SUPERFAMILY 1.75 HMM library and genome assignments server

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TPR-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Families:   Tetratricopeptide repeat (TPR) [ 48453] (17)
  Transcription factor MalT domain III [ 69094]
  BTAD-like [ 140845]
  PrgX C-terminal domain-like [ 140848]
  Atu0120-like [ 158772]
  SusD-like [ 158775] (3)
  HAT/Suf repeat [ 158782]
  CT2138-like [ 158785]


Superfamily statistics
Genomes (3,133) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 169,526 955,257 50
Proteins 125,432 730,800 49


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.5472Least InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.003141Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.5544Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.1413Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0012Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.002744Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.3264Moderately InformativeInherited
Enzyme Commission (EC)Methyltransferases0.1514Moderately InformativeInherited
Enzyme Commission (EC)Peptidylprolyl isomerase0InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.000000000004361InformativeDirect
Enzyme Commission (EC)Phosphoprotein phosphatase0.000000007897InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.7219Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.3353InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0002735Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.0004823Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3291Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.5525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1182Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.5187Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.1896InformativeInherited
Phenotypic Abnormality (PA)Nephronophthisis0.0004197Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1089Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal kidney epithelium morphology0.0008486Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0000001656Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000003069Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00002084Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.007707Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.007755Least InformativeInherited
Worm Phenotype (WP)cell development variant0.02179Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.02336Least InformativeInherited
Worm Phenotype (WP)larval development variant0.3787Least InformativeInherited
Worm Phenotype (WP)early embryonic lethal0.0002595Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002187Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.00414Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.00414Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.004178Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.004217Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.005234Moderately InformativeInherited
Worm Phenotype (WP)locomotion variant0.01514Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.03039Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.0999Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.1014Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.2253Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.3434Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.7881Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000002607InformativeDirect
Worm Phenotype (WP)male morphology variant0.00008734InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00009695InformativeDirect
Worm Phenotype (WP)embryonic cell organization biogenesis variant0.0003809InformativeDirect
Worm Phenotype (WP)pesticide response variant0.002023InformativeInherited
Worm Phenotype (WP)mechanosensation variant0.007786InformativeInherited
Worm Phenotype (WP)drug resistant0.01371InformativeInherited
Worm Phenotype (WP)chemotaxis variant0.04414InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.4378InformativeInherited
Worm Phenotype (WP)antihelmintic response variant0.00001306Highly InformativeDirect
Worm Phenotype (WP)nuclear number variant0.0003958Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0005093Highly InformativeDirect
Worm Phenotype (WP)division axis defective0.009442Highly InformativeInherited
Worm Phenotype (WP)touch resistant0.289Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)nervous system0.7134Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.9417Least InformativeInherited
Fly Anatomy (FA)adult1Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.1958Moderately InformativeInherited
Fly Anatomy (FA)head0.8957Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.9042Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.9972Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system1Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system1Moderately InformativeInherited
Fly Anatomy (FA)nerve0.1891InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.4487InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)embryonic structure0.1109InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)seed0.00000001357Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.04222Least InformativeInherited
Plant ANatomical entity (PAN)shoot axis0.1747Least InformativeInherited
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0.00004502Least InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.04718Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4854Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Lyases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.0000001048Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000002425Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.001503Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0.002097Moderately InformativeInherited
Enzyme Commission (EC)Nucleotidyltransferases0.06587Moderately InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1Moderately InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0.000000000001399InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0.00000000001779InformativeDirect
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0.00004557InformativeDirect
Enzyme Commission (EC)Phosphorus-oxygen lyases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000254Highly InformativeDirect
Enzyme Commission (EC)Adenylate cyclase0.000001944Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 51 hidden Markov models representing the TPR-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]