SUPERFAMILY 1.75 HMM library and genome assignments server

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Tetratricopeptide repeat (TPR) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Family:   Tetratricopeptide repeat (TPR) [ 48453] (17)


Family statistics
Genomes (860) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,602 14,142 31
Proteins 4,389 13,434 30


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.06133Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.2061Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00001861Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.03783Moderately InformativeInherited
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000006512InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000113InformativeDirect
Enzyme Commission (EC)Cis-trans Isomerases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.5535Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.1955InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.00002913Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.0354Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09097Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1868Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2551Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5844Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8581Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.03062Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.04345Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.0453Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1035Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1217Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4671Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.04167InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.2076InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.5681InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6034InformativeInherited
Phenotypic Abnormality (PA)Bronchitis0.006929Highly InformativeInherited
Phenotypic Abnormality (PA)Polydactyly0.06051Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral physiology0.1218Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.5667Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1584Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.05149InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.01001Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000659Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001235Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.004492Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2415Least InformativeInherited
Worm Phenotype (WP)movement variant0.0009893Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.1636Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.383Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6588Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0004867InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.09475Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1346Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.2104Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.3325Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4642Least InformativeInherited
Zebrafish Anatomy (ZA)cell1Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1555Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.5451Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.9471Moderately InformativeInherited
Zebrafish Anatomy (ZA)head1Moderately InformativeInherited
Zebrafish Anatomy (ZA)eye0.3988InformativeInherited
Zebrafish Anatomy (ZA)neuron0.9539InformativeInherited
Zebrafish Anatomy (ZA)retinal outer nuclear layer0.01454Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal photoreceptor layer0.01878Highly InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.1224Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.09403Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.7089Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.1846Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1895Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.000000000000004356InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000000006438InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000005524InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00004023InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00005298InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000004976Highly InformativeDirect
Enzyme Commission (EC)Cis-trans isomerases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]