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HLH, helix-loop-helix DNA-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   HLH-like [ 47458] (2)
Superfamily:   HLH, helix-loop-helix DNA-binding domain [ 47459]
Family:   HLH, helix-loop-helix DNA-binding domain [ 47460] (8)


Family statistics
Genomes (152) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,139 4,196 13
Proteins 1,139 4,196 13


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.01848Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.002004Moderately InformativeInherited
Disease Ontology (DO)disease of mental health0.1326Moderately InformativeInherited
Disease Ontology (DO)peripheral nervous system neoplasm0.01119InformativeInherited
Disease Ontology (DO)developmental disorder of mental health0.2274InformativeInherited
Disease Ontology (DO)autonomic nervous system neoplasm0.000001298Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.3345Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5616Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.0785Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7459Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.2216InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.5537InformativeInherited
Phenotypic Abnormality (PA)Abnormal 2nd finger morphology0.001901Highly InformativeInherited
Phenotypic Abnormality (PA)Triangular shaped phalanges of the hand0.1936Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.000002995Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.0000151Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.00003382Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.002664Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.004982Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.3655Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7239Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.0001884Moderately InformativeDirect
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0002198Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0006312Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal eye morphology0.001075Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.01098Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.01941Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic sensory system morphology0.04631Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.05462Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.05655Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1123Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.1587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.319Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.3769Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.5241Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.7459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.782Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.9498Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)normal phenotype0.00005571InformativeDirect
Mammalian Phenotype (MP)abnormal neuron differentiation0.0006293InformativeDirect
Mammalian Phenotype (MP)postnatal lethality0.0006698InformativeDirect
Mammalian Phenotype (MP)abnormal gas homeostasis0.009602InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.05412InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.0828InformativeInherited
Mammalian Phenotype (MP)abnormal brain development0.0859InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.09154InformativeInherited
Mammalian Phenotype (MP)abnormal neuron physiology0.1153InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.1778InformativeInherited
Mammalian Phenotype (MP)abnormal respiratory function0.1876InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.2119InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.3627InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.4021InformativeInherited
Mammalian Phenotype (MP)decreased neuron number0.5645InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.6067InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.9159InformativeInherited
Mammalian Phenotype (MP)increased sensory neuron number0.00002674Highly InformativeDirect
Mammalian Phenotype (MP)abnormal breathing pattern0.0003015Highly InformativeDirect
Mammalian Phenotype (MP)cyanosis0.0006441Highly InformativeDirect
Mammalian Phenotype (MP)abnormal amacrine cell morphology0.0007614Highly InformativeDirect
Mammalian Phenotype (MP)abnormal retinal bipolar cell morphology0.000986Highly InformativeDirect
Mammalian Phenotype (MP)abnormal telencephalon development0.001076Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.001093Highly InformativeInherited
Mammalian Phenotype (MP)pigmentation phenotype0.02555Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neuroendocrine gland morphology0.05785Highly InformativeInherited
Mammalian Phenotype (MP)abnormal rib morphology0.1908Highly InformativeInherited
Mammalian Phenotype (MP)abnormal catecholamine level0.1964Highly InformativeInherited
Mammalian Phenotype (MP)abnormal diencephalon morphology0.249Highly InformativeInherited
Mammalian Phenotype (MP)abnormal skeletal muscle fiber morphology0.4236Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.000007628Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001033Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.002552Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.002552Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.002899Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000187Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0.1091Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3434Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.5898Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9575Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.00000228InformativeDirect
Worm Phenotype (WP)RNA expression variant0.0003566InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.06266InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.4508InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.000004602Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0001025Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.0002251Highly InformativeDirect
Worm Phenotype (WP)hypoxia response variant0.0009417Highly InformativeDirect
Worm Phenotype (WP)aqueous positive chemotaxis variant0.00268Highly InformativeInherited
Worm Phenotype (WP)positive chemotaxis defective0.004079Highly InformativeInherited
Worm Phenotype (WP)apoptosis reduced0.004287Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

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YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)visible0.0000000001027Moderately InformativeDirect
Fly Phenotype (FP)behavior defective0.288InformativeInherited
Fly Phenotype (FP)locomotor rhythm defective0.0006402Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.0000002297Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.00001073Least InformativeDirect
Fly Anatomy (FA)adult0.00001387Least InformativeDirect
Fly Anatomy (FA)segment0.002496Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1613Least InformativeInherited
Fly Anatomy (FA)anatomical group0.305Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3334Least InformativeInherited
Fly Anatomy (FA)nervous system0.5509Least InformativeInherited
Fly Anatomy (FA)larva0.6675Least InformativeInherited
Fly Anatomy (FA)adult integumentary system0.0007817Moderately InformativeDirect
Fly Anatomy (FA)appendage0.002069Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.03518Moderately InformativeInherited
Fly Anatomy (FA)neuron0.05869Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.08922Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument0.1565Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.2503Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.3324Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3362Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.6527Moderately InformativeInherited
Fly Anatomy (FA)adult head1Moderately InformativeInherited
Fly Anatomy (FA)chaeta0.007583InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.009284InformativeInherited
Fly Anatomy (FA)mechanosensory system0.0153InformativeInherited
Fly Anatomy (FA)interneuron0.0481InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1203InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.156InformativeInherited
Fly Anatomy (FA)appendage segment0.2141InformativeInherited
Fly Anatomy (FA)antennal segment0.2433InformativeInherited
Fly Anatomy (FA)adult external head0.2447InformativeInherited
Fly Anatomy (FA)adult head sensillum0.4831InformativeInherited
Fly Anatomy (FA)leg0.5241InformativeInherited
Fly Anatomy (FA)EL neuron0.0003653Highly InformativeDirect
Fly Anatomy (FA)head bristle0.02077Highly InformativeInherited
Fly Anatomy (FA)mesothoracic leg0.02673Highly InformativeInherited
Fly Anatomy (FA)metatarsus0.1214Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.5693Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7796Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ1Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.02339Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.03691Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.539Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.7301Moderately InformativeInherited
Zebrafish Anatomy (ZA)neuron0.004772InformativeInherited
Zebrafish Anatomy (ZA)heart primordium0.00007709Highly InformativeDirect
Zebrafish Anatomy (ZA)spinal cord0.2918Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.000009196Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0.0007177Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0.004379Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.01527Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.8935Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.9243Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system1Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.0000000000002462Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0000000000008132Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.000004958Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.006465Moderately InformativeInherited
Xenopus ANatomical entity (XAN)brain0.01971Moderately InformativeInherited
Xenopus ANatomical entity (XAN)tail region0.4404Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Moderately InformativeInherited
Xenopus ANatomical entity (XAN)anatomical direction0InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.000000000000004966InformativeDirect
Xenopus ANatomical entity (XAN)spinal cord0.00000000000007935InformativeDirect
Xenopus ANatomical entity (XAN)eye0.0000000000004436InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00000000003631InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.00000000008775InformativeDirect
Xenopus ANatomical entity (XAN)anatomical space0.0000000003349InformativeDirect
Xenopus ANatomical entity (XAN)epithelium0.000000005972InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.00000002945InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.0000002905InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0000224InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0002888InformativeDirect
Xenopus ANatomical entity (XAN)primordium0.0009794InformativeDirect
Xenopus ANatomical entity (XAN)urinary system0.0113InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.08687InformativeInherited
Xenopus ANatomical entity (XAN)dermal system0.1974InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.377InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.438InformativeInherited
Xenopus ANatomical entity (XAN)tail0.7211InformativeInherited
Xenopus ANatomical entity (XAN)chordal neural plate0.0000000000478Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural plate border0.00000003255Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.00000006473Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00000006509Highly InformativeDirect
Xenopus ANatomical entity (XAN)hindbrain0.000000152Highly InformativeDirect
Xenopus ANatomical entity (XAN)somite0.0000002462Highly InformativeDirect
Xenopus ANatomical entity (XAN)intersomitic region0.0000002798Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural fold0.0000004952Highly InformativeDirect
Xenopus ANatomical entity (XAN)midbrain0.000001435Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.000006536Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.00001358Highly InformativeDirect
Xenopus ANatomical entity (XAN)forebrain0.00001407Highly InformativeDirect
Xenopus ANatomical entity (XAN)anterior neural ridge0.00001492Highly InformativeDirect
Xenopus ANatomical entity (XAN)circulatory system0.00001633Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.00002093Highly InformativeDirect
Xenopus ANatomical entity (XAN)neural groove0.00002664Highly InformativeDirect
Xenopus ANatomical entity (XAN)trunk musculature0.00003578Highly InformativeDirect
Xenopus ANatomical entity (XAN)presumptive midbrain-hindbrain boundary0.0001247Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic field0.000126Highly InformativeDirect
Xenopus ANatomical entity (XAN)ventral blood island0.000128Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.000251Highly InformativeDirect
Xenopus ANatomical entity (XAN)olfactory system0.0003027Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0005383Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0006263Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.0006832Highly InformativeDirect
Xenopus ANatomical entity (XAN)involuted dorsal mesoderm0.0008073Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00646Highly InformativeInherited
Xenopus ANatomical entity (XAN)fin0.008396Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial neural crest0.01468Highly InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)root1Least InformativeInherited
Plant ANatomical entity (PAN)megasporophyll1Least InformativeInherited
Plant ANatomical entity (PAN)gynoecium1Least InformativeInherited
Plant ANatomical entity (PAN)portion of ground tissue0.004087InformativeInherited
Plant ANatomical entity (PAN)root epidermal cell0.0003147Highly InformativeDirect
Plant ANatomical entity (PAN)primary root0.0003339Highly InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a HLH, helix-loop-helix DNA-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]