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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.07313Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.09428Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.116Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02992Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.0544Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.05478Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.07389Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.5034Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0002091InformativeDirect
Phenotypic Abnormality (PA)Flexion contracture0.1056InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2084InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the shoulder girdle musculature0.5383InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00002797Highly InformativeDirect
Phenotypic Abnormality (PA)Scapular winging0.0004781Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0007251Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0007891Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1193Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5378Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02415Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3973Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4631Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7022Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7825Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1093InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3182InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3479InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6739InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002203Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1488Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2537Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00000003255Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00009418Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000229Least InformativeDirect
Worm Phenotype (WP)cell development variant0.06296Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.001954Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.07336Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2353Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.438Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.000001092InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001715InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0004875InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.001273InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.005599InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.02052InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04956InformativeInherited
Worm Phenotype (WP)cell component localization variant0.05756InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6889InformativeInherited
Worm Phenotype (WP)reduced brood size0.0000004123Highly InformativeDirect
Worm Phenotype (WP)actin organization biogenesis variant0.000001828Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.000003427Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0002172Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003907Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.007272Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.1813Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.1129Least InformativeInherited
Fly Anatomy (FA)adult0.1131Least InformativeInherited
Fly Anatomy (FA)cell0.2354Least InformativeInherited
Fly Anatomy (FA)adult segment0.08225Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.1083Moderately InformativeInherited
Fly Anatomy (FA)thorax0.6884Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.00414InformativeInherited
Fly Anatomy (FA)muscle system0.006856InformativeInherited
Fly Anatomy (FA)flight muscle0.0006687Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000006503Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]