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Seven-hairpin glycosidases superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha/alpha toroid [ 48207] (6)
Superfamily:   Seven-hairpin glycosidases [ 48225]
Families:   Class I alpha-1;2-mannosidase, catalytic domain [ 48226]


Superfamily statistics
Genomes (488) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,198 8,307 9
Proteins 3,146 8,181 9


Functional annotation
General category Metabolism
Detailed category Carbohydrate metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.0002104 Least Informative Direct
Biological Process (BP) primary metabolic process 0.00000000003098 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.00000000002546 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00002303 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.1296 Least Informative Inherited
Biological Process (BP) response to stimulus 0.002785 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) response to organic substance 0.00002891 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000000000000215 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.000000000001142 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.000000000001418 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.00000000000006022 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.0000000002412 Moderately Informative Direct
Biological Process (BP) response to oxygen-containing compound 0.06281 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8429 Moderately Informative Inherited
Biological Process (BP) cell communication 0.5231 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.4457 Moderately Informative Inherited
Biological Process (BP) proteolysis 0.00000003786 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00000001088 Informative Direct
Biological Process (BP) response to nitrogen compound 0 Informative Direct
Biological Process (BP) glycoprotein metabolic process 0 Highly Informative Direct
Biological Process (BP) response to endoplasmic reticulum stress 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0.00002217 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0 Highly Informative Direct
Molecular Function (MF) hydrolase activity 8.27e-16 Least Informative Direct
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000006155 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0.0000002004 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1343 Least Informative Inherited
Cellular Component (CC) membrane 0.4059 Least Informative Inherited
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) bounding membrane of organelle 0.001265 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 0.00001937 Informative Direct
Cellular Component (CC) Golgi subcompartment 0.006093 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0.00000002809Moderately InformativeDirect
Biological processUnfolded protein response0Highly InformativeDirect
Cellular componentMembrane0.00002355Least InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentGolgi apparatus0.00000000001382Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.0000000002322Moderately InformativeDirect
DomainTransmembrane0.002554Least InformativeInherited
DomainSignal-anchor0InformativeDirect
Molecular functionMetal-binding0.00000000003058Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycoprotein0.000000000000002852Least InformativeDirect
Post-translational modificationDisulfide bond0.00000005337Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001382 SSF48225 Protein matches
Abstract

Glycoside hydrolase family 47 comprises enzymes with only one known activity; alpha-mannosidase .

Alpha-mannosidase is involved in the maturation of Asn-linked oligo-saccharides [PubMed8144580]. The enzyme hydrolyses terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(glcnac)(2) in a calcium-dependent manner. The mannose residues are trimmed away to produce, first, man(8)glcnac(2), then a man(5)(glcnac)(2) structure.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 5 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Seven-hairpin glycosidases domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 5 hidden Markov models representing the Seven-hairpin glycosidases superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]