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Cyclin-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cyclin-like [ 47953]
Superfamily:   Cyclin-like [ 47954] (3)
Families:   Cyclin [ 47955] (8)
  Transcription factor IIB (TFIIB), core domain [ 47965]
  Retinoblastoma tumor suppressor domains [ 47969]


Superfamily statistics
Genomes (726) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 26,119 74,787 69
Proteins 16,157 45,966 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.03966Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.007359Moderately InformativeInherited
Disease Ontology (DO)respiratory system cancer0.007272InformativeInherited
Disease Ontology (DO)retinal cell cancer0.000000004342Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.000008179Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the head0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.00004181Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.03738Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.2352Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.239Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4876Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.8601Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.002618Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.002705Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.0347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.04734Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.08504Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.1283Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1365Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1861Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system physiology0.1981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2631Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.2939Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.4997Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.5757Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.7617Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal somatic nervous system morphology0.7944Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cerebellum morphology0.003444InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.003535InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal growth/weight/body size0.01251InformativeInherited
Mammalian Phenotype (MP)abnormal retinal neuronal layer morphology0.02001InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.03055InformativeInherited
Mammalian Phenotype (MP)abnormal urine homeostasis0.04769InformativeInherited
Mammalian Phenotype (MP)abnormal eye physiology0.1301InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.289InformativeInherited
Mammalian Phenotype (MP)abnormal sensory neuron morphology0.4644InformativeInherited
Mammalian Phenotype (MP)abnormal neuron number0.564InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic stem cell morphology0.0003411Highly InformativeDirect
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.0006139Highly InformativeDirect
Mammalian Phenotype (MP)increased urinary system tumor incidence0.0008001Highly InformativeDirect
Mammalian Phenotype (MP)abnormal myeloid cell number0.007737Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryo size0.009499Highly InformativeInherited
Mammalian Phenotype (MP)abnormal retinal ganglion cell morphology0.01274Highly InformativeInherited
Mammalian Phenotype (MP)decreased sensory neuron number0.01759Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fibroblast proliferation0.07768Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)blast cell physiology variant0.0002788Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.0002802Least InformativeDirect
Worm Phenotype (WP)developmental timing variant0.0451Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.1249Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.1464Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.000203Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0005626Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0005626Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0005665Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0005705Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.00067Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.0122Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.02256Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.09535Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.1148Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.182Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.2539Moderately InformativeInherited
Worm Phenotype (WP)pigmentation variant0.0001027InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0006741InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.0006838InformativeDirect
Worm Phenotype (WP)nuclear appearance variant0.001805InformativeInherited
Worm Phenotype (WP)chromosome segregation variant0.005084InformativeInherited
Worm Phenotype (WP)protein modification variant0.09591InformativeInherited
Worm Phenotype (WP)cell number increased0.7312InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.8781InformativeInherited
Worm Phenotype (WP)nuclear number variant0.00000005429Highly InformativeDirect
Worm Phenotype (WP)cytoplasmic appearance variant0.0002795Highly InformativeDirect
Worm Phenotype (WP)division axis defective0.0003619Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0003707Highly InformativeDirect
Worm Phenotype (WP)general pace of development defective early emb0.0006587Highly InformativeDirect
Worm Phenotype (WP)slow development0.000752Highly InformativeDirect
Worm Phenotype (WP)nuclear appearance number defective early emb0.004809Highly InformativeInherited
Worm Phenotype (WP)nucleus defective early emb0.004809Highly InformativeInherited
Worm Phenotype (WP)pronucleus centrosomes defective early emb0.004809Highly InformativeInherited
Worm Phenotype (WP)pronuclear morphology defective early emb0.004809Highly InformativeInherited
Worm Phenotype (WP)pronuclear nuclear appearance defective early emb0.005421Highly InformativeInherited
Worm Phenotype (WP)nuclear morphology variation early emb0.006285Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.09924Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.000461InformativeDirect
Yeast Phenotype (YP)budding0.02309Highly InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.0009815InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.0000626Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)germline cell0.08564InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.3347Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.3695Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6458Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.01901Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.5727Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.1372InformativeInherited
Zebrafish Anatomy (ZA)cranial nerve II0.0004219Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)urogenital system0.009612Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.009702Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.02561Least InformativeInherited
Xenopus ANatomical entity (XAN)germ cell0.0005204Moderately InformativeDirect
Xenopus ANatomical entity (XAN)ectoderm0.3686Moderately InformativeInherited
Xenopus ANatomical entity (XAN)animal hemisphere0.002902InformativeInherited
Xenopus ANatomical entity (XAN)animal pole0.0002937Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.5988Least InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups0.000000002732Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000235Moderately InformativeDirect
Enzyme Commission (EC)Histone acetyltransferase0.00000007148InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.00000664InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR011028 SSF47954 Protein matches
Abstract

This domain is also found as the core domain in transcription factor IIB (TFIIB) and in the retinoblastoma tumour suppressor.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 29 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Cyclin-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 29 hidden Markov models representing the Cyclin-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]