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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 276,064 42
Proteins 69,282 232,456 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4142Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02098Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.1811InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004281Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006402Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5419Least InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.1257Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1652Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the pancreas0.1635InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the pancreas0.0007037Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4027Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5568Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4112Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5696Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6273Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7206Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04957InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002862Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005211Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.03244Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.6222Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.00206Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.04867Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.3933Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.0002979InformativeDirect
Worm Phenotype (WP)localized movement variant0.0003012InformativeDirect
Worm Phenotype (WP)body posture variant0.0006098InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0007371InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.001975InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.008517InformativeInherited
Worm Phenotype (WP)body width variant0.2415InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.000007184Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.000048Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0002356Highly InformativeDirect
Worm Phenotype (WP)fat0.0003423Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4097Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05809InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0003583Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.000000007326InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0000001491InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.08593Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1112Least InformativeInherited
Fly Anatomy (FA)adult0.1413Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3772Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sensory system0.05468Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1624Moderately InformativeInherited
Fly Anatomy (FA)head0.1808Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2208Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2451Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.3699Moderately InformativeInherited
Fly Anatomy (FA)appendage0.3886Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.009155InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.03054InformativeInherited
Fly Anatomy (FA)antennal segment0.09095InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6651InformativeInherited
Fly Anatomy (FA)adult antennal sense organ0.002657Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.006929Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.6964Least InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.4342Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000005941Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.005988Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.03181Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005742InformativeDirect
Enzyme Commission (EC)In linear amides0.00003094InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.0003505InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.007634InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.01494InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.0636InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000002493Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003039Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000007266Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]