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p53-like transcription factors superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Common fold of diphtheria toxin/transcription factors/cytochrome f [ 49379] (10)
Superfamily:   p53-like transcription factors [ 49417] (7)
Families:   p53 DNA-binding domain-like [ 81314] (2)
  Rel/Dorsal transcription factors, DNA-binding domain [ 81315] (6)
  T-box [ 81316] (2)
  STAT DNA-binding domain [ 81317] (3)
  RUNT domain [ 81318]
  DNA-binding domain from NDT80 [ 81992]
  DNA-binding protein LAG-1 (CSL) [ 110080]


Superfamily statistics
Genomes (367) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 6,320 19,251 53
Proteins 6,210 18,948 53


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1041Least InformativeInherited
Disease Ontology (DO)hematologic cancer0.001442Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.004839Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.01041Moderately InformativeInherited
Disease Ontology (DO)benign neoplasm0.0246Moderately InformativeInherited
Disease Ontology (DO)head and neck carcinoma0.0000002789InformativeDirect
Disease Ontology (DO)inflammatory bowel disease0.000002655InformativeDirect
Disease Ontology (DO)connective tissue cancer0.00009375InformativeDirect
Disease Ontology (DO)physical disorder0.001156InformativeInherited
Disease Ontology (DO)lymphoma0.007302InformativeInherited
Disease Ontology (DO)breast cancer0.008714InformativeInherited
Disease Ontology (DO)cell type benign neoplasm0.01092InformativeInherited
Disease Ontology (DO)respiratory system cancer0.1016InformativeInherited
Disease Ontology (DO)viral infectious disease0.2672InformativeInherited
Disease Ontology (DO)colitis0.000000088Highly InformativeDirect
Disease Ontology (DO)Burkitt lymphoma0.00002723Highly InformativeDirect
Disease Ontology (DO)mumps0.00006612Highly InformativeDirect
Disease Ontology (DO)Barrett's esophagus0.00007312Highly InformativeDirect
Disease Ontology (DO)gastritis0.0002504Highly InformativeDirect
Disease Ontology (DO)chronic leukemia0.0004027Highly InformativeDirect
Disease Ontology (DO)pertussis0.0004157Highly InformativeDirect
Disease Ontology (DO)progressive multifocal leukoencephalopathy0.000514Highly InformativeDirect
Disease Ontology (DO)laryngeal carcinoma0.0005401Highly InformativeDirect
Disease Ontology (DO)hemangioma0.0005585Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0007397Highly InformativeDirect
Disease Ontology (DO)large intestine cancer0.007613Highly InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.15Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.159Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.6078Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limbs0.7513Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the respiratory system0.0001419Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.01523Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1936Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.2245Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.2261Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.2971Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper limb0.4031Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the anterior pituitary0.002433InformativeInherited
Phenotypic Abnormality (PA)Abnormal leukocyte morphology0.01451InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia of the extremities0.05465InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thorax0.2836InformativeInherited
Phenotypic Abnormality (PA)Anterior hypopituitarism0.0006479Highly InformativeDirect
Phenotypic Abnormality (PA)Leukopenia0.0007182Highly InformativeDirect
Phenotypic Abnormality (PA)Aplasia/Hypoplasia involving bones of the thorax0.02197Highly InformativeInherited
Phenotypic Abnormality (PA)Aplasia/hypoplasia involving bones of the hand0.2284Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)growth/size/body region phenotype0.000001613Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.000002072Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.0001991Least InformativeDirect
Mammalian Phenotype (MP)cardiovascular system phenotype0.0003387Least InformativeDirect
Mammalian Phenotype (MP)hematopoietic system phenotype0.006084Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.00757Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.027Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.1983Least InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.000000009842Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal leukocyte physiology0.0000004954Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal skeleton morphology0.0000008399Moderately InformativeDirect
Mammalian Phenotype (MP)integument phenotype0.00000123Moderately InformativeDirect
Mammalian Phenotype (MP)embryo phenotype0.000001871Moderately InformativeDirect
Mammalian Phenotype (MP)respiratory system phenotype0.000005384Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal gland morphology0.000009362Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000009631Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.00002864Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal blood cell morphology0.00008684Moderately InformativeDirect
Mammalian Phenotype (MP)liver/biliary system phenotype0.0008506Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal inflammatory response0.001434Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.003571Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.005867Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.01525Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune system organ morphology0.01999Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.03041Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.03167Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.03407Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.0484Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.0545Moderately InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.0582Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.08255Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1005Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal protein level0.1339Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.4805Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hormone level0.7243Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal interleukin level0.00000001067InformativeDirect
Mammalian Phenotype (MP)increased susceptibility to infection0.0000003063InformativeDirect
Mammalian Phenotype (MP)abnormal liver physiology0.000003189InformativeDirect
Mammalian Phenotype (MP)abnormal thymus morphology0.00001343InformativeDirect
Mammalian Phenotype (MP)abnormal coat appearance0.00002017InformativeDirect
Mammalian Phenotype (MP)abnormal T cell differentiation0.00002985InformativeDirect
Mammalian Phenotype (MP)abnormal fluid regulation0.00004723InformativeDirect
Mammalian Phenotype (MP)normal phenotype0.00006634InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001193InformativeDirect
Mammalian Phenotype (MP)hemorrhage0.0001351InformativeDirect
Mammalian Phenotype (MP)altered tumor pathology0.0003112InformativeDirect
Mammalian Phenotype (MP)increased leukocyte cell number0.0004405InformativeDirect
Mammalian Phenotype (MP)abnormal cartilage morphology0.002027InformativeInherited
Mammalian Phenotype (MP)abnormal humoral immune response0.003854InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive thermogenesis0.004057InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.008815InformativeInherited
Mammalian Phenotype (MP)abnormal epidermal layer morphology0.01021InformativeInherited
Mammalian Phenotype (MP)abnormal circulating cytokine level0.01213InformativeInherited
Mammalian Phenotype (MP)abnormal gland physiology0.02284InformativeInherited
Mammalian Phenotype (MP)abnormal B lymphocyte antigen presentation0.02882InformativeInherited
Mammalian Phenotype (MP)abnormal lymph node morphology0.04135InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.04153InformativeInherited
Mammalian Phenotype (MP)abnormal interferon level0.07086InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.07522InformativeInherited
Mammalian Phenotype (MP)abnormal appendicular skeleton morphology0.07944InformativeInherited
Mammalian Phenotype (MP)abnormal thoracic cage morphology0.241InformativeInherited
Mammalian Phenotype (MP)abnormal natural killer cell mediated cytotoxicity0.2425InformativeInherited
Mammalian Phenotype (MP)abnormal stomach morphology0.3273InformativeInherited
Mammalian Phenotype (MP)increased hemolymphoid system tumor incidence0.3512InformativeInherited
Mammalian Phenotype (MP)increased carcinoma incidence0.3811InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.4831InformativeInherited
Mammalian Phenotype (MP)abnormal erythroid lineage cell morphology0.5382InformativeInherited
Mammalian Phenotype (MP)abnormal vertebrae morphology0.6989InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch morphology0.8938InformativeInherited
Mammalian Phenotype (MP)decreased B cell proliferation0.000006213Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland epithelium physiology0.000009099Highly InformativeDirect
Mammalian Phenotype (MP)respiratory system inflammation0.000009657Highly InformativeDirect
Mammalian Phenotype (MP)lethality throughout fetal growth and development, complete penetrance0.00002637Highly InformativeDirect
Mammalian Phenotype (MP)abnormal secondary palate development0.00006071Highly InformativeDirect
Mammalian Phenotype (MP)abnormal intervertebral disk morphology0.0001097Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.00012Highly InformativeDirect
Mammalian Phenotype (MP)impaired adaptive thermogenesis0.0001287Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cervical atlas morphology0.0001553Highly InformativeDirect
Mammalian Phenotype (MP)abnormal stomach epithelium morphology0.0001704Highly InformativeDirect
Mammalian Phenotype (MP)cleft palate0.0002123Highly InformativeDirect
Mammalian Phenotype (MP)abnormal level of surface class II molecules0.0002749Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thymus medulla morphology0.0003089Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0003219Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating insulin-like growth factor I level0.0005441Highly InformativeDirect
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.0006211Highly InformativeDirect
Mammalian Phenotype (MP)abnormal granulocyte number0.0006533Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mammary gland alveolus morphology0.0008596Highly InformativeDirect
Mammalian Phenotype (MP)abnormal vertebral arch morphology0.0008597Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.008997Highly InformativeInherited
Mammalian Phenotype (MP)abnormal IgG2a level0.01023Highly InformativeInherited
Mammalian Phenotype (MP)abnormal head movements0.01327Highly InformativeInherited
Mammalian Phenotype (MP)increased leukemia incidence0.01366Highly InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.01868Highly InformativeInherited
Mammalian Phenotype (MP)embryonic lethality during organogenesis0.0599Highly InformativeInherited
Mammalian Phenotype (MP)abnormal Peyer's patch size0.1245Highly InformativeInherited
Mammalian Phenotype (MP)abnormal peripheral lymph node morphology0.1485Highly InformativeInherited
Mammalian Phenotype (MP)abnormal epidermis stratum spinosum morphology0.2192Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurocranium morphology0.2649Highly InformativeInherited
Mammalian Phenotype (MP)increased IgG level0.356Highly InformativeInherited
Mammalian Phenotype (MP)abnormal sternum morphology0.8426Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organ system morphology variant0.02242Least InformativeInherited
Worm Phenotype (WP)cell development variant0.04947Least InformativeInherited
Worm Phenotype (WP)organism metabolism processing variant0.08677Least InformativeInherited
Worm Phenotype (WP)cell physiology variant0.131Least InformativeInherited
Worm Phenotype (WP)cell division variant0.08251Moderately InformativeInherited
Worm Phenotype (WP)pattern of transgene expression variant1Moderately InformativeInherited
Worm Phenotype (WP)developmental morphology variant0.0006114Highly InformativeDirect
Worm Phenotype (WP)gene expression level reduced0.0007862Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0008484Highly InformativeDirect
Worm Phenotype (WP)ectopic expression transgene0.0008928Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)size defective0.0007515InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organism subdivision0.004231Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.008166Least InformativeInherited
Fly Anatomy (FA)adult0.008401Least InformativeInherited
Fly Anatomy (FA)cell0.0168Least InformativeInherited
Fly Anatomy (FA)larva0.0387Least InformativeInherited
Fly Anatomy (FA)adult segment0.005454Moderately InformativeInherited
Fly Anatomy (FA)adult integumentary system0.007744Moderately InformativeInherited
Fly Anatomy (FA)thorax0.008551Moderately InformativeInherited
Fly Anatomy (FA)region of integument0.01294Moderately InformativeInherited
Fly Anatomy (FA)sensory system0.01757Moderately InformativeInherited
Fly Anatomy (FA)adult tagma0.06063Moderately InformativeInherited
Fly Anatomy (FA)embryo0.09529Moderately InformativeInherited
Fly Anatomy (FA)mechanosensory system0.000251InformativeDirect
Fly Anatomy (FA)embryonic/larval circulatory system0.0003048InformativeDirect
Fly Anatomy (FA)chaeta0.001088InformativeInherited
Fly Anatomy (FA)anatomical space0.001861InformativeInherited
Fly Anatomy (FA)mechanosensory chaeta0.00004374Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0001682Highly InformativeDirect
Fly Anatomy (FA)mesothoracic tergum0.0003916Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cell0.06261Least InformativeInherited
Zebrafish Anatomy (ZA)cardiovascular system0.01495Moderately InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.054Moderately InformativeInherited
Zebrafish Anatomy (ZA)primary germ layer0.0002565InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.1348Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.2751Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4019Least InformativeInherited
Xenopus ANatomical entity (XAN)nervous system0.6581Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.7455Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk1Least InformativeInherited
Xenopus ANatomical entity (XAN)multi-tissue structure0.0001289Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.000166Moderately InformativeDirect
Xenopus ANatomical entity (XAN)embryonic structure0.003643Moderately InformativeInherited
Xenopus ANatomical entity (XAN)musculoskeletal system0.03414Moderately InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.7418Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.7579Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.7688Moderately InformativeInherited
Xenopus ANatomical entity (XAN)mesenchyme0.0000009581InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000008425InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00001873InformativeDirect
Xenopus ANatomical entity (XAN)neural plate0.00004513InformativeDirect
Xenopus ANatomical entity (XAN)cranial placode0.0002353InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.0003196InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.000403InformativeDirect
Xenopus ANatomical entity (XAN)cardiovascular system0.0005322InformativeDirect
Xenopus ANatomical entity (XAN)peripheral nervous system0.005021InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.02864InformativeInherited
Xenopus ANatomical entity (XAN)surface structure0.06342InformativeInherited
Xenopus ANatomical entity (XAN)connective tissue0.6003InformativeInherited
Xenopus ANatomical entity (XAN)limb0.6248InformativeInherited
Xenopus ANatomical entity (XAN)solid compound organ0.808InformativeInherited
Xenopus ANatomical entity (XAN)muscle0.952InformativeInherited
Xenopus ANatomical entity (XAN)neurogenic placode0.00001116Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.00002138Highly InformativeDirect
Xenopus ANatomical entity (XAN)foregut0.0003687Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.000456Highly InformativeDirect
Xenopus ANatomical entity (XAN)neuron0.0008531Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranium0.001372Highly InformativeInherited
Xenopus ANatomical entity (XAN)gustatory system0.02536Highly InformativeInherited
Xenopus ANatomical entity (XAN)branchial arch0.2188Highly InformativeInherited
Xenopus ANatomical entity (XAN)pelvic appendage0.9841Highly InformativeInherited
Xenopus ANatomical entity (XAN)marginal zone1Highly InformativeInherited
Xenopus ANatomical entity (XAN)cranial nerve1Highly InformativeInherited
Xenopus DEvelopment stage (XDE)post-embryonic stage0.7782Least InformativeInherited
Xenopus DEvelopment stage (XDE)premetamorphosis stage0.01454Highly InformativeInherited

Document: XA annotation of SCOP domains

InterPro annotation
Cross references IPR008967 SSF49417 Protein matches
Abstract

This domain is found in a number of transcription factors, including p53, NFATC, TonEBP, STAT-1, and NFkappaB, where it is responsible for DNA-binding. These transcription factors play diverse roles in the regulation of cellular functions: the p53 tumour suppressor upregulates the expression of genes involved in cell cycle arrest and apoptosis [PubMed12826037]; NFATC regulates the production of effector proteins involved in coordinating the immune response [PubMed8990122]; TonEBP regulates gene expression induced by osmotic stress and helps regulate intracellular volume during cell growth [PubMed12729611]; STAT-1 plays an important role in B lymphocyte growth and function [PubMed12855573]; and NFkappaB is involved in the inflammatory response [PubMed12421671]. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilize the protein-DNA complex [PubMed11780147]. Protein interactions may also serve to stabilize the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PubMed9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 26 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a p53-like transcription factors domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 26 hidden Markov models representing the p53-like transcription factors superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]