SUPERFAMILY 1.75 HMM library and genome assignments server

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POU-specific domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Family:   POU-specific domain [ 47414] (3)


Family statistics
Genomes (125) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 630 1,793 8
Proteins 630 1,793 8


Disease Ontology (DO)

(
show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.05109Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.05974Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002226InformativeInherited
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0002062Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1343Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.008756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1489Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1989Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3086Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002434InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.006236InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01827InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.3281InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.7339InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.0002504Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hindbrain development0.02585Highly InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.04112Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1131Least InformativeInherited
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001498Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.005795Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.01002Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.01496Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.0426Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08369Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1618Moderately InformativeInherited
Fly Anatomy (FA)central brain0.000003064InformativeDirect
Fly Anatomy (FA)antennal segment0.00001767InformativeDirect
Fly Anatomy (FA)larval abdominal segment0.00003518InformativeDirect
Fly Anatomy (FA)synaptic neuropil domain0.00005836InformativeDirect
Fly Anatomy (FA)chemosensory system0.0001126InformativeDirect
Fly Anatomy (FA)adult brain0.0002574InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.0002743InformativeDirect
Fly Anatomy (FA)sensory organ cell0.009098InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.01078InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.05946InformativeInherited
Fly Anatomy (FA)neuromere0.06964InformativeInherited
Fly Anatomy (FA)larval abdominal segment A2-70.0000003641Highly InformativeDirect
Fly Anatomy (FA)maxillary palp olfactory receptor neuron0.001623Highly InformativeInherited
Fly Anatomy (FA)antennal lobe glomerulus0.2567Highly InformativeInherited
Fly Anatomy (FA)adult antennal lobe0.4073Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1226Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.1818Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.328Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.04338Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.00002491InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.0416Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1596Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2435Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.9266Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9499Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9922Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001041Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0021Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.02295Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2203Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.0000308InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0001275InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00213InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0253InformativeInherited
Xenopus ANatomical entity (XAN)eye0.04156InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.1331InformativeInherited
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0000003083Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00002486Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00003809Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.0000472Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00005753Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00007273Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0001631Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0005432Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]