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HLH, helix-loop-helix DNA-binding domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Families:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Superfamily statistics
Genomes (466) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,209 65,201 13
Proteins 26,141 65,023 13


Functional annotation
General category coiled coil
Detailed category This is a complex coiled arrangement. The details of which will appear on this page shortly (some coiled coil details are being checked before they are included on the site). If you want to see examples of the states please click here here. If you require further details urgently please contact Owen Rackham

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0197Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002084Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1339Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01674InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2779InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001169Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.4014Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4592Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6136Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.1102Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skull morphology0.213Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.803Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.6076InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.6397InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2682Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002034Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001322Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00002451Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002622Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3452Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.6933Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0001209Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal muscle morphology0.0001423Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.0004438Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.000952Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.001092Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.001253Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.009811Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.03925Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05478Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1172Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.2285Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2699Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.403Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system physiology0.6298Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.8069Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9647Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00003847InformativeDirect
Mammalian Phenotype (MP)abnormal cell differentiation0.0001921InformativeDirect
Mammalian Phenotype (MP)perinatal lethality0.000904InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009085InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.01707InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.06133InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.09244InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.1008InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1307InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.1394InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.2163InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3936InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6396InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.862InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00003156Highly InformativeDirect
Mammalian Phenotype (MP)premature neuronal precursor differentiation0.0001014Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic acinus morphology0.0001576Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003406Highly InformativeDirect
Mammalian Phenotype (MP)thin retinal inner nuclear layer0.0003429Highly InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0004975Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0005867Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating estradiol level0.0006611Highly InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle regeneration0.0007695Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0008687Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circadian rhythm0.001304Highly InformativeInherited
Mammalian Phenotype (MP)abnormal telencephalon development0.001592Highly InformativeInherited
Mammalian Phenotype (MP)abnormal brain ventricle morphology0.001913Highly InformativeInherited
Mammalian Phenotype (MP)abnormal CNS glial cell morphology0.003744Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circumventricular organ morphology0.004565Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.05744Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.2295Highly InformativeInherited
Mammalian Phenotype (MP)abnormal coat/hair pigmentation0.2995Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4375Highly InformativeInherited
Mammalian Phenotype (MP)abnormal pituitary gland morphology0.6855Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0000007387Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.000005161Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001633Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0002268Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0002918Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002936Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.02823Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.0008086Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0008086Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0008143Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0008197Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0009786Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.002877Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.0275Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3565Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.6069Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.000001526InformativeDirect
Worm Phenotype (WP)RNA expression variant0.0004337InformativeDirect
Worm Phenotype (WP)oxygen response variant0.008916InformativeInherited
Worm Phenotype (WP)positive chemotaxis variant0.3003InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4739InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000004458Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.00008684Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0001325Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis defective0.0005314Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0006449Highly InformativeDirect
Worm Phenotype (WP)apoptosis reduced0.005196Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.2652Moderately InformativeInherited
Fly Phenotype (FP)visible0.00000000004017InformativeDirect
Fly Phenotype (FP)circadian behavior defective0.004022Highly InformativeInherited
Fly Phenotype (FP)locomotor behavior defective0.6406Highly InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.000006275Least InformativeDirect
Fly Anatomy (FA)adult0.00000888Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1163Least InformativeInherited
Fly Anatomy (FA)somatic cell0.319Least InformativeInherited
Fly Anatomy (FA)nervous system0.4835Least InformativeInherited
Fly Anatomy (FA)larva0.6316Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)region of integument0.0006467Moderately InformativeDirect
Fly Anatomy (FA)adult integumentary system0.001623Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.002386Moderately InformativeInherited
Fly Anatomy (FA)appendage0.003998Moderately InformativeInherited
Fly Anatomy (FA)thorax0.008326Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04819Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3232Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.365Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.6231Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.6857Moderately InformativeInherited
Fly Anatomy (FA)head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.006729InformativeInherited
Fly Anatomy (FA)mechanosensory system0.01529InformativeInherited
Fly Anatomy (FA)interneuron0.05483InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1078InformativeInherited
Fly Anatomy (FA)head capsule0.1689InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1791InformativeInherited
Fly Anatomy (FA)leg0.4822InformativeInherited
Fly Anatomy (FA)sensory mother cell0.00008998Highly InformativeDirect
Fly Anatomy (FA)EL neuron0.0006835Highly InformativeDirect
Fly Anatomy (FA)tarsal segment0.01607Highly InformativeInherited
Fly Anatomy (FA)head bristle0.02882Highly InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.0711Highly InformativeInherited
Fly Anatomy (FA)antenna0.4001Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5886Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.8326Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ1Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.03304Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.04816Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5503Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.7107Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.006261InformativeInherited
Zebrafish Anatomy (ZA)Kolmer-Agduhr neuron0.0005671Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000005604Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0004009Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.003841Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.01731Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9303Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00000000000004738Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0000000000001068Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000001293Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.008271Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01951Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000000000000918InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00000000000007712InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00000000000009161InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000001713InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000000001179InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000002587InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000001006InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.00000001933InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00000006478InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.000004146InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.000005372InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.000007356InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001659InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.01099InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.08158InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1814InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.3518InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.353InformativeInherited
Xenopus ANatomical entity (XAN)tail0.6772InformativeInherited
Xenopus ANatomical entity (XAN)neural tube0.000000000007358Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.00000000001112Highly InformativeDirect
Xenopus ANatomical entity (XAN)proliferative region0.0000000005931Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.000000009948Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000002845Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000003883Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000004695Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior placodal area0.00000007215Highly InformativeDirect
Xenopus ANatomical entity (XAN)otic vesicle0.00000008394Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0000001249Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000001629Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000002198Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0000004788Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.0000008027Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000005589Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.0000059Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000007061Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001063Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00001159Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventricular zone0.00001632Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00001843Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail tip0.00002892Highly InformativeDirect
Xenopus ANatomical entity (XAN)intermediate mesoderm0.00004021Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.00007884Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.0001056Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0001731Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.000272Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0003038Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.000519Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0005976Highly InformativeDirect
Xenopus ANatomical entity (XAN)anatomical line0.0008736Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.005228Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.01108Highly InformativeInherited
Xenopus ANatomical entity (XAN)retinal neural layer0.4884Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)flower1Least InformativeInherited
Plant ANatomical entity (PAN)collective phyllome structure1Least InformativeInherited
Plant ANatomical entity (PAN)root system1Least InformativeInherited
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure1Least InformativeInherited
Plant ANatomical entity (PAN)root epidermis0.00003565InformativeDirect
Plant ANatomical entity (PAN)portion of ground tissue0.00313InformativeInherited
Plant ANatomical entity (PAN)primary root0.000356Highly InformativeDirect
Plant ANatomical entity (PAN)style0.001021Highly InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011598 SSF47459 Protein matches
Abstract

The helix-loop-helix (HLH) DNA-binding domain consists of a closed bundle of four helices in a left-handed twist with two crossover connections. The HLH domain directs dimerisation, and is juxtaposed to basic regions to create a DNA interaction interface surface that recognises specific DNA sequences. Basic region/HLH (bHLH) proteins regulate diverse biological pathways [PubMed10710415]. bHLH proteins include MyoD [PubMed12783965], SREBPs (sterol regulatory element binding proteins) [PubMed9634703], and yeast Pho4 (phosphatase system) [PubMed9303313].

In certain proteins the bHLH domain contains a leucine-zipper motif. The bHLH/leucine zipper (bHLHZip) domain specifies dimerisation within a network of proteins and determines sequence-specific DNA binding [PubMed10378692]. bHLHZip domains occur in the transcription factors Myc, Mad, Max and Usf [PubMed12553908, PubMed8306960].

This entry is bHLHZip, which covers the bHLH domain and the leucine zipper motif, when present.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the HLH, helix-loop-helix DNA-binding domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]