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GroEL equatorial domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GroEL equatorial domain-like [ 48591]
Superfamily:   GroEL equatorial domain-like [ 48592] (2)
Families:   GroEL chaperone, ATPase domain [ 48593]
  Group II chaperonin (CCT, TRIC), ATPase domain [ 48596]


Superfamily statistics
Genomes (3,199) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 11,456 59,402 29
Proteins 11,024 57,332 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)protein complex0.00068510.00000000000000156Least InformativeDirect
Cellular Component (CC)cytoplasmic part0.00024140Least InformativeDirect
Cellular Component (CC)cytosolic part0.000033460Moderately InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.00000000009891 Least Informative Direct
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) response to abiotic stimulus 0 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.3188 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.4263 Moderately Informative Inherited
Biological Process (BP) tissue development 0.6119 Moderately Informative Inherited
Biological Process (BP) single-organism transport 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1219 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4272 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2723 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.04681 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.144 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.02004 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6716 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9916 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.6184 Moderately Informative Inherited
Biological Process (BP) mitochondrion organization 0.00001389 Informative Direct
Biological Process (BP) response to temperature stimulus 0 Informative Direct
Biological Process (BP) regulation of protein localization 0.002736 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 1 Informative Inherited
Biological Process (BP) regulation of cellular localization 0.1736 Informative Inherited
Biological Process (BP) protein localization to organelle 0.03266 Informative Inherited
Biological Process (BP) embryo development 0.2477 Informative Inherited
Biological Process (BP) epithelium development 0.3402 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.003209 Informative Inherited
Biological Process (BP) organelle localization 0.0131 Informative Inherited
Biological Process (BP) cellular protein complex assembly 0.002936 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.04112 Informative Inherited
Biological Process (BP) regulation of secretion 0.1906 Informative Inherited
Biological Process (BP) regulation of peptide transport 0.09228 Informative Inherited
Biological Process (BP) interspecies interaction between organisms 0.1205 Informative Inherited
Biological Process (BP) intracellular transport 0.002928 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.689 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.5121 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.01723 Informative Inherited
Biological Process (BP) single organism reproductive process 0.05042 Informative Inherited
Biological Process (BP) protein transport 0.05684 Informative Inherited
Biological Process (BP) protein folding 0 Highly Informative Direct
Biological Process (BP) gastrulation 0.0009683 Highly Informative Direct
Biological Process (BP) response to cold 0 Highly Informative Direct
Biological Process (BP) fertilization 0.0000002071 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.00001983 Highly Informative Direct
Biological Process (BP) positive regulation of homeostatic process 0.0005541 Highly Informative Direct
Biological Process (BP) pigmentation 0.000001787 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.0002935 Highly Informative Direct
Biological Process (BP) establishment of protein localization to mitochondrion 0.0000003885 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0.0001369 Highly Informative Direct
Biological Process (BP) positive regulation of cellular protein localization 0.000773 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.01935 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.04647 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.07965 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 0.001561 Highly Informative Inherited
Biological Process (BP) biological adhesion 0.09799 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 0.06765 Highly Informative Inherited
Biological Process (BP) protein targeting 0.001022 Highly Informative Inherited
Biological Process (BP) mitochondrial transport 0.002675 Highly Informative Inherited
Molecular Function (MF) binding 0.9785 Least Informative Inherited
Cellular Component (CC) protein complex 0.00000000000000156 Least Informative Direct
Cellular Component (CC) cytoplasmic part 0 Least Informative Direct
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cytosolic part 0 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) plastid 0.3847 Informative Inherited
Cellular Component (CC) chloroplast stroma 0.0004313 Highly Informative Direct

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processStress response0InformativeDirect
Cellular componentCytoplasm0Least InformativeDirect
Cellular componentCell projection0.09806Moderately InformativeInherited
Cellular componentCilium0.0000006598InformativeDirect
DomainTransit peptide0.000001187Moderately InformativeDirect
Molecular functionNucleotide-binding0Least InformativeDirect
Post-translational modificationChaperone0InformativeDirect
Post-translational modificationIsopeptide bond0.000007483Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR008950 SSF48592 Protein matches
Abstract

Partially folded polypeptide chains, either newly made by ribosomes or emerging from mature proteins unfolded by stress, run the risk of aggregating with one another to the detriment of the organism. Folding of newly synthesised polypeptides in the crowded cellular environment requires the assistance of molecular chaperone proteins, such as the large bacterial chaperonins GroEL and GroES.

GroEL and GroES prevent aggregation by encapsulating individual chains within the so-called ┐Anfinsen cage┐ provided by the GroEL┐GroES complex, where they can fold in isolation from one another [PubMed12654267]. GroEL consists of two heptameric rings of identical ATPase subunits stacked back to back, containing a cage in each ring. Each subunit consists of three domains. The equatorial domain contains the nucleotide binding site and is connected by a flexible intermediate domain with the apical domain. The latter presents several hydrophobic amino-acid side chains at the top of the ring, orientated towards the cavity of the cage. These side chains are involved in binding either a partially folded polypeptide chain or a single molecule of GroES.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL equatorial domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL equatorial domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]