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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0.1498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.167Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.2037Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.02005Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1198Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal muscle morphology0.2452Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.2479Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0001859InformativeDirect
Phenotypic Abnormality (PA)Abnormal tendon morphology0.05827InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.201InformativeInherited
Phenotypic Abnormality (PA)Abnormality of joint mobility0.4898InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00002945Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0006069Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1193Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5378Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3978Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4628Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7019Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7831Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1088InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3187InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3478InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6725InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001607Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002205Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008021Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1497Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2523Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00000002627Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0000904Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00009089Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0006804Least InformativeDirect
Worm Phenotype (WP)cell development variant0.06188Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.004895Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2185Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.5301Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000007317InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001596InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002577InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.001059InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.004569InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.05118InformativeInherited
Worm Phenotype (WP)cell component localization variant0.05537InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6921InformativeInherited
Worm Phenotype (WP)cleavage furrow defective0.000003552Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.0001673Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003332Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.000398Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.003176Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.1849Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0.0669Least InformativeInherited
Fly Anatomy (FA)adult0.06708Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.1693Moderately InformativeInherited
Fly Anatomy (FA)thorax0.6861Moderately InformativeInherited
Fly Anatomy (FA)muscle system0.002395InformativeInherited
Fly Anatomy (FA)syncytium0.002912InformativeInherited
Fly Anatomy (FA)flight muscle0.0003449Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000006464Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]