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Fibronectin type III family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Fibronectin type III [ 49265]
Family:   Fibronectin type III [ 49266] (44)


Family statistics
Genomes (178) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 8,788 25,820 172
Proteins 5,142 15,784 117


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0.000000000000001381Least InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0.00000000004123Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2382Moderately InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0InformativeDirect
Enzyme Commission (EC)Chitinase0.0002342Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.5427Least InformativeInherited
Disease Ontology (DO)urinary system disease0.2379Moderately InformativeInherited
Disease Ontology (DO)neurodegenerative disease0.457Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.6443Moderately InformativeInherited
Disease Ontology (DO)kidney failure0.01628Highly InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.01017Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2513Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.6641Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.6914Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.912Least InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.004857Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.01883Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular development0.07524Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.1158Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.1384Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.2282Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.2368Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.7776Moderately InformativeInherited
Mammalian Phenotype (MP)adipose tissue phenotype0.8871Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.9097Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.9165Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron differentiation0.02879InformativeInherited
Mammalian Phenotype (MP)abnormal heart layer morphology0.1118InformativeInherited
Mammalian Phenotype (MP)abnormal white adipose tissue morphology0.3771InformativeInherited
Mammalian Phenotype (MP)abnormal spermatogenesis0.547InformativeInherited
Mammalian Phenotype (MP)abnormal adipose tissue amount0.8313InformativeInherited
Mammalian Phenotype (MP)abnormal axon guidance0.0002533Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating interferon-gamma level0.0003459Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spermiogenesis0.06434Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.003011Least InformativeInherited
Worm Phenotype (WP)organism behavior variant0.0876Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.000005464Moderately InformativeDirect
Worm Phenotype (WP)movement variant0.005001Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.03995Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.0000000003708InformativeDirect
Worm Phenotype (WP)locomotion reduced0.00004925InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001784InformativeDirect
Worm Phenotype (WP)body posture variant0.0002628InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.002557InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.03255InformativeInherited
Worm Phenotype (WP)anchor cell invasion variant0.0000000003796Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.000000009039Highly InformativeDirect
Worm Phenotype (WP)muscle arm development defective0.00000002659Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.000117Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.7006Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details) Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.000355Least InformativeDirect
Fly Anatomy (FA)anatomical group0.001057Least InformativeInherited
Fly Anatomy (FA)tagma0.005253Least InformativeInherited
Fly Anatomy (FA)nervous system0.00901Least InformativeInherited
Fly Anatomy (FA)adult0.02462Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.04397Least InformativeInherited
Fly Anatomy (FA)segment0.05804Least InformativeInherited
Fly Anatomy (FA)larva0.1548Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2687Least InformativeInherited
Fly Anatomy (FA)multi-cell-component structure0.000000002149Moderately InformativeDirect
Fly Anatomy (FA)larval tagma0.0006706Moderately InformativeDirect
Fly Anatomy (FA)ganglion0.00227Moderately InformativeInherited
Fly Anatomy (FA)central nervous system0.00676Moderately InformativeInherited
Fly Anatomy (FA)abdomen0.01584Moderately InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.03506Moderately InformativeInherited
Fly Anatomy (FA)neuron0.2355Moderately InformativeInherited
Fly Anatomy (FA)adult head0.3148Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.4668Moderately InformativeInherited
Fly Anatomy (FA)nerve0.0008824InformativeDirect
Fly Anatomy (FA)adult brain0.001495InformativeInherited
Fly Anatomy (FA)synaptic neuropil block0.002048InformativeInherited
Fly Anatomy (FA)central brain0.00334InformativeInherited
Fly Anatomy (FA)supraesophageal ganglion0.02108InformativeInherited
Fly Anatomy (FA)dorsal closure embryo0.02161InformativeInherited
Fly Anatomy (FA)primordium0.02209InformativeInherited
Fly Anatomy (FA)chemosensory system0.03188InformativeInherited
Fly Anatomy (FA)labral segment0.04784InformativeInherited
Fly Anatomy (FA)adult optic lobe neuron0.0517InformativeInherited
Fly Anatomy (FA)neuromere0.08197InformativeInherited
Fly Anatomy (FA)synaptic neuropil domain0.388InformativeInherited
Fly Anatomy (FA)tract0.4107InformativeInherited
Fly Anatomy (FA)adult procephalic segment0.4927InformativeInherited
Fly Anatomy (FA)s-LNv neuron0.000000001651Highly InformativeDirect
Fly Anatomy (FA)commissure0.000004583Highly InformativeDirect
Fly Anatomy (FA)neuron projection bundle of ventral nerve cord0.0002337Highly InformativeDirect
Fly Anatomy (FA)gustatory receptor neuron0.0007472Highly InformativeDirect
Fly Anatomy (FA)dorsal vessel primordium0.003046Highly InformativeInherited
Fly Anatomy (FA)cardioblast0.005216Highly InformativeInherited
Fly Anatomy (FA)adult protocerebrum0.2102Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)multi-tissue structure0.1102Least InformativeInherited
Zebrafish Anatomy (ZA)nervous system0.5605Least InformativeInherited
Zebrafish Anatomy (ZA)cavitated compound organ0.6341Least InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.2723Moderately InformativeInherited
Zebrafish Anatomy (ZA)sensory system0.7027Moderately InformativeInherited
Zebrafish Anatomy (ZA)diencephalon0.06384InformativeInherited
Zebrafish Anatomy (ZA)white matter0.0000007574Highly InformativeDirect
Zebrafish Anatomy (ZA)synencephalon0.0003653Highly InformativeDirect
Zebrafish Anatomy (ZA)brainstem0.002076Highly InformativeInherited
Zebrafish Anatomy (ZA)telencephalon0.214Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.6401Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.8553Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.9471Least InformativeInherited
Xenopus ANatomical entity (XAN)tissue1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.1847Moderately InformativeInherited
Xenopus ANatomical entity (XAN)sensory system0.4045Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.4141InformativeInherited
Xenopus ANatomical entity (XAN)retinal ganglion cell layer0.0002191Highly InformativeDirect
Xenopus DEvelopment stage (XDE)embryonic stage0.0000001994Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)shoot apex0Least InformativeDirect
Plant ANatomical entity (PAN)root0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0000003997Least InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000000000001155Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0.00003361Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.9689Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.0000001135InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.2002InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.8261InformativeInherited
Enzyme Commission (EC)Receptor protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 169 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Fibronectin type III domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]