SUPERFAMILY 1.75 HMM library and genome assignments server

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SMAD domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   SMAD domain [ 49880] (4)


Family statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 987 3,069 13
Proteins 985 3,053 13


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0Least InformativeDirect
Disease Ontology (DO)urinary system disease0.001217Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.01347Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.03912Moderately InformativeInherited
Disease Ontology (DO)glomerulonephritis0.0000019InformativeDirect
Disease Ontology (DO)scleroderma0.0001326InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

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HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.0952Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.008326Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart morphology0.0542Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal vascular morphology0.05623Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0006906InformativeDirect
Phenotypic Abnormality (PA)Abnormal systemic arterial morphology0.00289InformativeInherited
Phenotypic Abnormality (PA)Abnormal morphology of the great vessels0.004245InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.02075InformativeInherited
Phenotypic Abnormality (PA)Aortic dissection0.0000002401Highly InformativeDirect
Phenotypic Abnormality (PA)Aortic aneurysm0.00003133Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

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MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0Least InformativeDirect
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.0002311Least InformativeDirect
Mammalian Phenotype (MP)cellular phenotype0.004735Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.008765Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.0092Least InformativeInherited
Mammalian Phenotype (MP)nervous system phenotype0.02339Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular development0Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal craniofacial morphology0.000001511Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal embryo morphology0.000006926Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal reproductive system physiology0.00002059Moderately InformativeDirect
Mammalian Phenotype (MP)neoplasm0.00002984Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system morphology0.0000591Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system development0.0001252Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal brain morphology0.000728Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal hormone level0.009354Moderately InformativeInherited
Mammalian Phenotype (MP)prenatal lethality0.1118Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal reproductive system morphology0.1177Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3029Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal germ cell morphology0.000001092InformativeDirect
Mammalian Phenotype (MP)decreased litter size0.000002101InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic growth/weight/body size0.00002687InformativeDirect
Mammalian Phenotype (MP)abnormal heart development0.0002259InformativeDirect
Mammalian Phenotype (MP)increased gland tumor incidence0.000527InformativeDirect
Mammalian Phenotype (MP)abnormal ovary morphology0.001005InformativeInherited
Mammalian Phenotype (MP)abnormal skin physiology0.009131InformativeInherited
Mammalian Phenotype (MP)abnormal developmental patterning0.04125InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.1759InformativeInherited
Mammalian Phenotype (MP)abnormal heart septum morphology0.2758InformativeInherited
Mammalian Phenotype (MP)abnormal prenatal body size0.307InformativeInherited
Mammalian Phenotype (MP)hemorrhage0.8189InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal axis patterning0.0000000186Highly InformativeDirect
Mammalian Phenotype (MP)abnormal follicle stimulating hormone level0.0000003112Highly InformativeDirect
Mammalian Phenotype (MP)increased reproductive system tumor incidence0.00000258Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gastrulation0.000003416Highly InformativeDirect
Mammalian Phenotype (MP)abnormal embryonic epiblast morphology0.000007691Highly InformativeDirect
Mammalian Phenotype (MP)abnormal chorioallantoic fusion0.00001314Highly InformativeDirect
Mammalian Phenotype (MP)abnormal ovarian folliculogenesis0.00002984Highly InformativeDirect
Mammalian Phenotype (MP)premature aging0.0000358Highly InformativeDirect
Mammalian Phenotype (MP)abnormal keratinocyte physiology0.00003974Highly InformativeDirect
Mammalian Phenotype (MP)ventricular septal defect0.0005148Highly InformativeDirect
Mammalian Phenotype (MP)abnormal circulating gonadotropin level0.0005668Highly InformativeDirect
Mammalian Phenotype (MP)abnormal digestive system development0.0006262Highly InformativeDirect
Mammalian Phenotype (MP)internal hemorrhage0.001563Highly InformativeInherited
Mammalian Phenotype (MP)increased alimentary system tumor incidence0.01125Highly InformativeInherited
Mammalian Phenotype (MP)abnormal oogenesis0.04988Highly InformativeInherited
Mammalian Phenotype (MP)abnormal female germ cell morphology0.05192Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

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WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism behavior variant0.0002172Least InformativeDirect
Worm Phenotype (WP)cell development variant0.00075Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.005303Least InformativeInherited
Worm Phenotype (WP)pericellular component development variant0.00001761Moderately InformativeDirect
Worm Phenotype (WP)germ cell development variant0.002266Moderately InformativeInherited
Worm Phenotype (WP)organism segment morphology variant0.004391Moderately InformativeInherited
Worm Phenotype (WP)body region morphology variant0.004453Moderately InformativeInherited
Worm Phenotype (WP)level of transgene expression variant0.0281Moderately InformativeInherited
Worm Phenotype (WP)organ system development variant0.04457Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.5973Moderately InformativeInherited
Worm Phenotype (WP)sensillum morphology variant0.00000001214InformativeDirect
Worm Phenotype (WP)transgene expression reduced0.000001534InformativeDirect
Worm Phenotype (WP)male morphology variant0.0000356InformativeDirect
Worm Phenotype (WP)tail bend angle variant0.00004778InformativeDirect
Worm Phenotype (WP)velocity of movement variant0.00006563InformativeDirect
Worm Phenotype (WP)head movement variant0.00007454InformativeDirect
Worm Phenotype (WP)fat content variant0.000148InformativeDirect
Worm Phenotype (WP)body posture variant0.004437InformativeInherited
Worm Phenotype (WP)locomotor coordination variant0.009278InformativeInherited
Worm Phenotype (WP)RNA expression variant0.01639InformativeInherited
Worm Phenotype (WP)foraging behavior variant0.01725InformativeInherited
Worm Phenotype (WP)small0.08674InformativeInherited
Worm Phenotype (WP)dauer larva physiology variant1InformativeInherited
Worm Phenotype (WP)dauer formation variant0.000001114Highly InformativeDirect
Worm Phenotype (WP)social behavior variant0.000001129Highly InformativeDirect
Worm Phenotype (WP)pericellular component physiology variant0.000003283Highly InformativeDirect
Worm Phenotype (WP)germline proliferation variant0.000004172Highly InformativeDirect
Worm Phenotype (WP)short0.00001194Highly InformativeDirect
Worm Phenotype (WP)sexually dimorphic development variant0.00001825Highly InformativeDirect
Worm Phenotype (WP)roaming variant0.00001875Highly InformativeDirect
Worm Phenotype (WP)coiling frequency variant0.00002177Highly InformativeDirect
Worm Phenotype (WP)body posture amplitude variant0.00003843Highly InformativeDirect
Worm Phenotype (WP)backward point velocity variant0.00003939Highly InformativeDirect
Worm Phenotype (WP)nervous system development variant0.00004343Highly InformativeDirect
Worm Phenotype (WP)dye filling defect0.00006282Highly InformativeDirect
Worm Phenotype (WP)amplitude of sinusoidal movement variant0.00007771Highly InformativeDirect
Worm Phenotype (WP)frequency of body bend variant0.00008964Highly InformativeDirect
Worm Phenotype (WP)alimentary system morphology variant0.0002576Highly InformativeDirect
Worm Phenotype (WP)tail morphology variant0.001184Highly InformativeInherited
Worm Phenotype (WP)male ray morphology variant0.08674Highly InformativeInherited

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

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FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)cell number defective0.0003969InformativeDirect
Fly Phenotype (FP)decreased occurrence of cell division0.000009063Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

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FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)segment0.07296Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.1345Least InformativeInherited
Fly Anatomy (FA)tagma0.2104Least InformativeInherited
Fly Anatomy (FA)organ system subdivision0.231Least InformativeInherited
Fly Anatomy (FA)adult0.2315Least InformativeInherited
Fly Anatomy (FA)abdomen0.001315Moderately InformativeInherited
Fly Anatomy (FA)digestive system0.001971Moderately InformativeInherited
Fly Anatomy (FA)larval segment0.005795Moderately InformativeInherited
Fly Anatomy (FA)acellular anatomical structure0.008177Moderately InformativeInherited
Fly Anatomy (FA)appendage0.01477Moderately InformativeInherited
Fly Anatomy (FA)larval tagma0.01496Moderately InformativeInherited
Fly Anatomy (FA)adult external thorax0.01569Moderately InformativeInherited
Fly Anatomy (FA)adult mesothoracic segment0.01698Moderately InformativeInherited
Fly Anatomy (FA)female-specific anatomical entity0.02694Moderately InformativeInherited
Fly Anatomy (FA)gonad0.05123Moderately InformativeInherited
Fly Anatomy (FA)developing material anatomical entity0.05641Moderately InformativeInherited
Fly Anatomy (FA)epithelium0.1114Moderately InformativeInherited
Fly Anatomy (FA)epithelial tube0.0001964InformativeDirect
Fly Anatomy (FA)wing blade0.0002294InformativeDirect
Fly Anatomy (FA)larval thoracic segment0.0003026InformativeDirect
Fly Anatomy (FA)cuticular specialization0.001315InformativeInherited
Fly Anatomy (FA)imaginal disc0.001646InformativeInherited
Fly Anatomy (FA)germline cell0.01752InformativeInherited
Fly Anatomy (FA)ovariole0.02162InformativeInherited
Fly Anatomy (FA)female germline stem cell0.00001184Highly InformativeDirect
Fly Anatomy (FA)dorsal thoracic disc0.0000883Highly InformativeDirect
Fly Anatomy (FA)larval mesothoracic segment0.0001291Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

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ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)nervous system0Least InformativeDirect
Zebrafish Anatomy (ZA)organism subdivision0Least InformativeDirect
Zebrafish Anatomy (ZA)multi-tissue structure0Least InformativeDirect
Zebrafish Anatomy (ZA)cell0.07722Least InformativeInherited
Zebrafish Anatomy (ZA)portion of tissue0Moderately InformativeDirect
Zebrafish Anatomy (ZA)central nervous system0.1319Moderately InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic system0.0006477InformativeDirect
Zebrafish Anatomy (ZA)motile cell0.005494InformativeInherited
Zebrafish Anatomy (ZA)immune system0.00927InformativeInherited
Zebrafish Anatomy (ZA)hematopoietic cell0.05418InformativeInherited
Zebrafish Anatomy (ZA)floor plate0.0000005904Highly InformativeDirect
Zebrafish Anatomy (ZA)mononuclear phagocyte0.00004089Highly InformativeDirect
Zebrafish Anatomy (ZA)professional antigen presenting cell0.00005123Highly InformativeDirect
Zebrafish Anatomy (ZA)intermediate cell mass of mesoderm0.00008972Highly InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

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XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)trunk0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect
Xenopus ANatomical entity (XAN)anatomical cluster0.07489Least InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)brain0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)tail region0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0.0001402Moderately InformativeDirect
Xenopus ANatomical entity (XAN)viscus0.09838Moderately InformativeInherited
Xenopus ANatomical entity (XAN)cardiovascular system0.00000012InformativeDirect
Xenopus ANatomical entity (XAN)eye0.00006377InformativeDirect
Xenopus ANatomical entity (XAN)animal hemisphere0.0008686InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.0009194InformativeDirect
Xenopus ANatomical entity (XAN)vestibuloauditory system0.0215InformativeInherited
Xenopus ANatomical entity (XAN)ciliated cell0.000001649Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.00007242Highly InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]