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Nuclear receptor ligand-binding domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Nuclear receptor ligand-binding domain [ 48507]
Superfamily:   Nuclear receptor ligand-binding domain [ 48508]
Family:   Nuclear receptor ligand-binding domain [ 48509] (33)


Family statistics
Genomes (144) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,126 16,195 148
Proteins 5,100 16,165 148


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0184Least InformativeInherited
Disease Ontology (DO)disease of metabolism0.0000001475Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.003661Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.003733Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.006204Moderately InformativeInherited
Disease Ontology (DO)integumentary system disease0.02937Moderately InformativeInherited
Disease Ontology (DO)overnutrition0.00000004012InformativeDirect
Disease Ontology (DO)cell type benign neoplasm0.00007179InformativeDirect
Disease Ontology (DO)familial hyperlipidemia0.000129InformativeDirect
Disease Ontology (DO)hypotrichosis0.0002282InformativeDirect
Disease Ontology (DO)physical disorder0.01195InformativeInherited
Disease Ontology (DO)urinary system cancer0.02122InformativeInherited
Disease Ontology (DO)breast carcinoma0.02846InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.05554InformativeInherited
Disease Ontology (DO)endocrine gland cancer0.07153InformativeInherited
Disease Ontology (DO)organ system benign neoplasm0.2307InformativeInherited
Disease Ontology (DO)pancreas disease0.7381InformativeInherited
Disease Ontology (DO)hypospadias0.000005054Highly InformativeDirect
Disease Ontology (DO)gallbladder disease0.00005731Highly InformativeDirect
Disease Ontology (DO)rubella0.00008531Highly InformativeDirect
Disease Ontology (DO)lipid storage disease0.0001118Highly InformativeDirect
Disease Ontology (DO)uterine benign neoplasm0.0003377Highly InformativeDirect
Disease Ontology (DO)breast lobular carcinoma0.0003575Highly InformativeDirect
Disease Ontology (DO)endocrine pancreas disease0.0005654Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3847Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9663Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.002192Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.2515Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.412Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating hormone level0.0003603InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.02548InformativeInherited
Phenotypic Abnormality (PA)Neoplasm of the genitourinary tract0.02961InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.6279InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.6994InformativeInherited
Phenotypic Abnormality (PA)Abnormality of male external genitalia0.9327InformativeInherited
Phenotypic Abnormality (PA)Hyperpituitarism0.00001524Highly InformativeDirect
Phenotypic Abnormality (PA)Primary amenorrhea0.00005665Highly InformativeDirect
Phenotypic Abnormality (PA)Adrenal insufficiency0.001612Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.006402Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.000003516Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.00001158Least InformativeDirect
Mammalian Phenotype (MP)growth/size/body region phenotype0.00002685Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.000033Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.0002256Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.002327Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.009245Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.01447Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.03909Least InformativeInherited
Mammalian Phenotype (MP)abnormal lipid homeostasis0.00000001046Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.0000005306Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.000002459Moderately InformativeDirect
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.00003718Moderately InformativeDirect
Mammalian Phenotype (MP)adipose tissue phenotype0.005744Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.00934Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.01558Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal endocrine gland morphology0.01616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.01862Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone structure0.02692Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.05488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.05513Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryo morphology0.0663Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.07992Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.09748Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.09924Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.1251Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.1571Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1877Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal brain morphology0.2816Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.3705Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.3756Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4258Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.4808Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.5774Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.5957Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin morphology0.7369Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced morbidity/mortality0.000107InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.0002484InformativeDirect
Mammalian Phenotype (MP)abnormal metabolism0.0002875InformativeDirect
Mammalian Phenotype (MP)abnormal lipoprotein level0.0004834InformativeDirect
Mammalian Phenotype (MP)abnormal learning/memory/conditioning0.0006077InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.0007263InformativeDirect
Mammalian Phenotype (MP)abnormal macrophage morphology0.001132InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.002398InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.002832InformativeInherited
Mammalian Phenotype (MP)abnormal renal glomerulus morphology0.003682InformativeInherited
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.004429InformativeInherited
Mammalian Phenotype (MP)abnormal cartilage morphology0.004833InformativeInherited
Mammalian Phenotype (MP)abnormal thymus morphology0.005118InformativeInherited
Mammalian Phenotype (MP)abnormal cranial nerve morphology0.01366InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.03749InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.0396InformativeInherited
Mammalian Phenotype (MP)abnormal eyelid morphology0.05679InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.08051InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.1172InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.133InformativeInherited
Mammalian Phenotype (MP)abnormal heart development0.209InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2306InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.247InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system physiology0.5068InformativeInherited
Mammalian Phenotype (MP)abnormal testis morphology0.559InformativeInherited
Mammalian Phenotype (MP)abnormal anterior eye segment morphology0.6095InformativeInherited
Mammalian Phenotype (MP)abnormal skin appearance0.6267InformativeInherited
Mammalian Phenotype (MP)abnormal primary sex determination0.6322InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.8045InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.9802InformativeInherited
Mammalian Phenotype (MP)abnormal testis weight0.0000004436Highly InformativeDirect
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.000007474Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vasodilation0.0001539Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating pituitary hormone level0.0002981Highly InformativeDirect
Mammalian Phenotype (MP)abnormal energy expenditure0.0003666Highly InformativeDirect
Mammalian Phenotype (MP)decreased circulating insulin-like growth factor I level0.0003683Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0003837Highly InformativeDirect
Mammalian Phenotype (MP)decreased male germ cell number0.0003856Highly InformativeDirect
Mammalian Phenotype (MP)abnormal eye development0.000393Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland development0.0004218Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cellular cholesterol metabolism0.0006544Highly InformativeDirect
Mammalian Phenotype (MP)increased circulating leptin level0.0006735Highly InformativeDirect
Mammalian Phenotype (MP)narrow eye opening0.0007878Highly InformativeDirect
Mammalian Phenotype (MP)abnormal response/metabolism to endogenous compounds0.0007926Highly InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to atherosclerosis0.0007967Highly InformativeDirect
Mammalian Phenotype (MP)abnormal luteinizing hormone level0.0008564Highly InformativeDirect
Mammalian Phenotype (MP)abnormal optic nerve morphology0.0008754Highly InformativeDirect
Mammalian Phenotype (MP)abnormal physiological response to xenobiotic0.0008869Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory conducting tube morphology0.004185Highly InformativeInherited
Mammalian Phenotype (MP)abnormal social/conspecific interaction0.005772Highly InformativeInherited
Mammalian Phenotype (MP)abnormal compact bone morphology0.006151Highly InformativeInherited
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.008428Highly InformativeInherited
Mammalian Phenotype (MP)abnormal heart tube morphology0.01216Highly InformativeInherited
Mammalian Phenotype (MP)abnormal circadian rhythm0.01606Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vas deferens morphology0.01881Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thymus development0.02031Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cervical vertebrae morphology0.02701Highly InformativeInherited
Mammalian Phenotype (MP)abnormal basal ganglion morphology0.02907Highly InformativeInherited
Mammalian Phenotype (MP)abnormal fat cell morphology0.02978Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cornea morphology0.03569Highly InformativeInherited
Mammalian Phenotype (MP)decreased bone mass0.04195Highly InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0525Highly InformativeInherited
Mammalian Phenotype (MP)abnormal temporal bone morphology0.05925Highly InformativeInherited
Mammalian Phenotype (MP)vertebral transformation0.06027Highly InformativeInherited
Mammalian Phenotype (MP)abnormal seminiferous tubule morphology0.06116Highly InformativeInherited
Mammalian Phenotype (MP)abnormal ureter morphology0.07425Highly InformativeInherited
Mammalian Phenotype (MP)abnormal locomotor activation0.0798Highly InformativeInherited
Mammalian Phenotype (MP)abnormal midbrain morphology0.08804Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.09255Highly InformativeInherited
Mammalian Phenotype (MP)vertebral fusion0.1013Highly InformativeInherited
Mammalian Phenotype (MP)abnormal occipital bone morphology0.1069Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone volume0.1332Highly InformativeInherited
Mammalian Phenotype (MP)abnormal thyroid hormone level0.156Highly InformativeInherited
Mammalian Phenotype (MP)abnormal lens morphology0.1888Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epididymis morphology0.3377Highly InformativeInherited
Mammalian Phenotype (MP)abnormal middle ear morphology0.3667Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dorsal aorta morphology0.6163Highly InformativeInherited
Mammalian Phenotype (MP)abnormal enzyme/coenzyme activity0.7578Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant1Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant1Least InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.059Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant1Moderately InformativeInherited
Worm Phenotype (WP)transgene expression reduced0.00003268InformativeDirect
Worm Phenotype (WP)chemical hypersensitive0.2236InformativeInherited
Worm Phenotype (WP)fat content variant0.9092InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)fat content increased0.00000176Highly InformativeDirect
Worm Phenotype (WP)hatching variant0.0002758Highly InformativeDirect
Worm Phenotype (WP)social behavior variant0.01369Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0.06025Least InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)segment0.00129Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.008292Least InformativeInherited
Fly Anatomy (FA)adult0.00836Least InformativeInherited
Fly Anatomy (FA)tagma0.03474Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.2208Least InformativeInherited
Fly Anatomy (FA)anatomical group0.3081Least InformativeInherited
Fly Anatomy (FA)nervous system0.5441Least InformativeInherited
Fly Anatomy (FA)somatic cell0.5978Least InformativeInherited
Fly Anatomy (FA)larva0.7436Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0009326Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.005862Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.1067Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2724Moderately InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.00003798InformativeDirect
Fly Anatomy (FA)interneuron0.0001134InformativeDirect
Fly Anatomy (FA)central brain0.0006575InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion0.005379InformativeInherited
Fly Anatomy (FA)neuromere0.007361InformativeInherited
Fly Anatomy (FA)synaptic neuropil subdomain0.07349InformativeInherited
Fly Anatomy (FA)labral segment0.08715InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.1726InformativeInherited
Fly Anatomy (FA)mushroom body intrinsic neuron0.0000001479Highly InformativeDirect
Fly Anatomy (FA)mushroom body gamma-lobe0.0000004776Highly InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion neuron0.000001968Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.01758Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.1156Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.703Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7664Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1393Moderately InformativeInherited
Zebrafish Anatomy (ZA)endocrine system0.002184InformativeInherited
Zebrafish Anatomy (ZA)pleuroperitoneal region0.01761InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.02445InformativeInherited
Zebrafish Anatomy (ZA)embryonic structure0.1048InformativeInherited
Zebrafish Anatomy (ZA)gonad0.00001014Highly InformativeDirect
Zebrafish Anatomy (ZA)male organism0.00005537Highly InformativeDirect
Zebrafish Anatomy (ZA)female organism0.0001304Highly InformativeDirect
Zebrafish Anatomy (ZA)hypophysis0.0002062Highly InformativeDirect
Zebrafish Anatomy (ZA)otic vesicle0.0006137Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.1014Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.8976InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 59 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Nuclear receptor ligand-binding domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]