SUPERFAMILY 1.75 HMM library and genome assignments server

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POU-specific domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   lambda repressor-like DNA-binding domains [ 47412]
Superfamily:   lambda repressor-like DNA-binding domains [ 47413] (13)
Family:   POU-specific domain [ 47414] (3)


Family statistics
Genomes (125) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 630 1,793 8
Proteins 630 1,793 8


Disease Ontology (DO)

(
show details) Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.04961Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.0592Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.002267InformativeInherited
Phenotypic Abnormality (PA)Urinary tract neoplasm0.0002048Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1343Least InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00876Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1487Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1988Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.2289Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.3085Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.3139Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cochlear hair cell morphology0.002434InformativeInherited
Mammalian Phenotype (MP)abnormal hearing physiology0.006238InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.01826InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.328InformativeInherited
Mammalian Phenotype (MP)abnormal metencephalon morphology0.7338InformativeInherited
Mammalian Phenotype (MP)impaired hearing0.0002504Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.0005501Highly InformativeDirect
Mammalian Phenotype (MP)abnormal hindbrain development0.02584Highly InformativeInherited
Mammalian Phenotype (MP)neurodegeneration0.04111Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)adult body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0Moderately InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)neuroanatomy defective0InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)anatomical group0.1214Least InformativeInherited
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)neuron0Moderately InformativeDirect
Fly Anatomy (FA)ganglion0Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0Moderately InformativeDirect
Fly Anatomy (FA)appendage0Moderately InformativeDirect
Fly Anatomy (FA)tagmatic subdivision of integument0Moderately InformativeDirect
Fly Anatomy (FA)multi-cell-component structure0.001581Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.009958Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.01676Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04706Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.08324Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1627Moderately InformativeInherited
Fly Anatomy (FA)antennal segment0.00001945InformativeDirect
Fly Anatomy (FA)larval abdominal segment0.00003502InformativeDirect
Fly Anatomy (FA)synaptic neuropil domain0.00006149InformativeDirect
Fly Anatomy (FA)chemosensory system0.0001054InformativeDirect
Fly Anatomy (FA)adult procephalic segment0.0002888InformativeDirect
Fly Anatomy (FA)segmental subdivision of organ system0.00314InformativeInherited
Fly Anatomy (FA)adult central nervous system0.008627InformativeInherited
Fly Anatomy (FA)sensory organ cell0.009265InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.01069InformativeInherited
Fly Anatomy (FA)brain0.02231InformativeInherited
Fly Anatomy (FA)adult antennal lobe glomerulus0.0000003596Highly InformativeDirect
Fly Anatomy (FA)larval abdominal segment A2-70.0000003997Highly InformativeDirect
Fly Anatomy (FA)maxillary palp olfactory receptor neuron0.001607Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.1402Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1694Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.2377Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.01208Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.000002045InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.04178Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.1565Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.2437Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.9286Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9515Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.9904Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.001053Moderately InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.001236Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01902Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.2206Moderately InformativeInherited
Xenopus ANatomical entity (XAN)neuroectoderm0.0000311InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000125InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0006914InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00213InformativeInherited
Xenopus ANatomical entity (XAN)anatomical space0.02503InformativeInherited
Xenopus ANatomical entity (XAN)eye0.03437InformativeInherited
Xenopus ANatomical entity (XAN)urinary system0.1331InformativeInherited
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.000000316Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00002471Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric tubule0.00003856Highly InformativeDirect
Xenopus ANatomical entity (XAN)pronephric mesenchyme0.00004677Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00007409Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.0001686Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0005333Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a lambda repressor-like DNA-binding domains domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]