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STAT superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   STAT [ 47655]
Families:   STAT [ 47656] (3)


Superfamily statistics
Genomes (166) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 718 2,193 3
Proteins 708 2,168 3


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0923Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.0000818Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001714Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002688Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01722Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01809Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7662Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001194InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.00001934InformativeDirect
Disease Ontology (DO)asthma0.0001207InformativeDirect
Disease Ontology (DO)nephritis0.0003573InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1328InformativeInherited
Disease Ontology (DO)viral infectious disease0.2692InformativeInherited
Disease Ontology (DO)mumps0.00000000403Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001621Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001058Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001116Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06015Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1531Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.04186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.05038Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.06341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.3629Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.0003297InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.0005305InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.002021InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.0026InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01389InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.01724InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.03533InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.06484InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.00002994Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0001364Highly InformativeDirect
Phenotypic Abnormality (PA)Vertigo0.000196Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombocytopenia0.0002518Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.000435Highly InformativeDirect
Phenotypic Abnormality (PA)Gangrene0.0004556Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0004851Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.02164Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07361Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1053Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001725Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006627Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008913Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001816Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.005102Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03101Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.03702Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.04046Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.04575Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1732Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4357Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7132Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004251InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000008548InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001322InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003321InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000003814InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003424InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00006357InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001337InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002423InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.0003291InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003413InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0008736InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001121InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001145InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.00237InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.009418InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.009898InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.01065InformativeInherited
Mammalian Phenotype (MP)abnormal T cell differentiation0.01329InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04314InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05122InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05164InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.05164InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1363InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1451InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1656InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2318InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2471InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3237InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3297InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.3703InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000002778Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001533Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001552Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.000000181Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.00000108Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001598Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005291Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005953Highly InformativeDirect
Mammalian Phenotype (MP)decreased mean corpuscular hemoglobin0.000007492Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002108Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.0000312Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00007858Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0001041Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001345Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.000161Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002343Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002862Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004463Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.000527Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.0006794Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002511Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08474Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR015988 SSF47655 Protein matches
Abstract

This entry represents a domain consisting of four long helices that forms a bundle with a left-handed twist (coiled coil), in a right-handed superhelix.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a STAT domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the STAT superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]