SUPERFAMILY 1.75 HMM library and genome assignments server

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Heme oxygenase-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All alpha proteins [ 46456] (284)
Fold:   Heme oxygenase-like [ 48612]
Superfamily:   Heme oxygenase-like [ 48613] (4)
Families:   Eukaryotic type heme oxygenase [ 48614] (3)
  Heme oxygenase HemO (PigA) [ 63627]
  TENA/THI-4 [ 101458] (8)
  PqqC-like [ 101463] (2)


Superfamily statistics
Genomes (1,993) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 4,515 23,835 31
Proteins 4,505 23,762 31


Functional annotation
General category Metabolism
Detailed category Redox

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular aromatic compound metabolic process 0.0000002478 Least Informative Direct
Biological Process (BP) cellular nitrogen compound metabolic process 0.000006582 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0.0000133 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 0.00000003649 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 0.0000001678 Least Informative Direct
Biological Process (BP) organonitrogen compound metabolic process 0.00004495 Least Informative Direct
Biological Process (BP) biosynthetic process 0.2505 Least Informative Inherited
Biological Process (BP) response to stimulus 0.2924 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.05872 Least Informative Inherited
Biological Process (BP) biological regulation 1 Least Informative Inherited
Biological Process (BP) sulfur compound metabolic process 0.0001564 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0009815 Moderately Informative Direct
Biological Process (BP) small molecule biosynthetic process 0.0007825 Moderately Informative Direct
Biological Process (BP) cofactor metabolic process 0.000000000005601 Moderately Informative Direct
Biological Process (BP) organic substance catabolic process 0.001585 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1671 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.02484 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.04454 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.05141 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.05134 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.05097 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.009188 Moderately Informative Inherited
Biological Process (BP) response to oxidative stress 0.0003163 Informative Direct
Biological Process (BP) tetrapyrrole metabolic process 0 Informative Direct
Biological Process (BP) pigment metabolic process 0.0000000000004641 Informative Direct
Biological Process (BP) sulfur compound biosynthetic process 0.00002905 Informative Direct
Biological Process (BP) cation homeostasis 0.0001248 Informative Direct
Biological Process (BP) cellular chemical homeostasis 0.0001167 Informative Direct
Biological Process (BP) pyrimidine-containing compound biosynthetic process 0.0000004857 Informative Direct
Biological Process (BP) inorganic ion homeostasis 0.0001369 Informative Direct
Biological Process (BP) water-soluble vitamin biosynthetic process 0.1923 Informative Inherited
Biological Process (BP) response to hypoxia 0.000009629 Highly Informative Direct
Biological Process (BP) transition metal ion homeostasis 0.00000009673 Highly Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) oxidoreductase activity 0.0000000002977 Moderately Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.00000000001885 Informative Direct
Molecular Function (MF) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxyge 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000000001268 Highly Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.523 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.0889 Least Informative Inherited
Cellular Component (CC) plastid 0.00004078 Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0Least InformativeDirect
Enzyme Commission (EC)Acting on the CH-CH group of donors0Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000000000003708Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.04236Moderately InformativeInherited
Enzyme Commission (EC)Miscellaneous (requires further characterization)0InformativeDirect
Enzyme Commission (EC)Phosphotransferases with a phosphate group as acce0.001816InformativeInherited
Enzyme Commission (EC)With oxygen as acceptor0Highly InformativeDirect
Enzyme Commission (EC)In other compounds4.713e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processApoptosis0.00000842Moderately InformativeDirect
Biological processPhotosynthesis0.000000001391InformativeDirect
Biological processThiamine biosynthesis0Highly InformativeDirect
Cellular componentEndoplasmic reticulum0.00000000003014Moderately InformativeDirect
Cellular componentPlastid0.0002175Moderately InformativeDirect
Cellular componentChloroplast0.0001439InformativeDirect
Cellular componentMicrosome0.00000000001273Highly InformativeDirect
Molecular functionMetal-binding0.03682Least InformativeInherited
Molecular functionIron0.00000000000000246Moderately InformativeDirect
Molecular functionHeme0InformativeDirect
Post-translational modificationOxidoreductase0Moderately InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Heme oxygenase-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the Heme oxygenase-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]