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Six-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Six-hairpin glycosidases [ 48208] (9)
Families:   Glucoamylase [ 48209]
  Cellulases catalytic domain [ 48213] (11)
  N-acylglucosamine (NAG) epimerase [ 48222] (2)
  Glycosyltransferase family 36 C-terminal domain [ 63588] (2)
  Bacterial glucoamylase C-terminal domain-like [ 81850] (2)
  Hypothetical protein YteR [ 89108]
  Glycosyl Hydrolase Family 88 [ 109953]
  CPF0428-like [ 158737] (2)
  Trehalase-like [ 158742]


Superfamily statistics
Genomes (2,682) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 23,750 135,370 37
Proteins 23,535 134,538 37


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.99070.003816Least InformativeInherited
Biological Process (BP)primary metabolic process10.1368Least InformativeInherited
Biological Process (BP)macromolecule metabolic process0.28091Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000036870Moderately InformativeDirect
Biological Process (BP)organic substance catabolic process0.002220Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.0057250Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.011530Moderately InformativeInherited
Biological Process (BP)polysaccharide metabolic process0.0000000059680InformativeDirect
Biological Process (BP)carbohydrate catabolic process0.0001040InformativeDirect
Biological Process (BP)cellular carbohydrate metabolic process0.000065920InformativeDirect
Biological Process (BP)oligosaccharide catabolic process0.0000000064910Highly InformativeDirect
Biological Process (BP)cellular carbohydrate catabolic process0.0000036350Highly InformativeDirect
Molecular Function (MF)hydrolase activity0.43370.0000000000005611Least InformativeInherited
Molecular Function (MF)isomerase activity0.00013510.05029Moderately InformativeInherited
Molecular Function (MF)hydrolase activity, acting on glycosyl bonds0.000000040550InformativeDirect
Molecular Function (MF)racemase and epimerase activity0.00024980.0001217InformativeDirect
Molecular Function (MF)hydrolase activity, hydrolyzing O-glycosyl compounds0.0000000032340Highly InformativeDirect
Molecular Function (MF)racemase and epimerase activity, acting on carbohydrates and derivatives0.000000039330.0000005336Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.1368 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 0.003816 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.0005445 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0662 Moderately Informative Inherited
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0000005156 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.000000000001316 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.000305 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0.0000000000005611 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.05029 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 1 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring glycosyl groups 0.0003015 Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) racemase and epimerase activity 0.0001217 Informative Direct
Molecular Function (MF) kinase activity 1 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.96 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Molecular Function (MF) racemase and epimerase activity, acting on carbohydrates and derivatives 0.0000005336 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.6388 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) transferase complex 0.5763 Moderately Informative Inherited
Cellular Component (CC) transferase complex, transferring phosphorus-containing groups 0.02274 Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Racemases and epimerases0.03177Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.486Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbohydrates and derivatives0.0001283InformativeDirect
Enzyme Commission (EC)Cellulase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processPolysaccharide degradation0InformativeDirect
Biological processCell wall biogenesis/degradation0InformativeDirect
Biological processCellulose degradation0Highly InformativeDirect
Cellular componentMembrane0.714Least InformativeInherited
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPeriplasm0InformativeDirect
Cellular componentGPI-anchor0.000000002467InformativeDirect
DiseaseGlycogen storage disease0.00000000001432InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane1Least InformativeInherited
DomainSignal-anchor0.00000001061InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationCalmodulin-binding0.00000000000001015InformativeDirect
Post-translational modificationGlycosyltransferase0.0007299InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPrenylation0.0000239InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008928 SSF48208 Protein matches
Abstract

The six-hairpin glycoside transferase domain contains up to seven alpha-hairpins arranged in closed circular array. Protein families that contain domains with this structure include glucoamylases, various endocellulases and exocellulases (catalytic domain), N-acyl-D-glucosamine 2-epimerases, bacterial maltose phosphorylase (central domain), and bacterial glucoamylases (C-terminal domain).


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Six-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the Six-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]