SUPERFAMILY 1.75 HMM library and genome assignments server


SMAD/FHA domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Families:   SMAD domain [ 49880] (4)
  FHA domain [ 49885] (11)
  Interferon regulatory factor 3 (IRF3), transactivation domain [ 101630]
  EssC N-terminal domain-like [ 141143]


Superfamily statistics
Genomes (1,710) Uniprot 2013_05 PDB chains (SCOP 1.75)
Domains 15,808 19,439 38
Proteins 15,031 18,302 37


Functional annotation
General category Regulation
Detailed category DNA-binding

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)regulation of metabolic process0.043490.0006974Least InformativeInherited
Biological Process (BP)response to stimulus0.001370Least InformativeInherited
Biological Process (BP)single-organism cellular process0.025480Least InformativeInherited
Molecular Function (MF)binding0.0001040Least InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0 Least Informative Direct
Biological Process (BP) cellular macromolecule metabolic process 1.533e-10 Least Informative Direct
Biological Process (BP) single-organism cellular process 0 Least Informative Direct
Biological Process (BP) regulation of metabolic process 0.0006974 Least Informative Direct
Biological Process (BP) multicellular organismal process 0 Least Informative Direct
Biological Process (BP) developmental process 0 Least Informative Direct
Biological Process (BP) heterocycle metabolic process 7.515e-09 Least Informative Direct
Biological Process (BP) cellular aromatic compound metabolic process 1.733e-08 Least Informative Direct
Biological Process (BP) organic cyclic compound metabolic process 4.562e-07 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 4.006e-05 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 0.0001314 Least Informative Direct
Biological Process (BP) localization 0.07618 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.05746 Least Informative Inherited
Biological Process (BP) protein metabolic process 0.2162 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) signal transduction 0.0001696 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 2.513e-08 Moderately Informative Direct
Biological Process (BP) immune system process 1.204e-13 Moderately Informative Direct
Biological Process (BP) regulation of macromolecule biosynthetic process 1.646e-08 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 1.394e-07 Moderately Informative Direct
Biological Process (BP) response to organic substance 2.058e-07 Moderately Informative Direct
Biological Process (BP) reproduction 1.37e-06 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 1.804e-05 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.0001107 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.0001201 Moderately Informative Direct
Biological Process (BP) macromolecule catabolic process 0.0002259 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0003567 Moderately Informative Direct
Biological Process (BP) regulation of gene expression 0.001153 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.01512 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) regulation of signal transduction 0.3115 Moderately Informative Inherited
Biological Process (BP) homeostatic process 0.9771 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.09433 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.3963 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.3199 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 1 Moderately Informative Inherited
Biological Process (BP) tissue development 0.01371 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.7076 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of response to stimulus 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.12 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.002161 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.04731 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.9281 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.01726 Moderately Informative Inherited
Biological Process (BP) negative regulation of metabolic process 0.4041 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.002419 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.5416 Moderately Informative Inherited
Biological Process (BP) gene expression 0.7617 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.4443 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.4906 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.5121 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.766 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.8326 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.08437 Moderately Informative Inherited
Biological Process (BP) system process 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.07333 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.7305 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.005034 Moderately Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0 Informative Direct
Biological Process (BP) microtubule-based process 2.217e-13 Informative Direct
Biological Process (BP) response to DNA damage stimulus 1.091e-12 Informative Direct
Biological Process (BP) regulation of cell cycle 2.478e-10 Informative Direct
Biological Process (BP) DNA metabolic process 2.839e-10 Informative Direct
Biological Process (BP) regulation of transcription from RNA polymerase II promoter 3.601e-10 Informative Direct
Biological Process (BP) growth 1.416e-08 Informative Direct
Biological Process (BP) cellular process involved in reproduction 1.926e-08 Informative Direct
Biological Process (BP) immune response 1.063e-07 Informative Direct
Biological Process (BP) cell cycle process 1.173e-07 Informative Direct
Biological Process (BP) immune effector process 2.657e-07 Informative Direct
Biological Process (BP) chromosome organization 1.027e-06 Informative Direct
Biological Process (BP) multicellular organismal reproductive process 2.908e-06 Informative Direct
Biological Process (BP) cellular component movement 4.862e-06 Informative Direct
Biological Process (BP) cellular response to endogenous stimulus 6.02e-06 Informative Direct
Biological Process (BP) transcription, DNA-dependent 3.391e-05 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 4.48e-05 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 4.789e-05 Informative Direct
Biological Process (BP) tissue morphogenesis 0.0001052 Informative Direct
Biological Process (BP) regulation of growth 0.0002138 Informative Direct
Biological Process (BP) organelle localization 0.0002836 Informative Direct
Biological Process (BP) cell activation 0.0003872 Informative Direct
Biological Process (BP) positive regulation of nitrogen compound metabolic process 0.0003885 Informative Direct
Biological Process (BP) cardiovascular system development 0.0003957 Informative Direct
Biological Process (BP) protein catabolic process 0.0004453 Informative Direct
Biological Process (BP) embryonic morphogenesis 0.0004727 Informative Direct
Biological Process (BP) sexual reproduction 0.0008823 Informative Direct
Biological Process (BP) regulation of cytokine production 0.0008996 Informative Direct
Biological Process (BP) negative regulation of signaling 1 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 1 Informative Inherited
Biological Process (BP) negative regulation of cell communication 1 Informative Inherited
Biological Process (BP) cellular response to nitrogen compound 1 Informative Inherited
Biological Process (BP) response to cytokine stimulus 1 Informative Inherited
Biological Process (BP) defense response 0.671 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 1 Informative Inherited
Biological Process (BP) generation of neurons 0.03658 Informative Inherited
Biological Process (BP) cell projection organization 0.6924 Informative Inherited
Biological Process (BP) regulation of immune response 0.444 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of defense response 1 Informative Inherited
Biological Process (BP) positive regulation of gene expression 0.01117 Informative Inherited
Biological Process (BP) positive regulation of macromolecule biosynthetic process 0.0503 Informative Inherited
Biological Process (BP) positive regulation of cellular biosynthetic process 0.1326 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.08685 Informative Inherited
Biological Process (BP) cytoskeleton organization 1 Informative Inherited
Biological Process (BP) transmission of nerve impulse 0.09392 Informative Inherited
Biological Process (BP) organ morphogenesis 0.06826 Informative Inherited
Biological Process (BP) embryonic organ development 0.5387 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2329 Informative Inherited
Biological Process (BP) negative regulation of protein metabolic process 0.0256 Informative Inherited
Biological Process (BP) negative regulation of biosynthetic process 0.8644 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.04328 Informative Inherited
Biological Process (BP) negative regulation of developmental process 0.9582 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.9191 Informative Inherited
Biological Process (BP) locomotion 0.02848 Informative Inherited
Biological Process (BP) single organism reproductive process 0.00501 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.3595 Informative Inherited
Biological Process (BP) RNA processing 0.4736 Informative Inherited
Biological Process (BP) negative regulation of gene expression 1 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.03212 Informative Inherited
Biological Process (BP) response to bacterium 0.5003 Informative Inherited
Biological Process (BP) response to lipid 1 Informative Inherited
Biological Process (BP) hematopoietic or lymphoid organ development 0.2896 Informative Inherited
Biological Process (BP) proteolysis 0.02936 Informative Inherited
Biological Process (BP) cell-cell signaling 0.08253 Informative Inherited
Biological Process (BP) regulation of nervous system development 1 Informative Inherited
Biological Process (BP) regulation of cell development 0.3066 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.0583 Informative Inherited
Biological Process (BP) epithelium development 0.01957 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1298 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.008969 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 0.2896 Informative Inherited
Biological Process (BP) sensory organ development 1 Informative Inherited
Biological Process (BP) embryo development ending in birth or egg hatching 1 Informative Inherited
Biological Process (BP) pattern specification process 0 Highly Informative Direct
Biological Process (BP) microtubule-based movement 2.92e-13 Highly Informative Direct
Biological Process (BP) regulation of binding 2.309e-12 Highly Informative Direct
Biological Process (BP) cellular response to growth factor stimulus 3.431e-09 Highly Informative Direct
Biological Process (BP) double-strand break repair 4.784e-09 Highly Informative Direct
Biological Process (BP) protein ubiquitination 9.703e-09 Highly Informative Direct
Biological Process (BP) leukocyte activation involved in immune response 1.465e-08 Highly Informative Direct
Biological Process (BP) response to ionizing radiation 1.795e-07 Highly Informative Direct
Biological Process (BP) response to lipopolysaccharide 8.29e-07 Highly Informative Direct
Biological Process (BP) developmental growth 2.525e-06 Highly Informative Direct
Biological Process (BP) cell proliferation 9.534e-06 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 3.017e-05 Highly Informative Direct
Biological Process (BP) B cell activation 3.262e-05 Highly Informative Direct
Biological Process (BP) cellular process involved in reproduction in multicellular organism 3.348e-05 Highly Informative Direct
Biological Process (BP) Golgi vesicle transport 8.373e-05 Highly Informative Direct
Biological Process (BP) renal system development 0.000106 Highly Informative Direct
Biological Process (BP) cellular response to biotic stimulus 0.0001333 Highly Informative Direct
Biological Process (BP) DNA recombination 0.0003691 Highly Informative Direct
Biological Process (BP) neuron projection development 0.0004115 Highly Informative Direct
Biological Process (BP) post-embryonic development 0.0005434 Highly Informative Direct
Biological Process (BP) regulation of DNA metabolic process 0.0006409 Highly Informative Direct
Biological Process (BP) cellular response to organic cyclic compound 0.6453 Highly Informative Inherited
Biological Process (BP) regulation of innate immune response 0.00118 Highly Informative Inherited
Biological Process (BP) cytokine-mediated signaling pathway 0.7385 Highly Informative Inherited
Biological Process (BP) positive regulation of transcription, DNA-dependent 0.02275 Highly Informative Inherited
Biological Process (BP) regulation of protein complex assembly 0.03293 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.06602 Highly Informative Inherited
Biological Process (BP) microtubule cytoskeleton organization 0.6052 Highly Informative Inherited
Biological Process (BP) cell part morphogenesis 0.2532 Highly Informative Inherited
Biological Process (BP) skeletal system development 0.001524 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.2636 Highly Informative Inherited
Biological Process (BP) cell morphogenesis involved in differentiation 0.4369 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.05817 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.01337 Highly Informative Inherited
Biological Process (BP) regulation of translation 0.5677 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.001611 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.06443 Highly Informative Inherited
Biological Process (BP) regulation of organ morphogenesis 0.001043 Highly Informative Inherited
Biological Process (BP) negative regulation of multicellular organismal process 0.6605 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle phase transition 0.1123 Highly Informative Inherited
Biological Process (BP) negative regulation of growth 0.001223 Highly Informative Inherited
Biological Process (BP) regulation of multi-organism process 0.02418 Highly Informative Inherited
Biological Process (BP) cell division 0.01588 Highly Informative Inherited
Biological Process (BP) eye morphogenesis 0.6825 Highly Informative Inherited
Biological Process (BP) regulation of gene expression, epigenetic 0.8737 Highly Informative Inherited
Biological Process (BP) innate immune response 1 Highly Informative Inherited
Biological Process (BP) histone modification 0.01067 Highly Informative Inherited
Biological Process (BP) positive regulation of cytokine production 0.00404 Highly Informative Inherited
Biological Process (BP) chemotaxis 0.04308 Highly Informative Inherited
Biological Process (BP) gene silencing 0.08868 Highly Informative Inherited
Biological Process (BP) female gamete generation 0.1839 Highly Informative Inherited
Biological Process (BP) stem cell development 0.00255 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 0.3301 Highly Informative Inherited
Biological Process (BP) mesenchyme development 0.2131 Highly Informative Inherited
Biological Process (BP) cell growth 0.06544 Highly Informative Inherited
Biological Process (BP) limb morphogenesis 0.237 Highly Informative Inherited
Biological Process (BP) morphogenesis of embryonic epithelium 0.6604 Highly Informative Inherited
Biological Process (BP) stress-activated protein kinase signaling cascade 0.1065 Highly Informative Inherited
Biological Process (BP) MAPK cascade 0.19 Highly Informative Inherited
Biological Process (BP) chromosome segregation 0.13 Highly Informative Inherited
Biological Process (BP) mitosis 0.4948 Highly Informative Inherited
Biological Process (BP) leukocyte mediated immunity 0.008497 Highly Informative Inherited
Biological Process (BP) epithelial tube morphogenesis 0.1277 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.2465 Highly Informative Inherited
Biological Process (BP) ossification 0.005293 Highly Informative Inherited
Biological Process (BP) cell cycle checkpoint 0.007327 Highly Informative Inherited
Molecular Function (MF) binding 0 Least Informative Direct
Molecular Function (MF) hydrolase activity 0.3064 Least Informative Inherited
Molecular Function (MF) hydrolase activity, acting on ester bonds 0.7864 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.001039 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding transcription factor activity 4.538e-12 Informative Direct
Molecular Function (MF) chromatin binding 1.353e-11 Informative Direct
Molecular Function (MF) DNA binding 2.761e-10 Informative Direct
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 5.182e-07 Informative Direct
Molecular Function (MF) nucleoside-triphosphatase activity 6.494e-06 Informative Direct
Molecular Function (MF) nuclease activity 0.0008985 Informative Direct
Molecular Function (MF) protein dimerization activity 0.724 Informative Inherited
Molecular Function (MF) enzyme binding 0.06105 Informative Inherited
Molecular Function (MF) cytoskeletal protein binding 0.4919 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.9028 Informative Inherited
Molecular Function (MF) sequence-specific DNA binding transcription factor activity 1.168e-13 Highly Informative Direct
Molecular Function (MF) transcription regulatory region DNA binding 4.42e-11 Highly Informative Direct
Molecular Function (MF) small conjugating protein ligase activity 9.593e-09 Highly Informative Direct
Molecular Function (MF) transcription factor binding 2.284e-06 Highly Informative Direct
Molecular Function (MF) tubulin binding 2.264e-05 Highly Informative Direct
Molecular Function (MF) protein homodimerization activity 4.278e-05 Highly Informative Direct
Molecular Function (MF) Ras GTPase binding 0.0003254 Highly Informative Direct
Molecular Function (MF) structure-specific DNA binding 0.1797 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1.393e-06 Least Informative Direct
Cellular Component (CC) protein complex 0.0009667 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9307 Least Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.004248 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.3281 Moderately Informative Inherited
Cellular Component (CC) nuclear part 0.005108 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.03702 Moderately Informative Inherited
Cellular Component (CC) chromosome 5.049e-09 Informative Direct
Cellular Component (CC) microtubule cytoskeleton 7.084e-09 Informative Direct
Cellular Component (CC) nucleoplasm part 0.04165 Informative Inherited
Cellular Component (CC) cell-cell junction 0.006351 Informative Inherited
Cellular Component (CC) microtubule associated complex 2.021e-09 Highly Informative Direct
Cellular Component (CC) adherens junction 8.746e-06 Highly Informative Direct
Cellular Component (CC) cytoplasmic microtubule 9.953e-06 Highly Informative Direct
Cellular Component (CC) nuclear body 0.01936 Highly Informative Inherited
Cellular Component (CC) cell-substrate junction 0.008791 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.1289Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases7.375e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red8.23e-09Moderately InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation1.841e-12InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)genetic disease0.05606Moderately InformativeInherited
Disease Ontology (DO)autosomal dominant disease0.04522InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of cardiac morphology0.279Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the aortic valve0.0007013InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)mortality/aging0.08932Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1221Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.1743Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3743Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.588Least InformativeInherited
Mammalian Phenotype (MP)tumorigenesis0.002409Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukopoiesis0.01294Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system physiology0.1079Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic system physiology0.1085Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal mononuclear cell morphology0.1481Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1805Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell morphology0.387Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3985Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal immune cell physiology0.5055Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell-mediated immunity0.5186Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal adaptive immunity0.5453Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal hematopoietic cell number0.836Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation5.308e-05InformativeDirect
Mammalian Phenotype (MP)abnormal chromosome stability0.004189InformativeInherited
Mammalian Phenotype (MP)abnormal preimplantation embryo development0.02553InformativeInherited
Mammalian Phenotype (MP)abnormal B cell physiology0.04718InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.05855InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.2245InformativeInherited
Mammalian Phenotype (MP)decreased germ cell number0.2542InformativeInherited
Mammalian Phenotype (MP)decreased hematopoietic cell number0.2955InformativeInherited
Mammalian Phenotype (MP)abnormal fertility/fecundity0.4315InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8318InformativeInherited
Mammalian Phenotype (MP)increased gonad tumor incidence3.34e-07Highly InformativeDirect
Mammalian Phenotype (MP)abnormal mesoderm development0.0001215Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.0002195Highly InformativeDirect
Mammalian Phenotype (MP)absent primordial germ cells0.0007732Highly InformativeDirect
Mammalian Phenotype (MP)chromosomal instability0.0009806Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.00456Highly InformativeInherited
Mammalian Phenotype (MP)abnormal dendritic cell number0.007788Highly InformativeInherited
Mammalian Phenotype (MP)internal hemorrhage0.2346Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.0007819Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.006304Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.0008956Moderately InformativeDirect
Worm Phenotype (WP)organ system development variant0.06159Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.07533Moderately InformativeInherited
Worm Phenotype (WP)male morphology variant0.0002998InformativeDirect
Worm Phenotype (WP)sensillum morphology variant0.02206InformativeInherited
Worm Phenotype (WP)organism pathogen response variant0.1066InformativeInherited
Worm Phenotype (WP)cuticle development variant2.22e-07Highly InformativeDirect
Worm Phenotype (WP)male tail morphology variant1.188e-05Highly InformativeDirect
Worm Phenotype (WP)male nervous system morphology variant3.954e-05Highly InformativeDirect
Worm Phenotype (WP)dauer development variant0.0001088Highly InformativeDirect
Worm Phenotype (WP)pathogen susceptibility increased0.0001284Highly InformativeDirect
Worm Phenotype (WP)dauer arrest variant0.0003818Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.003015Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)mitotic cell cycle defective8.361e-06InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)organ system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0.04478Least InformativeInherited
Fly Anatomy (FA)cell0.1039Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1057Least InformativeInherited
Fly Anatomy (FA)anatomical group0.1244Least InformativeInherited
Fly Anatomy (FA)anterior-posterior subdivision of organism1Least InformativeInherited
Fly Anatomy (FA)peripheral nervous system0.000223Moderately InformativeDirect
Fly Anatomy (FA)portion of tissue0.002297Moderately InformativeInherited
Fly Anatomy (FA)adult nervous system0.00471Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.01133Moderately InformativeInherited
Fly Anatomy (FA)neuron0.01695Moderately InformativeInherited
Fly Anatomy (FA)cell cluster organ0.02135Moderately InformativeInherited
Fly Anatomy (FA)sense organ0.04499Moderately InformativeInherited
Fly Anatomy (FA)reproductive system0.1133Moderately InformativeInherited
Fly Anatomy (FA)thoracic segment0.312Moderately InformativeInherited
Fly Anatomy (FA)head0.3686Moderately InformativeInherited
Fly Anatomy (FA)germline stem cell0.00198InformativeInherited
Fly Anatomy (FA)prepupa0.005193InformativeInherited
Fly Anatomy (FA)pupa0.006125InformativeInherited
Fly Anatomy (FA)cell component0.008519InformativeInherited
Fly Anatomy (FA)imaginal precursor0.03918InformativeInherited
Fly Anatomy (FA)female germline stem cell0.0001931Highly InformativeDirect
Fly Anatomy (FA)wing disc0.0005334Highly InformativeDirect
Fly Anatomy (FA)synapse0.0008626Highly InformativeDirect

Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)genital system0Least InformativeDirect
Xenopus ANatomical entity (XAN)portion of tissue0.2034Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus1Least InformativeInherited
Xenopus ANatomical entity (XAN)heart0.458InformativeInherited

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorous-containing groups3.214e-09Least InformativeDirect
Enzyme Commission (EC)Oxidoreductases0.1375Least InformativeInherited
Enzyme Commission (EC)Lyases0.4124Least InformativeInherited
Enzyme Commission (EC)Hydrolases0.9096Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases3.914e-13Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.0002186Moderately InformativeDirect
Enzyme Commission (EC)Carbon-oxygen lyases0.08029Moderately InformativeInherited
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen1.357e-08InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation of one atom of oxygen5.585e-12Highly InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases4.092e-06Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCell cycle0Moderately InformativeDirect
Biological processDNA damage0Moderately InformativeDirect
Biological processTranscription regulation2.553e-07Moderately InformativeDirect
Biological processDifferentiation0.0002414Moderately InformativeDirect
Biological processMitosis2.466e-13InformativeDirect
Biological processMeiosis1.081e-10InformativeDirect
Biological processUbl conjugation pathway2.413e-10InformativeDirect
Biological processInnate immunity1.514e-09InformativeDirect
Biological processAngiogenesis1.886e-06InformativeDirect
Biological processCell adhesion0.0004507InformativeDirect
Biological processAbscisic acid biosynthesis0Highly InformativeDirect
Biological processAntiviral defense2.307e-11Highly InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm1Least InformativeInherited
Cellular componentCytoskeleton0Moderately InformativeDirect
Cellular componentMicrotubule0InformativeDirect
Cellular componentChromosome1.668e-14InformativeDirect
Cellular componentTelomere1.799e-07Highly InformativeDirect
DiseaseDisease mutation0.0002297Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainZinc-finger6.333e-12Moderately InformativeDirect
Molecular functionDNA-binding0Least InformativeDirect
Molecular functionZinc0Least InformativeDirect
Molecular functionMetal-binding8.486e-05Least InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationActivator1.208e-08Moderately InformativeDirect
Post-translational modificationDevelopmental protein1.398e-05Moderately InformativeDirect
Post-translational modificationKinase0.02412Moderately InformativeInherited
Post-translational modificationSerine/threonine-protein kinase1.09e-09InformativeDirect
Post-translational modificationChromatin regulator5.426e-08InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationAcetylation0.0003001Least InformativeDirect
Post-translational modificationUbl conjugation0Moderately InformativeDirect
Post-translational modificationIsopeptide bond0Moderately InformativeDirect
Post-translational modificationADP-ribosylation5.397e-06InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism2.674e-06Least InformativeDirect
UniPathway (UP)protein ubiquitination2.586e-10Moderately InformativeDirect
UniPathway (UP)plant hormone biosynthesis3.458e-11InformativeDirect
UniPathway (UP)terpene metabolism2.912e-09InformativeDirect
UniPathway (UP)sesquiterpene biosynthesis4.278e-16Highly InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR008984 SSF49879 Protein matches
Abstract

FHA and SMAD (MH2) domains share a common structure consisting of a sandwich of eleven beta strands in two sheets with Greek key topology. Forkhead-associated (FHA) domains were originally identified as a sequence profile of about 75 amino acids, whereas the full-length domain is closer to about 150 amino acids. FHA domains are found in transcription factors, kinesin motors, and in a variety of other signalling molecules in organisms ranging from eubacteria to humans. FHA domains are protein-protein interaction domains that are specific for phosphoproteins. FHA-containing proteins function in maintaining cell-cycle checkpoints, DNA repair and transcriptional regulation. FHA domain proteins include the Chk2/Rad53/Cds1 family of proteins that contain one or more FHA domains, as well as a Ser/Thr kinase domain [PubMed11106755, PubMed12121644, PubMed12049740].

SMAD domain proteins are found in a range of species from nematodes to humans. These highly conserved proteins contain an N-terminal MH1 domain that contacts DNA, and is separated by a short linker region from the C-terminal MH2 domain, the later showing a striking similarity to FHA domains. SMAD proteins mediate signalling by the TGF-beta/activin/BMP-2/4 cytokines from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD proteins fall into three functional classes: the receptor-regulated SMADs (R-SMADs), including SMAD1, -2, -3, -5, and -8, each of which is involved in a ligand-specific signalling pathway [PubMed11779503]; the comediator SMADs (co-SMADs), including SMAD4, which interact with R-SMADs to participate in signalling [PubMed9214508]; and the inhibitory SMADs (I-SMADs), including SMAD6 and -7, which block the activation of R-SMADs and Co-SMADs, thereby negatively regulating signalling pathways [PubMed11483516].


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

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Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 19 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 19 hidden Markov models representing the SMAD/FHA domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]