17920.0008591InformativeInherited
Biological Process (BP)negative regulation of response to stimulus0.0005450.2512InformativeInherited
Biological Process (BP)regulation of response to external stimulus0.38840.002066InformativeInherited
Biological Process (BP)response to organic cyclic compound0.66641InformativeInherited
Biological Process (BP)peptidyl-amino acid modification0.033090.2004InformativeInherited
Biological Process (BP)phosphorylation0.0064560.3387InformativeInherited
Biological Process (BP)anion transport0.005380.003272InformativeInherited
Biological Process (BP)response to radiation11InformativeInherited
Biological Process (BP)behavior0.0049040.5969InformativeInherited
Biological Process (BP)vesicle-mediated transport0.0034661InformativeInherited
Biological Process (BP)lipid localization0.00000065960.001282InformativeInherited
Biological Process (BP)intracellular protein transport0.97851InformativeInherited
Biological Process (BP)single-organism intracellular transport0.04221InformativeInherited
Biological Process (BP)protein localization to organelle0.0024690.09114InformativeInherited
Biological Process (BP)regulation of peptide transport0.00024180.06InformativeInherited
Biological Process (BP)immune effector process0.0053980.000000002349InformativeInherited
Biological Process (BP)positive regulation of cytokine production0.00000011880.000000000001122Highly InformativeDirect
Biological Process (BP)response to molecule of bacterial origin0.000020230.000002335Highly InformativeDirect
Biological Process (BP)leukocyte differentiation00Highly InformativeDirect
Biological Process (BP)regulation of cytokine production involved in immune response0.000011050.0000935Highly InformativeDirect
Biological Process (BP)sodium ion transport0.00056450.000004296Highly InformativeDirect
Biological Process (BP)response to osmotic stress0.000000000013350Highly InformativeDirect
Biological Process (BP)digestion0.000000000094240.0000000000002651Highly InformativeDirect
Biological Process (BP)cell proliferation0.0000000000000031190Highly InformativeDirect
Biological Process (BP)protein secretion0.0000000000019390Highly InformativeDirect
Biological Process (BP)response to virus00Highly InformativeDirect
Biological Process (BP)photoperiodism0.00006190.000007977Highly InformativeDirect
Biological Process (BP)negative regulation of catabolic process0.0000000000014150Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport00Highly InformativeDirect
Biological Process (BP)cytokine-mediated signaling pathway00Highly InformativeDirect
Biological Process (BP)myeloid cell differentiation0.000000041650.0000000000005376Highly InformativeDirect
Biological Process (BP)regulation of cell killing00Highly InformativeDirect
Biological Process (BP)response to nutrient levels00Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.000037530.00001371Highly InformativeDirect
Biological Process (BP)response to amino acid0.000000000045240.00000000000001783Highly InformativeDirect
Biological Process (BP)response to peptide hormone0.000040050.0000002439Highly InformativeDirect
Biological Process (BP)negative regulation of multi-organism process0.00000000020930.000000000009609Highly InformativeDirect
Biological Process (BP)regulation of endocrine process0.00000000090240Highly InformativeDirect
Biological Process (BP)protein targeting to nucleus0.000000045780.000007584Highly InformativeDirect
Biological Process (BP)positive regulation of cell adhesion0.0000066810.000002533Highly InformativeDirect
Biological Process (BP)lymphocyte activation0.000000054380.0001148Highly InformativeDirect
Biological Process (BP)regulation of lymphocyte proliferation0.000089970.00000003442Highly InformativeDirect
Biological Process (BP)coagulation0.00000061860.000004038Highly InformativeDirect
Biological Process (BP)regulation of sequence-specific DNA binding transcription factor activity0.00000000000036540.000000000001568Highly InformativeDirect
Biological Process (BP)regulation of oxidoreductase activity0.00000000340.00000000000005932Highly InformativeDirect
Biological Process (BP)response to glucocorticoid00Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling0.0002880.000008505Highly InformativeDirect
Biological Process (BP)regulation of vesicle-mediated transport0.000011540.000006299Highly InformativeDirect
Biological Process (BP)positive regulation of leukocyte proliferation0.00000000012090Highly InformativeDirect
Biological Process (BP)regulation of leukocyte differentiation0.00003570.000000001169Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.0000000045760.0000000000003209Highly InformativeDirect
Biological Process (BP)positive regulation of secretion by cell0.00000000017410.000000000000003764Highly InformativeDirect
Biological Process (BP)regulation of cation transmembrane transport0.00000038330Highly InformativeDirect
Biological Process (BP)negative regulation of establishment of protein localization0.000010120.0000009485Highly InformativeDirect
Biological Process (BP)regulation of lipid localization0.00046060.00001022Highly InformativeDirect
Biological Process (BP)positive regulation of reactive oxygen species metabolic process0.0000000094420Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0022090.000005864Highly InformativeInherited
Biological Process (BP)positive regulation of transporter activity0.16460Highly InformativeInherited
Biological Process (BP)activation of protein kinase activity0.32580.4025Highly InformativeInherited
Biological Process (BP)regulation of reproductive process0.056690.2653Highly InformativeInherited
Biological Process (BP)regulation of viral process0.030080.008398Highly InformativeInherited
Biological Process (BP)regulation of transmembrane transporter activity0.0028950.00000008443Highly InformativeInherited
Biological Process (BP)negative regulation of protein modification process11Highly InformativeInherited
Biological Process (BP)cellular response to biotic stimulus0.053110.001097Highly InformativeInherited
Biological Process (BP)negative regulation of cell proliferation0.000020830.005331Highly InformativeInherited
Biological Process (BP)renal system process0.16240.01337Highly InformativeInherited
Biological Process (BP)positive regulation of apoptotic process0.50381Highly InformativeInherited
Biological Process (BP)regulation of cytokine secretion0.046850.02267Highly InformativeInherited
Biological Process (BP)negative regulation of peptide secretion0.03440.02875Highly InformativeInherited
Biological Process (BP)signal release0.060990Highly InformativeInherited
Biological Process (BP)positive regulation of production of molecular mediator of immune response11Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte mediated immunity0.98761Highly InformativeInherited
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.66140.05325Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation0.80980.6724Highly InformativeInherited
Biological Process (BP)positive regulation of lipid metabolic process0.24760.00001914Highly InformativeInherited
Biological Process (BP)regulation of cellular ketone metabolic process0.023640.0000000002431Highly InformativeInherited
Biological Process (BP)negative regulation of lipid metabolic process10.02194Highly InformativeInherited
Biological Process (BP)regulation of DNA metabolic process0.17230.5222Highly InformativeInherited
Biological Process (BP)regulation of T cell activation11Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport10.003681Highly InformativeInherited
Biological Process (BP)protein import0.00011320.05463Highly InformativeInherited
Biological Process (BP)positive regulation of cellular protein localization0.2080.2348Highly InformativeInherited
Biological Process (BP)positive regulation of intracellular transport0.98171Highly InformativeInherited
Biological Process (BP)regulation of protein import into nucleus0.066860.02231Highly InformativeInherited
Biological Process (BP)positive regulation of protein transport0.027260.6823Highly InformativeInherited
Biological Process (BP)innate immune response0.14171Highly InformativeInherited
Biological Process (BP)regulation of toll-like receptor signaling pathway0.030370.05399Highly InformativeInherited
Biological Process (BP)regulation of cellular response to stress0.00019970.09969Highly InformativeInherited
Biological Process (BP)positive regulation of MAPK cascade0.98421Highly InformativeInherited
Biological Process (BP)positive regulation of hydrolase activity0.94940.01221Highly InformativeInherited
Biological Process (BP)positive regulation of transmembrane transport10.000001352Highly InformativeInherited
Biological Process (BP)positive regulation of catabolic process0.040660.1326Highly InformativeInherited
Biological Process (BP)regulation of autophagy0.0067930.01455Highly InformativeInherited
Biological Process (BP)single-organism behavior0.00041450.3824Highly InformativeInherited
Biological Process (BP)hemostasis0.0045720.1421Highly InformativeInherited
Biological Process (BP)wound healing0.024590.01699Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.000033250.002055Highly InformativeInherited
Biological Process (BP)regulation of epithelial cell proliferation0.71421Highly InformativeInherited
Molecular Function (MF)hydrolase activity11Least InformativeInherited
Molecular Function (MF)binding0.00000010780.216Least InformativeInherited
Molecular Function (MF)molecular function regulator0.06520.5667Moderately InformativeInherited
Molecular Function (MF)receptor binding00InformativeDirect
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides0.85350.0000531InformativeInherited
Molecular Function (MF)enzyme activator activity0.000059050.0155InformativeInherited
Molecular Function (MF)macromolecular complex binding0.0088720.4399InformativeInherited
Molecular Function (MF)cytokine receptor binding0.00000000000012840Highly InformativeDirect
Molecular Function (MF)cysteine-type endopeptidase activity0.0040540Highly InformativeInherited
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)extracellular space00.00000000000002355InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.006511 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) reproduction 0.00002393 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.00000000000275 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0 Moderately Informative Direct
Biological Process (BP) positive regulation of metabolic process 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000005129 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.000000003991 Moderately Informative Direct
Biological Process (BP) regulation of localization 0 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.000000000000007367 Moderately Informative Direct
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) positive regulation of cellular process 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00000001091 Moderately Informative Direct
Biological Process (BP) system development 0.0000000003749 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.0009366 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00008579 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000000003469 Moderately Informative Direct
Biological Process (BP) multi-organism process 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0000001547 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.00000007887 Moderately Informative Direct
Biological Process (BP) organic substance transport 0 Moderately Informative Direct
Biological Process (BP) nitrogen compound transport 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.1158 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.8403 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.2448 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3516 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.001526 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.5231 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.09322 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.008065 Moderately Informative Inherited
Biological Process (BP) cell activation 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0 Informative Direct
Biological Process (BP) immune effector process 0.000000002349 Informative Direct
Biological Process (BP) immune response 0.000000000002536 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) cell-cell signaling 0 Informative Direct
Biological Process (BP) regulation of catabolic process 0.000000000000001945 Informative Direct
Biological Process (BP) positive regulation of signal transduction 0.0000000000516 Informative Direct
Biological Process (BP) positive regulation of gene expression 0 Informative Direct
Biological Process (BP) regulation of hormone levels 0 Informative Direct
Biological Process (BP) organic acid transport 0.0002276 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0.0000000002411 Informative Direct
Biological Process (BP) regulation of defense response 0.0000000000001856 Informative Direct
Biological Process (BP) regulation of protein modification process 0.00002551 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0.0000002232 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0 Informative Direct
Biological Process (BP) regulation of phosphorylation 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.0008591 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.0000000000001514 Informative Direct
Biological Process (BP) ion homeostasis 0.00000006434 Informative Direct
Biological Process (BP) regulation of secretion 0.000001032 Informative Direct
Biological Process (BP) positive regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) positive regulation of multicellular organismal process 0.00000006759 Informative Direct
Biological Process (BP) negative regulation of cell death 0 Informative Direct
Biological Process (BP) reproductive system development 0.0007073 Informative Direct
Biological Process (BP) regulation of establishment of protein localization 0.000001587 Informative Direct
Biological Process (BP) defense response to other organism 0.00006907 Informative Direct
Biological Process (BP) response to nitrogen compound 0.000000000226 Informative Direct
Biological Process (BP) regulation of intracellular signal transduction 0.000000001692 Informative Direct
Biological Process (BP) regulation of system process 0.01596 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.06 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.111 Informative Inherited
Biological Process (BP) positive regulation of cell death 0.8124 Informative Inherited
Biological Process (BP) regulation of ion transport 0.9642 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.724 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.8534 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.02967 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) response to bacterium 0.9832 Informative Inherited
Biological Process (BP) cellular response to lipid 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) metal ion transport 0.399 Informative Inherited
Biological Process (BP) system process 0.6753 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.06136 Informative Inherited
Biological Process (BP) regulation of transcription, DNA-templated 1 Informative Inherited
Biological Process (BP) regulation of proteolysis 1 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 1 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.02388 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.04138 Informative Inherited
Biological Process (BP) response to acid chemical 0.3529 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.01289 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) response to extracellular stimulus 0.002283 Informative Inherited
Biological Process (BP) tissue development 1 Informative Inherited
Biological Process (BP) growth 0.1924 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.2512 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 0.002066 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.2004 Informative Inherited
Biological Process (BP) phosphorylation 0.3387 Informative Inherited
Biological Process (BP) anion transport 0.003272 Informative Inherited
Biological Process (BP) regulation of transferase activity 0.1378 Informative Inherited
Biological Process (BP) response to radiation 1 Informative Inherited
Biological Process (BP) behavior 0.5969 Informative Inherited
Biological Process (BP) multi-organism reproductive process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 1 Informative Inherited
Biological Process (BP) lipid localization 0.001282 Informative Inherited
Biological Process (BP) intracellular protein transport 1 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) protein localization to organelle 0.09114 Informative Inherited
Biological Process (BP) positive regulation of immune response 1 Informative Inherited
Biological Process (BP) regulation of locomotion 1 Informative Inherited
Biological Process (BP) regulation of cellular component movement 1 Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.000000000001122 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.000002335 Highly Informative Direct
Biological Process (BP) leukocyte differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of cytokine production involved in immune response 0.0000935 Highly Informative Direct
Biological Process (BP) sodium ion transport 0.000004296 Highly Informative Direct
Biological Process (BP) response to osmotic stress 0 Highly Informative Direct
Biological Process (BP) digestion 0.0000000000002651 Highly Informative Direct
Biological Process (BP) cell proliferation 0 Highly Informative Direct
Biological Process (BP) protein secretion 0 Highly Informative Direct
Biological Process (BP) response to virus 0 Highly Informative Direct
Biological Process (BP) photoperiodism 0.000007977 Highly Informative Direct
Biological Process (BP) negative regulation of catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of cellular ketone metabolic process 0.0000000002431 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transporter activity 0.00000008443 Highly Informative Direct
Biological Process (BP) signal release 0 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0000000000005376 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) response to nutrient levels 0 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00001371 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.000001352 Highly Informative Direct
Biological Process (BP) response to amino acid 0.00000000000001783 Highly Informative Direct
Biological Process (BP) response to peptide hormone 0.0000002439 Highly Informative Direct
Biological Process (BP) negative regulation of multi-organism process 0.000000000009609 Highly Informative Direct
Biological Process (BP) regulation of endocrine process 0 Highly Informative Direct
Biological Process (BP) protein targeting to nucleus 0.000007584 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0.000002533 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00001914 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.0001148 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.000005864 Highly Informative Direct
Biological Process (BP) regulation of lymphocyte proliferation 0.00000003442 Highly Informative Direct
Biological Process (BP) coagulation 0.000004038 Highly Informative Direct
Biological Process (BP) regulation of sequence-specific DNA binding transcription factor activity 0.000000000001568 Highly Informative Direct
Biological Process (BP) regulation of oxidoreductase activity 0.00000000000005932 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.000008505 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000006299 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.000000001169 Highly Informative Direct
Biological Process (BP) regulation of reactive oxygen species biosynthetic process 0.000000000589 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0000000000003209 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.000000000000003764 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0000009485 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.00001022 Highly Informative Direct
Biological Process (BP) positive regulation of reactive oxygen species metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of intracellular transport 1 Highly Informative Inherited
Biological Process (BP) activation of protein kinase activity 0.4025 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 0.2653 Highly Informative Inherited
Biological Process (BP) regulation of viral process 0.008398 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of MAPK cascade 1 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.001097 Highly Informative Inherited
Biological Process (BP) negative regulation of cell proliferation 0.005331 Highly Informative Inherited
Biological Process (BP) renal system process 0.01337 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 1 Highly Informative Inherited
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.3958 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 0.6027 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.05325 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte mediated immunity 1 Highly Informative Inherited
Biological Process (BP) negative regulation of lipid metabolic process 0.02194 Highly Informative Inherited
Biological Process (BP) positive regulation of production of molecular mediator of immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of steroid biosynthetic process 0.4017 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.5222 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.003681 Highly Informative Inherited
Biological Process (BP) protein import 0.05463 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular protein localization 0.2348 Highly Informative Inherited
Biological Process (BP) positive regulation of protein transport 0.6823 Highly Informative Inherited
Biological Process (BP) regulation of protein import into nucleus 0.02231 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.6724 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.05399 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.09969 Highly Informative Inherited
Biological Process (BP) positive regulation of hydrolase activity 0.01221 Highly Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.1326 Highly Informative Inherited
Biological Process (BP) regulation of autophagy 0.01455 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.3824 Highly Informative Inherited
Biological Process (BP) hemostasis 0.1421 Highly Informative Inherited
Biological Process (BP) wound healing 0.01699 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.002084 Highly Informative Inherited
Biological Process (BP) regulation of cytokine secretion 0.02267 Highly Informative Inherited
Biological Process (BP) negative regulation of peptide secretion 0.02875 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.002055 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte migration 1 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 1 Highly Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) binding 0.216 Least Informative Inherited
Molecular Function (MF) molecular function regulator 0.5667 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0 Informative Direct
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.0000531 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0155 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.4399 Informative Inherited
Molecular Function (MF) cysteine-type endopeptidase activity 0 Highly Informative Direct
Molecular Function (MF) cytokine receptor binding 0 Highly Informative Direct
Cellular Component (CC) macromolecular complex 1 Least Informative Inherited
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cell projection 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00000000000002355 Informative Direct
Cellular Component (CC) lamellipodium 0.00000008344 Highly Informative Direct

Document: GO annotation of SCOP domains

Disease Ontology (DO)

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DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0001717Least InformativeDirect
Disease Ontology (DO)nervous system disease0.09163Least InformativeInherited
Disease Ontology (DO)skin disease0.000000001331Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.00000001455Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00000006804Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.0000002227Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.00001172Moderately InformativeDirect
Disease Ontology (DO)syndrome0.0001251Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0003579Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.0004577Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.1059Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1136Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.3535Moderately InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.4677Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.4784Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.8255Moderately InformativeInherited
Disease Ontology (DO)asthma0.00000000001642InformativeDirect
Disease Ontology (DO)periodontal disease0.0000000000328InformativeDirect
Disease Ontology (DO)multiple sclerosis0.00000003719InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0000001872InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.0000002403InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000002807InformativeDirect
Disease Ontology (DO)bullous pemphigoid0.00002728InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.00009936InformativeDirect
Disease Ontology (DO)muscle tissue disease0.0002089InformativeDirect
Disease Ontology (DO)arthropathy0.0004069InformativeDirect
Disease Ontology (DO)schizophrenia0.03385InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.09158InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type IV disease0.1379InformativeInherited
Disease Ontology (DO)lymphoma0.1536InformativeInherited
Disease Ontology (DO)collagen disease0.1611InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.2078InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.2594InformativeInherited
Disease Ontology (DO)rheumatic disease0.3076InformativeInherited
Disease Ontology (DO)viral infectious disease0.311InformativeInherited
Disease Ontology (DO)arthritis0.898InformativeInherited
Disease Ontology (DO)parasitic protozoa infectious disease0.9599InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)rheumatoid arthritis0.00000003512Highly InformativeDirect
Disease Ontology (DO)celiac disease0.00000008896Highly InformativeDirect
Disease Ontology (DO)Chagas disease0.000001734Highly InformativeDirect
Disease Ontology (DO)opportunistic mycosis0.000004751Highly InformativeDirect
Disease Ontology (DO)agammaglobulinemia0.00004818Highly InformativeDirect
Disease Ontology (DO)otitis media0.0001167Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.0001453Highly InformativeDirect
Disease Ontology (DO)aggressive systemic mastocytosis0.0005019Highly InformativeDirect
Disease Ontology (DO)pertussis0.0007752Highly InformativeDirect
Disease Ontology (DO)eating disorder0.01485Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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