SUPERFAMILY 1.75 HMM library and genome assignments server

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POU-specific domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Family:   POU-specific domain [ 47414] (3)


Family statistics
Genomes (125) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 630 1,793 8
Proteins 630 1,793 8


Disease Ontology (DO)

(
show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04961Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0592Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002267InformativeInherited
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0002048Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1341Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00876Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1993Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2288Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3078Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002433InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.006234InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01826InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.328InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.7338InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.0002504Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.0005498Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hindbrain development0.02584Highly InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.04116Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)adult body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1163Least InformativeInherited
Fly Anatomy (FA)larva0.2075Least InformativeInherited
Fly Anatomy (FA)head0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001543Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.01836Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02883Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.05003Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.07068Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08108Moderately InformativeInherited
Fly Anatomy (FA)chemosensory system0.0001022InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.0001913InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.0003559InformativeDirect
Fly Anatomy (FA)adult external head0.001005InformativeInherited
Fly Anatomy (FA)larval abdominal segment0.001438InformativeInherited
Fly Anatomy (FA)adult head sensillum0.002668InformativeInherited
Fly Anatomy (FA)segmental subdivision of organ system0.003054InformativeInherited
Fly Anatomy (FA)sensory organ cell0.004684InformativeInherited
Fly Anatomy (FA)adult central nervous system0.02026InformativeInherited
Fly Anatomy (FA)brain0.02176InformativeInherited
Fly Anatomy (FA)adult antennal lobe glomerulus0.0000003726Highly InformativeDirect
Fly Anatomy (FA)larval abdominal segment 20.00002145Highly InformativeDirect
Fly Anatomy (FA)maxillary palp olfactory receptor neuron0.002203Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.14Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1696Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.2375Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.01197Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.000001976InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.04234Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1581Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2437Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.951Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9905Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001064Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00118Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01931Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2189Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.00003049InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.0001257InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0006571InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.002028InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.0248InformativeInherited
Xenopus ANatomical entity (XAN)eye0.03476InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.1329InformativeInherited
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0000003236Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00002542Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00003843Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.00004823Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0000739Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0004017Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0005165Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]