SUPERFAMILY 1.75 HMM library and genome assignments server

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I set domains family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Immunoglobulin [ 48726] (4)
Family:   I set domains [ 49159] (38)


Family statistics
Genomes (81) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 4,969 13,306 162
Proteins 3,085 8,095 101


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.0000006059Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.002937Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Peroxidases0.00001477InformativeDirect
Enzyme Commission (EC)Peroxidase0.00000000003677Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.4727Least InformativeInherited
Disease Ontology (DO)disease by infectious agent0.04039Moderately InformativeInherited
Disease Ontology (DO)urinary system disease0.1456Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.3092Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.7992Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.853Moderately InformativeInherited
Disease Ontology (DO)autoimmune disease of skin and connective tissue0.01989InformativeInherited
Disease Ontology (DO)lymphoma0.1161InformativeInherited
Disease Ontology (DO)mature T-cell and NK-cell lymphoma0.0007087Highly InformativeDirect
Disease Ontology (DO)synostosis0.002116Highly InformativeInherited
Disease Ontology (DO)kidney failure0.1286Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.5882Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6469Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.7473Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the hand0.4141Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal anterior eye segment morphology0.4236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lower limb0.4494Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.4922Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal lower limb bone morphology0.2877InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.367InformativeInherited
Phenotypic Abnormality (PA)Abnormality of toe0.3805InformativeInherited
Phenotypic Abnormality (PA)Abnormality of calvarial morphology0.4803InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the extremities0.5559InformativeInherited
Phenotypic Abnormality (PA)Abnormal finger phalanx morphology0.8235InformativeInherited
Phenotypic Abnormality (PA)Corneal erosion0.009397Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of toe0.05317Highly InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the phalanges of the toes0.1281Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/Hypoplasia of the phalanges of the hand0.2046Highly InformativeInherited
Phenotypic Abnormality (PA)Short digit0.6263Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01609Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.05843Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.1227Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.442Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.7513Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.9233Least InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.000595Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal neuron morphology0.03806Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.03974Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.03977Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.06754Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.1197Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.2106Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.2508Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.383Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.3878Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.8149Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.8711Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.8738Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.9519Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal innervation0.000963InformativeDirect
Mammalian Phenotype (MP)abnormal skeletal muscle morphology0.03374InformativeInherited
Mammalian Phenotype (MP)abnormal neurite morphology0.2119InformativeInherited
Mammalian Phenotype (MP)abnormal immunoglobulin level0.3514InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.3613InformativeInherited
Mammalian Phenotype (MP)abnormal fat pad morphology0.5281InformativeInherited
Mammalian Phenotype (MP)decreased cell proliferation0.7InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.8588InformativeInherited
Mammalian Phenotype (MP)abnormal urothelium morphology0.0006877Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.06127Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hypaxial muscle morphology0.1877Highly InformativeInherited
Mammalian Phenotype (MP)abnormal axon morphology0.3397Highly InformativeInherited
Mammalian Phenotype (MP)abnormal uterus morphology0.3401Highly InformativeInherited
Mammalian Phenotype (MP)abnormal abdominal fat pad morphology0.4036Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.0001617Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.003776Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.008422Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.01858Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.3526Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.00007889Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.00009656Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.0001978Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.0002033Moderately InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.01002Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.03294Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.1949Moderately InformativeInherited
Worm Phenotype (WP)reproductive system morphology variant0.5063Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.00000006627InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.00000153InformativeDirect
Worm Phenotype (WP)body posture variant0.00003768InformativeDirect
Worm Phenotype (WP)locomotion reduced0.0001209InformativeDirect
Worm Phenotype (WP)vulva morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)cell migration variant0.001406InformativeInherited
Worm Phenotype (WP)mitochondria morphology variant0.003217InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.003803InformativeInherited
Worm Phenotype (WP)cell fate specification variant0.008379InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.01289InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.02093InformativeInherited
Worm Phenotype (WP)epithelial system development variant0.04458InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.04989InformativeInherited
Worm Phenotype (WP)protein metabolism variant0.1393InformativeInherited
Worm Phenotype (WP)cell component localization variant0.3204InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000001214Highly InformativeDirect
Worm Phenotype (WP)axon guidance variant0.000000002793Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.000000004117Highly InformativeDirect
Worm Phenotype (WP)protein degradation variant0.00001237Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00001675Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00001804Highly InformativeDirect
Worm Phenotype (WP)exploded through vulva0.00005031Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00006179Highly InformativeDirect
Worm Phenotype (WP)muscle cell attachment variant0.0005146Highly InformativeDirect
Worm Phenotype (WP)synapse morphology variant0.0006206Highly InformativeDirect
Worm Phenotype (WP)loss of left right asymmetry0.03881Highly InformativeInherited
Worm Phenotype (WP)neuronal cell fate specification variant0.1258Highly InformativeInherited
Worm Phenotype (WP)neurite development variant0.1827Highly InformativeInherited
Worm Phenotype (WP)pausing variant0.1889Highly InformativeInherited
Worm Phenotype (WP)path curvature variant0.3043Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell migration defective0.00004415Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)anatomical group0.00804Least InformativeInherited
Fly Anatomy (FA)tagma0.03102Least InformativeInherited
Fly Anatomy (FA)nervous system0.05314Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.06878Least InformativeInherited
Fly Anatomy (FA)adult0.1077Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1083Least InformativeInherited
Fly Anatomy (FA)somatic cell0.1238Least InformativeInherited
Fly Anatomy (FA)segment0.2029Least InformativeInherited
Fly Anatomy (FA)larva0.274Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.00002387Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0.001525Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.001572Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.006301Moderately InformativeInherited
Fly Anatomy (FA)ganglion0.006454Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.01164Moderately InformativeInherited
Fly Anatomy (FA)neuron0.0883Moderately InformativeInherited
Fly Anatomy (FA)adult head0.1034Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3065Moderately InformativeInherited
Fly Anatomy (FA)adult brain0.00003378InformativeDirect
Fly Anatomy (FA)synaptic neuropil block0.0005478InformativeDirect
Fly Anatomy (FA)synaptic neuropil subdomain0.000919InformativeDirect
Fly Anatomy (FA)supraesophageal ganglion0.001421InformativeInherited
Fly Anatomy (FA)primordium0.001462InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.002683InformativeInherited
Fly Anatomy (FA)syncytium0.003749InformativeInherited
Fly Anatomy (FA)muscle cell0.008099InformativeInherited
Fly Anatomy (FA)central brain0.01046InformativeInherited
Fly Anatomy (FA)sensory organ cell0.01104InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.01538InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.01595InformativeInherited
Fly Anatomy (FA)chemosensory system0.01908InformativeInherited
Fly Anatomy (FA)neuromere0.02868InformativeInherited
Fly Anatomy (FA)labral segment0.05035InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.05046InformativeInherited
Fly Anatomy (FA)extended germ band embryo0.05228InformativeInherited
Fly Anatomy (FA)ventral nerve cord0.05536InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.05621InformativeInherited
Fly Anatomy (FA)anatomical cluster0.07438InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.1058InformativeInherited
Fly Anatomy (FA)mechanosensory system0.2952InformativeInherited
Fly Anatomy (FA)tract0.3288InformativeInherited
Fly Anatomy (FA)s-LNv neuron0.0000001011Highly InformativeDirect
Fly Anatomy (FA)connective0.00003773Highly InformativeDirect
Fly Anatomy (FA)gustatory receptor neuron0.00006314Highly InformativeDirect
Fly Anatomy (FA)dorsal vessel primordium0.000226Highly InformativeDirect
Fly Anatomy (FA)antennal lobe glomerulus0.0002386Highly InformativeDirect
Fly Anatomy (FA)commissure0.0002558Highly InformativeDirect
Fly Anatomy (FA)cardioblast0.0002611Highly InformativeDirect
Fly Anatomy (FA)neuropil glial sheath0.0004899Highly InformativeDirect
Fly Anatomy (FA)mechanosensory system neuron0.000851Highly InformativeDirect
Fly Anatomy (FA)embryonic/larval glial cell0.009707Highly InformativeInherited
Fly Anatomy (FA)sensory cluster0.01028Highly InformativeInherited
Fly Anatomy (FA)CNS glial cell0.01277Highly InformativeInherited
Fly Anatomy (FA)early extended germ band embryo0.03102Highly InformativeInherited
Fly Anatomy (FA)adult protocerebrum0.06974Highly InformativeInherited
Fly Anatomy (FA)germ layer derivative0.07799Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.02683Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.7196Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.7502Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.1485Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.1362InformativeInherited
Zebrafish Anatomy (ZA)white matter0.00001294Highly InformativeDirect
Zebrafish Anatomy (ZA)synencephalon0.000105Highly InformativeDirect
Zebrafish Anatomy (ZA)brainstem0.008348Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3395Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4321Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.4875Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.4901Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9021Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.00316Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.01213Moderately InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0.7438Moderately InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.00008306InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.00466InformativeInherited
Xenopus ANatomical entity (XAN)eye0.004797InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.005593InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.00001578Highly InformativeDirect
Xenopus ANatomical entity (XAN)retinal inner nuclear layer0.00003511Highly InformativeDirect
Xenopus ANatomical entity (XAN)optic vesicle0.0007994Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.03195Highly InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.7423Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases1Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0.0000004823Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.0002304InformativeDirect
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect
Enzyme Commission (EC)Peroxidases0.00001865Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 450 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Immunoglobulin domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]