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Bromodomain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Bromodomain-like [ 47363] (15)
Superfamily:   Bromodomain [ 47370]
Family:   Bromodomain [ 47371] (4)


Family statistics
Genomes (415) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,306 4,151 8
Proteins 1,180 3,724 7


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.6062Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Methyltransferases0.005645Moderately InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001965InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.4203Moderately InformativeInherited
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.0004982Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.02536Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.03684Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1086Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.1138Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.3963Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.4264Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.4568Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.5959Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.001037Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.003772Moderately InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving the central nervous system0.0154Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cerebrum0.02086Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skull size0.02748Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.02854Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.03702Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.04256Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.0542Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.06157Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.07257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.1006Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1117Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1423Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.1506Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.1524Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vertebral column0.253Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.7082Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Obesity0.0003423InformativeDirect
Phenotypic Abnormality (PA)Intellectual disability0.0004297InformativeDirect
Phenotypic Abnormality (PA)Abnormal hair quantity0.0004483InformativeDirect
Phenotypic Abnormality (PA)Joint hypermobility0.0004517InformativeDirect
Phenotypic Abnormality (PA)Abnormal facial shape0.0005002InformativeDirect
Phenotypic Abnormality (PA)Microcephaly0.0005565InformativeDirect
Phenotypic Abnormality (PA)Abnormal conjugate eye movement0.00109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.002662InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.002928InformativeInherited
Phenotypic Abnormality (PA)Impairment in personality functioning0.004915InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.009574InformativeInherited
Phenotypic Abnormality (PA)Regional abnormality of skin0.0117InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the palm0.02307InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.07631InformativeInherited
Phenotypic Abnormality (PA)Abnormal lacrimal duct morphology0.00005332Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pinna0.00007175Highly InformativeDirect
Phenotypic Abnormality (PA)Spina bifida occulta0.0001148Highly InformativeDirect
Phenotypic Abnormality (PA)Cryptorchidism0.0001222Highly InformativeDirect
Phenotypic Abnormality (PA)Thick eyebrow0.0001642Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the philtrum0.0002104Highly InformativeDirect
Phenotypic Abnormality (PA)Hyperactivity0.0003179Highly InformativeDirect
Phenotypic Abnormality (PA)Delayed skeletal maturation0.0004605Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal dermatoglyphics0.0005815Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal eyelash morphology0.001519Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal emotion/affect behavior0.008934Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hairline0.1922Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the knee0.3057Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.0003012Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.6504Least InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.02283Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.02911Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.0663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1198Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube morphology0.164InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.5201InformativeInherited
Mammalian Phenotype (MP)abnormal neural tube closure0.0003451Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.00003691Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.001215Least InformativeInherited
Worm Phenotype (WP)cell development variant0.02835Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.07839Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000000182Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.04798Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.4659Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.00003472InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.00009853InformativeDirect
Worm Phenotype (WP)sick0.0003011InformativeDirect
Worm Phenotype (WP)cell number increased0.0004414InformativeDirect
Worm Phenotype (WP)drug resistant0.00886InformativeInherited
Worm Phenotype (WP)vulva development variant0.01986InformativeInherited
Worm Phenotype (WP)chemical resistant0.03602InformativeInherited
Worm Phenotype (WP)gonad development variant0.5851InformativeInherited
Worm Phenotype (WP)organism UV response variant0.0000004155Highly InformativeDirect
Worm Phenotype (WP)multivulva0.00000158Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)development0.002858Moderately InformativeInherited
Yeast Phenotype (YP)chromosome/plasmid maintenance0.0001938InformativeDirect
Yeast Phenotype (YP)lifespan0.2146InformativeInherited
Yeast Phenotype (YP)radiation resistance0.0005092Highly InformativeDirect
Yeast Phenotype (YP)ionic stress resistance0.0006442Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)modifier of variegation0.0001573InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.3575Least InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.000352InformativeDirect
Zebrafish Anatomy (ZA)hematopoietic cell0.0009907InformativeDirect
Zebrafish Anatomy (ZA)blood0.00003685Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)embryo0.0001058Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.000000000001023Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.8663Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.001422Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002137InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.06524InformativeInherited
Enzyme Commission (EC)In phosphorus-containing anhydrides0.1842InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.5898InformativeInherited
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.000000005311Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Bromodomain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]