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GroEL equatorial domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   GroEL equatorial domain-like [ 48591]
Superfamily:   GroEL equatorial domain-like [ 48592] (2)
Families:   GroEL chaperone, ATPase domain [ 48593]
  Group II chaperonin (CCT, TRIC), ATPase domain [ 48596]


Superfamily statistics
Genomes (3,199) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 11,456 71,532 29
Proteins 11,024 69,029 29


Functional annotation
General category Processes_IC
Detailed category Protein modification

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.00414Moderately InformativeInherited
Disease Ontology (DO)autosomal recessive disease0.002349InformativeInherited
Disease Ontology (DO)Bardet-Biedl syndrome0.0000000671Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the musculature0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of limbs0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.1006Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the integument0.1053Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1393Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.1757Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.2015Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.9058Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormal posterior eye segment morphology0.008178Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.0565Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.08272Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.08297Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.08656Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.1011Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.1355Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.1797Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.2342Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.3318Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.3782Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ovary0.0007551InformativeDirect
Phenotypic Abnormality (PA)Abnormal retinal morphology0.002329InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.01106InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.01113InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal physiology0.01259InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.03204InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the outer ear0.04204InformativeInherited
Phenotypic Abnormality (PA)Abnormality of muscle size0.05062InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.1239InformativeInherited
Phenotypic Abnormality (PA)Rod-cone dystrophy0.000001709Highly InformativeDirect
Phenotypic Abnormality (PA)Hepatic fibrosis0.00003674Highly InformativeDirect
Phenotypic Abnormality (PA)Generalized hirsutism0.00004245Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal ovarian morphology0.0000836Highly InformativeDirect
Phenotypic Abnormality (PA)Hand polydactyly0.0001333Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal electroretinogram0.0003066Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.0003377Highly InformativeDirect
Phenotypic Abnormality (PA)Posteriorly rotated ears0.002073Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal 5th finger morphology0.002672Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormal eyebrow morphology0.005502Highly InformativeInherited
Phenotypic Abnormality (PA)Low-set ears0.01144Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nasal bridge0.03192Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of retinal pigmentation0.07745Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.06825Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.2592Least InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.007268Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.01964Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal body composition0.2468Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.5344Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating leptin level0.00006704InformativeDirect
Mammalian Phenotype (MP)increased body weight0.0002438InformativeDirect
Mammalian Phenotype (MP)obese0.000003718Highly InformativeDirect
Mammalian Phenotype (MP)retinal degeneration0.00000479Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0Least InformativeDirect
Worm Phenotype (WP)cell development variant0Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0Least InformativeDirect
Worm Phenotype (WP)larval development variant0Least InformativeDirect
Worm Phenotype (WP)larval growth variant0Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.000007922Least InformativeDirect
Worm Phenotype (WP)blast cell physiology variant0.0000158Least InformativeDirect
Worm Phenotype (WP)cell physiology variant0.00001585Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.00003556Least InformativeDirect
Worm Phenotype (WP)reproductive system morphology variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0Moderately InformativeDirect
Worm Phenotype (WP)germ cell differentiation variant0Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)level of transgene expression variant0Moderately InformativeDirect
Worm Phenotype (WP)protein protein interaction variant0.000000002159Moderately InformativeDirect
Worm Phenotype (WP)early embryonic lethal0.000000005785Moderately InformativeDirect
Worm Phenotype (WP)germ cell morphology variant0.00000007462Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.000000976Moderately InformativeDirect
Worm Phenotype (WP)feeding behavior variant0.0002756Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.001202Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.001202Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.001206Moderately InformativeInherited
Worm Phenotype (WP)adult body morphology variant0.001211Moderately InformativeInherited
Worm Phenotype (WP)body morphology variant0.001331Moderately InformativeInherited
Worm Phenotype (WP)cell division variant0.002047Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.002588Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.002815Moderately InformativeInherited
Worm Phenotype (WP)reproductive system development variant0.1126Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1309Moderately InformativeInherited
Worm Phenotype (WP)transgene expression increased0InformativeDirect
Worm Phenotype (WP)pleiotropic defects severe early emb0.00000000000105InformativeDirect
Worm Phenotype (WP)pachytene progression during oogenesis variant0.000000000002148InformativeDirect
Worm Phenotype (WP)germ cell compartment expansion variant0.00000000003498InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.0000000009463InformativeDirect
Worm Phenotype (WP)avoids bacterial lawn0.00000000653InformativeDirect
Worm Phenotype (WP)vesicle morphology variant0.0000001134InformativeDirect
Worm Phenotype (WP)pigmentation variant0.000000417InformativeDirect
Worm Phenotype (WP)protruding vulva0.000000573InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000001181InformativeDirect
Worm Phenotype (WP)endocytic transport defect0.000002079InformativeDirect
Worm Phenotype (WP)protein metabolism variant0.000002709InformativeDirect
Worm Phenotype (WP)accumulated germline cell corpses0.000005425InformativeDirect
Worm Phenotype (WP)nuclear positioning variant0.00001099InformativeDirect
Worm Phenotype (WP)somatic gonad development variant0.00001338InformativeDirect
Worm Phenotype (WP)sick0.0002319InformativeDirect
Worm Phenotype (WP)oocyte physiology variant0.0002819InformativeDirect
Worm Phenotype (WP)life span variant0.0003318InformativeDirect
Worm Phenotype (WP)cell component localization variant0.00308InformativeInherited
Worm Phenotype (WP)mitosis variant0.09426InformativeInherited
Worm Phenotype (WP)rachis morphology variant0.2252InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.2466InformativeInherited
Worm Phenotype (WP)meiotic chromosome organization variant0.568InformativeInherited
Worm Phenotype (WP)oocytes small0.000000000000003551Highly InformativeDirect
Worm Phenotype (WP)unfolded protein response variant0.000000000119Highly InformativeDirect
Worm Phenotype (WP)RAB-11 recycling endosome localization variant0.000000006533Highly InformativeDirect
Worm Phenotype (WP)germ cell compartment anucleate0.00000003697Highly InformativeDirect
Worm Phenotype (WP)male somatic gonad development variant0.0000003136Highly InformativeDirect
Worm Phenotype (WP)gonad arm morphology variant0.0000006353Highly InformativeDirect
Worm Phenotype (WP)no oocytes0.000003233Highly InformativeDirect
Worm Phenotype (WP)chromosome condensation variant0.00003421Highly InformativeDirect
Worm Phenotype (WP)no induction of antimicrobial peptide expression after infection0.00006575Highly InformativeDirect
Worm Phenotype (WP)cell membrane organization biogenesis variant0.0004285Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)adult0.0398Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3108Least InformativeInherited
Fly Anatomy (FA)adult heart0.0000000004487InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.756Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.01574Moderately InformativeInherited
Zebrafish Anatomy (ZA)electrically active cell0.09916Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal muscle0.0001075InformativeDirect
Zebrafish Anatomy (ZA)muscle cell0.0008209InformativeDirect
Zebrafish Anatomy (ZA)myotome0.00001026Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0.03726Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue0.1236Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical system1Least InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.0003402Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.00422Moderately InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.000002438InformativeDirect
Xenopus ANatomical entity (XAN)immune system0.0001544InformativeDirect
Xenopus ANatomical entity (XAN)dermal system0.0002262InformativeDirect
Xenopus ANatomical entity (XAN)endocrine system0.0002744InformativeDirect
Xenopus ANatomical entity (XAN)anatomical entity in vitro0.0006838InformativeDirect
Xenopus ANatomical entity (XAN)endomesoderm0.0007319InformativeDirect
Xenopus ANatomical entity (XAN)tail0.0008999InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.002709InformativeInherited
Xenopus ANatomical entity (XAN)mesoderm0.02519InformativeInherited
Xenopus ANatomical entity (XAN)anterior dorsal lateral plate region0.0003578Highly InformativeDirect
Xenopus DEvelopment stage (XDE)unspecified stage0.0009184Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)whole plant0Least InformativeDirect
Plant ANatomical entity (PAN)seed0Least InformativeDirect
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)inflorescence0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect
Plant ANatomical entity (PAN)shoot axis0Least InformativeDirect
Plant ANatomical entity (PAN)leaf0Least InformativeDirect
Plant ANatomical entity (PAN)cardinal part of multi-tissue plant structure0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)seed development stage0.000000004758InformativeDirect
Plant structure DEvelopment stage (PDE)0 seed germination stage0.0002307InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases altering macromolecular conformation0InformativeDirect
Enzyme Commission (EC)Enzymes altering polypeptide conformation or assembly0Highly InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR008950 SSF48592 Protein matches
Abstract

Partially folded polypeptide chains, either newly made by ribosomes or emerging from mature proteins unfolded by stress, run the risk of aggregating with one another to the detriment of the organism. Folding of newly synthesised polypeptides in the crowded cellular environment requires the assistance of molecular chaperone proteins, such as the large bacterial chaperonins GroEL and GroES.

GroEL and GroES prevent aggregation by encapsulating individual chains within the so-called ┐Anfinsen cage┐ provided by the GroEL┐GroES complex, where they can fold in isolation from one another [PubMed12654267]. GroEL consists of two heptameric rings of identical ATPase subunits stacked back to back, containing a cage in each ring. Each subunit consists of three domains. The equatorial domain contains the nucleotide binding site and is connected by a flexible intermediate domain with the apical domain. The latter presents several hydrophobic amino-acid side chains at the top of the ring, orientated towards the cavity of the cage. These side chains are involved in binding either a partially folded polypeptide chain or a single molecule of GroES.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 7 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a GroEL equatorial domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 7 hidden Markov models representing the GroEL equatorial domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]