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Transthyretin (synonym: prealbumin) superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Prealbumin-like [ 49451] (7)
Superfamily:   Transthyretin (synonym: prealbumin) [ 49472]
Families:   Transthyretin (synonym: prealbumin) [ 49473]

Superfamily statistics
Genomes (1,049) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 1,343 7,236 27
Proteins 1,337 7,224 27

Functional annotation
General category General
Detailed category General

Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)cellular component organization or biogenesis0.000031330.0007846Least InformativeDirect
Biological Process (BP)biological regulation0.11250.5482Least InformativeInherited
Biological Process (BP)macromolecular complex subunit organization0.00067270.000009717Moderately InformativeDirect
Biological Process (BP)protein complex biogenesis0.0000000086310.0000000007024Moderately InformativeDirect
Biological Process (BP)cellular component assembly0.0044450.0003189Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.00050440.01045Moderately InformativeInherited
Biological Process (BP)regulation of hormone levels0.0000001460.0000004786InformativeDirect
Biological Process (BP)protein oligomerization0.0000000001250.000000000002076InformativeDirect
Molecular Function (MF)binding0.0025450.03528Least InformativeInherited
Molecular Function (MF)hormone binding08.27e-16Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular component organization or biogenesis 0.0007846 Least Informative Direct
Biological Process (BP) biological regulation 0.5482 Least Informative Inherited
Biological Process (BP) cellular component assembly 0.0003189 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.000009717 Moderately Informative Direct
Biological Process (BP) protein complex biogenesis 0.0000000007024 Moderately Informative Direct
Biological Process (BP) regulation of biological quality 0.01045 Moderately Informative Inherited
Biological Process (BP) regulation of hormone levels 0.0000004786 Informative Direct
Biological Process (BP) protein oligomerization 0.000000000002076 Informative Direct
Molecular Function (MF) binding 0.03528 Least Informative Inherited
Molecular Function (MF) hormone binding 8.27e-16 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)In cyclic amides0InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0.00000000176Least InformativeDirect
Biological processPurine metabolism0Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPeriplasm0.0000006868InformativeDirect
DomainSignal0Least InformativeDirect
Post-translational modificationHydrolase0.0000007118Least InformativeDirect
Post-translational modificationHormone0Highly InformativeDirect
Post-translational modificationGlycoprotein0.0001351Least InformativeDirect
Post-translational modificationGamma-carboxyglutamic acid0Highly InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR000895 SSF49472 Protein matches

Transthyretin (formerly prealbumin) is one of 3 thyroid hormone-binding proteins found in the blood of vertebrates [PubMed1833190]. It is produced in the liver and circulates in the bloodstream, where it binds retinol and thyroxine (T4) [PubMed4054629]. It differs from the other 2 hormone-binding proteins (T4-binding globulin and albumin) in 3 distinct ways: (1) the gene is expressed at a high rate in the brain choroid plexus; (2) it is enriched in cerebrospinal fluid; and (3) no genetically caused absence has been observed, suggesting an essential role in brain function, distinct from that played in the bloodstream [PubMed1833190]. The protein consists of around 130 amino acids, which assemble as a homotetramer that contains an internal channel in which T4 is bound. Within this complex, T4 appears to be transported across the blood-brain barrier, where, in the choroid plexus, the hormone stimulates further synthesis of transthyretin. The protein then diffuses back into the bloodstream, where it binds T4 for transport back to the brain [PubMed1833190].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 4 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Transthyretin (synonym: prealbumin) domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 4 hidden Markov models representing the Transthyretin (synonym: prealbumin) superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]