SUPERFAMILY 1.75 HMM library and genome assignments server

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C1 set domains (antibody constant domain-like) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   C1 set domains (antibody constant domain-like) [ 48942] (23)


Family statistics
Genomes (50) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,954 23,383 988
Proteins 2,739 22,744 954


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.008057Least InformativeInherited
Disease Ontology (DO)organ system cancer0.1708Least InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.00000001975Moderately InformativeDirect
Disease Ontology (DO)disease of metabolism0.0000001644Moderately InformativeDirect
Disease Ontology (DO)disease by infectious agent0.000003199Moderately InformativeDirect
Disease Ontology (DO)hematopoietic system disease0.00001823Moderately InformativeDirect
Disease Ontology (DO)connective tissue disease0.00002395Moderately InformativeDirect
Disease Ontology (DO)gastrointestinal system disease0.0002952Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.0009343Moderately InformativeDirect
Disease Ontology (DO)hematologic cancer0.00292Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03188Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.03351Moderately InformativeInherited
Disease Ontology (DO)syndrome0.1674Moderately InformativeInherited
Disease Ontology (DO)multiple sclerosis0.0000000000006131InformativeDirect
Disease Ontology (DO)liver disease0.00000002503InformativeDirect
Disease Ontology (DO)Kawasaki disease0.0000001129InformativeDirect
Disease Ontology (DO)vasculitis0.00003333InformativeDirect
Disease Ontology (DO)hypotrichosis0.00004805InformativeDirect
Disease Ontology (DO)hemorrhagic disease0.0003129InformativeDirect
Disease Ontology (DO)autosomal recessive disease0.0003588InformativeDirect
Disease Ontology (DO)arthropathy0.01104InformativeInherited
Disease Ontology (DO)bullous skin disease0.01245InformativeInherited
Disease Ontology (DO)upper respiratory tract disease0.04475InformativeInherited
Disease Ontology (DO)eye disease0.06102InformativeInherited
Disease Ontology (DO)glucose metabolism disease1InformativeInherited
Disease Ontology (DO)Graves' disease0.00000000007061Highly InformativeDirect
Disease Ontology (DO)psoriatic arthritis0.0000003861Highly InformativeDirect
Disease Ontology (DO)sickle cell anemia0.0000009922Highly InformativeDirect
Disease Ontology (DO)Behcet's disease0.000001341Highly InformativeDirect
Disease Ontology (DO)hemochromatosis0.0000018Highly InformativeDirect
Disease Ontology (DO)spondylitis0.000008751Highly InformativeDirect
Disease Ontology (DO)neuromyelitis optica0.00001489Highly InformativeDirect
Disease Ontology (DO)pemphigus0.00001789Highly InformativeDirect
Disease Ontology (DO)sarcoidosis0.00002391Highly InformativeDirect
Disease Ontology (DO)intrahepatic cholestasis0.00003804Highly InformativeDirect
Disease Ontology (DO)vascular hemostatic disease0.00007335Highly InformativeDirect
Disease Ontology (DO)uveitis0.0001274Highly InformativeDirect
Disease Ontology (DO)rheumatic fever0.0002952Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0008331Highly InformativeDirect
Disease Ontology (DO)thyroid gland disease0.001791Highly InformativeInherited
Disease Ontology (DO)neuromuscular disease0.02601Highly InformativeInherited
Disease Ontology (DO)primary immunodeficiency disease0.4258Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Mode of Inheritance (MI)Multifactorial inheritance0.000000002349InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the immune system0.00001596Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the integument0.006124Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.07064Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.07684Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.186Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.196Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the digestive system0.2681Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.3122Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.3141Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.542Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.001988Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.002668Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system morphology0.007721Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the gastrointestinal tract0.01258Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.02723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of body weight0.04731Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal inflammatory response0.04906Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.05522Moderately InformativeInherited
Phenotypic Abnormality (PA)Localized skin lesion0.07684Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1322Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.1723Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.2088Moderately InformativeInherited
Phenotypic Abnormality (PA)Unusual infection0.2499Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the ear0.2751Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal ocular adnexa morphology0.423Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.4245Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.4529Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.4982Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skin adnexa morphology0.5192Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.5368Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Inflammatory abnormality of the eye0.000004792InformativeDirect
Phenotypic Abnormality (PA)Abnormality of skin physiology0.0000255InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.000121InformativeDirect
Phenotypic Abnormality (PA)Weight loss0.0002086InformativeDirect
Phenotypic Abnormality (PA)Abnormal intestine morphology0.0003826InformativeDirect
Phenotypic Abnormality (PA)Recurrent infections0.0004226InformativeDirect
Phenotypic Abnormality (PA)Unusual infection by anatomical site0.001204InformativeInherited
Phenotypic Abnormality (PA)Abnormal hair quantity0.02193InformativeInherited
Phenotypic Abnormality (PA)Abnormal cellular physiology0.0289InformativeInherited
Phenotypic Abnormality (PA)Stomatitis0.03164InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper respiratory tract0.2308InformativeInherited
Phenotypic Abnormality (PA)Pain0.2853InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.3651InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.389InformativeInherited
Phenotypic Abnormality (PA)Functional respiratory abnormality0.5661InformativeInherited
Phenotypic Abnormality (PA)Arthralgia0.0000002507Highly InformativeDirect
Phenotypic Abnormality (PA)Meningitis0.000001353Highly InformativeDirect
Phenotypic Abnormality (PA)Pericarditis0.00000494Highly InformativeDirect
Phenotypic Abnormality (PA)Cough0.00001746Highly InformativeDirect
Phenotypic Abnormality (PA)Bronchiectasis0.0001036Highly InformativeDirect
Phenotypic Abnormality (PA)Abdominal pain0.0001282Highly InformativeDirect
Phenotypic Abnormality (PA)Skin ulcer0.0001592Highly InformativeDirect
Phenotypic Abnormality (PA)Recurrent aphthous stomatitis0.0001741Highly InformativeDirect
Phenotypic Abnormality (PA)Alopecia0.0002482Highly InformativeDirect
Phenotypic Abnormality (PA)Glomerulopathy0.000262Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal sputum0.0005077Highly InformativeDirect
Phenotypic Abnormality (PA)Pulmonary infiltrates0.0005224Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal erythrocyte sedimentation rate0.0006124Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes insipidus0.0006147Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pleura0.0006305Highly InformativeDirect
Phenotypic Abnormality (PA)Chest pain0.0006625Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of pancreas physiology0.0006903Highly InformativeDirect
Phenotypic Abnormality (PA)Vasculitis0.0006972Highly InformativeDirect
Phenotypic Abnormality (PA)Otitis media0.139Highly InformativeInherited
Phenotypic Abnormality (PA)Conjunctivitis0.2239Highly InformativeInherited
Phenotypic Abnormality (PA)Keratitis0.321Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)immune system phenotype0.00000008049Least InformativeDirect
Mammalian Phenotype (MP)nervous system phenotype0.438Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.00000003334Moderately InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to infection0.0000476Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.02531Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal T cell morphology0.03691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1785Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.1981Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3191Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.6649Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal antigen presentation0.0000009245InformativeDirect
Mammalian Phenotype (MP)altered susceptibility to autoimmune disorder0.0001292InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.0005296InformativeDirect
Mammalian Phenotype (MP)abnormal CD8-positive, alpha beta T cell morphology0.04043InformativeInherited
Mammalian Phenotype (MP)decreased T cell number0.2753InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.2791InformativeInherited
Mammalian Phenotype (MP)abnormal alpha-beta T cell number0.3257InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.545InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.000001462Highly InformativeDirect
Mammalian Phenotype (MP)enhanced paired-pulse facilitation0.00006667Highly InformativeDirect
Mammalian Phenotype (MP)decreased CD8-positive, alpha-beta T cell number0.2652Highly InformativeInherited

Document: MP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0Least InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Xenopus Anatomy (XA) · Internal database links ]