SUPERFAMILY 1.75 HMM library and genome assignments server

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Calponin-homology domain, CH-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CH domain-like [ 47575] (3)
Superfamily:   Calponin-homology domain, CH-domain [ 47576]
Families:   Calponin-homology domain, CH-domain [ 47577] (9)


Superfamily statistics
Genomes (509) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 12,940 39,216 21
Proteins 12,673 38,606 21


Functional annotation
General category General
Detailed category General

Document:
Function annotation of SCOP domain superfamilies

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.06808Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.08972Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.1101Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of connective tissue0.0291Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.05146Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.07916Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal physiology0.502Moderately InformativeInherited
Phenotypic Abnormality (PA)Lipodystrophy0.0002214InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the limbs0.05712InformativeInherited
Phenotypic Abnormality (PA)Flexion contracture0.1089InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2016InformativeInherited
Phenotypic Abnormality (PA)Decreased cervical spine flexion due to contractures of posterior cervical muscles0.00002903Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the musculature of the lower limbs0.0006871Highly InformativeDirect
Phenotypic Abnormality (PA)Contractures of the joints of the lower limbs0.0007642Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.1191Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5374Least InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.02416Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.1102Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.3969Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.4624Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.7031Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.7829Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell morphology0.1088InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.3188InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.3478InformativeInherited
Mammalian Phenotype (MP)increased leukocyte cell number0.6734InformativeInherited
Mammalian Phenotype (MP)abnormal exercise endurance0.0001407Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T1 B cell morphology0.0001608Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage T2 B cell morphology0.0002204Highly InformativeDirect
Mammalian Phenotype (MP)intestinal ulcer0.0008006Highly InformativeDirect
Mammalian Phenotype (MP)decreased immature B cell number0.1496Highly InformativeInherited
Mammalian Phenotype (MP)increased B cell number0.2523Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell morphology variant0.00000002408Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0001167Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0001174Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.0001857Least InformativeDirect
Worm Phenotype (WP)cell development variant0.06384Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.005472Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.04954Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.241Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.5266Moderately InformativeInherited
Worm Phenotype (WP)brood size variant0.0000008537InformativeDirect
Worm Phenotype (WP)cytokinesis variant emb0.0001574InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.0002482InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.001055InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.00538InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.05015InformativeInherited
Worm Phenotype (WP)cell component localization variant0.05786InformativeInherited
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.6813InformativeInherited
Worm Phenotype (WP)reduced brood size0.0000003233Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective0.000003217Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000168Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003536Highly InformativeDirect
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.0004475Highly InformativeDirect
Worm Phenotype (WP)cytokinesis defective early emb0.002791Highly InformativeInherited
Worm Phenotype (WP)body wall muscle thick filament variant0.1818Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.05947Least InformativeInherited
Fly Anatomy (FA)somatic cell0.07319Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)adult segment0.08182Moderately InformativeInherited
Fly Anatomy (FA)thorax0.6925Moderately InformativeInherited
Fly Anatomy (FA)syncytium0.00352InformativeInherited
Fly Anatomy (FA)muscle cell0.007212InformativeInherited
Fly Anatomy (FA)flight muscle0.000473Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.000000000000006472Least InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Calponin-homology domain, CH-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Calponin-homology domain, CH-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]