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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 530,434 2,226
Proteins 61,415 198,234 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.002367Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4421Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002195Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04606Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06205Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.0969Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.119Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9675Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000000948InformativeDirect
Disease Ontology (DO)allergic rhinitis0.000297InformativeDirect
Disease Ontology (DO)alopecia0.0004158InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1565InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.2537InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7839InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004627Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002573Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.0001291Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.01749Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.6775Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.1034Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.151Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.5374Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.5826Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.6875Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.7479Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.9649Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.08557Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.09391Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.2242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.4812Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.4821Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.4938Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.5242Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.6085Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.6847Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin morphology0.8468Moderately InformativeInherited
Phenotypic Abnormality (PA)Behavioral abnormality0.9749Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual CNS infection0.000902InformativeDirect
Phenotypic Abnormality (PA)Internal hemorrhage0.1612InformativeInherited
Phenotypic Abnormality (PA)Abnormal lung morphology0.3231InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.4887InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.5663InformativeInherited
Phenotypic Abnormality (PA)Abnormal bone structure0.5736InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.6455InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7858InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Diabetes insipidus0.00005795Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.00008953Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.0002663Highly InformativeDirect
Phenotypic Abnormality (PA)Short toe0.07985Highly InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the skin0.1435Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.2008Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001295Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000278Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2601Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06819Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5637Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9953Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003257InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006156InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.5416InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9395InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9865InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.000249Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004439Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0008947Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.002273Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03531Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.05657Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.6389Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9139Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000002462Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0002688Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.0004214Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0006655Moderately InformativeDirect
Worm Phenotype (WP)metabolic pathway variant0.00943Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.02393Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.09366Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.0000000001043InformativeDirect
Worm Phenotype (WP)neurite morphology variant0.00000002922InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.00000568InformativeDirect
Worm Phenotype (WP)body posture variant0.0000107InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002565InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00003731InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005889InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001808InformativeDirect
Worm Phenotype (WP)neuron migration variant0.6351InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.7432InformativeInherited
Worm Phenotype (WP)muscle arm development defective0.000000000269Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00009586Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003484Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001806Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.00008689Highly InformativeDirect
Fly Phenotype (FP)cell adhesion defective0.0009665Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0004469Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001451Least InformativeInherited
Fly Anatomy (FA)nervous system0.002877Least InformativeInherited
Fly Anatomy (FA)larva0.0376Least InformativeInherited
Fly Anatomy (FA)somatic cell0.05758Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1201Least InformativeInherited
Fly Anatomy (FA)adult0.1256Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00000003788Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001283Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.007455Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.0078Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.03469Moderately InformativeInherited
Fly Anatomy (FA)developing embryonic structure0.04275Moderately InformativeInherited
Fly Anatomy (FA)neuron0.07333Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.09466Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1348Moderately InformativeInherited
Fly Anatomy (FA)somatic precursor cell0.3463Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6004Moderately InformativeInherited
Fly Anatomy (FA)head0.695Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.862Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9515Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.9632Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000002835InformativeDirect
Fly Anatomy (FA)nerve0.000372InformativeDirect
Fly Anatomy (FA)embryonic/larval peripheral nervous system0.0005117InformativeDirect
Fly Anatomy (FA)primordium0.004416InformativeInherited
Fly Anatomy (FA)brain0.009856InformativeInherited
Fly Anatomy (FA)syncytium0.01861InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.03693InformativeInherited
Fly Anatomy (FA)abdominal segment0.04604InformativeInherited
Fly Anatomy (FA)muscle system0.05408InformativeInherited
Fly Anatomy (FA)chaeta0.0848InformativeInherited
Fly Anatomy (FA)adult central nervous system0.0924InformativeInherited
Fly Anatomy (FA)chemosensory system0.09305InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.1177InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.6515InformativeInherited
Fly Anatomy (FA)tract0.6619InformativeInherited
Fly Anatomy (FA)leg0.6961InformativeInherited
Fly Anatomy (FA)embryonic heart cardioblast0.000002804Highly InformativeDirect
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.00003809Highly InformativeDirect
Fly Anatomy (FA)heart primordium0.0000418Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.00009588Highly InformativeDirect
Fly Anatomy (FA)connective0.0001048Highly InformativeDirect
Fly Anatomy (FA)LNv neuron0.0001214Highly InformativeDirect
Fly Anatomy (FA)commissure0.0002536Highly InformativeDirect
Fly Anatomy (FA)abdominal segmental nerve0.00084Highly InformativeDirect
Fly Anatomy (FA)larval VNC neuropil glial cell0.01825Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.06907Least InformativeInherited
Zebrafish Anatomy (ZA)compound organ0.1018Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.7529Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system1Moderately InformativeInherited
Zebrafish Anatomy (ZA)forebrain0.399InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.00007761Highly InformativeDirect
Zebrafish Anatomy (ZA)glomerular layer0.001039Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)post-embryonic stage1Least InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.0000006325Moderately InformativeDirect
Xenopus DEvelopment stage (XDE)adult frog stage0.0001897Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.07662Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.00003032InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 450 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]