SUPERFAMILY 1.75 HMM library and genome assignments server

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Laminin G-like module family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Concanavalin A-like lectins/glucanases [ 49898]
Superfamily:   Concanavalin A-like lectins/glucanases [ 49899] (25)
Family:   Laminin G-like module [ 49944] (6)

Family statistics
Genomes (96) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,194 3,714 22
Proteins 949 3,113 19

Human Phenotype (HP)

show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the eye0.0171Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.1334Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the voice0.03051InformativeInherited
Phenotypic Abnormality (PA)Abnormal fundus morphology0.2178InformativeInherited
Phenotypic Abnormality (PA)Weak cry0.0001233Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of retinal pigmentation0.1308Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.000001353Least InformativeDirect
Mammalian Phenotype (MP)mortality/aging0.03759Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.1911Least InformativeInherited
Mammalian Phenotype (MP)lethality during fetal growth through weaning0.01751Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal nervous system development0.0739Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal synaptic transmission0.09183Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal axial skeleton morphology0.09329Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)perinatal lethality0.0002377InformativeDirect
Mammalian Phenotype (MP)abnormal nervous system tract morphology0.04949InformativeInherited
Mammalian Phenotype (MP)abnormal vertebral column morphology0.2316InformativeInherited
Mammalian Phenotype (MP)abnormal glial cell morphology0.3028InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord morphology0.3943InformativeInherited
Mammalian Phenotype (MP)abnormal CNS synaptic transmission0.5027InformativeInherited
Mammalian Phenotype (MP)abnormal spinal cord ventral commissure morphology0.000001153Highly InformativeDirect
Mammalian Phenotype (MP)abnormal basement membrane morphology0.0000134Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spine curvature0.00003001Highly InformativeDirect
Mammalian Phenotype (MP)decreased excitatory postsynaptic current amplitude0.00009219Highly InformativeDirect
Mammalian Phenotype (MP)abnormal GABA-mediated receptor currents0.0007573Highly InformativeDirect
Mammalian Phenotype (MP)abnormal spinal cord white matter morphology0.001419Highly InformativeInherited
Mammalian Phenotype (MP)abnormal glutamate-mediated receptor currents0.01134Highly InformativeInherited
Mammalian Phenotype (MP)abnormal neurotransmitter secretion0.03332Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)larval lethal0Least InformativeDirect
Worm Phenotype (WP)larval arrest0Least InformativeDirect
Worm Phenotype (WP)cell development variant0.0023Least InformativeInherited
Worm Phenotype (WP)cell morphology variant0.04438Least InformativeInherited
Worm Phenotype (WP)organ system development variant0.006094Moderately InformativeInherited
Worm Phenotype (WP)cell type morphology variant0.01195Moderately InformativeInherited
Worm Phenotype (WP)neuronal outgrowth variant0.0000005519InformativeDirect
Worm Phenotype (WP)nervous system morphology variant0.009239InformativeInherited
Worm Phenotype (WP)axon guidance variant0.00000003804Highly InformativeDirect
Worm Phenotype (WP)myopodia present0.000001129Highly InformativeDirect
Worm Phenotype (WP)axon morphology variant0.000006054Highly InformativeDirect
Worm Phenotype (WP)muscle system development variant0.0001969Highly InformativeDirect

Document: WP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)cell polarity defective0.0000009012InformativeDirect
Fly Phenotype (FP)cell number defective0.003978InformativeInherited

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)embryo0.02432Least InformativeInherited
Fly Anatomy (FA)anatomical group0.04836Least InformativeInherited
Fly Anatomy (FA)nervous system0.06349Least InformativeInherited
Fly Anatomy (FA)larva0.1276Least InformativeInherited
Fly Anatomy (FA)neuron0.07304Moderately InformativeInherited
Fly Anatomy (FA)photoreceptor cell0.002486InformativeInherited
Fly Anatomy (FA)embryonic/larval circulatory system0.022InformativeInherited
Fly Anatomy (FA)embryonic/larval dorsal vessel0.0008086Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.01175Least InformativeInherited
Xenopus ANatomical entity (XAN)urogenital system0.03397Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2281Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.4811Least InformativeInherited
Xenopus ANatomical entity (XAN)spinal cord0.0002961InformativeDirect

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Superfamily level     Family level

Alignments of sequences to 253 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Concanavalin A-like lectins/glucanases domain.

Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Jump to [ Top of page · SCOP classification · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]