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Domain of poly(ADP-ribose) polymerase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Domain of poly(ADP-ribose) polymerase [ 47586]
Superfamily:   Domain of poly(ADP-ribose) polymerase [ 47587]
Families:   Domain of poly(ADP-ribose) polymerase [ 47588]


Superfamily statistics
Genomes (359) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,004 2,316 5
Proteins 996 2,301 5


Functional annotation
General category Information
Detailed category Transcription

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.0000000000002738 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.0000000004466 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 0.000000000616 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.000000002287 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000000004031 Least Informative Direct
Biological Process (BP) response to stimulus 0.00000001911 Least Informative Direct
Biological Process (BP) biosynthetic process 0.00003876 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0002889 Least Informative Direct
Biological Process (BP) biological regulation 0.003479 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.5244 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.2995 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.09732 Least Informative Inherited
Biological Process (BP) cellular response to stress 0 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0000000000001264 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000000007696 Moderately Informative Direct
Biological Process (BP) nucleoside phosphate metabolic process 0.00000001008 Moderately Informative Direct
Biological Process (BP) cellular macromolecule biosynthetic process 0.00000001222 Moderately Informative Direct
Biological Process (BP) purine-containing compound metabolic process 0.00006936 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.00008509 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.0002941 Moderately Informative Direct
Biological Process (BP) organelle organization 0.02142 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.01403 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.4663 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.01577 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.03388 Moderately Informative Inherited
Biological Process (BP) DNA metabolic process 0.0000000000002694 Informative Direct
Biological Process (BP) ATP metabolic process 0.000000000002314 Informative Direct
Biological Process (BP) cell death 0.00000003631 Informative Direct
Biological Process (BP) cellular response to oxygen-containing compound 0.000007442 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.00003758 Informative Direct
Biological Process (BP) chromosome organization 0.00005657 Informative Direct
Biological Process (BP) regulation of system process 0.0002292 Informative Direct
Biological Process (BP) response to oxidative stress 0.001637 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.002783 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02385 Informative Inherited
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) macromolecule glycosylation 0 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.00000009098 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.0000006691 Highly Informative Direct
Biological Process (BP) cellular response to reactive oxygen species 0.000001026 Highly Informative Direct
Biological Process (BP) regulation of membrane potential 0.000002103 Highly Informative Direct
Biological Process (BP) response to hydrogen peroxide 0.00002704 Highly Informative Direct
Molecular Function (MF) transferase activity 0.000000000005093 Least Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) transferase activity, transferring pentosyl groups 0 Highly Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.0000001249 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.0002316 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.959 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.009755 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.2267 Moderately Informative Inherited
Cellular Component (CC) chromosome 0.0197 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processDNA damage0.0000001619Moderately InformativeDirect
Biological processDNA repair0.0000001245InformativeDirect
Cellular componentNucleus0Least InformativeDirect
DomainRepeat0.0000000246Least InformativeDirect
DomainZinc-finger0.00000000001361Moderately InformativeDirect
Molecular functionZinc0.000007726Least InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationADP-ribosylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR004102 SSF47587 Protein matches
Abstract

Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The regulatory domain of the polymerase is almost always associated with the C-terminal catalytic domain (see ).

This domain consists of a duplication of two helix-loop-helix structural repeats [PubMed9521710].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Domain of poly(ADP-ribose) polymerase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Domain of poly(ADP-ribose) polymerase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]