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Citrate synthase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Citrate synthase [ 48255]
Superfamily:   Citrate synthase [ 48256]
Families:   Citrate synthase [ 48257]


Superfamily statistics
Genomes (2,556) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 5,417 33,425 13
Proteins 5,391 33,365 13


Functional annotation
General category Metabolism
Detailed category Energy

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)single-organism metabolic process0.00000000013190.000000000001163Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00000025890.0005059Least InformativeDirect
Biological Process (BP)primary metabolic process0.042240.01525Least InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.00000000058260Moderately InformativeDirect
Biological Process (BP)lipid metabolic process0.00082430.00004083Moderately InformativeDirect
Biological Process (BP)oxidation-reduction process0.0000021150.0000000000009632Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.21990.3482Moderately InformativeInherited
Biological Process (BP)fatty acid metabolic process0.0000018340.0000001InformativeDirect
Biological Process (BP)cellular respiration0.60950.04205InformativeInherited
Biological Process (BP)citrate metabolic process00Highly InformativeDirect
Biological Process (BP)aerobic respiration0.000000000000006150Highly InformativeDirect
Biological Process (BP)propionate metabolic process00Highly InformativeDirect
Molecular Function (MF)transferase activity0.000000034830Least InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups00InformativeDirect
Molecular Function (MF)transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0.000000000001163 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.0005059 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.01525 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.00000000001685 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0.00004083 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.0000000000009632 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.006031 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.662 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.4069 Moderately Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.001394 Moderately Informative Inherited
Biological Process (BP) monocarboxylic acid metabolic process 0.3482 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.9812 Moderately Informative Inherited
Biological Process (BP) fatty acid metabolic process 0.0000001 Informative Direct
Biological Process (BP) lipid catabolic process 0.0006381 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.000006085 Informative Direct
Biological Process (BP) coenzyme biosynthetic process 0.01083 Informative Inherited
Biological Process (BP) cellular respiration 0.04205 Informative Inherited
Biological Process (BP) citrate metabolic process 0 Highly Informative Direct
Biological Process (BP) aerobic respiration 0 Highly Informative Direct
Biological Process (BP) propionate metabolic process 0 Highly Informative Direct
Biological Process (BP) acyl-CoA biosynthetic process 0.00005272 Highly Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups 0 Informative Direct
Molecular Function (MF) transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1285 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.001594 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.0000002369 Moderately Informative Direct
Cellular Component (CC) microbody 0.0006327 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acyl groups converted into alkyl on transfer0InformativeDirect
Enzyme Commission (EC)ATP citrate synthase0.00005061Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processLipid metabolism0.0007439Moderately InformativeDirect
Biological processTricarboxylic acid cycle0InformativeDirect
Biological processLipid biosynthesis0.0000002585InformativeDirect
Cellular componentMitochondrion0Moderately InformativeDirect
Cellular componentPeroxisome0.00000004597InformativeDirect
DomainTransit peptide0Moderately InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationAcetylation0.00003489Least InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Citrate synthase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Citrate synthase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]