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Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48339]
Superfamily:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48340]
Families:   Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [ 48341]


Superfamily statistics
Genomes (262) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,356 2,664 1
Proteins 1,331 2,592 1


Functional annotation
General category Processes_EC
Detailed category Immune response

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00.00000008273Least InformativeDirect
Biological Process (BP)defense response00Moderately InformativeDirect
Biological Process (BP)response to organic substance00Moderately InformativeDirect
Biological Process (BP)cellular response to chemical stimulus00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)immune response00InformativeDirect
Biological Process (BP)innate immune response00Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000008273 Least Informative Direct
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.6989 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.002866 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) defense response 0 Moderately Informative Direct
Biological Process (BP) response to organic substance 0 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0000000000003292 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0000000003186 Moderately Informative Direct
Biological Process (BP) cellular component assembly 0.0000000004006 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000003286 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.0001111 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.04017 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.04359 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.2818 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1228 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.07836 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.9506 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.00644 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.4048 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.01486 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.008723 Moderately Informative Inherited
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) response to bacterium 0 Informative Direct
Biological Process (BP) protein oligomerization 0 Informative Direct
Biological Process (BP) regulation of cytokine production 0.000001961 Informative Direct
Biological Process (BP) interspecies interaction between organisms 0.000009973 Informative Direct
Biological Process (BP) negative regulation of transport 0.00001138 Informative Direct
Biological Process (BP) regulation of defense response 0.00001612 Informative Direct
Biological Process (BP) regulation of peptide transport 0.0001132 Informative Direct
Biological Process (BP) regulation of cellular localization 0.0001751 Informative Direct
Biological Process (BP) negative regulation of cellular protein metabolic process 0.0002612 Informative Direct
Biological Process (BP) regulation of protein localization 0.0003352 Informative Direct
Biological Process (BP) cellular response to lipid 0.09252 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.3748 Informative Inherited
Biological Process (BP) generation of neurons 0.02702 Informative Inherited
Biological Process (BP) cell development 0.07804 Informative Inherited
Biological Process (BP) defense response to other organism 0.004044 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.002688 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.00546 Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.006001 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.04598 Informative Inherited
Biological Process (BP) innate immune response 0 Highly Informative Direct
Biological Process (BP) endomembrane system organization 0.000000000000003734 Highly Informative Direct
Biological Process (BP) biological adhesion 0.0000000000001663 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000000004355 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.0000001737 Highly Informative Direct
Biological Process (BP) defense response to Gram-positive bacterium 0.000000322 Highly Informative Direct
Biological Process (BP) negative regulation of protein modification process 0.00001065 Highly Informative Direct
Biological Process (BP) negative regulation of phosphate metabolic process 0.00001425 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0.0002285 Highly Informative Direct
Biological Process (BP) negative regulation of cytokine production 0.0003706 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0.0008146 Highly Informative Direct
Biological Process (BP) neuron development 0.003128 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.004518 Highly Informative Inherited
Molecular Function (MF) binding 0.08675 Least Informative Inherited
Molecular Function (MF) hydrolase activity 0.001234 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00000001941 Moderately Informative Direct
Molecular Function (MF) carbohydrate derivative binding 0.00000266 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000006957 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0.00003455 Moderately Informative Direct
Molecular Function (MF) identical protein binding 0.000000002942 Informative Direct
Molecular Function (MF) purine nucleotide binding 0.000000003906 Informative Direct
Molecular Function (MF) ribonucleotide binding 0.000000004915 Informative Direct
Molecular Function (MF) purine ribonucleoside triphosphate binding 0.0001563 Informative Direct
Molecular Function (MF) purine nucleoside binding 0.00000000000006382 Highly Informative Direct
Cellular Component (CC) cytoplasmic part 0.00000000000001446 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.08872 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) vesicle 0.000000001946 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0.00000003207 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.00000008 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.000001999 Moderately Informative Direct
Cellular Component (CC) extracellular organelle 0.0000000003423 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0.00001771 Informative Direct
Cellular Component (CC) Golgi apparatus 0.004981 Informative Inherited
Cellular Component (CC) Golgi subcompartment 0.09462 Highly Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processImmunity0.0000000002936Moderately InformativeDirect
Biological processAntiviral defense0.000000000004822Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0Moderately InformativeDirect
Cellular componentCell projection0.0000005988Moderately InformativeDirect
DomainTransmembrane0.00003483Least InformativeDirect
DomainCoiled coil0.0000000000003464Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Molecular functionGTP-binding0InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationAntimicrobial0.0000000004569InformativeDirect
Post-translational modificationMethylation0.00000002146Moderately InformativeDirect
Post-translational modificationPrenylation0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR015900 SSF48340 Protein matches
Abstract

Guanylate-binding protein is a GTPase that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma are key to the protective immunity against microbial and viral pathogens. These GTPases are classified into three groups: the small 47-kd GTPases, the Mx proteins, and the large 65- to 67-kd GTPases. Guanylate-binding proteins (GBP) fall into the last class. In humans, there are seven GBPs (hGBP1-7) [PubMed17266443]. Structurally, hGBP1 consists of two domains: a compact globular N-terminal domain harbouring the GTPase function , and an alpha-helical finger-like C-terminal domain. Human GBP1 is secreted from cells without the need of a leader peptide, and has been shown to exhibit antiviral activity against Vesicular stomatitis virus and Encephalomyocarditis virus, as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to IFN-gamma [PubMed16936281].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]