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Nuclear receptor ligand-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Nuclear receptor ligand-binding domain [ 48507]
Superfamily:   Nuclear receptor ligand-binding domain [ 48508]
Family:   Nuclear receptor ligand-binding domain [ 48509] (33)


Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,126 16,195 148
Proteins 5,100 16,165 148


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0184Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.0000001475Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.003661Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.003733Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.006204Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.02937Moderately InformativeInherited
Disease Ontology (DO)overnutrition0.00000004012InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.00007179InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.000129InformativeDirect
Disease Ontology (DO)hypotrichosis0.0002282InformativeDirect
Disease Ontology (DO)physical disorder0.01195InformativeInherited
Disease Ontology (DO)urinary system cancer0.02122InformativeInherited
Disease Ontology (DO)breast carcinoma0.02846InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05554InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.07153InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2307InformativeInherited
Disease Ontology (DO)pancreas disease0.7381InformativeInherited
Disease Ontology (DO)hypospadias0.000005054Highly InformativeDirect
Disease Ontology (DO)gallbladder disease0.00005731Highly InformativeDirect
Disease Ontology (DO)rubella0.00008531Highly InformativeDirect
Disease Ontology (DO)lipid storage disease0.0001118Highly InformativeDirect
Disease Ontology (DO)uterine benign neoplasm0.0003377Highly InformativeDirect
Disease Ontology (DO)breast lobular carcinoma0.0003575Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.0005654Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3734Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9692Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.001925Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2481Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.3917Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0003777InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.02618InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.03035InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.6183InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.6918InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.9302InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.00001195Highly InformativeDirect
Phenotypic Abnormality (PA)Primary amenorrhea0.00005605Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.001578Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.005606Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.000003528Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0000115Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00002696Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.00003315Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.000226Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.002335Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.009207Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01442Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03903Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00000001054Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0000005347Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.000002469Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00003726Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.005745Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.009402Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.01558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01615Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01861Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.05459Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05486Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.06625Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.07995Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.09743Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.09975Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1251Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1571Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2272Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2814Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3697Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3749Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4273Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.5767Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5967Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.7369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.0001071InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0002488InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.0002882InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0.0004843InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0006082InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0007271InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.001147InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.002398InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.002831InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.003684InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.004427InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004852InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.005131InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.01365InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.03772InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.03957InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.05677InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.08047InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1172InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.133InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.2096InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2315InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.2469InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.5068InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.5591InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.6094InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.6267InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.6322InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.8046InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.9802InformativeInherited
Mammalian Phenotype (MP)abnormal testis weight0.0000004448Highly InformativeDirect
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.000007479Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vasodilation0.0001539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.0002981Highly InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0.0003669Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating insulin-like growth factor I level0.0003683Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0003835Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.000386Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.0003928Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0004219Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.0006546Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0006736Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.0007881Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0007924Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.000797Highly InformativeDirect
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.0008558Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.0008751Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.0008887Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory conducting tube morphology0.004184Highly InformativeInherited
Mammalian Phenotype (MP)abnormal social/conspecific interaction0.005786Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.006147Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.008429Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart tube morphology0.01215Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.01608Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.0188Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02029Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.02701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.02906Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.02979Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.03568Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04195Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.05248Highly InformativeInherited
Mammalian Phenotype (MP)abnormal temporal bone morphology0.05924Highly InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.06024Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.06113Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.07452Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.07978Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08801Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.09254Highly InformativeInherited
Mammalian Phenotype (MP)vertebral fusion0.1013Highly InformativeInherited
Mammalian Phenotype (MP)abnormal occipital bone morphology0.1069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1331Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid hormone level0.1559Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.1887Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.3376Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.3667Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.6164Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.7577Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.05303Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.993Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.00002813InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.195InformativeInherited
Worm Phenotype (WP)fat content variant0.9025InformativeInherited
Worm Phenotype (WP)fat content increased0.000001752Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002286Highly InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.001799Highly InformativeInherited
Worm Phenotype (WP)social behavior variant0.01381Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.0649Least InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.001631Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.01107Least InformativeInherited
Fly Anatomy (FA)adult0.012Least InformativeInherited
Fly Anatomy (FA)tagma0.04699Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2488Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3356Least InformativeInherited
Fly Anatomy (FA)nervous system0.6069Least InformativeInherited
Fly Anatomy (FA)somatic cell0.6363Least InformativeInherited
Fly Anatomy (FA)larva0.7204Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.001035Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.006363Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1038Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2923Moderately InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.000042InformativeDirect
Fly Anatomy (FA)interneuron0.0001177InformativeDirect
Fly Anatomy (FA)segmental subdivision of organ system0.008381InformativeInherited
Fly Anatomy (FA)brain0.011InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.07392InformativeInherited
Fly Anatomy (FA)labral segment0.08636InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1749InformativeInherited
Fly Anatomy (FA)mushroom body intrinsic neuron0.0000001262Highly InformativeDirect
Fly Anatomy (FA)mushroom body gamma-lobe0.0000003735Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.000001848Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0.1203Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7722Least InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.01597InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.09492InformativeInherited
Zebrafish Anatomy (ZA)gonad0.000007278Highly InformativeDirect
Zebrafish Anatomy (ZA)male organism0.0000288Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.00009492Highly InformativeDirect
Zebrafish Anatomy (ZA)otic vesicle0.0004983Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.09839Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.898InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nuclear receptor ligand-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]