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HLH, helix-loop-helix DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Family:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Family statistics
Genomes (152) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,139 4,196 13
Proteins 1,139 4,196 13


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01848Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002004Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1326Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01119InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2274InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001298Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.351Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5682Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.4823Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7496Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.226InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.5379InformativeInherited
Phenotypic Abnormality (PA)Abnormal 2nd finger morphology0.002177Highly InformativeInherited
Phenotypic Abnormality (PA)Triangular shaped phalanges of the hand0.1945Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002971Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00001499Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00003363Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002655Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.004979Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3663Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7246Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.0001881Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002201Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0006314Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.001072Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.04632Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.05657Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1123Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.32Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.3769Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.5241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.746Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7827Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9499Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.0000555InformativeDirect
Mammalian Phenotype (MP)abnormal neuron differentiation0.0006294InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0006702InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009599InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.0541InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.08382InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.08593InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.0915InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1153InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1779InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.1876InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.2119InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3628InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4021InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.5645InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6068InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.916InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00002672Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003013Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0006431Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0007618Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.0009865Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001076Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.00109Highly InformativeInherited
Mammalian Phenotype (MP)pigmentation phenotype0.02554Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neuroendocrine gland morphology0.05787Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.1922Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.1964Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diencephalon morphology0.2491Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4236Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00003028Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0004535Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0006504Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.004923Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.2223Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.0002291Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.1622Moderately InformativeInherited
Worm Phenotype (WP)organism stress response variant0.8101Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.8947Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.000001654InformativeDirect
Worm Phenotype (WP)RNA expression variant0.0003231InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.01392InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1976InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000006342Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0001148Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.00277Highly InformativeInherited
Worm Phenotype (WP)positive chemotaxis defective0.00404Highly InformativeInherited
Worm Phenotype (WP)apoptosis reduced0.00432Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0000000000766Moderately InformativeDirect
Fly Phenotype (FP)circadian rhythm defective0.01155InformativeInherited
Fly Phenotype (FP)behavior defective0.2876InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.0006778Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.00000006722Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.000004491Least InformativeDirect
Fly Anatomy (FA)adult0.000004602Least InformativeDirect
Fly Anatomy (FA)segment0.002466Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1271Least InformativeInherited
Fly Anatomy (FA)anatomical group0.2647Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2795Least InformativeInherited
Fly Anatomy (FA)nervous system0.4503Least InformativeInherited
Fly Anatomy (FA)larva0.7054Least InformativeInherited
Fly Anatomy (FA)appendage0.001956Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.02199Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.03566Moderately InformativeInherited
Fly Anatomy (FA)neuron0.04909Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.07083Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.0907Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2104Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.237Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3382Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.5628Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.6666Moderately InformativeInherited
Fly Anatomy (FA)adult head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.005868InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.009302InformativeInherited
Fly Anatomy (FA)mechanosensory system0.01591InformativeInherited
Fly Anatomy (FA)interneuron0.05069InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1128InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.1672InformativeInherited
Fly Anatomy (FA)appendage segment0.2089InformativeInherited
Fly Anatomy (FA)antennal segment0.2377InformativeInherited
Fly Anatomy (FA)adult external head0.2404InformativeInherited
Fly Anatomy (FA)neuromere0.2406InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.5044InformativeInherited
Fly Anatomy (FA)leg0.5169InformativeInherited
Fly Anatomy (FA)EL neuron0.0003334Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02063Highly InformativeInherited
Fly Anatomy (FA)larval neuromere0.02587Highly InformativeInherited
Fly Anatomy (FA)mesothoracic leg0.02604Highly InformativeInherited
Fly Anatomy (FA)metatarsus0.1208Highly InformativeInherited
Fly Anatomy (FA)macrochaeta0.2678Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4893Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7716Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ1Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01244Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.024Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.5326Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.7193Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.006091InformativeInherited
Zebrafish Anatomy (ZA)heart primordium0.0001197Highly InformativeDirect
Zebrafish Anatomy (ZA)spinal cord0.3031Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000008821Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0006991Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.004988Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.006816Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8886Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9205Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0000000000006914Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.000000000001192Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000004491Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.01673Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.02434Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.2735Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.000000000000004453InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000000000001335InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0000000000004263InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000003797InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000000003506InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000001019InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00000001912InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000002892InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.00002204InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0006365InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.01127InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.04045InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1951InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.3733InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.4342InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7213InformativeInherited
Xenopus ANatomical entity (XAN)sensorial layer of neurectoderm0.000000000002245Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.000000000004515Highly InformativeDirect
Xenopus ANatomical entity (XAN)chordal neural plate0.000000000005808Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.00000000449Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.00000004988Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.00000005735Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000006087Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000006493Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.00000008242Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000002803Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.0000004373Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000001192Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.000001747Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00000506Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00001102Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.00001423Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00001665Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00002595Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0.00003662Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.00008303Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0001114Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.0001227Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.0001282Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.0002235Highly InformativeDirect
Xenopus ANatomical entity (XAN)periocular region0.0004734Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0005541Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0006441Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0006713Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0008286Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0009348Highly InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.001877Highly InformativeInherited
Xenopus ANatomical entity (XAN)fin0.007412Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.01459Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root1Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)gynoecium1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004087InformativeInherited
Plant ANatomical entity (PAN)root epidermal cell0.0003147Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0003339Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]