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Immunoglobulin superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Families:   V set domains (antibody variable domain-like) [ 48727] (32)
  C1 set domains (antibody constant domain-like) [ 48942] (23)
  C2 set domains [ 49142] (8)
  I set domains [ 49159] (38)


Superfamily statistics
Genomes (309) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 172,246 0 2,226
Proteins 61,415 0 1,346


Functional annotation
General category Processes_EC
Detailed category Cell adhesion

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0001702Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0000000000000076Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2423Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00002546InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000001632Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.00237Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4433Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.00002113Moderately InformativeDirect
Disease Ontology (DO)urinary system disease0.04495Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.06178Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.09661Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.1188Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.9683Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.00000000000009281InformativeDirect
Disease Ontology (DO)allergic rhinitis0.0002947InformativeDirect
Disease Ontology (DO)alopecia0.000412InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.1563InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.2535InformativeInherited
Disease Ontology (DO)connective tissue cancer0.7846InformativeInherited
Disease Ontology (DO)Graves' disease0.0000004566Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.00002541Highly InformativeDirect
Disease Ontology (DO)acute kidney failure0.000128Highly InformativeDirect
Disease Ontology (DO)lupus erythematosus0.0174Highly InformativeInherited
Disease Ontology (DO)osteosarcoma0.678Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the integument0.1082Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skeletal system0.6579Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.6736Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.6879Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7531Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.143Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.168Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the oral cavity0.4728Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.5196Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.6073Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.6317Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.7122Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.7452Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the skull0.9049Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.0001997InformativeDirect
Phenotypic Abnormality (PA)Abnormality of toe0.4993InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.5884InformativeInherited
Phenotypic Abnormality (PA)Abnormality of lower limb bone0.6445InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.7956InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the calvaria0.8988InformativeInherited
Phenotypic Abnormality (PA)Increased inflammatory response1InformativeInherited
Phenotypic Abnormality (PA)Cough0.0002315Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the middle phalanges of the toes0.001349Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin physiology0.05144Highly InformativeInherited
Phenotypic Abnormality (PA)Short toe0.08345Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.8525Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.000000001325Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.0000000284Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.2598Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis1Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging1Least InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06832Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1437Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.5636Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.5947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.9953Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)autoimmune response0.000000003281InformativeDirect
Mammalian Phenotype (MP)abnormal innervation0.0006194InformativeDirect
Mammalian Phenotype (MP)abnormal mature B cell morphology0.5416InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.9396InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.9866InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection induced morbidity/mortality0.0002491Highly InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0004449Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.0008175Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.004605Least InformativeInherited
Worm Phenotype (WP)cell development variant0.03385Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08439Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.639Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.9198Least InformativeInherited
Worm Phenotype (WP)organism behavior variant1Least InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.0000002884Moderately InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.0001381Moderately InformativeDirect
Worm Phenotype (WP)reproductive system development variant0.0006582Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.001192Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.007494Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.01075Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.1581Moderately InformativeInherited
Worm Phenotype (WP)cell component morphology variant0.9986Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant1Moderately InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.000005757InformativeDirect
Worm Phenotype (WP)body posture variant0.000006359InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00002752InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00003222InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00005252InformativeDirect
Worm Phenotype (WP)growth rate variant0.00009703InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001722InformativeDirect
Worm Phenotype (WP)neuronal outgrowth variant0.002375InformativeInherited
Worm Phenotype (WP)neuron migration variant0.6308InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.737InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.0000000002714Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.0003677Highly InformativeDirect
Worm Phenotype (WP)neuropil development variant0.001804Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.0003904Least InformativeDirect
Fly Anatomy (FA)anatomical group0.0009605Least InformativeDirect
Fly Anatomy (FA)nervous system0.003143Least InformativeInherited
Fly Anatomy (FA)embryo0.009667Least InformativeInherited
Fly Anatomy (FA)larva0.02256Least InformativeInherited
Fly Anatomy (FA)adult0.05557Least InformativeInherited
Fly Anatomy (FA)somatic cell0.07431Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1335Least InformativeInherited
Fly Anatomy (FA)integumentary system0.6758Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.0000001653Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.002157Moderately InformativeInherited
Fly Anatomy (FA)sensory neuron0.01391Moderately InformativeInherited
Fly Anatomy (FA)late embryo0.02535Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0434Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.08018Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.1147Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.1175Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1479Moderately InformativeInherited
Fly Anatomy (FA)adult segment0.6302Moderately InformativeInherited
Fly Anatomy (FA)adult thorax0.9472Moderately InformativeInherited
Fly Anatomy (FA)appendage0.9828Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment1Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system1Moderately InformativeInherited
Fly Anatomy (FA)tagmatic subdivision of integument1Moderately InformativeInherited
Fly Anatomy (FA)larval abdomen0.0000006746InformativeDirect
Fly Anatomy (FA)nerve0.0002189InformativeDirect
Fly Anatomy (FA)synaptic neuropil0.000558InformativeDirect
Fly Anatomy (FA)brain0.01694InformativeInherited
Fly Anatomy (FA)syncytium0.01875InformativeInherited
Fly Anatomy (FA)muscle system0.02712InformativeInherited
Fly Anatomy (FA)abdominal segment0.06098InformativeInherited
Fly Anatomy (FA)adult central nervous system0.07919InformativeInherited
Fly Anatomy (FA)chemosensory system0.09394InformativeInherited
Fly Anatomy (FA)chaeta0.1013InformativeInherited
Fly Anatomy (FA)midline crossing tract0.4221InformativeInherited
Fly Anatomy (FA)leg0.6997InformativeInherited
Fly Anatomy (FA)ipsilateral tract0.8497InformativeInherited
Fly Anatomy (FA)prothoracic leg taste bristle chemosensory neuron0.0000433Highly InformativeDirect
Fly Anatomy (FA)longitudinal muscle0.0001048Highly InformativeDirect
Fly Anatomy (FA)abdominal nerve0.0001352Highly InformativeDirect
Fly Anatomy (FA)connective0.0001499Highly InformativeDirect
Fly Anatomy (FA)commissure0.0003473Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.0004102Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.05137Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system1Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.826Moderately InformativeInherited
Zebrafish Anatomy (ZA)medial longitudinal fasciculus0.0009946Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.0000005457Moderately InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.1466Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Acting on a peroxide as acceptor0.0000279InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport1Least InformativeInherited
Biological processDifferentiation0Moderately InformativeDirect
Biological processImmunity0Moderately InformativeDirect
Biological processHost-virus interaction0Moderately InformativeDirect
Biological processApoptosis0.00000162Moderately InformativeDirect
Biological processIon transport1Moderately InformativeInherited
Biological processAngiogenesis0InformativeDirect
Biological processCell adhesion0InformativeDirect
Biological processNeurogenesis0InformativeDirect
Biological processInflammatory response0.00000000612InformativeDirect
Biological processChemotaxis0.00000007773InformativeDirect
Biological processVirus entry into host cell0.0000004442InformativeDirect
Biological processViral immunoevasion1InformativeInherited
Biological processAdaptive immunity0Highly InformativeDirect
Biological processSodium transport0.0000000000003729Highly InformativeDirect
Biological processPhagocytosis0.000007954Highly InformativeDirect
Biological processNotch signaling pathway0.00003663Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCell projection0Moderately InformativeDirect
Cellular componentEndosome0Moderately InformativeDirect
Cellular componentCell membrane0.00000000001358Moderately InformativeDirect
Cellular componentVirion0.00000003843Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0.000002578Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.0001279Moderately InformativeDirect
Cellular componentGPI-anchor0InformativeDirect
Cellular componentLysosome0InformativeDirect
Cellular componentExtracellular matrix0.00000002062InformativeDirect
Cellular componentViral envelope protein0.000000000000001961Highly InformativeDirect
Cellular componentHost endosome0.000006482Highly InformativeDirect
Cellular componentTight junction0.0003166Highly InformativeDirect
Coding sequence diversityPolymorphism0Moderately InformativeDirect
Developmental stageLate protein0.0002974Least InformativeDirect
DiseaseDisease mutation0.0002579Least InformativeDirect
DiseaseProto-oncogene0.000008268Moderately InformativeDirect
DiseaseCraniosynostosis0.00004481Highly InformativeDirect
DomainRepeat0Least InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0Least InformativeDirect
DomainImmunoglobulin domain0InformativeDirect
DomainLeucine-rich repeat0InformativeDirect
DomainSushi0.0000002163Highly InformativeDirect
Molecular functionLectin0InformativeDirect
Molecular functionSodium0.0000003912InformativeDirect
Post-translational modificationHydrolase1Least InformativeInherited
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDevelopmental protein0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationKinase0.00000442Moderately InformativeDirect
Post-translational modificationHeparin-binding0InformativeDirect
Post-translational modificationProtein phosphatase0.00000001351InformativeDirect
Post-translational modificationActin-binding0.000009246InformativeDirect
Post-translational modificationIon channel0.01975InformativeInherited
Post-translational modificationProtease inhibitor0.1261InformativeInherited
Post-translational modificationMuscle protein0Highly InformativeDirect
Post-translational modificationTyrosine-protein kinase0Highly InformativeDirect
Post-translational modificationVoltage-gated channel0.000000009129Highly InformativeDirect
Post-translational modificationMetalloenzyme inhibitor0.0000005169Highly InformativeDirect
Post-translational modificationHost cell receptor for virus entry0.000002411Highly InformativeDirect
Post-translational modificationCytokine0.000003595Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0.0000001764InformativeDirect
Post-translational modificationProteoglycan0.00001571InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 336 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 336 hidden Markov models representing the Immunoglobulin superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]