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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01963Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002089Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.134Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01674InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.278InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001172Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.4978Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.5743Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6317Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1589Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.2913Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7952Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.4995InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.6133InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2847Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002004Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001323Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002456Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002655Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3462Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6952Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0001225Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001426Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004396Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0009568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001258Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009826Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003906InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.000191InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0009109InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009093InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01694InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06128InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09205InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1009InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1307InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1393InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2162InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3931InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6394InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.8615InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003157Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001013Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0001576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.000341Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003432Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.000501Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005879Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007717Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008724Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001305Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001598Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001921Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.003758Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004563Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05743Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2296Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2996Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4373Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6855Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0000006493Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000009902Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001326Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001736Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0002197Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.000221Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.02502Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.6904Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0004426InformativeDirect
Worm Phenotype (WP)oxygen response variant0.008961InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.3066InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4734InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000004903Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00008544Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0001267Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0005388Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006436Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005181Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000000002894Moderately InformativeDirect
Fly Phenotype (FP)behavior defective0.238Moderately InformativeInherited
Fly Phenotype (FP)circadian rhythm defective0.008874InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.6307InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.0005745Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.0000005888Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000006068Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.112Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2899Least InformativeInherited
Fly Anatomy (FA)nervous system0.4428Least InformativeInherited
Fly Anatomy (FA)larva0.5932Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)region of integument0.001224Moderately InformativeInherited
Fly Anatomy (FA)thorax0.007732Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01028Moderately InformativeInherited
Fly Anatomy (FA)appendage0.02325Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.02931Moderately InformativeInherited
Fly Anatomy (FA)neuron0.03887Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.1921Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3096Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3539Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4487Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.6041Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.01497InformativeInherited
Fly Anatomy (FA)interneuron0.04953InformativeInherited
Fly Anatomy (FA)larval segment0.1025InformativeInherited
Fly Anatomy (FA)eo-type sensillum0.1362InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1832InformativeInherited
Fly Anatomy (FA)neuromere0.2224InformativeInherited
Fly Anatomy (FA)adult external head0.347InformativeInherited
Fly Anatomy (FA)sensory mother cell0.00009314Highly InformativeDirect
Fly Anatomy (FA)5-6I of thorax0.0009727Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02807Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.05535Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.2402Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5261Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8327Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.9402Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01476Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.03889Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6145Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.6887Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.004651InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.000571Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000006093Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0004504Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.02013Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9426Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00000000000001552Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000000000004496Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000001185Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.009345Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02314Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000000000001009InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00000000000001862InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00000000000003566InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000000000001488InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00000000002756InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000000001947InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000004031InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000000005775InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00000001151InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00000005215InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000005898InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000002727InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000002845InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.00006204InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.006538InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.05086InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1582InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.3124InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.4187InformativeInherited
Xenopus ANatomical entity (XAN)tail0.6153InformativeInherited
Xenopus ANatomical entity (XAN)neural tube0.0000000000008429Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000000000009865Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.00000000007218Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.000000007158Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.00000002022Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00000002263Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000002304Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000002476Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior placodal area0.00000005665Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00000005964Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00000007778Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000001839Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000005118Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000002632Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.000005382Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000006133Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.000006525Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.000009977Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00001608Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00001881Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.00005231Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.00006861Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00007413Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00009974Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0001556Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.0002624Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.0003701Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0005186Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0005384Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.002439Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.00963Highly InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.4565Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003565InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00313InformativeInherited
Plant ANatomical entity (PAN)primary root0.000356Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001021Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]