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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 276,064 42
Proteins 69,282 232,456 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4141Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02098Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1809InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004291Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006417Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.6149Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1516Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1757Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.2055InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the pancreas0.0009128Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4027Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5568Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6273Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04957InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002862Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005211Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.04948Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.6432Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00109Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.03395Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.03395Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.0342Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.03444Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.04114Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3717Moderately InformativeInherited
Worm Phenotype (WP)body bend variant0.00004283InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0002868InformativeDirect
Worm Phenotype (WP)localized movement variant0.0002881InformativeDirect
Worm Phenotype (WP)body posture variant0.0005826InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0006703InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.008146InformativeInherited
Worm Phenotype (WP)directionality variant0.08002InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.00000708Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00004708Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0002602Highly InformativeDirect
Worm Phenotype (WP)fat0.0002787Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4054Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05809InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.000351Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.000000009074InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0000001742InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.09052Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1139Least InformativeInherited
Fly Anatomy (FA)adult0.1431Least InformativeInherited
Fly Anatomy (FA)somatic cell0.361Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sensory system0.05693Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1626Moderately InformativeInherited
Fly Anatomy (FA)head0.1838Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2215Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2544Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.3701Moderately InformativeInherited
Fly Anatomy (FA)appendage0.3833Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.009837InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.03222InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6654InformativeInherited
Fly Anatomy (FA)antennal sense organ0.002383Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.007652Highly InformativeInherited
Fly Anatomy (FA)segment of antenna0.01048Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.7029Least InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.4188Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000005942Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.004665Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.03169Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005846InformativeDirect
Enzyme Commission (EC)In linear amides0.00003081InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.00035InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.009662InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.01496InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.06344InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000002501Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003042Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000007289Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]