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Ankyrin repeat superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   Alpha and beta proteins (a+b) [ 53931] (376)
Fold:   beta-hairpin-alpha-hairpin repeat [ 74651] (2)
Superfamily:   Ankyrin repeat [ 48403]
Families:   Ankyrin repeat [ 48404] (17)


Superfamily statistics
Genomes (1,789) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 80,489 276,064 42
Proteins 69,282 232,456 42


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on acid anhydrides0.4016Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1213Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)In linear amides0.000000001232Moderately InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases0.0008122Moderately InformativeDirect
Enzyme Commission (EC)In phosphorous-containing anhydrides0.001342Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3822Moderately InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000344InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0.0000000000002201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4146Least InformativeInherited
Disease Ontology (DO)benign neoplasm0.02096Moderately InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.181InformativeInherited
Disease Ontology (DO)skin hemangioma0.000004287Highly InformativeDirect
Disease Ontology (DO)rhabdomyosarcoma0.0006412Highly InformativeDirect

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.4036Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.5578Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.4082Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.5689Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.6281Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.7216Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.04957InformativeInherited
Mammalian Phenotype (MP)incomplete somite formation0.0002863Highly InformativeDirect
Mammalian Phenotype (MP)extramedullary hematopoiesis0.0005201Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.01783Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.608Least InformativeInherited
Worm Phenotype (WP)organism stress response variant0.002078Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.01083Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.03023Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.03023Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.03045Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.03066Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.03604Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.2211Moderately InformativeInherited
Worm Phenotype (WP)body bend variant0.00002882InformativeDirect
Worm Phenotype (WP)localized movement variant0.0002856InformativeDirect
Worm Phenotype (WP)forward locomotion variant0.0003173InformativeDirect
Worm Phenotype (WP)body posture variant0.0004426InformativeDirect
Worm Phenotype (WP)mechanosensation variant0.0004764InformativeDirect
Worm Phenotype (WP)chemotaxis variant0.0005206InformativeDirect
Worm Phenotype (WP)foraging behavior variant0.006072InformativeInherited
Worm Phenotype (WP)directionality variant0.07567InformativeInherited
Worm Phenotype (WP)odorant negative chemotaxis defective0.000006876Highly InformativeDirect
Worm Phenotype (WP)octanol chemotaxis variant0.00003735Highly InformativeDirect
Worm Phenotype (WP)fat0.0002862Highly InformativeDirect
Worm Phenotype (WP)organism heat response variant0.0002941Highly InformativeDirect
Worm Phenotype (WP)body posture wavelength variant0.4053Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)cell cycle progression0.05809InformativeInherited

Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)behavior defective0.0005785Moderately InformativeDirect
Fly Phenotype (FP)sensory perception defective0.00000001536InformativeDirect
Fly Phenotype (FP)neurophysiology defective0.0000002951InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.08309Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.1017Least InformativeInherited
Fly Anatomy (FA)adult0.189Least InformativeInherited
Fly Anatomy (FA)somatic cell0.3601Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)sensory system0.07442Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.1542Moderately InformativeInherited
Fly Anatomy (FA)head0.1872Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.2089Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.2125Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2299Moderately InformativeInherited
Fly Anatomy (FA)appendage0.3708Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.4307Moderately InformativeInherited
Fly Anatomy (FA)adult external head0.009557InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.03034InformativeInherited
Fly Anatomy (FA)mechanosensory system0.6724InformativeInherited
Fly Anatomy (FA)antennal sense organ0.002592Highly InformativeInherited
Fly Anatomy (FA)cholinergic neuron0.008286Highly InformativeInherited
Fly Anatomy (FA)segment of antenna0.01031Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.661Least InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.4172Least InformativeInherited
Enzyme Commission (EC)Transferring phosphorus-containing groups1Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000000005856Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.004636Moderately InformativeInherited
Enzyme Commission (EC)Acting on carbon-nitrogen bonds, other than peptide bonds0.03163Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Transferring groups other than amino-acyl groups1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000005828InformativeDirect
Enzyme Commission (EC)In linear amides0.00003086InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0.000349InformativeDirect
Enzyme Commission (EC)In phosphorus-containing anhydrides0.009664InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases0.01491InformativeInherited
Enzyme Commission (EC)Pentosyltransferases0.06323InformativeInherited
Enzyme Commission (EC)NAD(+) ADP-ribosyltransferase0.000000000000002505Highly InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0.00000000003033Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.00000007247Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR002110 SSF48403 Protein matches
Abstract

The ankyrin repeat is one of the most common protein-protein interaction motifs in nature. Ankyrin repeats are tandemly repeated modules of about 33 amino acids. They occur in a large number of functionally diverse proteins mainly from eukaryotes. The few known examples from prokaryotes and viruses may be the result of horizontal gene transfers [PubMed8108379]. The repeat has been found in proteins of diverse function such as transcriptional initiators, cell-cycle regulators, cytoskeletal, ion transporters and signal transducers. The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it.

The conserved fold of the ankyrin repeat unit is known from several crystal and solution structures [PubMed8875926, PubMed9353127, PubMed9461436, PubMed9865693]. Each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90o angle. The repeats stack together to form an L-shaped structure [PubMed8875926, PubMed12461176].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 46 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Ankyrin repeat domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 46 hidden Markov models representing the Ankyrin repeat superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]