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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (302) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 167,048 193,084 2,226
Proteins 60,071 85,490 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)response to stimulus00Least InformativeDirect
Biological Process (BP)biological regulation00Least InformativeDirect
Biological Process (BP)single-organism cellular process0.00000001450Least InformativeDirect
Biological Process (BP)primary metabolic process01Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.67130Least InformativeInherited
Biological Process (BP)macromolecule metabolic process01Least InformativeInherited
Biological Process (BP)cell communication00Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus00Moderately InformativeDirect
Biological Process (BP)signaling00Moderately InformativeDirect
Biological Process (BP)immune system process00Moderately InformativeDirect
Biological Process (BP)single-organism transport00Moderately InformativeDirect
Biological Process (BP)anatomical structure morphogenesis0.00024250Moderately InformativeDirect
Biological Process (BP)multi-organism process0.00085420.000000000000003692Moderately InformativeDirect
Biological Process (BP)regulation of localization10.04782Moderately InformativeInherited
Biological Process (BP)response to external stimulus10.000000000009194Moderately InformativeInherited
Biological Process (BP)regulation of molecular function11Moderately InformativeInherited
Biological Process (BP)regulation of biological quality11Moderately InformativeInherited
Biological Process (BP)regulation of developmental process10Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process10.8481Moderately InformativeInherited
Biological Process (BP)regulation of signaling10.7454Moderately InformativeInherited
Biological Process (BP)regulation of cell communication10.83Moderately InformativeInherited
Biological Process (BP)regulation of multicellular organismal process10Moderately InformativeInherited
Biological Process (BP)system development0.0089540Moderately InformativeInherited
Biological Process (BP)cellular developmental process0.220Moderately InformativeInherited
Biological Process (BP)regulation of cellular metabolic process11Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.044040.00000000001328Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization10.00000000000005819Moderately InformativeInherited
Biological Process (BP)negative regulation of cellular process11Moderately InformativeInherited
Biological Process (BP)cellular component assembly0.052491Moderately InformativeInherited
Biological Process (BP)organelle organization0.17861Moderately InformativeInherited
Biological Process (BP)response to stress11Moderately InformativeInherited
Biological Process (BP)regulation of immune response00InformativeDirect
Biological Process (BP)positive regulation of immune system process00InformativeDirect
Biological Process (BP)cell surface receptor signaling pathway00InformativeDirect
Biological Process (BP)immune response00InformativeDirect
Biological Process (BP)vesicle-mediated transport00InformativeDirect
Biological Process (BP)cell adhesion0.00000000000031670.000000006284InformativeDirect
Biological Process (BP)regulation of nervous system development0.0000000000051090InformativeDirect
Biological Process (BP)generation of neurons0.0000000030450InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.00000001280.00000002756InformativeDirect
Biological Process (BP)regulation of transferase activity0.00000038420.0000007829InformativeDirect
Biological Process (BP)anatomical structure formation involved in morphogenesis0.0000011380.000000003542InformativeDirect
Biological Process (BP)regulation of phosphorylation0.000075860.00000001571InformativeDirect
Biological Process (BP)cytoskeleton organization0.00014130.0000000002452InformativeDirect
Biological Process (BP)regulation of protein modification process0.00014580.0000000000001098InformativeDirect
Biological Process (BP)cell development0.0007650InformativeDirect
Biological Process (BP)regulation of cell differentiation0.2260InformativeInherited
Biological Process (BP)animal organ morphogenesis0.0000075870.5088InformativeInherited
Biological Process (BP)regulation of hydrolase activity0.000014070.382InformativeInherited
Biological Process (BP)positive regulation of catalytic activity0.0017510.000005285InformativeInherited
Biological Process (BP)regulation of ion transport0.00000064420.08045InformativeInherited
Biological Process (BP)regulation of transmembrane transport0.00000025050.202InformativeInherited
Biological Process (BP)regulation of cellular component movement0.078790.0000000314InformativeInherited
Biological Process (BP)negative regulation of signaling0.0000030130.492InformativeInherited
Biological Process (BP)negative regulation of cell communication0.0000043170.5286InformativeInherited
Biological Process (BP)negative regulation of response to stimulus11InformativeInherited
Biological Process (BP)circulatory system development0.00036660.08271InformativeInherited
Biological Process (BP)regulation of locomotion0.08630.000000005167InformativeInherited
Biological Process (BP)symbiosis, encompassing mutualism through parasitism0.00000000012850.01815InformativeInherited
Biological Process (BP)multi-organism cellular process0.00000014890.1152InformativeInherited
Biological Process (BP)negative regulation of cellular component organization0.00000000022080.5151InformativeInherited
Biological Process (BP)regulation of anatomical structure morphogenesis0.0076610.000000000000003692InformativeInherited
Biological Process (BP)positive regulation of transport10.5239InformativeInherited
Biological Process (BP)regulation of cellular localization0.00030541InformativeInherited
Biological Process (BP)regulation of anatomical structure size0.16810.0004286InformativeInherited
Biological Process (BP)leukocyte mediated immunity00Highly InformativeDirect
Biological Process (BP)endocytosis00.000000000000003692Highly InformativeDirect
Biological Process (BP)regulation of T cell activation00.000000000000003692Highly InformativeDirect
Biological Process (BP)humoral immune response00.00000000004618Highly InformativeDirect
Biological Process (BP)cell junction assembly0.0000000000000030420.0000001954Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion0.0000000000010120.0000001889Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.0000000000029790.00000006574Highly InformativeDirect
Biological Process (BP)neuron development0.00000000050610Highly InformativeDirect
Biological Process (BP)angiogenesis0.0000000022240.00000000001945Highly InformativeDirect
Biological Process (BP)sensory organ morphogenesis0.00000020060.00001173Highly InformativeDirect
Biological Process (BP)regulation of cell morphogenesis involved in differentiation0.000006250Highly InformativeDirect
Biological Process (BP)antigen processing and presentation of exogenous peptide antigen0.0006470.0002362Highly InformativeDirect
Biological Process (BP)regulation of leukocyte mediated immunity0.00076280Highly InformativeDirect
Biological Process (BP)regulation of cell size0.00098730.00000008844Highly InformativeDirect
Biological Process (BP)positive regulation of cell adhesion0.0015730Highly InformativeInherited
Biological Process (BP)positive regulation of ion transport0.000000029560.007071Highly InformativeInherited
Biological Process (BP)regulation of calcium ion transport0.015220.2811Highly InformativeInherited
Biological Process (BP)regulation of cation transmembrane transport0.000000000011010.01926Highly InformativeInherited
Biological Process (BP)positive regulation of lymphocyte activation00.07836Highly InformativeInherited
Biological Process (BP)negative regulation of immune system process0.31960.0000000000009363Highly InformativeInherited
Biological Process (BP)regulation of neuron projection development0.0069140Highly InformativeInherited
Biological Process (BP)camera-type eye development0.0000000001880.1299Highly InformativeInherited
Biological Process (BP)negative regulation of cell development0.0000000021040.1375Highly InformativeInherited
Biological Process (BP)regulation of ion homeostasis0.037770.4191Highly InformativeInherited
Biological Process (BP)positive regulation of adaptive immune response based on somatic recombination of immune receptors b0.00011180.1685Highly InformativeInherited
Biological Process (BP)positive regulation of immune effector process10.2529Highly InformativeInherited
Molecular Function (MF)binding0.0000000023150Least InformativeDirect
Molecular Function (MF)hydrolase activity01Least InformativeInherited
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)carbohydrate derivative binding0.079681Moderately InformativeInherited
Molecular Function (MF)protein binding10Moderately InformativeInherited
Molecular Function (MF)anion binding0.031741Moderately InformativeInherited
Molecular Function (MF)structural molecule activity0.086570Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.16230.000000000003547Moderately InformativeInherited
Molecular Function (MF)peptidase activity, acting on L-amino acid peptides00.0000000000302InformativeDirect
Molecular Function (MF)amide binding0.000017850InformativeDirect
Molecular Function (MF)receptor binding0.00010980.00001276InformativeDirect
Molecular Function (MF)phospholipid binding0.0000000013710.6471InformativeInherited
Molecular Function (MF)kinase activity0.056370InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.01130InformativeInherited
Molecular Function (MF)serine hydrolase activity00Highly InformativeDirect
Molecular Function (MF)glycolipid binding00.0000000001195Highly InformativeDirect
Molecular Function (MF)peptide binding0.000000022660Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.0010060Highly InformativeInherited
Cellular Component (CC)membrane00Least InformativeDirect
Cellular Component (CC)plasma membrane00Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)vesicle0.000000000000072950Moderately InformativeDirect
Cellular Component (CC)cell projection0.032830Moderately InformativeInherited
Cellular Component (CC)cell surface0.0000000000016680InformativeDirect
Cellular Component (CC)extracellular organelle0.000000000013180InformativeDirect
Cellular Component (CC)site of polarized growth0.0000000016670.000000001153InformativeDirect
Cellular Component (CC)side of membrane0.00000052790InformativeDirect
Cellular Component (CC)neuron projection0.0000010930InformativeDirect
Cellular Component (CC)extracellular space0.0086631InformativeInherited
Cellular Component (CC)cell projection part0.00049230.002003InformativeInherited
Cellular Component (CC)blood microparticle00.00000007355Highly InformativeDirect
Cellular Component (CC)growth cone0.000000000000015990.0000002193Highly InformativeDirect
Cellular Component (CC)external side of plasma membrane0.000000023360Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0 Least Informative Direct
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cell communication 0 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0 Moderately Informative Direct
Biological Process (BP) signaling 0 Moderately Informative Direct
Biological Process (BP) immune system process 0 Moderately Informative Direct
Biological Process (BP) single-organism transport 0 Moderately Informative Direct
Biological Process (BP) anatomical structure morphogenesis 0 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.000000000000003692 Moderately Informative Direct
Biological Process (BP) system development 0 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00000000001328 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00000000000005819 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.000000000009194 Moderately Informative Direct
Biological Process (BP) ion transport 1 Moderately Informative Inherited
Biological Process (BP) regulation of localization 0.04782 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7454 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 1 Moderately Informative Inherited
Biological Process (BP) reproduction 0.031 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8481 Moderately Informative Inherited
Biological Process (BP) response to organic substance 0.87 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.8474 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) response to stress 1 Moderately Informative Inherited
Biological Process (BP) cellular localization 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.83 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.02284 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 1 Moderately Informative Inherited
Biological Process (BP) regulation of immune response 0 Informative Direct
Biological Process (BP) positive regulation of immune system process 0 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0 Informative Direct
Biological Process (BP) immune response 0 Informative Direct
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) cell adhesion 0.000000006284 Informative Direct
Biological Process (BP) regulation of nervous system development 0 Informative Direct
Biological Process (BP) generation of neurons 0 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00000002756 Informative Direct
Biological Process (BP) regulation of transferase activity 0.0000007829 Informative Direct
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.000000003542 Informative Direct
Biological Process (BP) regulation of phosphorylation 0.00000001571 Informative Direct
Biological Process (BP) cytoskeleton organization 0.0000000002452 Informative Direct
Biological Process (BP) regulation of protein modification process 0.0000000000001098 Informative Direct
Biological Process (BP) cell development 0 Informative Direct
Biological Process (BP) positive regulation of catalytic activity 0.000005285 Informative Direct
Biological Process (BP) regulation of anatomical structure morphogenesis 0.000000000000003692 Informative Direct
Biological Process (BP) phosphorylation 0 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000000314 Informative Direct
Biological Process (BP) regulation of locomotion 0.000000005167 Informative Direct
Biological Process (BP) cellular component morphogenesis 0 Informative Direct
Biological Process (BP) regulation of anatomical structure size 0.0004286 Informative Direct
Biological Process (BP) regulation of cell differentiation 0 Informative Direct
Biological Process (BP) locomotion 0 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0 Informative Direct
Biological Process (BP) positive regulation of cellular protein metabolic process 0 Informative Direct
Biological Process (BP) response to cytokine 0 Informative Direct
Biological Process (BP) growth 0 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.000000000001748 Informative Direct
Biological Process (BP) regulation of defense response 0.000000000003447 Informative Direct
Biological Process (BP) positive regulation of phosphate metabolic process 0.00000002818 Informative Direct
Biological Process (BP) central nervous system development 0.00000005632 Informative Direct
Biological Process (BP) response to bacterium 0.0000002505 Informative Direct
Biological Process (BP) actin filament-based process 0.0000006447 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0000019 Informative Direct
Biological Process (BP) negative regulation of cell death 0.000005146 Informative Direct
Biological Process (BP) organelle assembly 0.0002982 Informative Direct
Biological Process (BP) regulation of secretion 0.0003205 Informative Direct
Biological Process (BP) system process 0.0009942 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) regulation of apoptotic process 0.3822 Informative Inherited
Biological Process (BP) negative regulation of molecular function 0.9988 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.492 Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.5286 Informative Inherited
Biological Process (BP) positive regulation of transport 0.5239 Informative Inherited
Biological Process (BP) regulation of organelle organization 1 Informative Inherited
Biological Process (BP) regulation of system process 1 Informative Inherited
Biological Process (BP) protein targeting 1 Informative Inherited
Biological Process (BP) positive regulation of cell death 1 Informative Inherited
Biological Process (BP) regulation of growth 0.63 Informative Inherited
Biological Process (BP) reproductive system development 1 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 1 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.202 Informative Inherited
Biological Process (BP) epithelium development 1 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) single organism reproductive process 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5088 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of cell cycle 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.33 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08075 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 1 Informative Inherited
Biological Process (BP) single-organism membrane organization 1 Informative Inherited
Biological Process (BP) regulation of lipid metabolic process 0.0392 Informative Inherited
Biological Process (BP) single-organism intracellular transport 1 Informative Inherited
Biological Process (BP) secretion 0.8277 Informative Inherited
Biological Process (BP) regulation of cellular localization 1 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 1 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 1 Informative Inherited
Biological Process (BP) transmembrane transport 1 Informative Inherited
Biological Process (BP) intracellular signal transduction 1 Informative Inherited
Biological Process (BP) regulation of protein localization 1 Informative Inherited
Biological Process (BP) embryo development 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) cellular response to hormone stimulus 1 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.002297 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.003462 Informative Inherited
Biological Process (BP) symbiosis, encompassing mutualism through parasitism 0.01815 Informative Inherited
Biological Process (BP) multicellular organism reproduction 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.5098 Informative Inherited
Biological Process (BP) multi-organism cellular process 0.1152 Informative Inherited
Biological Process (BP) regulation of ion transport 0.08045 Informative Inherited
Biological Process (BP) negative regulation of cellular component organization 0.5151 Informative Inherited
Biological Process (BP) regulation of hydrolase activity 0.382 Informative Inherited
Biological Process (BP) regulation of hormone levels 1 Informative Inherited
Biological Process (BP) amine metabolic process 0.878 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.5208 Informative Inherited
Biological Process (BP) metal ion transport 1 Informative Inherited
Biological Process (BP) circulatory system development 0.08271 Informative Inherited
Biological Process (BP) regulation of response to external stimulus 1 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 1 Informative Inherited
Biological Process (BP) behavior 0.6932 Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) endocytosis 0.000000000000003692 Highly Informative Direct
Biological Process (BP) regulation of T cell activation 0.000000000000003692 Highly Informative Direct
Biological Process (BP) humoral immune response 0.00000000004618 Highly Informative Direct
Biological Process (BP) cell junction assembly 0.0000001954 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.0000001889 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000006574 Highly Informative Direct
Biological Process (BP) neuron development 0 Highly Informative Direct
Biological Process (BP) angiogenesis 0.00000000001945 Highly Informative Direct
Biological Process (BP) sensory organ morphogenesis 0.00001173 Highly Informative Direct
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) antigen processing and presentation of exogenous peptide antigen 0.0002362 Highly Informative Direct
Biological Process (BP) regulation of leukocyte mediated immunity 0 Highly Informative Direct
Biological Process (BP) regulation of cell size 0.00000008844 Highly Informative Direct
Biological Process (BP) positive regulation of cell adhesion 0 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.00002927 Highly Informative Direct
Biological Process (BP) regulation of neuron projection development 0 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.00004797 Highly Informative Direct
Biological Process (BP) response to molecule of bacterial origin 0 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.0000000000009363 Highly Informative Direct
Biological Process (BP) cell projection organization 0 Highly Informative Direct
Biological Process (BP) chemotaxis 0 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in differentiation 0 Highly Informative Direct
Biological Process (BP) regulation of cell killing 0 Highly Informative Direct
Biological Process (BP) cytokine-mediated signaling pathway 0 Highly Informative Direct
Biological Process (BP) response to mechanical stimulus 0 Highly Informative Direct
Biological Process (BP) cell growth 0 Highly Informative Direct
Biological Process (BP) sex differentiation 0 Highly Informative Direct
Biological Process (BP) detection of stimulus 0.000000000000007239 Highly Informative Direct
Biological Process (BP) transmembrane receptor protein tyrosine kinase signaling pathway 0.0000000000002489 Highly Informative Direct
Biological Process (BP) brain development 0.000000000000393 Highly Informative Direct
Biological Process (BP) muscle structure development 0.000000000008921 Highly Informative Direct
Biological Process (BP) cell migration 0.000000000037 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.00000000004196 Highly Informative Direct
Biological Process (BP) positive regulation of MAPK cascade 0.00000000005902 Highly Informative Direct
Biological Process (BP) developmental growth involved in morphogenesis 0.0000000001457 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000000007241 Highly Informative Direct
Biological Process (BP) positive regulation of leukocyte proliferation 0.000000001933 Highly Informative Direct
Biological Process (BP) cellular component assembly involved in morphogenesis 0.00000001076 Highly Informative Direct
Biological Process (BP) regulation of cytokine secretion 0.00000001236 Highly Informative Direct
Biological Process (BP) hemostasis 0.00000221 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.000002941 Highly Informative Direct
Biological Process (BP) regulation of cell shape 0.000004927 Highly Informative Direct
Biological Process (BP) regulation of toll-like receptor signaling pathway 0.00001216 Highly Informative Direct
Biological Process (BP) positive regulation of cytokine production 0.0000123 Highly Informative Direct
Biological Process (BP) protein dephosphorylation 0.00001468 Highly Informative Direct
Biological Process (BP) cell killing 0.00002167 Highly Informative Direct
Biological Process (BP) positive regulation of mitotic cell cycle 0.00002676 Highly Informative Direct
Biological Process (BP) regeneration 0.00002841 Highly Informative Direct
Biological Process (BP) heart contraction 0.00003753 Highly Informative Direct
Biological Process (BP) regulation of neuron apoptotic process 0.00004361 Highly Informative Direct
Biological Process (BP) positive regulation of protein secretion 0.00006238 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.00008155 Highly Informative Direct
Biological Process (BP) ovulation cycle process 0.0001115 Highly Informative Direct
Biological Process (BP) innate immune response 0.0001628 Highly Informative Direct
Biological Process (BP) actomyosin structure organization 0.0002774 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.0009755 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0.7754 Highly Informative Inherited
Biological Process (BP) regulation of leukocyte differentiation 0.02281 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell migration 0.7221 Highly Informative Inherited
Biological Process (BP) wound healing 0.03319 Highly Informative Inherited
Biological Process (BP) negative regulation of cell development 0.1375 Highly Informative Inherited
Biological Process (BP) regulation of binding 0.8366 Highly Informative Inherited
Biological Process (BP) transition metal ion transport 0.5422 Highly Informative Inherited
Biological Process (BP) renal system process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of ion transport 0.007071 Highly Informative Inherited
Biological Process (BP) regulation of peptide transport 0.4693 Highly Informative Inherited
Biological Process (BP) regulation of hormone secretion 0.8038 Highly Informative Inherited
Biological Process (BP) positive regulation of lipid metabolic process 0.0277 Highly Informative Inherited
Biological Process (BP) regulation of membrane potential 1 Highly Informative Inherited
Biological Process (BP) establishment of protein localization to membrane 0.4759 Highly Informative Inherited
Biological Process (BP) endomembrane system organization 1 Highly Informative Inherited
Biological Process (BP) vesicle-mediated transport to the plasma membrane 1 Highly Informative Inherited
Biological Process (BP) protein secretion 0.08456 Highly Informative Inherited
Biological Process (BP) response to drug 1 Highly Informative Inherited
Biological Process (BP) regulation of protein serine/threonine kinase activity 0.8728 Highly Informative Inherited
Biological Process (BP) actin filament organization 0.4469 Highly Informative Inherited
Biological Process (BP) positive regulation of apoptotic process 1 Highly Informative Inherited
Biological Process (BP) regulation of cell growth 0.7338 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 0.75 Highly Informative Inherited
Biological Process (BP) protein folding 0.03328 Highly Informative Inherited
Biological Process (BP) regulation of reproductive process 1 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 1 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 1 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9434 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.03584 Highly Informative Inherited
Biological Process (BP) appendage development 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.5154 Highly Informative Inherited
Biological Process (BP) regulation of nuclear division 0.001196 Highly Informative Inherited
Biological Process (BP) positive regulation of organelle organization 1 Highly Informative Inherited
Biological Process (BP) regulation of calcium ion transport 0.2811 Highly Informative Inherited
Biological Process (BP) regulation of cation transmembrane transport 0.01926 Highly Informative Inherited
Biological Process (BP) sensory perception 0.001394 Highly Informative Inherited
Biological Process (BP) positive regulation of lymphocyte activation 0.07836 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.2229 Highly Informative Inherited
Biological Process (BP) metamorphosis 1 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 1 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.01208 Highly Informative Inherited
Biological Process (BP) viral life cycle 1 Highly Informative Inherited
Biological Process (BP) camera-type eye development 0.1299 Highly Informative Inherited
Biological Process (BP) positive regulation of cell cycle process 0.007669 Highly Informative Inherited
Biological Process (BP) positive regulation of cell development 1 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.001902 Highly Informative Inherited
Biological Process (BP) cell maturation 1 Highly Informative Inherited
Biological Process (BP) leukocyte cell-cell adhesion 0.2638 Highly Informative Inherited
Biological Process (BP) single-organism membrane fusion 0.7921 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.09201 Highly Informative Inherited
Biological Process (BP) myeloid leukocyte activation 1 Highly Informative Inherited
Biological Process (BP) regulated exocytosis 0.006054 Highly Informative Inherited
Biological Process (BP) leukocyte activation involved in immune response 1 Highly Informative Inherited
Biological Process (BP) establishment of organelle localization 1 Highly Informative Inherited
Biological Process (BP) regulation of vesicle-mediated transport 0.3163 Highly Informative Inherited
Biological Process (BP) regulation of lymphocyte proliferation 0.8455 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.6684 Highly Informative Inherited
Biological Process (BP) monovalent inorganic cation transport 0.6811 Highly Informative Inherited
Biological Process (BP) inorganic cation transmembrane transport 1 Highly Informative Inherited
Biological Process (BP) calcium-mediated signaling 0.3028 Highly Informative Inherited
Biological Process (BP) cell proliferation 0.002229 Highly Informative Inherited
Biological Process (BP) hemopoiesis 0.4407 Highly Informative Inherited
Biological Process (BP) pattern specification process 1 Highly Informative Inherited
Biological Process (BP) response to peptide hormone 0.3513 Highly Informative Inherited
Biological Process (BP) cellular response to organonitrogen compound 1 Highly Informative Inherited
Biological Process (BP) gliogenesis 1 Highly Informative Inherited
Biological Process (BP) regulation of ion homeostasis 0.4191 Highly Informative Inherited
Biological Process (BP) cellular hormone metabolic process 0.603 Highly Informative Inherited
Biological Process (BP) hormone biosynthetic process 0.09186 Highly Informative Inherited
Biological Process (BP) multi-multicellular organism process 0.03205 Highly Informative Inherited
Biological Process (BP) germ cell development 1 Highly Informative Inherited
Biological Process (BP) female gamete generation 1 Highly Informative Inherited
Biological Process (BP) muscle system process 0.7625 Highly Informative Inherited
Biological Process (BP) positive regulation of response to external stimulus 1 Highly Informative Inherited
Biological Process (BP) multi-organism behavior 0.5324 Highly Informative Inherited
Biological Process (BP) regulation of epithelial cell proliferation 0.695 Highly Informative Inherited
Biological Process (BP) positive regulation of immune effector process 0.2529 Highly Informative Inherited
Biological Process (BP) positive regulation of adaptive immune response based on somatic recombination of immune receptors b 0.1685 Highly Informative Inherited
Biological Process (BP) regulation of inflammatory response 0.02573 Highly Informative Inherited
Biological Process (BP) inflammatory response 1 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0 Moderately Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.000000000003547 Moderately Informative Direct
Molecular Function (MF) protein binding 0 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 1 Moderately Informative Inherited
Molecular Function (MF) anion binding 1 Moderately Informative Inherited
Molecular Function (MF) carbohydrate derivative binding 1 Moderately Informative Inherited
Molecular Function (MF) small molecule binding 1 Moderately Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 1 Moderately Informative Inherited
Molecular Function (MF) peptidase activity, acting on L-amino acid peptides 0.0000000000302 Informative Direct
Molecular Function (MF) amide binding 0 Informative Direct
Molecular Function (MF) receptor binding 0.00001276 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) molecular transducer activity 0 Informative Direct
Molecular Function (MF) signal transducer activity 0 Informative Direct
Molecular Function (MF) identical protein binding 0.0000000001394 Informative Direct
Molecular Function (MF) protein dimerization activity 0.0004691 Informative Direct
Molecular Function (MF) enzyme binding 1 Informative Inherited
Molecular Function (MF) macromolecular complex binding 1 Informative Inherited
Molecular Function (MF) phospholipid binding 0.6471 Informative Inherited
Molecular Function (MF) carboxylic acid binding 0.3527 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 1 Informative Inherited
Molecular Function (MF) sulfur compound binding 0.005325 Informative Inherited
Molecular Function (MF) passive transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) monovalent inorganic cation transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) metal ion transmembrane transporter activity 1 Informative Inherited
Molecular Function (MF) phosphoric ester hydrolase activity 0.7297 Informative Inherited
Molecular Function (MF) serine hydrolase activity 0 Highly Informative Direct
Molecular Function (MF) glycolipid binding 0.0000000001195 Highly Informative Direct
Molecular Function (MF) peptide binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct
Molecular Function (MF) transmembrane signaling receptor activity 0 Highly Informative Direct
Molecular Function (MF) heparin binding 0.0000000005059 Highly Informative Direct
Molecular Function (MF) phosphoprotein phosphatase activity 0.000002344 Highly Informative Direct
Molecular Function (MF) kinase binding 0.03069 Highly Informative Inherited
Molecular Function (MF) ion channel activity 0.8362 Highly Informative Inherited
Molecular Function (MF) gated channel activity 0.3149 Highly Informative Inherited
Molecular Function (MF) sodium ion transmembrane transporter activity 0.002692 Highly Informative Inherited
Cellular Component (CC) membrane 0 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) protein complex 0.05881 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) plasma membrane 0 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) cell projection 0 Moderately Informative Direct
Cellular Component (CC) endoplasmic reticulum 0 Moderately Informative Direct
Cellular Component (CC) intrinsic component of membrane 0 Moderately Informative Direct
Cellular Component (CC) vacuole 0.00000002043 Moderately Informative Direct
Cellular Component (CC) organelle membrane 0.000002326 Moderately Informative Direct
Cellular Component (CC) whole membrane 0.000002906 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0004129 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 1 Moderately Informative Inherited
Cellular Component (CC) cell surface 0 Informative Direct
Cellular Component (CC) extracellular organelle 0 Informative Direct
Cellular Component (CC) site of polarized growth 0.000000001153 Informative Direct
Cellular Component (CC) side of membrane 0 Informative Direct
Cellular Component (CC) neuron projection 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0 Informative Direct
Cellular Component (CC) cytoplasmic vesicle part 0 Informative Direct
Cellular Component (CC) cell junction 0 Informative Direct
Cellular Component (CC) lytic vacuole 0 Informative Direct
Cellular Component (CC) transport vesicle 0 Informative Direct
Cellular Component (CC) Golgi apparatus 0 Informative Direct
Cellular Component (CC) endosome 0 Informative Direct
Cellular Component (CC) endoplasmic reticulum membrane 0 Informative Direct
Cellular Component (CC) vacuolar part 0.00000000000034 Informative Direct
Cellular Component (CC) lipid particle 0.000002096 Informative Direct
Cellular Component (CC) synapse 0.00001431 Informative Direct
Cellular Component (CC) membrane region 0.2792 Informative Inherited
Cellular Component (CC) extracellular space 1 Informative Inherited
Cellular Component (CC) cell projection part 0.002003 Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.9544 Informative Inherited
Cellular Component (CC) secretory vesicle 1 Informative Inherited
Cellular Component (CC) transporter complex 0.3594 Informative Inherited
Cellular Component (CC) blood microparticle 0.00000007355 Highly Informative Direct
Cellular Component (CC) growth cone 0.0000002193 Highly Informative Direct
Cellular Component (CC) external side of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) extracellular exosome 0.0001214 Highly Informative Direct
Cellular Component (CC) coated vesicle 0 Highly Informative Direct
Cellular Component (CC) lytic vacuole membrane 0 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 0 Highly Informative Direct
Cellular Component (CC) integral component of endoplasmic reticulum membrane 0 Highly Informative Direct
Cellular Component (CC) vesicle membrane 0 Highly Informative Direct
Cellular Component (CC) contractile fiber part 0 Highly Informative Direct
Cellular Component (CC) intrinsic component of plasma membrane 0 Highly Informative Direct
Cellular Component (CC) endosome membrane 0 Highly Informative Direct
Cellular Component (CC) early endosome 0.000000000002549 Highly Informative Direct
Cellular Component (CC) receptor complex 0.0000000000437 Highly Informative Direct
Cellular Component (CC) myofibril 0.00000004669 Highly Informative Direct
Cellular Component (CC) late endosome 0.00002686 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.0001683 Highly Informative Direct
Cellular Component (CC) sperm part 0.0004519 Highly Informative Direct
Cellular Component (CC) extracellular matrix 0.01591 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.007196 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

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