SUPERFAMILY 1.75 HMM library and genome assignments server

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CO dehydrogenase ISP C-domain like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   CO dehydrogenase ISP C-domain like [ 47740]
Superfamily:   CO dehydrogenase ISP C-domain like [ 47741]
Families:   CO dehydrogenase ISP C-domain like [ 47742] (6)


Superfamily statistics
Genomes (1,393) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,454 28,730 10
Proteins 4,429 28,653 10


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0002462 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.8422 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.5717 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.01039 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.6322 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6637 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) purine-containing compound metabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.000000002245 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.000005744 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.01062 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.001888 Moderately Informative Inherited
Biological Process (BP) purine-containing compound catabolic process 0 Highly Informative Direct
Biological Process (BP) nucleobase metabolic process 0 Highly Informative Direct
Molecular Function (MF) binding 0.0007198 Least Informative Direct
Molecular Function (MF) oxidoreductase activity 0 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) metal ion binding 0.00000000000000397 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000001936 Moderately Informative Direct
Molecular Function (MF) coenzyme binding 0 Informative Direct
Molecular Function (MF) protein dimerization activity 0.000000000000001615 Informative Direct
Molecular Function (MF) identical protein binding 0.00000000000001826 Informative Direct
Molecular Function (MF) iron-sulfur cluster binding 0 Highly Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on the aldehyde or oxo group of donors 0 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0 Highly Informative Direct
Molecular Function (MF) iron ion binding 0.000000000001864 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.003681 Least Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the aldehyde or oxo group of donors0.00000001062Moderately InformativeDirect
Enzyme Commission (EC)Acting on CH or CH(2) groups7.054e-16InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor0Highly InformativeDirect
Enzyme Commission (EC)With oxygen as acceptor0.0000000001187Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Biological processAuxin biosynthesis0Highly InformativeDirect
Cellular componentPeroxisome0InformativeDirect
Molecular functionMetal-binding0Least InformativeDirect
Molecular functionIron0Moderately InformativeDirect
Molecular functionIron-sulfur0Moderately InformativeDirect
Molecular functionNAD0Moderately InformativeDirect
Molecular functionFlavoprotein0Moderately InformativeDirect
Molecular functionFAD0InformativeDirect
Molecular function2Fe-2S0InformativeDirect
Molecular functionMolybdenum0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR002888 SSF47741 Protein matches
Abstract The [2Fe-2S] binding domain is found in a range of enzymes including dehydrogenases, oxidases and oxidoreductases.

The aldehyde oxido-reductase (Mop) from the sulphate reducing anaerobic Gram-negative bacterium Desulfovibrio gigas is a homodimer of 907 amino acid residues subunits and is a member of the xanthine oxidase family. The protein contains a molybdopterin cofactor (Mo-co) and two different [2Fe-2S] centres. It is folded into four domains of which the first two bind the iron sulphur centres and the last two are involved in Mo-co binding. Mo-co is a molybdenum molybdopterin cytosine dinucleotide. Molybdopterin forms a tricyclic system with the pterin bicycle annealed to a pyran ring. The molybdopterin dinucleotide is deeply buried in the protein. The cis-dithiolene group of the pyran ring binds the molybdenum, which is coordinated by three more (oxygen) ligands [PubMed7502041].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a CO dehydrogenase ISP C-domain like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the CO dehydrogenase ISP C-domain like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]