SUPERFAMILY 1.75 HMM library and genome assignments server

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Cytochrome P450 family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Cytochrome P450 [ 48263]
Superfamily:   Cytochrome P450 [ 48264]
Family:   Cytochrome P450 [ 48265] (22)


Family statistics
Genomes (1,231) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 35,479 143,933 76
Proteins 35,014 142,677 76


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Isomerases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.7873Moderately InformativeInherited
Enzyme Commission (EC)Hydro-lyases1Moderately InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0003169InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, 0Highly InformativeDirect
Enzyme Commission (EC)Miscellaneous (requires further characterization)0.7602Highly InformativeInherited

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)connective tissue disease0.01319Moderately InformativeInherited
Disease Ontology (DO)physical disorder0.04342InformativeInherited
Disease Ontology (DO)hypospadias0.0001175Highly InformativeDirect
Disease Ontology (DO)hyperandrogenism0.0001938Highly InformativeDirect
Disease Ontology (DO)bone remodeling disease0.000675Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07938Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.4775Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6885Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.742Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9136Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system0.224Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.3283Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.6886Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of ion homeostasis0.00194InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.01875InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.08006InformativeInherited
Phenotypic Abnormality (PA)Abnormality of circulating hormone level0.09459InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.123InformativeInherited
Phenotypic Abnormality (PA)Abnormality of adrenal physiology0.2108InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.2679InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2752InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin pigmentation0.3277InformativeInherited
Phenotypic Abnormality (PA)Hyperaldosteronism0.000001574Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal circulating renin0.000001574Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of potassium homeostasis0.0001654Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urinary electrolyte concentration0.00038Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.0007779Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of circulating adrenocorticotropin level0.001129Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal epiphyseal ossification0.00133Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.006261Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.02214Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal breast morphology0.02757Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of epiphysis morphology0.08273Highly InformativeInherited
Phenotypic Abnormality (PA)Hyperpigmentation of the skin0.08566Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2261Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.7612Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.774Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.0004876Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.1885Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.2405Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.4011Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal systemic arterial blood pressure0.00005521InformativeDirect
Mammalian Phenotype (MP)abnormal fat-soluble vitamin level0.0003853Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.7149Least InformativeInherited
Worm Phenotype (WP)defecation variant0InformativeDirect
Worm Phenotype (WP)metal response variant0.0003559InformativeDirect
Worm Phenotype (WP)defecation cycle variant0Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0.1087Least InformativeInherited
Fly Anatomy (FA)embryo0.1568Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3176Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.333Least InformativeInherited
Fly Anatomy (FA)larva0.424Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5404Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.604Least InformativeInherited
Fly Anatomy (FA)nervous system0.6963Least InformativeInherited
Fly Anatomy (FA)digestive system0.004697Moderately InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.03107Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.03636Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.05147Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1373Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.1617Moderately InformativeInherited
Fly Anatomy (FA)embryonic/larval nervous system0.1864Moderately InformativeInherited
Fly Anatomy (FA)tract0.0001015InformativeDirect
Fly Anatomy (FA)midgut0.0006368InformativeDirect
Fly Anatomy (FA)alimentary canal0.00196InformativeInherited
Fly Anatomy (FA)embryonic/larval digestive system0.005554InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.01737InformativeInherited
Fly Anatomy (FA)primordium0.03093InformativeInherited
Fly Anatomy (FA)commissure0.000006776Highly InformativeDirect
Fly Anatomy (FA)neuropil associated CNS glial cell0.00001441Highly InformativeDirect
Fly Anatomy (FA)presumptive embryonic/larval central nervous system0.00004476Highly InformativeDirect
Fly Anatomy (FA)midgut primordium0.0001896Highly InformativeDirect
Fly Anatomy (FA)embryonic head0.0008358Highly InformativeDirect
Fly Anatomy (FA)embryonic epidermis0.3441Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage0.3427Least InformativeInherited
Xenopus DEvelopment stage (XDE)NF stage 620.00001449Highly InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)fruit0.02501InformativeInherited

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0.8609InformativeInherited
Enzyme Commission (EC)With NAD(+) or NADP(+) as acceptor1InformativeInherited
Enzyme Commission (EC)Acting on NADH or NADPH1InformativeInherited
Enzyme Commission (EC)Hydro-lyases1InformativeInherited
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen0Highly InformativeDirect
Enzyme Commission (EC)With incorporation of two atoms of oxygen0.03035Highly InformativeInherited
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen0.2452Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 23 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytochrome P450 domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]