SUPERFAMILY 1.75 HMM library and genome assignments server


Clathrin adaptor appendage domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Immunoglobulin-like beta-sandwich [ 48725] (28)
Superfamily:   Clathrin adaptor appendage domain [ 49348] (3)
Families:   Alpha-adaptin ear subdomain-like [ 49349] (2)
  gamma-adaptin C-terminal appendage domain-like [ 74857] (3)
  Coatomer appendage domain [ 101536]


Superfamily statistics
Genomes (506) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 3,185 3,589 16
Proteins 3,181 3,582 16


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) localization 0 Least Informative Direct
Biological Process (BP) single-organism cellular process 2.432e-08 Least Informative Direct
Biological Process (BP) developmental process 0.4261 Least Informative Inherited
Biological Process (BP) multicellular organismal process 0.228 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.0206 Least Informative Inherited
Biological Process (BP) cellular localization 0 Moderately Informative Direct
Biological Process (BP) system process 1.048e-06 Moderately Informative Direct
Biological Process (BP) macromolecule localization 1.084e-05 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.1158 Moderately Informative Inherited
Biological Process (BP) organ development 0.8759 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.4056 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.4642 Moderately Informative Inherited
Biological Process (BP) immune system process 0.3607 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.004328 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5707 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.1575 Moderately Informative Inherited
Biological Process (BP) vesicle-mediated transport 0 Informative Direct
Biological Process (BP) protein transport 0 Informative Direct
Biological Process (BP) synaptic transmission 6.09e-12 Informative Direct
Biological Process (BP) secretion by cell 1.315e-05 Informative Direct
Biological Process (BP) cellular membrane organization 1.542e-05 Informative Direct
Biological Process (BP) regulation of immune effector process 0.0001606 Informative Direct
Biological Process (BP) regulation of defense response 0.004962 Informative Inherited
Biological Process (BP) sensory organ development 0.00101 Informative Inherited
Biological Process (BP) cellular macromolecular complex assembly 0.01915 Informative Inherited
Biological Process (BP) organelle localization 0.2241 Informative Inherited
Biological Process (BP) vesicle organization 0 Highly Informative Direct
Biological Process (BP) regulation of neurotransmitter levels 7.883e-08 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 4.873e-06 Highly Informative Direct
Biological Process (BP) antigen processing and presentation 5.808e-06 Highly Informative Direct
Biological Process (BP) neurotransmitter transport 1.568e-05 Highly Informative Direct
Biological Process (BP) regulation of multi-organism process 0.0002943 Highly Informative Direct
Biological Process (BP) multi-organism cellular process 0.0006176 Highly Informative Direct
Biological Process (BP) establishment of synaptic vesicle localization 0.08391 Highly Informative Inherited
Biological Process (BP) signal release 0.008017 Highly Informative Inherited
Molecular Function (MF) binding 0.0003816 Least Informative Direct
Molecular Function (MF) transporter activity 1.361e-06 Moderately Informative Direct
Molecular Function (MF) enzyme binding 0.005832 Informative Inherited
Molecular Function (MF) protein transporter activity 0 Highly Informative Direct
Molecular Function (MF) kinase binding 0.01711 Highly Informative Inherited
Cellular Component (CC) membrane 6.088e-15 Least Informative Direct
Cellular Component (CC) cytoplasmic part 3.028e-05 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.000101 Least Informative Direct
Cellular Component (CC) intracellular organelle part 0.1706 Least Informative Inherited
Cellular Component (CC) protein complex 0.006428 Least Informative Inherited
Cellular Component (CC) vesicle 0 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0 Moderately Informative Direct
Cellular Component (CC) organelle membrane 1.763e-10 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.3035 Moderately Informative Inherited
Cellular Component (CC) Golgi apparatus 3.095e-15 Informative Direct
Cellular Component (CC) coated vesicle 1.634e-07 Informative Direct
Cellular Component (CC) synapse part 2.07e-05 Informative Direct
Cellular Component (CC) endosome 0.01907 Informative Inherited
Cellular Component (CC) trans-Golgi network 0 Highly Informative Direct
Cellular Component (CC) Golgi-associated vesicle 2.933e-12 Highly Informative Direct
Cellular Component (CC) cytoplasmic vesicle membrane 1.866e-07 Highly Informative Direct
Cellular Component (CC) endocytic vesicle 1 Highly Informative Inherited
Cellular Component (CC) clathrin-coated vesicle 0.268 Highly Informative Inherited
Cellular Component (CC) transport vesicle 0.002378 Highly Informative Inherited

Document: GO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body phenotype0.1089Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4761Least InformativeInherited
Mammalian Phenotype (MP)abnormal postnatal growth/weight/body size0.7755Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal circulating glucose level0.006588InformativeInherited
Mammalian Phenotype (MP)abnormal total tissue mass0.1582InformativeInherited
Mammalian Phenotype (MP)decreased body size0.2223InformativeInherited
Mammalian Phenotype (MP)decreased birth weight4.628e-05Highly InformativeDirect
Mammalian Phenotype (MP)hypoglycemia5.598e-05Highly InformativeDirect
Mammalian Phenotype (MP)postnatal growth retardation0.03151Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)growth variant0Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.01832Least InformativeInherited
Worm Phenotype (WP)locomotion variant0.0009551Moderately InformativeDirect
Worm Phenotype (WP)pattern of transgene expression variant0.00121Moderately InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)anatomical group0Least InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)alimentary system0Least InformativeDirect
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)central nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)male organism0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)viscus0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)gonad0Least InformativeDirect
Xenopus ANatomical entity (XAN)ovary0Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect

Document: AP annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processProtein transport0Moderately InformativeDirect
Biological processEndocytosis0InformativeDirect
Biological processER-Golgi transport0Highly InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentGolgi apparatus0Moderately InformativeDirect
Cellular componentCytoplasmic vesicle0Moderately InformativeDirect
Cellular componentEndosome2.204e-10Moderately InformativeDirect
Cellular componentCoated pit0Highly InformativeDirect
DomainRepeat1.079e-14Least InformativeDirect
Molecular functionLipid-binding1.769e-09InformativeDirect
Post-translational modificationPhosphoprotein8.371e-06Least InformativeDirect
Post-translational modificationUbl conjugation0.0008032Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR013041 SSF49348 Protein matches
Abstract

This entry represents a beta-sandwich structural motif found in the appendage (ear) domain of alpha-, beta- and gamma-adaptin from AP clathrin adaptor complexes, the GAE (gamma-adaptin ear) domain of GGA adaptor proteins, and the appendage domain of the gamma subunit of coatomer complexes. These domains have an immunoglobulin-like beta-sandwich fold containing 7 or 8 strands in 2 beta-sheets in a Greek key topology [PubMed12042876, PubMed12808037, PubMed14527408]. Although the appendage domains from AP / GGA adaptins and coatomers share a similar fold, there is little sequence identity between them. However, they also share similar motif-based cargo recognition and accessory factor recruitment mechanisms.

More information about these proteins can be found at Protein of the Month: Clathrin.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 8 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Clathrin adaptor appendage domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 8 hidden Markov models representing the Clathrin adaptor appendage domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · UniProtKB KeyWords (KW) · Internal database links ]