SUPERFAMILY 1.75 HMM library and genome assignments server

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FHA domain family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   SMAD/FHA domain [ 49878]
Superfamily:   SMAD/FHA domain [ 49879] (4)
Family:   FHA domain [ 49885] (11)


Family statistics
Genomes (365) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,226 3,947 21
Proteins 1,189 3,874 21


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Oxidoreductases0.09997Least InformativeInherited
Enzyme Commission (EC)Protein-serine/threonine kinases0.00000000000001563Moderately InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or red0.000000001588Moderately InformativeDirect
Enzyme Commission (EC)Non-specific serine/threonine protein kinase0InformativeDirect
Enzyme Commission (EC)With NADH or NADPH as one donor, and incorporation0.0000000000001689InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.0902Least InformativeInherited
Disease Ontology (DO)nervous system cancer0.006076Moderately InformativeInherited
Disease Ontology (DO)genetic disease0.03391Moderately InformativeInherited
Disease Ontology (DO)hereditary breast ovarian cancer syndrome0.0004942InformativeDirect
Disease Ontology (DO)retinal cell cancer0.0005714InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.0172Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.07876Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature0.179Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.245Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.6134Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.01987Moderately InformativeInherited
Phenotypic Abnormality (PA)Neoplasm0.09554Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral nervous system morphology0.1084Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of movement0.1236Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.3417Moderately InformativeInherited
Phenotypic Abnormality (PA)Malignant neoplasm of the central nervous system0.0002869InformativeDirect
Phenotypic Abnormality (PA)Abnormality of muscle size0.009676InformativeInherited
Phenotypic Abnormality (PA)Neoplasm by histology0.05599InformativeInherited
Phenotypic Abnormality (PA)Abnormal reflex0.07175InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the forehead0.2891InformativeInherited
Phenotypic Abnormality (PA)Abnormal peripheral myelination0.00006996Highly InformativeDirect
Phenotypic Abnormality (PA)Skeletal muscle atrophy0.0001798Highly InformativeDirect
Phenotypic Abnormality (PA)Areflexia0.0007444Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.2979Least InformativeInherited
Mammalian Phenotype (MP)mortality/aging0.4186Least InformativeInherited
Mammalian Phenotype (MP)growth/size/body region phenotype0.4274Least InformativeInherited
Mammalian Phenotype (MP)endocrine/exocrine gland phenotype0.5737Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.7836Least InformativeInherited
Mammalian Phenotype (MP)immune system phenotype0.8024Least InformativeInherited
Mammalian Phenotype (MP)abnormal B cell morphology0.02347Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal head morphology0.051Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal induced morbidity/mortality0.06151Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology/development0.1233Moderately InformativeInherited
Mammalian Phenotype (MP)neoplasm0.1678Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal professional antigen presenting cell physiology0.1909Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.2363Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood cell morphology0.395Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal leukocyte physiology0.4077Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.4093Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal metabolism0.00147InformativeInherited
Mammalian Phenotype (MP)abnormal mammary gland morphology0.02195InformativeInherited
Mammalian Phenotype (MP)increased gland tumor incidence0.02543InformativeInherited
Mammalian Phenotype (MP)abnormal B cell differentiation0.03496InformativeInherited
Mammalian Phenotype (MP)increased malignant tumor incidence0.3155InformativeInherited
Mammalian Phenotype (MP)chromosomal instability0.000004205Highly InformativeDirect
Mammalian Phenotype (MP)abnormal DNA repair0.0001003Highly InformativeDirect
Mammalian Phenotype (MP)increased mammary gland tumor incidence0.001696Highly InformativeInherited
Mammalian Phenotype (MP)increased adenocarcinoma incidence0.006424Highly InformativeInherited
Mammalian Phenotype (MP)increased sensitivity to induced cell death0.3527Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell development variant0.1194Least InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.1018Moderately InformativeInherited
Worm Phenotype (WP)axon outgrowth variant0.000835InformativeDirect
Worm Phenotype (WP)axon morphology variant0.0004056Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details) Document: YP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)developing material anatomical entity0Moderately InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)cavitated compound organ0Least InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)plant sperm cell0.00003632InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferases0.00003283Least InformativeDirect
Enzyme Commission (EC)Hydrolases0.0958Least InformativeInherited
Enzyme Commission (EC)Oxidoreductases0.6136Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0.00000001286Moderately InformativeDirect
Enzyme Commission (EC)Acting on ester bonds0.00000005402Moderately InformativeDirect
Enzyme Commission (EC)Lyases1Moderately InformativeInherited
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0.000000000002195InformativeDirect
Enzyme Commission (EC)Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporate0.0000001024InformativeDirect
Enzyme Commission (EC)Other carbon-oxygen lyases0.00006781Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 27 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a SMAD/FHA domain domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]