SUPERFAMILY 1.75 HMM library and genome assignments server

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Tetratricopeptide repeat (TPR) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   alpha-alpha superhelix [ 48370] (24)
Superfamily:   TPR-like [ 48452] (8)
Family:   Tetratricopeptide repeat (TPR) [ 48453] (17)


Family statistics
Genomes (860) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,602 14,142 31
Proteins 4,389 13,434 30


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.06133Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.2061Least InformativeInherited
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00001861Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.03783Moderately InformativeInherited
Enzyme Commission (EC)Phosphoprotein phosphatase0.00000000006512InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.000113InformativeDirect
Enzyme Commission (EC)Cis-trans Isomerases1InformativeInherited
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporatio0Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.5535Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.1955InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.00002895Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0.03525Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.09078Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.1864Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.2546Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.5842Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.03068Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.04317Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lymphatic system0.04489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.103Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1213Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4667Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of prenatal development or birth0.04173InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.2082InformativeInherited
Phenotypic Abnormality (PA)Respiratory tract infection0.5703InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.6052InformativeInherited
Phenotypic Abnormality (PA)Bronchitis0.006918Highly InformativeInherited
Phenotypic Abnormality (PA)Polydactyly0.06072Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral physiology0.1218Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.567Least InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1579Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule morphology0.05089InformativeInherited
Mammalian Phenotype (MP)abnormal renal tubule epithelium morphology0.009465Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.000644Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.001208Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.004466Least InformativeInherited
Worm Phenotype (WP)cell development variant0.2404Least InformativeInherited
Worm Phenotype (WP)movement variant0.0009894Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.1634Moderately InformativeInherited
Worm Phenotype (WP)cell cycle variant0.384Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.6593Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0004831InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.09623Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.14Least InformativeInherited
Zebrafish Anatomy (ZA)organism subdivision0.219Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.34Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.4701Least InformativeInherited
Zebrafish Anatomy (ZA)cell1Least InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.1635Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.531Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.9483Moderately InformativeInherited
Zebrafish Anatomy (ZA)head1Moderately InformativeInherited
Zebrafish Anatomy (ZA)retina0.1967InformativeInherited
Zebrafish Anatomy (ZA)neuron0.9461InformativeInherited
Zebrafish Anatomy (ZA)retinal outer nuclear layer0.01452Highly InformativeInherited
Zebrafish Anatomy (ZA)retinal photoreceptor layer0.01885Highly InformativeInherited
Zebrafish Anatomy (ZA)receptor cell (sensu Animalia)0.122Highly InformativeInherited

Document: ZA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.09403Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.7089Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.1846Moderately InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.1895Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.000000000000004356InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000000000006438InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.000005524InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.00004023InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.00005298InformativeDirect
Enzyme Commission (EC)With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors0Highly InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine phosphatase0.00000000004976Highly InformativeDirect
Enzyme Commission (EC)Cis-trans isomerases1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 51 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a TPR-like domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]