SUPERFAMILY 1.75 HMM library and genome assignments server

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Cytochrome P450 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Family:   Cytochrome P450 [ 48265] (22)


Family statistics
Genomes (1,231) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,479 143,933 76
Proteins 35,014 142,677 76


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7873Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0003169InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0.7602Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01319Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.04342InformativeInherited
Disease Ontology (DO)hypospadias0.0001175Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0001938Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.000675Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07545Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4536Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6955Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.7184Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9332Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.2085Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3247Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.6777Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.002002InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.01782InformativeInherited
Phenotypic Abnormality (PA)Abnormal breast morphology0.02786InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.0803InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.09884InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.1241InformativeInherited
Phenotypic Abnormality (PA)Abnormality of adrenal physiology0.217InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2539InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2611InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.3416InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001593Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001593Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of potassium homeostasis0.0001696Highly InformativeDirect
Phenotypic Abnormality (PA)Gynecomastia0.0002594Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.0003897Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal delivery0.0007576Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.0007951Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.001106Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal epiphyseal ossification0.001354Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.006413Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.02281Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpigmentation of the skin0.08608Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.09154Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2262Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7612Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7741Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0004877Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1885Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2404Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00005521InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003857Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.7112Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0003491InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.1124Least InformativeInherited
Fly Anatomy (FA)embryo0.1626Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3215Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.3419Least InformativeInherited
Fly Anatomy (FA)larva0.4256Least InformativeInherited
Fly Anatomy (FA)somatic cell0.54Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.6039Least InformativeInherited
Fly Anatomy (FA)nervous system0.7072Least InformativeInherited
Fly Anatomy (FA)digestive system0.004801Moderately InformativeInherited
Fly Anatomy (FA)non-connected developing system0.01496Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03355Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.03872Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.05225Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1402Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1646Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.1888Moderately InformativeInherited
Fly Anatomy (FA)tract0.0001198InformativeDirect
Fly Anatomy (FA)midgut0.0006101InformativeDirect
Fly Anatomy (FA)alimentary canal0.001935InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.005813InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01734InformativeInherited
Fly Anatomy (FA)primordium0.03253InformativeInherited
Fly Anatomy (FA)commissure0.000007697Highly InformativeDirect
Fly Anatomy (FA)neuropil associated CNS glial cell0.00001438Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00005057Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0002226Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0008562Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.3558Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.3327Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00001482Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.02501InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8535InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydro-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.001018Highly InformativeInherited
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.02956Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]