SUPERFAMILY 1.75 HMM library and genome assignments server

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DBL homology domain (DH-domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   DBL homology domain (DH-domain) [ 48064]
Superfamily:   DBL homology domain (DH-domain) [ 48065]
Family:   DBL homology domain (DH-domain) [ 48066] (10)


Family statistics
Genomes (289) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,844 15,876 16
Proteins 4,666 15,301 16


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.4321Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.5771Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.7118Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.7858Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.01364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07121Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.1182Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1221Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.1792Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2124Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.2984Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.3551Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.4614Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.5489Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.6432Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6572Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.7186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell proliferation0.003349InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.08294InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.1882InformativeInherited
Mammalian Phenotype (MP)abnormal intestine morphology0.2297InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.2383InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.2778InformativeInherited
Mammalian Phenotype (MP)increased lymphocyte cell number0.5095InformativeInherited
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.0001199Highly InformativeDirect
Mammalian Phenotype (MP)decreased B cell proliferation0.0004124Highly InformativeDirect
Mammalian Phenotype (MP)abnormal transitional stage B cell morphology0.0007825Highly InformativeDirect
Mammalian Phenotype (MP)gastrointestinal ulcer0.001416Highly InformativeInherited
Mammalian Phenotype (MP)increased immature B cell number0.005586Highly InformativeInherited
Mammalian Phenotype (MP)abnormal anterior uvea morphology0.02258Highly InformativeInherited
Mammalian Phenotype (MP)decreased immature B cell number0.02737Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.0716Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intestinal mucosa morphology0.09788Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.00001088Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.01172Least InformativeInherited
Worm Phenotype (WP)blast cell physiology variant0.01172Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.0232Least InformativeInherited
Worm Phenotype (WP)body region morphology variant0.0000001198Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0000001198Moderately InformativeDirect
Worm Phenotype (WP)developmental morphology variant0.0000001212Moderately InformativeDirect
Worm Phenotype (WP)adult body morphology variant0.0000001228Moderately InformativeDirect
Worm Phenotype (WP)body morphology variant0.0000001478Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.1916Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.9099Moderately InformativeInherited
Worm Phenotype (WP)tail morphology variant0.00000000000001835InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.00006949InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00016InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.0007891InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.008893InformativeInherited
Worm Phenotype (WP)cell component localization variant0.01106InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.01542InformativeInherited
Worm Phenotype (WP)pathogen resistance increased0Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.000397Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.4805Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.8356Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.3543Moderately InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.4006Moderately InformativeInherited
Zebrafish Anatomy (ZA)vasculature0.2732InformativeInherited
Zebrafish Anatomy (ZA)endothelial cell0.005636Highly InformativeInherited
Zebrafish Anatomy (ZA)epithelial cell0.04235Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 12 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a DBL homology domain (DH-domain) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]