SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


BCR-homology GTPase activation domain (BH-domain) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GTPase activation domain, GAP [ 48349]
Superfamily:   GTPase activation domain, GAP [ 48350] (2)
Family:   BCR-homology GTPase activation domain (BH-domain) [ 48351] (5)


Family statistics
Genomes (330) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 3,631 11,326 8
Proteins 3,627 11,321 8


Disease Ontology (DO)

(
show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)hematopoietic system disease0.154Moderately InformativeInherited
Disease Ontology (DO)bone marrow disease0.000108Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Somatic mutation0.0003464Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the eye0.4248Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.4088Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal uvea morphology0.1383InformativeInherited
Phenotypic Abnormality (PA)Abnormality iris morphology0.05567Highly InformativeInherited

Document: HP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.00004823Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.06281Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.03364Moderately InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.06083Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.4468Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.0000000000004005InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.001525InformativeInherited
Worm Phenotype (WP)cytokinesis variant emb0.006877InformativeInherited
Worm Phenotype (WP)cell component localization variant0.1701InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.2649InformativeInherited
Worm Phenotype (WP)axon morphology variant0.00000000000003991Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.00005944Highly InformativeDirect
Worm Phenotype (WP)cleavage furrow defective early emb0.0005646Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)development0.0004643Moderately InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Least InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.002418InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.003906Least InformativeInherited
Enzyme Commission (EC)Transferases0.1977Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.000003887Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000000002749InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000005076InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 14 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a GTPase activation domain, GAP domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]