SUPERFAMILY 1.75 HMM library and genome assignments server

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PLC-like (P variant) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   C2 domain-like [ 49561] (5)
Superfamily:   C2 domain (Calcium/lipid-binding domain, CaLB) [ 49562] (2)
Family:   PLC-like (P variant) [ 49563] (11)


Family statistics
Genomes (100) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,571 4,560 18
Proteins 1,571 4,559 18


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Carboxylic ester hydrolases1Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep0.02382Moderately InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.000001033InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0Highly InformativeDirect
Enzyme Commission (EC)Phosphatidylinositol-4,5-bisphosphate 3-kinase0Highly InformativeDirect
Enzyme Commission (EC)Phospholipase A(2)3.476e-16Highly InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the immune system0.2531Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.2772Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.1458Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.5915Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the thyroid gland0.1109InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the tongue0.0004309Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)hematopoietic system phenotype0.01901Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.02326Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.3141Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4012Least InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.002041Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte cell number0.006151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.01578Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.05417Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.09691Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.1488Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.1712Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal myeloid cell morphology0.2088Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal neuron morphology0.2947Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2983Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.3474Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.5385Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00002836InformativeDirect
Mammalian Phenotype (MP)abnormal B-1 B cell number0.0001199InformativeDirect
Mammalian Phenotype (MP)abnormal B cell proliferation0.0001269InformativeDirect
Mammalian Phenotype (MP)abnormal interferon-gamma secretion0.001588InformativeInherited
Mammalian Phenotype (MP)abnormal ion homeostasis0.04329InformativeInherited
Mammalian Phenotype (MP)abnormal kidney physiology0.09598InformativeInherited
Mammalian Phenotype (MP)abnormal mature B cell number0.1985InformativeInherited
Mammalian Phenotype (MP)decreased B cell number0.2009InformativeInherited
Mammalian Phenotype (MP)abnormal T cell physiology0.7304InformativeInherited
Mammalian Phenotype (MP)abnormal calcium ion homeostasis0.00002395Highly InformativeDirect
Mammalian Phenotype (MP)abnormal synaptic vesicle number0.00007381Highly InformativeDirect
Mammalian Phenotype (MP)decreased interleukin-2 secretion0.0003659Highly InformativeDirect
Mammalian Phenotype (MP)renal/urinary system inflammation0.003909Highly InformativeInherited
Mammalian Phenotype (MP)abnormal platelet morphology0.2119Highly InformativeInherited
Mammalian Phenotype (MP)abnormal cytotoxic T cell physiology0.4505Highly InformativeInherited
Mammalian Phenotype (MP)decreased mature B cell number0.5306Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0001044Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001698Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.0002123Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.000632Least InformativeDirect
Worm Phenotype (WP)cell homeostasis metabolism variant0.00000005806Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.0000005456Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.00002509Moderately InformativeDirect
Worm Phenotype (WP)cell type morphology variant0.0002116Moderately InformativeDirect
Worm Phenotype (WP)chemical response variant0.01166Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.4813Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.8947Moderately InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.00000000009631InformativeDirect
Worm Phenotype (WP)muscle cell physiology variant0.000002257InformativeDirect
Worm Phenotype (WP)defecation variant0.000007697InformativeDirect
Worm Phenotype (WP)cell stress response variant0.000008696InformativeDirect
Worm Phenotype (WP)oocyte morphology variant0.00003541InformativeDirect
Worm Phenotype (WP)hermaphrodite physiology variant0.00006073InformativeDirect
Worm Phenotype (WP)body wall muscle sarcomere morphology variant0.0001298InformativeDirect
Worm Phenotype (WP)locomotor coordination variant0.0002657InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.0005576InformativeDirect
Worm Phenotype (WP)fat content variant0.0009602InformativeDirect
Worm Phenotype (WP)chemosensory response variant0.01864InformativeInherited
Worm Phenotype (WP)organism temperature response variant0.03176InformativeInherited
Worm Phenotype (WP)acetylcholinesterase inhibitor response variant0.09624InformativeInherited
Worm Phenotype (WP)pattern protein expression variant0.1097InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)defecation contraction variant0.0000000000003391Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.00000000007458Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.000000001588Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.00000003695Highly InformativeDirect
Worm Phenotype (WP)organism osmotic stress response variant0.0000004165Highly InformativeDirect
Worm Phenotype (WP)thermotaxis variant0.00000663Highly InformativeDirect
Worm Phenotype (WP)dauer formation variant0.0002235Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0003767Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)planar polarity defective0.0001032InformativeDirect
Fly Phenotype (FP)decreased cell size0.000002832Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.09608Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1334Least InformativeInherited
Fly Anatomy (FA)nervous system0.1548Least InformativeInherited
Fly Anatomy (FA)segment0.2254Least InformativeInherited
Fly Anatomy (FA)somatic cell0.2696Least InformativeInherited
Fly Anatomy (FA)adult0.3092Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.3854Least InformativeInherited
Fly Anatomy (FA)tagma0.5514Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.0301Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.05116Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.05531Moderately InformativeInherited
Fly Anatomy (FA)circulatory system0.07341Moderately InformativeInherited
Fly Anatomy (FA)neuron0.1278Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.3856Moderately InformativeInherited
Fly Anatomy (FA)anatomical space0.01291InformativeInherited
Fly Anatomy (FA)primordium0.03725InformativeInherited
Fly Anatomy (FA)anatomical cluster0.09337InformativeInherited
Fly Anatomy (FA)embryonic/larval neuron0.1011InformativeInherited
Fly Anatomy (FA)imaginal disc0.1077InformativeInherited
Fly Anatomy (FA)mesothoracic tergum0.0005713Highly InformativeDirect
Fly Anatomy (FA)head mesoderm derived embryonic hemocyte0.0009925Highly InformativeDirect
Fly Anatomy (FA)larval multidendritic neuron0.001157Highly InformativeInherited
Fly Anatomy (FA)sensory cluster0.00378Highly InformativeInherited
Fly Anatomy (FA)eye disc0.01991Highly InformativeInherited

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus DEvelopment stage (XDE)embryonic stage0.1815Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.5999InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details) Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Transferases0.6709Least InformativeInherited
Enzyme Commission (EC)Acting on ester bonds0Moderately InformativeDirect
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor0.03328Moderately InformativeInherited
Enzyme Commission (EC)Acyltransferases0.2807Moderately InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0.00009287InformativeDirect
Enzyme Commission (EC)Carboxylic ester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphoric monoester hydrolases1InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Highly InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0.0000000000002663Highly InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0000000188Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0.00004361Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 45 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a C2 domain (Calcium/lipid-binding domain, CaLB) domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]