SUPERFAMILY 1.75 HMM library and genome assignments server


SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,377) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 14,169 19,439 38
Proteins 13,625 18,302 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.034960.005415Least InformativeInherited
Biological Process (BP)growth8.266e-051.438e-07InformativeDirect
Molecular Function (MF)binding0.00028920Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 6.206e-07 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 2.456e-06 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 6.234e-06 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 7.182e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000245 Least Informative Direct
Biological Process (BP) localization 0.343 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.005262 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.005415 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.1413 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 0.001619 Least Informative Inherited
Biological Process (BP) signal transduction 0.0001791 Moderately Informative Direct
Biological Process (BP) regulation of cellular metabolic process 0.00072 Moderately Informative Direct
Biological Process (BP) immune system process 4.655e-12 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 9.885e-10 Moderately Informative Direct
Biological Process (BP) regulation of nitrogen compound metabolic process 1.735e-09 Moderately Informative Direct
Biological Process (BP) response to organic substance 1.415e-07 Moderately Informative Direct
Biological Process (BP) reproduction 8.484e-07 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.058e-05 Moderately Informative Direct
Biological Process (BP) cellular response to chemical stimulus 9.447e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0001693 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.0002378 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0002595 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0003785 Moderately Informative Direct
Biological Process (BP) response to endogenous stimulus 0.009263 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signaling 0.7252 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 1 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of molecular function 1 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01365 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.8283 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.2491 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.7565 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.1044 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.001767 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.2317 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.5707 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.8489 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.5432 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.008822 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.59 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.9005 Moderately Informative Inherited
Biological Process (BP) gene expression 1 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.7245 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8304 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.1828 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.1361 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.0178 Moderately Informative Inherited
Biological Process (BP) growth 1.438e-07 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) DNA metabolic process 3.807e-11 Informative Direct
Biological Process (BP) response to DNA damage stimulus 6.987e-11 Informative Direct
Biological Process (BP) microtubule-based process 4.62e-10 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 6.936e-10 Informative Direct
Biological Process (BP) cellular process involved in reproduction 7.321e-09 Informative Direct
Biological Process (BP) immune response 3.977e-08 Informative Direct
Biological Process (BP) chromosome organization 7.438e-08 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 2.59e-06 Informative Direct
Biological Process (BP) immune effector process 2.771e-06 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 3.848e-06 Informative Direct
Biological Process (BP) cell cycle process 6.589e-06 Informative Direct
Biological Process (BP) anatomical structure homeostasis 6.765e-06 Informative Direct
Biological Process (BP) cell proliferation 9.678e-06 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 3.033e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001878 Informative Direct
Biological Process (BP) cell activation 0.0002411 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0002517 Informative Direct
Biological Process (BP) cardiovascular system development 0.0003833 Informative Direct
Biological Process (BP) regulation of growth 0.0004062 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.000451 Informative Direct
Biological Process (BP) sexual reproduction 0.0006359 Informative Direct
Biological Process (BP) protein catabolic process 0.0007897 Informative Direct
Biological Process (BP) regulation of cell cycle process 0.006909 Informative Inherited
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.6227 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation or removal 0.005893 Informative Inherited
Biological Process (BP) regulation of immune response 0.6079 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.007065 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.04112 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1116 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.02959 Informative Inherited
Biological Process (BP) synaptic transmission 0.04995 Informative Inherited
Biological Process (BP) organ morphogenesis 0.09392 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.001596 Informative Inherited
Biological Process (BP) embryonic organ development 0.4936 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2836 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.3531 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.02951 Informative Inherited
Biological Process (BP) negative regulation of cellular metabolic process 0.7999 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.943 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.02012 Informative Inherited
Biological Process (BP) regulation of response to stress 0.06279 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.837 Informative Inherited
Biological Process (BP) regulation of mitotic cell cycle 0.2012 Informative Inherited
Biological Process (BP) cellular macromolecule catabolic process 0.005918 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.8941 Informative Inherited
Biological Process (BP) response to other organism 0.005763 Informative Inherited
Biological Process (BP) locomotion 0.01963 Informative Inherited
Biological Process (BP) response to external stimulus 1 Informative Inherited
Biological Process (BP) single organism reproductive process 0.002003 Informative Inherited
Biological Process (BP) developmental process involved in reproduction 0.02623 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.2382 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.02402 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2357 Informative Inherited
Biological Process (BP) proteolysis 0.0696 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.8661 Informative Inherited
Biological Process (BP) regulation of cell development 0.3092 Informative Inherited
Biological Process (BP) cellular component movement 0.001929 Informative Inherited
Biological Process (BP) generation of neurons 0.02638 Informative Inherited
Biological Process (BP) cell projection organization 0.523 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0546 Informative Inherited
Biological Process (BP) epithelium development 0.0125 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.85 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.01621 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2682 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) chordate embryonic development 0.9725 Informative Inherited
Biological Process (BP) tube development 0.002432 Informative Inherited
Biological Process (BP) microtubule-based movement 0 Highly Informative Direct
Biological Process (BP) pattern specification process 4.008e-15 Highly Informative Direct
Biological Process (BP) regulation of binding 3.169e-12 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 9.405e-09 Highly Informative Direct
Biological Process (BP) DNA damage checkpoint 1.639e-08 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 2.676e-08 Highly Informative Direct
Biological Process (BP) germ cell development 6.761e-08 Highly Informative Direct
Biological Process (BP) protein ubiquitination 1.07e-07 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.73e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 1.229e-06 Highly Informative Direct
Biological Process (BP) developmental growth 1.656e-06 Highly Informative Direct
Biological Process (BP) axonogenesis 3.096e-06 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 9.554e-06 Highly Informative Direct
Biological Process (BP) gastrulation 1.82e-05 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 5.378e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 0.0001086 Highly Informative Direct
Biological Process (BP) B cell activation 0.0001125 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0001192 Highly Informative Direct
Biological Process (BP) protein complex localization 0.000202 Highly Informative Direct
Biological Process (BP) regulation of innate immune response 0.0002572 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0008538 Highly Informative Direct
Biological Process (BP) negative regulation of signal transduction 0.6748 Highly Informative Inherited
Biological Process (BP) cellular response to biotic stimulus 0.007943 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.6658 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.07033 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.003388 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.1964 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.02903 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01878 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.4115 Highly Informative Inherited
Biological Process (BP) negative regulation of cellular macromolecule biosynthetic process 1 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001587 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.08388 Highly Informative Inherited
Biological Process (BP) regulation of DNA metabolic process 0.06047 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6622 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle 0.5456 Highly Informative Inherited
Biological Process (BP) mitotic cell cycle checkpoint 0.23 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.009094 Highly Informative Inherited
Biological Process (BP) cell division 0.01615 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.06389 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6581 Highly Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8808 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.008512 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.001862 Highly Informative Inherited
Biological Process (BP) cellular response to organic cyclic compound 0.5394 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.2449 Highly Informative Inherited
Biological Process (BP) stem cell development 0.0023 Highly Informative Inherited
Biological Process (BP) cell growth 0.04969 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.1892 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.02586 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis 0.3804 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6302 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.07469 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.08614 Highly Informative Inherited
Biological Process (BP) nuclear division 0.001056 Highly Informative Inherited
Biological Process (BP) DNA packaging 0.01095 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.1214 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.01772 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.003149 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.09933 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.1851 Highly Informative Inherited
Biological Process (BP) ossification 0.004289 Highly Informative Inherited
Biological Process (BP) cell cycle phase transition 0.6197 Highly Informative Inherited
Biological Process (BP) DNA repair 0.00272 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.3667 Least Informative Inherited
Molecular Function (MF) protein binding 1.859e-06 Moderately Informative Direct
Molecular Function (MF) heterocyclic compound binding 1.619e-05 Moderately Informative Direct
Molecular Function (MF) organic cyclic compound binding 3.35e-05 Moderately Informative Direct
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.8222 Moderately Informative Inherited
Molecular Function (MF) DNA binding 1.384e-10 Informative Direct
Molecular Function (MF) nucleic acid binding transcription factor activity 3.371e-09 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 1.061e-06 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 8.004e-06 Informative Direct
Molecular Function (MF) protein dimerization activity 0.649 Informative Inherited
Molecular Function (MF) enzyme binding 0.3292 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.4556 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9445 Informative Inherited
Molecular Function (MF) nuclease activity 0.001227 Informative Inherited
Molecular Function (MF) chromatin binding 2.774e-12 Highly Informative Direct
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 2.459e-10 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 2.296e-08 Highly Informative Direct
Molecular Function (MF) transcription factor binding 7.606e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 2.403e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 3.175e-05 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1267 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1.467e-07 Least Informative Direct
Cellular Component (CC) protein complex 0.0009591 Least Informative Direct
Cellular Component (CC) intracellular membrane-bounded organelle 0.8152 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.002023 Least Informative Inherited
Cellular Component (CC) nuclear part 0.0008481 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.0113 Moderately Informative Inherited
Cellular Component (CC) cytoskeleton 0.6241 Moderately Informative Inherited
Cellular Component (CC) microtubule cytoskeleton 3.303e-11 Informative Direct
Cellular Component (CC) chromosome 1.025e-08 Informative Direct
Cellular Component (CC) cell junction 0.0004699 Informative Direct
Cellular Component (CC) nucleoplasm part 0.04836 Informative Inherited
Cellular Component (CC) microtubule associated complex 1.616e-09 Highly Informative Direct
Cellular Component (CC) adherens junction 6.756e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 0.000122 Highly Informative Direct
Cellular Component (CC) nuclear body 0.01174 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.05838 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 0.8711 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.375e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red8.23e-09Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation1.841e-12InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease by infectious agent0.0001164Moderately InformativeDirect
Disease Ontology (DO)genetic disease0.0426Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.04256InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of head and neck0.341Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the mouth0.4832Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the lip0.1194InformativeInherited
Phenotypic Abnormality (PA)Abnormality of upper lip0.02095Highly InformativeInherited
Phenotypic Abnormality (PA)Oral cleft0.027Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.03437Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.06245Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.07813Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.4716Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.001035Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.02262Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lymphocyte morphology0.02703Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal bone marrow cell morphology/development0.04153Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell differentiation0.05159Moderately InformativeInherited
Mammalian Phenotype (MP)embryogenesis phenotype0.1143Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.205Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.4039Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.5471Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5475Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5587Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5832Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.8283Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation2.4e-05InformativeDirect
Mammalian Phenotype (MP)abnormal extraembryonic tissue morphology0.02776InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.04319InformativeInherited
Mammalian Phenotype (MP)malignant tumors0.219InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.25InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.2968InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4341InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8669InformativeInherited
Mammalian Phenotype (MP)gonad tumor1.766e-07Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability9.942e-05Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0003648Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0006094Highly InformativeDirect
Mammalian Phenotype (MP)decreased dendritic cell number0.002899Highly InformativeInherited
Mammalian Phenotype (MP)premature aging0.003475Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.1305Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant2.22e-07Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant1.188e-05Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant3.954e-05Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective1.243e-05InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)multi-tissue structure0.1042Least InformativeInherited
Fly Anatomy (FA)cell0.2964Least InformativeInherited
Fly Anatomy (FA)neuron0.004093Moderately InformativeInherited
Fly Anatomy (FA)portion of tissue0.02121Moderately InformativeInherited
Fly Anatomy (FA)gonad0.04779Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.0006925InformativeDirect
Fly Anatomy (FA)cell component0.007085InformativeInherited
Fly Anatomy (FA)ovariole0.01506InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001797Highly InformativeDirect
Fly Anatomy (FA)synapse0.0009185Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)portion of tissue0.1969Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.4582InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant cell0.005506Least InformativeInherited
Plant ANatomical entity (PAN)plant sperm cell0.0009527InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups3.235e-09Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1284Least InformativeInherited
Enzyme Commission (EC)Lyases0.4173Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.915Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.471e-15Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000209Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08255Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1.087e-08InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen3.906e-12Highly InformativeDirect
Enzyme Commission (EC)DNA-(apurinic or apyrimidinic site) lyase3.003e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation3.311e-07Moderately InformativeDirect
Biological processDifferentiation0.0001839Moderately InformativeDirect
Biological processMitosis1.387e-13InformativeDirect
Biological processMeiosis6.968e-11InformativeDirect
Biological processUbl conjugation pathway1.698e-10InformativeDirect
Biological processInnate immunity6.723e-10InformativeDirect
Biological processAngiogenesis1.024e-06InformativeDirect
Biological processCell adhesion0.0006577InformativeDirect
Biological processVirulence0.0008411InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense1.103e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome1.481e-14InformativeDirect
Cellular componentTelomere1.974e-07Highly InformativeDirect
DiseaseDisease mutation0.0002074Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding2.384e-05Least InformativeDirect
Molecular functionDNA-binding0Moderately InformativeDirect
Molecular functionZinc-finger2.515e-15Moderately InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator9.067e-09Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.034e-05Moderately InformativeDirect
Post-translational modificationKinase0.02147Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase9.719e-10InformativeDirect
Post-translational modificationChromatin regulator4.494e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationAcetylation0.0006403Moderately InformativeDirect
Post-translational modificationADP-ribosylation2.004e-05InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism2.532e-11Least InformativeDirect
UniPathway (UP)protein ubiquitination0.0001074Moderately InformativeDirect
UniPathway (UP)hormone metabolism3.331e-14InformativeDirect
UniPathway (UP)terpene metabolism1.899e-12InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis0Highly InformativeDirect
UniPathway (UP)plant hormone biosynthesis2.243e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]