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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0197Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002084Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1339Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01674InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2779InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001169Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.4209Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4869Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6222Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1172Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.2272Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.8101Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.5934InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.6328InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2752Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002016Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001315Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002439Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002614Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3459Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.694Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.000121Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001422Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004428Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0009521Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001252Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009806Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03921Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1173Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2286Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8074Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9647Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003829InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001922InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.0009039InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009076InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01707InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06126InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09248InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1009InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1307InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1393InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2163InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3938InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6396InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.8614InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003154Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001013Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0001575Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003406Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003431Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0004976Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.000586Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006604Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007688Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008689Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001302Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001593Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001911Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.003743Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004566Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05743Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2296Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2996Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4375Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6855Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00000362Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00002617Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.00005082Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00006097Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000467Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.09022Least InformativeInherited
Worm Phenotype (WP)apoptosis variant0.003192Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.03747Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.8468Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.000001115InformativeDirect
Worm Phenotype (WP)RNA expression variant0.0003537InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.0007068InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.00554InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1747InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000006698Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00009681Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0001652Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0005299Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006681Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005288Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.2667Moderately InformativeInherited
Fly Phenotype (FP)visible0.00000000003041InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.01085InformativeInherited
Fly Phenotype (FP)circadian behavior defective0.00474Highly InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.6395Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.00000001226Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000002602Least InformativeDirect
Fly Anatomy (FA)adult0.000002845Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.08923Least InformativeInherited
Fly Anatomy (FA)nervous system0.3866Least InformativeInherited
Fly Anatomy (FA)cell0.5269Least InformativeInherited
Fly Anatomy (FA)larva0.6755Least InformativeInherited
Fly Anatomy (FA)region of integument0.0003989Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.001015Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.002516Moderately InformativeInherited
Fly Anatomy (FA)appendage0.003796Moderately InformativeInherited
Fly Anatomy (FA)thorax0.007934Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04077Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.04381Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3306Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3317Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.6365Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.687Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.005079InformativeInherited
Fly Anatomy (FA)mechanosensory system0.01644InformativeInherited
Fly Anatomy (FA)interneuron0.05747InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1025InformativeInherited
Fly Anatomy (FA)head capsule0.1673InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1903InformativeInherited
Fly Anatomy (FA)adult head sensillum0.467InformativeInherited
Fly Anatomy (FA)leg0.4745InformativeInherited
Fly Anatomy (FA)sensory mother cell0.00007624Highly InformativeDirect
Fly Anatomy (FA)EL neuron0.0006163Highly InformativeDirect
Fly Anatomy (FA)tarsal segment0.01441Highly InformativeInherited
Fly Anatomy (FA)head bristle0.02841Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.07839Highly InformativeInherited
Fly Anatomy (FA)antenna0.4046Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.516Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8294Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ1Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.0182Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.03098Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5416Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.7117Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.007609InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.0005229Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000005429Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0003919Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.004327Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.007748Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.927Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.00000000000008939Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0000000000002456Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000001171Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.02078Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02292Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.000000000000001546InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00000000000007709InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00000000000008556InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000000000007128InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000000001255InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.0000000004115InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.000000002183InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000000003606InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.000000009873InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000001089InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000001353InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000007237InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0003831InformativeDirect
Xenopus ANatomical entity (XAN)neural crest0.0007935InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.01097InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.03748InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1793InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.348InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.3487InformativeInherited
Xenopus ANatomical entity (XAN)tail0.6788InformativeInherited
Xenopus ANatomical entity (XAN)neural tube0.0000000000008318Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000000000001227Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.000000001234Highly InformativeDirect
Xenopus ANatomical entity (XAN)preplacodal ectoderm0.000000004244Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000001405Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000002687Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00000002757Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000000336Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000003862Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0000001342Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000001627Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000007616Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0000009694Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.000001145Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.000006019Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.000006133Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.00000738Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.00001601Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.000018Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00002888Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.00004348Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00007038Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.00007169Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.0001028Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0001537Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0002655Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0003206Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0005322Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0006571Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.000942Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.00122Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.01098Highly InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.4151Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003565InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00313InformativeInherited
Plant ANatomical entity (PAN)primary root0.000356Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001021Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]