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Transcription factor STAT-4 N-domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Transcription factor STAT-4 N-domain [ 48091]
Superfamily:   Transcription factor STAT-4 N-domain [ 48092]
Families:   Transcription factor STAT-4 N-domain [ 48093]


Superfamily statistics
Genomes (125) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 639 1,854 1
Proteins 639 1,840 1


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0923Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.0000818Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.001714Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.002688Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.01722Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.01809Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.7662Moderately InformativeInherited
Disease Ontology (DO)inflammatory bowel disease0.000001194InformativeDirect
Disease Ontology (DO)head and neck carcinoma0.00001934InformativeDirect
Disease Ontology (DO)asthma0.0001207InformativeDirect
Disease Ontology (DO)nephritis0.0003573InformativeDirect
Disease Ontology (DO)myeloid leukemia0.1328InformativeInherited
Disease Ontology (DO)viral infectious disease0.2692InformativeInherited
Disease Ontology (DO)mumps0.00000000403Highly InformativeDirect
Disease Ontology (DO)colitis0.0000001621Highly InformativeDirect
Disease Ontology (DO)Sjogren's syndrome0.00001058Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.00001116Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.06006Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.06407Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.1529Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.04174Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.05024Moderately InformativeInherited
Phenotypic Abnormality (PA)Growth abnormality0.06348Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1606Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.363Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal urine cytology0.0003298InformativeDirect
Phenotypic Abnormality (PA)Abnormal thrombocyte morphology0.0005308InformativeDirect
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.002023InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral mucosa morphology0.002602InformativeInherited
Phenotypic Abnormality (PA)Abnormality of temperature regulation0.01394InformativeInherited
Phenotypic Abnormality (PA)Constitutional symptom0.01716InformativeInherited
Phenotypic Abnormality (PA)Decreased body weight0.03535InformativeInherited
Phenotypic Abnormality (PA)Functional abnormality of the inner ear0.0649InformativeInherited
Phenotypic Abnormality (PA)Leukopenia0.00002996Highly InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0001365Highly InformativeDirect
Phenotypic Abnormality (PA)Vertigo0.000196Highly InformativeDirect
Phenotypic Abnormality (PA)Thrombocytopenia0.0002518Highly InformativeDirect
Phenotypic Abnormality (PA)Neutropenia0.0004353Highly InformativeDirect
Phenotypic Abnormality (PA)Gangrene0.0004578Highly InformativeDirect
Phenotypic Abnormality (PA)Fatigue0.0004855Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)abnormal homeostasis0.02163Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.07362Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.1053Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal protein level0.00001715Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.0006631Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008915Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cell death0.001816Moderately InformativeInherited
Mammalian Phenotype (MP)integument phenotype0.005105Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02364Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.03103Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.0369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.04047Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0458Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.1731Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.3418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.4363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.7127Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.000000004254InformativeDirect
Mammalian Phenotype (MP)abnormal circulating cytokine level0.000000008562InformativeDirect
Mammalian Phenotype (MP)abnormal interleukin secretion0.0000001324InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland morphology0.0000003331InformativeDirect
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.0000003826InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.00000343InformativeDirect
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.00006368InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.0001338InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0002425InformativeDirect
Mammalian Phenotype (MP)abnormal circulating leptin level0.000329InformativeDirect
Mammalian Phenotype (MP)decreased cell proliferation0.0003412InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0008738InformativeDirect
Mammalian Phenotype (MP)increased body weight0.001121InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.001145InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.002369InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.009425InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.009894InformativeInherited
Mammalian Phenotype (MP)abnormal lean body mass0.01065InformativeInherited
Mammalian Phenotype (MP)abnormal consumption behavior0.04319InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.05122InformativeInherited
Mammalian Phenotype (MP)abnormal pancreas morphology0.05164InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.05168InformativeInherited
Mammalian Phenotype (MP)abnormal triglyceride level0.1362InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.1458InformativeInherited
Mammalian Phenotype (MP)abnormal circulating lipid level0.1657InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.2317InformativeInherited
Mammalian Phenotype (MP)abnormal effector T cell morphology0.2465InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.3236InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell morphology0.3291InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.3703InformativeInherited
Mammalian Phenotype (MP)abnormal T cell activation0.00000002782Highly InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0000001533Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.0000001533Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0000001812Highly InformativeDirect
Mammalian Phenotype (MP)increased interferon-gamma secretion0.000001084Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.000001603Highly InformativeDirect
Mammalian Phenotype (MP)increased percent body fat/body weight0.000005302Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.000005961Highly InformativeDirect
Mammalian Phenotype (MP)decreased mean corpuscular hemoglobin0.000007494Highly InformativeDirect
Mammalian Phenotype (MP)obese0.00002111Highly InformativeDirect
Mammalian Phenotype (MP)abnormal corpus luteum morphology0.00003124Highly InformativeDirect
Mammalian Phenotype (MP)increased lean body mass0.00007869Highly InformativeDirect
Mammalian Phenotype (MP)increased total body fat amount0.0001043Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating triglyceride level0.0001345Highly InformativeDirect
Mammalian Phenotype (MP)abnormal endocrine pancreas secretion0.0001612Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic beta cell physiology0.0002344Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002864Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pancreatic islet morphology0.0004463Highly InformativeDirect
Mammalian Phenotype (MP)decreased lean body mass0.0005273Highly InformativeDirect
Mammalian Phenotype (MP)abnormal fat pad morphology0.00068Highly InformativeDirect
Mammalian Phenotype (MP)abnormal food intake0.002512Highly InformativeInherited
Mammalian Phenotype (MP)abnormal liver size0.08473Highly InformativeInherited

Document: MP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR013799 SSF48092 Protein matches
Abstract

This entry represents the N-terminal domain, which is responsible for protein interactions. This domain has a multi-helical structure that can be subdivided into two structural sub-domains.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 3 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Transcription factor STAT-4 N-domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 3 hidden Markov models representing the Transcription factor STAT-4 N-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]