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t-snare proteins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   STAT-like [ 47654] (6)
Superfamily:   t-snare proteins [ 47661]
Families:   t-snare proteins [ 47662] (5)


Superfamily statistics
Genomes (550) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 6,451 14,887 13
Proteins 6,420 14,817 13


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details) Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.00000000000009681 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0000009222 Least Informative Direct
Biological Process (BP) biological regulation 0.1567 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.000000003037 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.00008714 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0002863 Moderately Informative Direct
Biological Process (BP) cell communication 0.000738 Moderately Informative Direct
Biological Process (BP) organelle organization 0.0008647 Moderately Informative Direct
Biological Process (BP) reproduction 0.1407 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.5739 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7856 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.7805 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.3096 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.9271 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.008643 Moderately Informative Inherited
Biological Process (BP) intracellular transport 0 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) secretion by cell 0 Informative Direct
Biological Process (BP) single-organism membrane organization 0 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00009815 Informative Direct
Biological Process (BP) positive regulation of transport 0.0004872 Informative Direct
Biological Process (BP) organelle localization 0.0008903 Informative Direct
Biological Process (BP) single organism reproductive process 0.1622 Informative Inherited
Biological Process (BP) cell cycle process 0.1932 Informative Inherited
Biological Process (BP) protein localization to organelle 1 Informative Inherited
Biological Process (BP) regulation of secretion 0.002673 Informative Inherited
Biological Process (BP) vesicle organization 0 Highly Informative Direct
Biological Process (BP) cell-cell signaling 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 0 Highly Informative Direct
Biological Process (BP) organelle fusion 0 Highly Informative Direct
Biological Process (BP) autophagy 0.0000000000002407 Highly Informative Direct
Biological Process (BP) single-organism membrane fusion 0.000000000001676 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.00000002441 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.0000000844 Highly Informative Direct
Biological Process (BP) establishment of organelle localization 0.0000001974 Highly Informative Direct
Biological Process (BP) cellular component disassembly 0.00000353 Highly Informative Direct
Biological Process (BP) positive regulation of secretion by cell 0.00001395 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0003303 Highly Informative Direct
Biological Process (BP) meiotic cell cycle 0.002652 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000001233 Least Informative Direct
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) protein complex 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000001859 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.01124 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9398 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.000000000000005967 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.00000006591 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.00003706 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0822 Moderately Informative Inherited
Cellular Component (CC) intrinsic component of membrane 1 Moderately Informative Inherited
Cellular Component (CC) cytosolic part 0.1819 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) vacuolar part 0.00000000005217 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0.00001991 Informative Direct
Cellular Component (CC) endosome 0.00006285 Informative Direct
Cellular Component (CC) plasma membrane bounded cell projection part 0.06647 Informative Inherited
Cellular Component (CC) neuron projection 0.06719 Informative Inherited
Cellular Component (CC) transporter complex 0.1337 Informative Inherited
Cellular Component (CC) SNARE complex 0 Highly Informative Direct
Cellular Component (CC) Golgi subcompartment 0.00000001123 Highly Informative Direct
Cellular Component (CC) endoplasmic reticulum-Golgi intermediate compartment 0.0000000941 Highly Informative Direct
Cellular Component (CC) presynapse 0.00004137 Highly Informative Direct
Cellular Component (CC) intrinsic component of organelle membrane 0.0001676 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0003086 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 1 Highly Informative Inherited
Cellular Component (CC) exocytic vesicle 0.02739 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processAutophagy0.00000113InformativeDirect
Biological processNeurotransmitter transport0Highly InformativeDirect
Biological processExocytosis0.000000001916Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000000000007587Moderately InformativeDirect
Cellular componentCell junction0.00003422Moderately InformativeDirect
Cellular componentSynapse0.00000002388InformativeDirect
Cellular componentLysosome0.00001441InformativeDirect
Cellular componentSynaptosome0.0002942Highly InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Post-translational modificationAcetylation9.634e-16Least InformativeDirect
Post-translational modificationPhosphoprotein0.0000004416Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR010989 SSF47661 Protein matches
Abstract

Soluble N-ethylmaleimide attachment protein receptor (SNARE) proteins are a family of membrane-associated proteins characterised by an alpha-helical coiled-coil domain called the SNARE motif [PubMed12827282]. These proteins are classified as v-SNAREs and t-SNAREs based on their localisation on vesicle or target membrane; another classification scheme defines R-SNAREs and Q-SNAREs, as based on the conserved arginine or glutamine residue in the centre of the SNARE motif. SNAREs are localised to distinct membrane compartments of the secretory and endocytic trafficking pathways, and contribute to the specificity of intracellular membrane fusion processes.

The t-SNARE domain consists of a 4-helical bundle with a coiled-coil twist. The SNARE motif contributes to the fusion of two membranes. SNARE motifs fall into four classes: homologues of syntaxin 1a (t-SNARE), VAMP-2 (v-SNARE), and the N- and C-terminal SNARE motifs of SNAP-25. It is thought that one member from each class interacts to form a SNARE complex.

The SNARE motif represented in this entry is found in the N-terminal domains of certain syntaxin family members: syntaxin 1a, which is required for neurotransmitter release[PubMed10913252], syntaxin 6, which is found in endosomal transport vesicles [PubMed12082176], yeast Sso1p [PubMed11839791], and Vam3p, a yeast syntaxin essential for vacuolar fusion [PubMed11224573]. The SNARE motifs in these proteins share structural similarity, despite having a low level of sequence similarity.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 6 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a t-snare proteins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 6 hidden Markov models representing the t-snare proteins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]