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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01961Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002087Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1338Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01673InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2781InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001169Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.0003883InformativeDirect
Mode of Inheritance (MI)Polygenic inheritance0.00004024Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.3966Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4167Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.4855Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1212Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.1931Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.8229Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.5168InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.6457InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2339Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002004Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001323Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002456Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002655Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3462Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6952Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0001225Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001426Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004396Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0009568Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001258Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009826Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03928Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05527Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1184Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2287Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6297Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8075Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9648Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003906InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.000191InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0009109InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009093InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01694InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06128InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09205InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1009InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1307InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1393InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2162InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3931InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6394InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.8615InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003157Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001013Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0001576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.000341Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003432Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.000501Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005879Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006628Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007717Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008724Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001305Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001598Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001921Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.003758Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004563Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05743Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2296Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2996Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4373Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6855Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000001994Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000006448Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001272Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001403Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.001377Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02417Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.002641Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9131Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)RNA expression variant0.0004551InformativeDirect
Worm Phenotype (WP)oxygen response variant0.008926InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.3092InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4822InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000004766Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0000826Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0001225Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0005246Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006608Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005113Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.00000000008713Moderately InformativeDirect
Fly Phenotype (FP)behavior defective0.2166Moderately InformativeInherited
Fly Phenotype (FP)circadian rhythm defective0.007747InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.6355InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.0005284Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.0000009339Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.00005755Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1699Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2809Least InformativeInherited
Fly Anatomy (FA)nervous system0.3669Least InformativeInherited
Fly Anatomy (FA)larva0.5126Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)region of integument0.001747Moderately InformativeInherited
Fly Anatomy (FA)thorax0.004998Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.01315Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01525Moderately InformativeInherited
Fly Anatomy (FA)neuron0.06348Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.06982Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.268Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.347Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.4121Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.4498Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.5425Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.008438InformativeInherited
Fly Anatomy (FA)interneuron0.03701InformativeInherited
Fly Anatomy (FA)eo-type sensillum0.0622InformativeInherited
Fly Anatomy (FA)larval segment0.07282InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1222InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.2025InformativeInherited
Fly Anatomy (FA)antennal segment0.2309InformativeInherited
Fly Anatomy (FA)adult external head0.2901InformativeInherited
Fly Anatomy (FA)neuromere0.3587InformativeInherited
Fly Anatomy (FA)sensory mother cell0.0000937Highly InformativeDirect
Fly Anatomy (FA)third segment of antenna0.0008739Highly InformativeDirect
Fly Anatomy (FA)5-6I of thorax0.0009734Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02358Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.05707Highly InformativeInherited
Fly Anatomy (FA)segment of leg0.2462Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.512Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8324Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.9415Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01445Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.03981Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.6221Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.6923Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.004992InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.000592Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000004919Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0003884Least InformativeDirect
Xenopus ANatomical entity (XAN)head0.01981Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9424Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00000000000001543Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000000000002466Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000001049Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.00926Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02231Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.3102Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000000000000004637InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00000000000001235InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00000000000003389InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.0000000000003497InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0000000000006834InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.00000000006563InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000000001439InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000000204InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000002044InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000000004175InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00000003786InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.0000002235InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000001966InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000002351InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001145InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.005699InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.03185InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1491InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.3092InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.4172InformativeInherited
Xenopus ANatomical entity (XAN)tail0.598InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.00000000001037Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.00000000001458Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.000000007428Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.000000009348Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00000001424Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000002299Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.00000002359Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000002576Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.00000004739Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior placodal area0.00000005869Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000001904Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000004923Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000002702Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordoneural hinge0.000004431Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000005239Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.000006428Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001013Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00001455Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00001634Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.00002185Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0000739Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.00009326Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.0001546Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.0001579Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0003021Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0005455Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0005527Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.009782Highly InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.4141Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003565InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00313InformativeInherited
Plant ANatomical entity (PAN)primary root0.000356Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001021Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]