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Cytochrome P450 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Family:   Cytochrome P450 [ 48265] (22)


Family statistics
Genomes (1,231) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,479 143,933 76
Proteins 35,014 142,677 76


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7873Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0003169InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0.7602Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.04152InformativeInherited
Disease Ontology (DO)hypospadias0.0001109Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.1055Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.7951Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.8979Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.1822Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.4341Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.0009348InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.08245InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.08713InformativeInherited
Phenotypic Abnormality (PA)Abnormality of adrenal physiology0.2268InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.258InformativeInherited
Phenotypic Abnormality (PA)Abnormality of fluid regulation0.3482InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001139Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001139Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of potassium homeostasis0.0001229Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0003748Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.0006794Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.001013Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.006004Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpigmentation of the skin0.07349Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.227Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7619Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7753Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0004679Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1898Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2418Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4027Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00005529InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.000388Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.5266Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0003545InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.1084Least InformativeInherited
Fly Anatomy (FA)embryo0.1622Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3227Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3875Least InformativeInherited
Fly Anatomy (FA)larva0.4315Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5515Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.6102Least InformativeInherited
Fly Anatomy (FA)nervous system0.6938Least InformativeInherited
Fly Anatomy (FA)digestive system0.005393Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03261Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.05771Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1263Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1669Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.1913Moderately InformativeInherited
Fly Anatomy (FA)tract0.0001137InformativeDirect
Fly Anatomy (FA)midgut0.0006594InformativeDirect
Fly Anatomy (FA)cuboidal/columnar epithelium0.0007134InformativeDirect
Fly Anatomy (FA)foregut0.00385InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.005394InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01804InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.02136InformativeInherited
Fly Anatomy (FA)primordium0.0311InformativeInherited
Fly Anatomy (FA)hindgut0.000001028Highly InformativeDirect
Fly Anatomy (FA)commissure0.000006675Highly InformativeDirect
Fly Anatomy (FA)neuropil associated CNS glial cell0.00001275Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004627Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001863Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0006658Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.2972Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.3588Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00001433Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.02426InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8624InformativeInherited
Enzyme Commission (EC)Hydro-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.0293Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 117 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]