SUPERFAMILY 1.75 HMM library and genome assignments server


SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,747) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 16,428 0 38
Proteins 15,640 0 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.041720.0006283Least InformativeInherited
Biological Process (BP)response to stimulus0.0024640Least InformativeInherited
Biological Process (BP)single-organism cellular process0.026360Least InformativeInherited
Molecular Function (MF)binding0.00010580Least InformativeDirect
Cellular Component (CC)intracellular organelle part0.027384.794e-08Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.046410.7136Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.0005010.004292Moderately InformativeInherited
Cellular Component (CC)nuclear part0.0081780.0001933Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.196e-09 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0006283 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 1.077e-14 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 1.337e-08 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 3.05e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 8.006e-07 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 4.152e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0001395 Least Informative Direct
Biological Process (BP) localization 0.1771 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.03056 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.3268 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 3.139e-05 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 1.705e-08 Moderately Informative Direct
Biological Process (BP) immune system process 4.045e-12 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 9.578e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.505e-07 Moderately Informative Direct
Biological Process (BP) reproduction 6.22e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.163e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001997 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0004901 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0008732 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0009709 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.01838 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3231 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.8733 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.1161 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3124 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3189 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.0182 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7592 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1406 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001372 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.06088 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2046 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9758 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.03288 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.478 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.004359 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5049 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7699 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.404 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4397 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.465 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.7212 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.01696 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1066 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.09733 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7234 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.003182 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.99e-13 Informative Direct
Biological Process (BP) microtubule-based process 5.824e-13 Informative Direct
Biological Process (BP) DNA metabolic process 5.89e-11 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 4.768e-10 Informative Direct
Biological Process (BP) cell cycle process 1.102e-08 Informative Direct
Biological Process (BP) cellular process involved in reproduction 2.712e-08 Informative Direct
Biological Process (BP) growth 5.608e-08 Informative Direct
Biological Process (BP) immune effector process 1.068e-07 Informative Direct
Biological Process (BP) immune response 2.165e-07 Informative Direct
Biological Process (BP) chromosome organization 2.6e-07 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 3.411e-06 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.773e-06 Informative Direct
Biological Process (BP) cellular component movement 9.855e-06 Informative Direct
Biological Process (BP) transcription, DNA-dependent 9.96e-06 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 6.288e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 7.818e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001263 Informative Direct
Biological Process (BP) cardiovascular system development 0.0001529 Informative Direct
Biological Process (BP) regulation of growth 0.0002498 Informative Direct
Biological Process (BP) organelle localization 0.000281 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0003665 Informative Direct
Biological Process (BP) protein catabolic process 0.0004025 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0004465 Informative Direct
Biological Process (BP) tube development 0.0007712 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0009502 Informative Direct
Biological Process (BP) sexual reproduction 0.000981 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.004162 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.7548 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.002307 Informative Inherited
Biological Process (BP) cell projection organization 0.7478 Informative Inherited
Biological Process (BP) generation of neurons 0.8882 Informative Inherited
Biological Process (BP) regulation of immune response 0.4115 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.0106 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.04858 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1283 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.09621 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.1369 Informative Inherited
Biological Process (BP) organ morphogenesis 0.08442 Informative Inherited
Biological Process (BP) embryonic organ development 0.5552 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2636 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.1093 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.03085 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.924 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.047 Informative Inherited
Biological Process (BP) regulation of response to stress 0.04997 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9865 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.05811 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9387 Informative Inherited
Biological Process (BP) response to other organism 0.003272 Informative Inherited
Biological Process (BP) locomotion 0.05286 Informative Inherited
Biological Process (BP) single organism reproductive process 0.007068 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.04173 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3769 Informative Inherited
Biological Process (BP) RNA processing 0.5163 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.034 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.4025 Informative Inherited
Biological Process (BP) proteolysis 0.02838 Informative Inherited
Biological Process (BP) mitotic cell cycle 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) cell-cell signaling 0.1326 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.313 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.05391 Informative Inherited
Biological Process (BP) epithelium development 0.02137 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.09562 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01853 Informative Inherited
Biological Process (BP) leukocyte activation 0.00838 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2915 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 9.39e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 3.692e-12 Highly Informative Direct
Biological Process (BP) regulation of striated muscle tissue development 4.057e-10 Highly Informative Direct
Biological Process (BP) double-strand break repair 9.865e-10 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 3.962e-09 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.091e-08 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 2.478e-08 Highly Informative Direct
Biological Process (BP) protein ubiquitination 3.148e-08 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.893e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.605e-06 Highly Informative Direct
Biological Process (BP) developmental growth 3.277e-06 Highly Informative Direct
Biological Process (BP) axon development 1.652e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.191e-05 Highly Informative Direct
Biological Process (BP) B cell activation 3.28e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 4.465e-05 Highly Informative Direct
Biological Process (BP) DNA recombination 9.838e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001141 Highly Informative Direct
Biological Process (BP) renal system development 0.0001181 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.000155 Highly Informative Direct
Biological Process (BP) cell morphogenesis involved in neuron differentiation 0.0004109 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.000708 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0007788 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.001127 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7571 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.02326 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03678 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.07216 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6134 Highly Informative Inherited
Biological Process (BP) cell projection morphogenesis 0.1204 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.001686 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.254 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.0219 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.5841 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001493 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.07449 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001135 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6757 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.08539 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001651 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02479 Highly Informative Inherited
Biological Process (BP) cell division 0.01413 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8742 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01257 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.004576 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.04532 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1918 Highly Informative Inherited
Biological Process (BP) stem cell development 0.002637 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3447 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6691 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.2096 Highly Informative Inherited
Biological Process (BP) cell growth 0.07442 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.06815 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1715 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6754 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1091 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.1861 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.0645 Highly Informative Inherited
Biological Process (BP) mitosis 0.5783 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.007266 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2461 Highly Informative Inherited
Biological Process (BP) ossification 0.006749 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.4704 Least Informative Inherited
Molecular Function (MF) nucleic acid binding 0.0008515 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.7821 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 1.008e-12 Informative Direct
Molecular Function (MF) chromatin binding 2.62e-11 Informative Direct
Molecular Function (MF) DNA binding 2.358e-10 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.341e-06 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 2.05e-05 Informative Direct
Molecular Function (MF) protein dimerization activity 0.7409 Informative Inherited
Molecular Function (MF) enzyme binding 0.07486 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.5257 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.8977 Informative Inherited
Molecular Function (MF) nuclease activity 0.001438 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 2.633e-13 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 9.302e-11 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.599e-08 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 1.621e-06 Highly Informative Direct
Molecular Function (MF) transcription factor binding 1.924e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 1.991e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 0.0001022 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0005197 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1952 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 4.794e-08 Least Informative Direct
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0001594 Least Informative Direct
Cellular Component (CC) protein complex 0.0009092 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.7136 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0001933 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.004292 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6808 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 2.5e-09 Informative Direct
Cellular Component (CC) chromosome 4.614e-08 Informative Direct
Cellular Component (CC) nucleoplasm part 0.1168 Informative Inherited
Cellular Component (CC) cell-cell junction 0.9336 Informative Inherited
Cellular Component (CC) microtubule associated complex 5.199e-09 Highly Informative Direct
Cellular Component (CC) adherens junction 6.569e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 1.406e-05 Highly Informative Direct
Cellular Component (CC) nuclear body 0.02095 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.03909 Highly Informative Inherited
Cellular Component (CC) apical junction complex 0.04133 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.375e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red8.23e-09Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation1.841e-12InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05565Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.04498InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.2792Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.000697InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.09022Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1742Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3727Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.597Least InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01265Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.01827Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.06143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.107Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.134Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1827Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.3938Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.4325Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5025Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5148Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5413Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell physiology0.6879Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.8408Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal tumor incidence0.9062Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation5.079e-05InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.003012InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.02528InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.03931InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.04911InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.05879InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.06808InformativeInherited
Mammalian Phenotype (MP)decreased leukocyte cell number0.1924InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2315InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.2481InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4352InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8266InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence3.163e-07Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.0001269Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.0001439Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002289Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0006778Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.004453Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.008498Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2331Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant2.22e-07Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant1.188e-05Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant3.954e-05Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell cycle defective0.0001504InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.04624Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1052Least InformativeInherited
Fly Anatomy (FA)cell0.1101Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1283Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.000248Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002225Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.004676Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.0113Moderately InformativeInherited
Fly Anatomy (FA)neuron0.02017Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02122Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04522Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1121Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.3214Moderately InformativeInherited
Fly Anatomy (FA)head0.3681Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.002075InformativeInherited
Fly Anatomy (FA)prepupa0.005128InformativeInherited
Fly Anatomy (FA)pupa0.006405InformativeInherited
Fly Anatomy (FA)larval segment0.01386InformativeInherited
Fly Anatomy (FA)cell component0.01517InformativeInherited
Fly Anatomy (FA)ovariole0.0153InformativeInherited
Fly Anatomy (FA)imaginal precursor0.03925InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0002115Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0005374Highly InformativeDirect
Fly Anatomy (FA)bouton0.0007411Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2068Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.9994Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.4598InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups6.369e-09Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.06662Least InformativeInherited
Enzyme Commission (EC)Lyases0.4373Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.9309Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases3.778e-13Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002456Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08807Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen4.595e-10InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen6.165e-14Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases4.817e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation2.445e-07Moderately InformativeDirect
Biological processDifferentiation0.0002876Moderately InformativeDirect
Biological processMitosis2.469e-13InformativeDirect
Biological processMeiosis1.669e-10InformativeDirect
Biological processUbl conjugation pathway3.169e-10InformativeDirect
Biological processInnate immunity1.972e-09InformativeDirect
Biological processAngiogenesis2.052e-06InformativeDirect
Biological processVirulence0.0001931InformativeDirect
Biological processCell adhesion0.0005114InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense2.409e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome2.231e-14InformativeDirect
Cellular componentTelomere2.975e-07Highly InformativeDirect
DiseaseDisease mutation0.0001319Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger9.273e-12Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding0.000273Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator1.383e-08Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.53e-05Moderately InformativeDirect
Post-translational modificationKinase0.0263Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase1.207e-09InformativeDirect
Post-translational modificationChromatin regulator6.352e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0002372Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation5.106e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism9.02e-11Least InformativeDirect
UniPathway (UP)protein ubiquitination9.559e-05Moderately InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)terpene metabolism2.462e-14InformativeDirect
UniPathway (UP)plant hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]