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Homodimeric domain of signal transducing histidine kinase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   ROP-like [ 47379] (8)
Superfamily:   Homodimeric domain of signal transducing histidine kinase [ 47384]
Families:   Homodimeric domain of signal transducing histidine kinase [ 47385] (3)


Superfamily statistics
Genomes (2,845) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 56,110 387,391 3
Proteins 55,935 386,532 3


Functional annotation
General category coiled coil
Detailed category The code refers to a Dimeric_canonical_parallel_coiled_coils in the CC+ database. Please click on the link for more information and to visit the CC+ website.

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.104 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01796 Least Informative Inherited
Biological Process (BP) single organism signaling 0 Moderately Informative Direct
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.000000001424 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9601 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.0287 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.6346 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.8294 Moderately Informative Inherited
Biological Process (BP) ion transport 0.002911 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) intracellular signal transduction 0 Informative Direct
Biological Process (BP) phosphorylation 0.0000009731 Informative Direct
Biological Process (BP) anion transport 0.00009765 Informative Direct
Biological Process (BP) cellular response to hormone stimulus 0.0004881 Informative Direct
Biological Process (BP) negative regulation of signaling 0.1149 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.1019 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.1152 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.266 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.3314 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5898 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.03535 Informative Inherited
Biological Process (BP) organic acid transport 0.001155 Informative Inherited
Biological Process (BP) response to osmotic stress 0.00000000007006 Highly Informative Direct
Biological Process (BP) dicarboxylic acid transport 0.0000008095 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular signal transduction 0.0006595 Highly Informative Direct
Biological Process (BP) response to alcohol 0.0008355 Highly Informative Direct
Biological Process (BP) pathogenesis 0.0009676 Highly Informative Direct
Biological Process (BP) hormone-mediated signaling pathway 0.03761 Highly Informative Inherited
Biological Process (BP) cellular response to abiotic stimulus 0.001908 Highly Informative Inherited
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.03896 Moderately Informative Inherited
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.000006495 Informative Direct
Molecular Function (MF) phosphatase activity 0.0000296 Informative Direct
Molecular Function (MF) protein kinase activity 0.000000000432 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 1 Highly Informative Inherited
Cellular Component (CC) membrane 0.107 Least Informative Inherited
Cellular Component (CC) intrinsic component of membrane 0.0007035 Moderately Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-histidine kinases0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processVirulence0Moderately InformativeDirect
Biological processBiological rhythms0InformativeDirect
Biological processNitrogen fixation0.000000000000006605InformativeDirect
Biological processSensory transduction0.000000003131InformativeDirect
Biological processChemotaxis0.0000002264InformativeDirect
Biological processSporulation0.000002605InformativeDirect
Biological processAntibiotic resistance0.000007747InformativeDirect
Biological processEthylene signaling pathway0Highly InformativeDirect
Biological processTwo-component regulatory system0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0000000004188Moderately InformativeDirect
DomainTransmembrane0Least InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionCopper0InformativeDirect
Molecular functionChromophore0.0000001572InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationProtein phosphatase0InformativeDirect
Post-translational modificationPhotoreceptor protein0.000000002883Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR009082 SSF47384 Protein matches
Abstract

Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [PubMed8868347]. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation [PubMed10426948], and CheA, which plays a central role in the chemotaxis system [PubMed9989504]. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and the phosphotransfer from aspartyl phosphate back to ADP or to water [PubMed11145881]. The homodimeric domain includes the site of histidine autophosphorylation and phosphate transfer reactions. The structure of the homodimeric domain comprises a closed, four-helical bundle with a left-handed twist, formed by two identical alpha-hairpin subunits.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Homodimeric domain of signal transducing histidine kinase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Homodimeric domain of signal transducing histidine kinase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]