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SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,760) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 17,071 62,667 38
Proteins 16,293 59,099 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Cellular Component (CC)intracellular organelle part0.0052410.0002506Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.067260.1297Least InformativeInherited
Cellular Component (CC)intracellular organelle lumen0.000029830.000123Moderately InformativeDirect
Cellular Component (CC)nuclear part0.000011570.008589Moderately InformativeInherited

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0 Least Informative Direct
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0000155 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.0001663 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.009939 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.7663 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.008566 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.04461 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.07787 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.01099 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) immune system process 0.0000000000006912 Moderately Informative Direct
Biological Process (BP) single organism signaling 0.0000000001638 Moderately Informative Direct
Biological Process (BP) cell communication 0.000000001639 Moderately Informative Direct
Biological Process (BP) response to organic substance 0.0000001653 Moderately Informative Direct
Biological Process (BP) reproduction 0.0000002042 Moderately Informative Direct
Biological Process (BP) cellular localization 0.000000563 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001167 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.00003943 Moderately Informative Direct
Biological Process (BP) multi-organism process 0.00005718 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 0.0001715 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000438 Moderately Informative Direct
Biological Process (BP) cellular response to stress 0.000543 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 0.0006802 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) carbohydrate derivative metabolic process 1 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5975 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.3248 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9097 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.6149 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 1 Moderately Informative Inherited
Biological Process (BP) system development 0.8584 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 1 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.1469 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8425 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.003227 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.1214 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.001052 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 0.08109 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.1504 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.2787 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001125 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.6653 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to biotic stimulus 0.5153 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.006376 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.07849 Moderately Informative Inherited
Biological Process (BP) cell cycle process 0 Informative Direct
Biological Process (BP) microtubule-based process 0 Informative Direct
Biological Process (BP) cellular response to DNA damage stimulus 0.000000000000117 Informative Direct
Biological Process (BP) regulation of cell cycle 0.00000000003332 Informative Direct
Biological Process (BP) DNA metabolic process 0.0000000002936 Informative Direct
Biological Process (BP) cell surface receptor signaling pathway 0.000000002628 Informative Direct
Biological Process (BP) organelle localization 0.0000002773 Informative Direct
Biological Process (BP) single-organism intracellular transport 0.0000006806 Informative Direct
Biological Process (BP) movement of cell or subcellular component 0.000002254 Informative Direct
Biological Process (BP) immune effector process 0.00007888 Informative Direct
Biological Process (BP) proteolysis 0.00008709 Informative Direct
Biological Process (BP) cell activation 0.0001285 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0002098 Informative Direct
Biological Process (BP) chromosome organization 0.0003469 Informative Direct
Biological Process (BP) growth 0.0003515 Informative Direct
Biological Process (BP) regulation of transcription, DNA-templated 0.0007636 Informative Direct
Biological Process (BP) single organism reproductive process 0.0008602 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.07489 Informative Inherited
Biological Process (BP) positive regulation of nucleobase-containing compound metabolic process 0.08979 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.4122 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.811 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.8405 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) response to cytokine 0.5885 Informative Inherited
Biological Process (BP) protein oligomerization 0.3561 Informative Inherited
Biological Process (BP) generation of neurons 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.06512 Informative Inherited
Biological Process (BP) regulation of phosphorylation 0.3762 Informative Inherited
Biological Process (BP) regulation of cellular component biogenesis 0.0442 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.968 Informative Inherited
Biological Process (BP) cytoskeleton organization 0.9451 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.01437 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.4003 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.5884 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.2478 Informative Inherited
Biological Process (BP) regulation of growth 0.008808 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.01906 Informative Inherited
Biological Process (BP) regulation of cell differentiation 0.6477 Informative Inherited
Biological Process (BP) multi-organism reproductive process 0.1126 Informative Inherited
Biological Process (BP) response to nitrogen compound 1 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.3237 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) negative regulation of macromolecule biosynthetic process 0.1424 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.3542 Informative Inherited
Biological Process (BP) regulation of cellular amide metabolic process 1 Informative Inherited
Biological Process (BP) regulation of organelle organization 0.9301 Informative Inherited
Biological Process (BP) regulation of cytokine production 0.2166 Informative Inherited
Biological Process (BP) cell development 0.4231 Informative Inherited
Biological Process (BP) locomotion 0.2553 Informative Inherited
Biological Process (BP) response to organic cyclic compound 1 Informative Inherited
Biological Process (BP) multicellular organism reproduction 0.1244 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) mitotic cell cycle 0.06574 Informative Inherited
Biological Process (BP) response to radiation 0.00471 Informative Inherited
Biological Process (BP) cell-cell signaling 0.4605 Informative Inherited
Biological Process (BP) post-embryonic development 0.04178 Informative Inherited
Biological Process (BP) tissue development 0.1091 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.377 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.07821 Informative Inherited
Biological Process (BP) embryo development 0.001588 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.1079 Informative Inherited
Biological Process (BP) phosphorylation 0.007537 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.7335 Informative Inherited
Biological Process (BP) circulatory system development 0.001407 Informative Inherited
Biological Process (BP) immune response 0.001926 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) cell cycle checkpoint 0 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 0 Highly Informative Direct
Biological Process (BP) pattern specification process 0.000000000000007367 Highly Informative Direct
Biological Process (BP) lymphocyte activation 0.000000000045 Highly Informative Direct
Biological Process (BP) microtubule-based movement 0.0000000001108 Highly Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 0.000000000509 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000000001201 Highly Informative Direct
Biological Process (BP) double-strand break repair 0.00000002467 Highly Informative Direct
Biological Process (BP) cell proliferation 0.0000002105 Highly Informative Direct
Biological Process (BP) response to virus 0.0000002176 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0000002425 Highly Informative Direct
Biological Process (BP) nuclear division 0.00000103 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0000112 Highly Informative Direct
Biological Process (BP) regulation of fibroblast proliferation 0.00001359 Highly Informative Direct
Biological Process (BP) anatomical structure homeostasis 0.00003311 Highly Informative Direct
Biological Process (BP) germ cell development 0.00005479 Highly Informative Direct
Biological Process (BP) cell division 0.0000874 Highly Informative Direct
Biological Process (BP) myeloid cell differentiation 0.0001147 Highly Informative Direct
Biological Process (BP) negative regulation of mitotic cell cycle 0.0001575 Highly Informative Direct
Biological Process (BP) regulation of chromosome organization 0.0001597 Highly Informative Direct
Biological Process (BP) amino sugar metabolic process 0.0002397 Highly Informative Direct
Biological Process (BP) protein-DNA complex subunit organization 0.0003532 Highly Informative Direct
Biological Process (BP) cell growth 0.0005941 Highly Informative Direct
Biological Process (BP) regulation of leukocyte differentiation 0.0008649 Highly Informative Direct
Biological Process (BP) regulation of cellular response to stress 0.1227 Highly Informative Inherited
Biological Process (BP) negative regulation of immune system process 0.608 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-templated 0.99 Highly Informative Inherited
Biological Process (BP) vesicle localization 0.7172 Highly Informative Inherited
Biological Process (BP) kidney development 0.1525 Highly Informative Inherited
Biological Process (BP) neuron development 0.6906 Highly Informative Inherited
Biological Process (BP) negative regulation of phosphate metabolic process 0.009192 Highly Informative Inherited
Biological Process (BP) negative regulation of protein modification process 0.02886 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.4237 Highly Informative Inherited
Biological Process (BP) positive regulation of cellular component biogenesis 0.1713 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.2361 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.01964 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.001991 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.01843 Highly Informative Inherited
Biological Process (BP) positive regulation of nervous system development 0.2552 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02212 Highly Informative Inherited
Biological Process (BP) regulation of T cell activation 0.06735 Highly Informative Inherited
Biological Process (BP) gene silencing 0.2202 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.9056 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular amide metabolic process 0.6777 Highly Informative Inherited
Biological Process (BP) innate immune response 0.6378 Highly Informative Inherited
Biological Process (BP) histone modification 0.03329 Highly Informative Inherited
Biological Process (BP) negative regulation of transcription, DNA-templated 0.6811 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.1144 Highly Informative Inherited
Biological Process (BP) plasma membrane bounded cell projection organization 0.002859 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.2317 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.08343 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.004512 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.4648 Highly Informative Inherited
Biological Process (BP) leukocyte differentiation 0.08853 Highly Informative Inherited
Biological Process (BP) modification-dependent macromolecule catabolic process 0.001207 Highly Informative Inherited
Biological Process (BP) proteolysis involved in cellular protein catabolic process 0.001227 Highly Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0.7682 Highly Informative Inherited
Biological Process (BP) regulation of cell shape 0.05876 Highly Informative Inherited
Biological Process (BP) sensory organ morphogenesis 0.6807 Highly Informative Inherited
Biological Process (BP) gliogenesis 0.04674 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.002279 Highly Informative Inherited
Biological Process (BP) appendage development 0.01217 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.0731 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 0.9191 Highly Informative Inherited
Biological Process (BP) developmental growth involved in morphogenesis 0.004361 Highly Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.178 Highly Informative Inherited
Biological Process (BP) meiotic cell cycle 0.1122 Highly Informative Inherited
Biological Process (BP) aminoglycan biosynthetic process 0.001149 Highly Informative Inherited
Biological Process (BP) gastrulation 0.008293 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.5386 Least Informative Inherited
Molecular Function (MF) transferase activity 0.9075 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.00009692 Moderately Informative Direct
Molecular Function (MF) nucleic acid binding 0.0005241 Moderately Informative Direct
Molecular Function (MF) DNA binding 0.0000001913 Informative Direct
Molecular Function (MF) transcription factor activity, sequence-specific DNA binding 0.000009033 Informative Direct
Molecular Function (MF) enzyme binding 0.1694 Informative Inherited
Molecular Function (MF) ATPase activity 0.7138 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.9983 Informative Inherited
Molecular Function (MF) signal transducer activity 0.1863 Informative Inherited
Molecular Function (MF) chromatin binding 0.000000001201 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0.000001213 Highly Informative Direct
Molecular Function (MF) protein phosphatase binding 0.000008112 Highly Informative Direct
Molecular Function (MF) transcription factor binding 0.00001895 Highly Informative Direct
Molecular Function (MF) small GTPase binding 0.0004742 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.004686 Highly Informative Inherited
Molecular Function (MF) tubulin binding 0.003116 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 0.0002506 Least Informative Direct
Cellular Component (CC) non-membrane-bounded organelle 0.001117 Least Informative Inherited
Cellular Component (CC) macromolecular complex 0.01049 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1297 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.000123 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.008589 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.2364 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 0.000000004357 Informative Direct
Cellular Component (CC) chromosome 0.00000009358 Informative Direct
Cellular Component (CC) nucleoplasm part 0.2447 Informative Inherited
Cellular Component (CC) supramolecular polymer 0.2838 Informative Inherited
Cellular Component (CC) cytoplasmic microtubule 0.00001333 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0001527 Highly Informative Direct
Cellular Component (CC) cell-substrate adherens junction 0.4244 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.6126 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000000007375Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.00000000823Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.000000000001841InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0003139Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.03787Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.0007175InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.1973Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6167Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.4832InformativeInherited
Phenotypic Abnormality (PA)Oral cleft0.2723Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.05229Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.1471Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.2912Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4485Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.4824Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.001873Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.007942Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.02722Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.05335Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.07473Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal digestive system morphology0.1219Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.1419Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell morphology0.1505Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1549Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune serum protein physiology0.2109Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.2414Moderately InformativeInherited
Mammalian Phenotype (MP)reproductive system phenotype0.2515Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.2551Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3024Moderately InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.4686Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.5723Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte cell number0.699Moderately InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.000171InformativeDirect
Mammalian Phenotype (MP)increased carcinoma incidence0.0002093InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0002899InformativeDirect
Mammalian Phenotype (MP)abnormal response to radiation0.002726InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.009682InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.01155InformativeInherited
Mammalian Phenotype (MP)abnormal interferon secretion0.03857InformativeInherited
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.06584InformativeInherited
Mammalian Phenotype (MP)abnormal sensitivity to induced morbidity/mortality0.08209InformativeInherited
Mammalian Phenotype (MP)abnormal internal female genitalia morphology0.1198InformativeInherited
Mammalian Phenotype (MP)abnormal female reproductive gland morphology0.1997InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.2217InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4072InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.6915InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence0.000002151Highly InformativeDirect
Mammalian Phenotype (MP)abnormal germ layer development0.000006017Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.00002541Highly InformativeDirect
Mammalian Phenotype (MP)abnormal cumulus expansion0.00002681Highly InformativeDirect
Mammalian Phenotype (MP)decreased interferon-alpha secretion0.0001573Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system development0.0004256Highly InformativeDirect
Mammalian Phenotype (MP)abnormal oocyte number0.0004294Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0007207Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.004693Highly InformativeInherited
Mammalian Phenotype (MP)decreased dendritic cell number0.0055Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.3406Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0005117Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.002497Least InformativeInherited
Worm Phenotype (WP)organ system morphology variant0.003455Least InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.0000316Moderately InformativeDirect
Worm Phenotype (WP)pericellular component development variant0.001955Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07086Moderately InformativeInherited
Worm Phenotype (WP)chemical response variant0.09287Moderately InformativeInherited
Worm Phenotype (WP)feeding behavior variant0.2772Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.6727Moderately InformativeInherited
Worm Phenotype (WP)velocity of movement variant0.0001667InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.0007379InformativeDirect
Worm Phenotype (WP)male morphology variant0.00143InformativeInherited
Worm Phenotype (WP)localized movement variant0.003437InformativeInherited
Worm Phenotype (WP)tail morphology variant0.004906InformativeInherited
Worm Phenotype (WP)body posture variant0.01099InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.01108InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.02843InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.0491InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.05376InformativeInherited
Worm Phenotype (WP)body length variant0.503InformativeInherited
Worm Phenotype (WP)locomotion reduced0.7864InformativeInherited
Worm Phenotype (WP)cuticle development variant0.0000008929Highly InformativeDirect
Worm Phenotype (WP)cuticle physiology variant0.000002983Highly InformativeDirect
Worm Phenotype (WP)male nervous system development variant0.00001792Highly InformativeDirect
Worm Phenotype (WP)social behavior variant0.00002149Highly InformativeDirect
Worm Phenotype (WP)short0.00002338Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00004037Highly InformativeDirect
Worm Phenotype (WP)coiling frequency0.00005447Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.00005995Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant0.00009444Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.0001016Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.0001045Highly InformativeDirect
Worm Phenotype (WP)nose movement variant0.0001881Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant0.000219Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.0002216Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.0002424Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0004246Highly InformativeDirect
Worm Phenotype (WP)path curvature variant0.06294Highly InformativeInherited
Worm Phenotype (WP)body posture wavelength variant0.3839Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)mitotic cell cycle defective0.000007828InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.07832Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.003711Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.04547Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.05219Moderately InformativeInherited
Fly Anatomy (FA)gonad0.07025Moderately InformativeInherited
Fly Anatomy (FA)stem cell0.1232Moderately InformativeInherited
Fly Anatomy (FA)prepupa0.006812InformativeInherited
Fly Anatomy (FA)pupa0.009438InformativeInherited
Fly Anatomy (FA)larval thoracic segment0.01438InformativeInherited
Fly Anatomy (FA)ovariole0.02309InformativeInherited
Fly Anatomy (FA)germline cell0.06889InformativeInherited
Fly Anatomy (FA)imaginal precursor0.0736InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0004275Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0007343Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0.09336Least InformativeInherited
Zebrafish Anatomy (ZA)multi-tissue structure0.1005Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0.00379Moderately InformativeInherited
Zebrafish Anatomy (ZA)central nervous system0.05789Moderately InformativeInherited
Zebrafish Anatomy (ZA)cell0.05863Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.000001558InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.0001436InformativeDirect
Zebrafish Anatomy (ZA)circulating cell0.0003552InformativeDirect
Zebrafish Anatomy (ZA)immune system0.01482InformativeInherited
Zebrafish Anatomy (ZA)mononuclear phagocyte0.000000001184Highly InformativeDirect
Zebrafish Anatomy (ZA)professional antigen presenting cell0.000000001455Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.0000002361Highly InformativeDirect
Zebrafish Anatomy (ZA)floor plate0.00002295Highly InformativeDirect
Zebrafish Anatomy (ZA)granulocyte0.00002591Highly InformativeDirect
Zebrafish Anatomy (ZA)embryonic structure0.2298Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3672Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster0.4739Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.3022InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0.1171Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.4135Least InformativeInherited
Enzyme Commission (EC)Lyases0.8741Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.0000000000008196Moderately InformativeDirect
Enzyme Commission (EC)Acyltransferases0.00000001254Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.281Moderately InformativeInherited
Enzyme Commission (EC)RING-type E3 ubiquitin transferase0InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.00000003787InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase0.00001984Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processUbl conjugation pathway0.000000001027Moderately InformativeDirect
Biological processTranscription regulation0.0000003827Moderately InformativeDirect
Biological processImmunity0.000006565Moderately InformativeDirect
Biological processVirulence0.0005067Moderately InformativeDirect
Biological processDifferentiation0.0006536Moderately InformativeDirect
Biological processMitosis0.0000000000004588InformativeDirect
Biological processMeiosis0.00000000003234InformativeDirect
Biological processInnate immunity0.00000001158InformativeDirect
Biological processAngiogenesis0.000002851InformativeDirect
Biological processCell adhesion0.0006996InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense0.000000000001151Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome0.00000000000001217InformativeDirect
Cellular componentTelomere0.0000002491Highly InformativeDirect
DiseaseDisease mutation0.0005048Least InformativeDirect
DiseaseNeurodegeneration0.0007063Highly InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger0.00000000001811Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationDNA-binding0Moderately InformativeDirect
Post-translational modificationActivator0.000000009897Moderately InformativeDirect
Post-translational modificationDevelopmental protein0.000001903Moderately InformativeDirect
Post-translational modificationKinase0.04168Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase0.000000003825InformativeDirect
Post-translational modificationChromatin regulator0.0000001208InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.00008187Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.00000000000001022Moderately InformativeDirect
Post-translational modificationADP-ribosylation0.000001062InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0.0000000001078Least InformativeDirect
UniPathway (UP)protein ubiquitination0.0001106Moderately InformativeDirect
UniPathway (UP)plant hormone metabolism0InformativeDirect
UniPathway (UP)terpene biosynthesis0.0000000000000143InformativeDirect
UniPathway (UP)plant hormone biosynthesis0Highly InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]