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Phoshoinositide 3-kinase (PI3K) helical domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   ARM repeat [ 48371] (23)
Family:   Phoshoinositide 3-kinase (PI3K) helical domain [ 48399]


Family statistics
Genomes (160) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 521 1,319 4
Proteins 521 1,319 4


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1896Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.0000007007InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4-phosphate 3-kinase5.205e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of connective tissue0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0Moderately InformativeDirect
Phenotypic Abnormality (PA)Splenomegaly0InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal homeostasis0Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.01483Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.01636Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.04172Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.04528Least InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.0007708Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal body size0.002226Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.002783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.007168Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.008428Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.009722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.01783Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.06851Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.1669Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2461Moderately InformativeInherited
Mammalian Phenotype (MP)increased hematopoietic cell number0.2975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.3281Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00001576InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.00008814InformativeDirect
Mammalian Phenotype (MP)abnormal CD4-positive, alpha beta T cell morphology0.0002166InformativeDirect
Mammalian Phenotype (MP)abnormal cholesterol homeostasis0.0002671InformativeDirect
Mammalian Phenotype (MP)abnormal sterol level0.0002698InformativeDirect
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.0003584InformativeDirect
Mammalian Phenotype (MP)abnormal heart size0.0007076InformativeDirect
Mammalian Phenotype (MP)abnormal prenatal body size0.001465InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.002359InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.003247InformativeInherited
Mammalian Phenotype (MP)abnormal granulocyte morphology0.02734InformativeInherited
Mammalian Phenotype (MP)abnormal glycogen level0.00003269Highly InformativeDirect
Mammalian Phenotype (MP)skin lesions0.00004857Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating insulin level0.0002029Highly InformativeDirect
Mammalian Phenotype (MP)impaired glucose tolerance0.0007526Highly InformativeDirect
Mammalian Phenotype (MP)abnormal neutrophil cell number0.0008865Highly InformativeDirect
Mammalian Phenotype (MP)increased granulocyte number0.0009649Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)slow growth0Least InformativeDirect
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)progeny variant0Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0Least InformativeDirect
Worm Phenotype (WP)protein expression variant0Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0Moderately InformativeDirect
Worm Phenotype (WP)cell death variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0InformativeDirect
Worm Phenotype (WP)pattern protein expression variant0InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)adult0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)urogenital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1678InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 75 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a ARM repeat domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]