Home > SCOP hierarchy > SH3-domain superfamily

SH3-domain superfamily

Root:	SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:	All beta proteins [ 48724] (165)
Fold:	SH3-like barrel [ 50036] (18)
	barrel, partly opened; n=4, S=8; meander the last strand is interrupted by a turn of 3-10 helix
Superfamily:	SH3-domain [ 50044]
Families:	SH3-domain [ 50045] (38)

Superfamily statistics

	Genomes (309)	UniProt 15.0	PDB chains (SCOP 1.73)
Domains	23,620	7,856	121
Proteins	18,460	6,202	117

Functional annotation

General category	Regulation
Detailed category	Signal transduction

Function annotation of SCOP domain superfamilies

InterPro annotation

Cross references

IPR001452 SSF50044 Protein matches

Abstract

SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [ PubMed

15335710,

11256992]. They are found in a great variety of intracellular or membrane-associated proteins [ PubMed

1639195,

14731533,

7531822] for example, in a variety of proteins with enzymatic activity, in adaptor proteins that lack catalytic sequences and in cytoskeletal proteins, such as fodrin and yeast actin binding protein ABP-1.

The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH2-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [ PubMed 7953536].

InterPro database

PDBeMotif information about ligands, sequence and structure motifs

Cross references

PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 56 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a SH3-domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 56 hidden Markov models representing the SH3-domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Internal database links ]

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SH3-domain superfamily