SUPERFAMILY 1.75 HMM library and genome assignments server

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Fibroblast growth factors (FGF) family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Trefoil [ 50352] (8)
Superfamily:   Cytokine [ 50353] (2)
Family:   Fibroblast growth factors (FGF) [ 50354] (9)


Family statistics
Genomes (86) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 1,516 3,670 44
Proteins 1,516 3,666 44


Disease Ontology (DO)

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show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)physical disorder0.0000005771InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the face0.05022Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.06677Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.5902Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.2624Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye physiology0.8108Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.07366InformativeInherited
Phenotypic Abnormality (PA)Abnormal renal morphology0.09922InformativeInherited
Phenotypic Abnormality (PA)Reduced number of teeth0.0002188Highly InformativeDirect
Phenotypic Abnormality (PA)Color vision defect0.0009849Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.2638Least InformativeInherited
Mammalian Phenotype (MP)cellular phenotype0.3602Least InformativeInherited
Mammalian Phenotype (MP)limbs/digits/tail phenotype0.01005Moderately InformativeInherited
Mammalian Phenotype (MP)hearing/vestibular/ear phenotype0.02634Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.07201Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal renal/urinary system morphology0.1616Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.4218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skin adnexa morphology0.4278Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal long bone morphology0.002597InformativeInherited
Mammalian Phenotype (MP)abnormal cell migration0.003848InformativeInherited
Mammalian Phenotype (MP)abnormal limb bone morphology0.02454InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.181InformativeInherited
Mammalian Phenotype (MP)abnormal heart size0.4899InformativeInherited
Mammalian Phenotype (MP)abnormal coat appearance0.9926InformativeInherited
Mammalian Phenotype (MP)abnormal heart atrium morphology0.00002157Highly InformativeDirect
Mammalian Phenotype (MP)abnormal thoracic aorta morphology0.00373Highly InformativeInherited
Mammalian Phenotype (MP)abnormal urinary system development0.005076Highly InformativeInherited
Mammalian Phenotype (MP)abnormal embryonic tissue physiology0.01441Highly InformativeInherited
Mammalian Phenotype (MP)abnormal hair growth0.1774Highly InformativeInherited

Document: MP annotation of SCOP domains

Fly Phenotype (FP)

(show details)
FP termFDR (all)SDFP levelAnnotation (direct or inherited)
Fly Phenotype (FP)increased mortality0Least InformativeDirect
Fly Phenotype (FP)cell migration defective0Highly InformativeDirect

Document: FP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)tagma0Least InformativeDirect
Fly Anatomy (FA)segment0Least InformativeDirect
Fly Anatomy (FA)embryo0Least InformativeDirect
Fly Anatomy (FA)larva0Least InformativeDirect
Fly Anatomy (FA)nervous system0Least InformativeDirect
Fly Anatomy (FA)organ system subdivision0Least InformativeDirect
Fly Anatomy (FA)somatic cell0Least InformativeDirect
Fly Anatomy (FA)abdomen0Moderately InformativeDirect
Fly Anatomy (FA)central nervous system0Moderately InformativeDirect
Fly Anatomy (FA)extended germ band embryo0InformativeDirect
Fly Anatomy (FA)dorsal closure embryo0InformativeDirect
Fly Anatomy (FA)primordium0InformativeDirect
Fly Anatomy (FA)early extended germ band embryo0Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)organism subdivision0.2823Least InformativeInherited
Zebrafish Anatomy (ZA)anatomical cluster0.3469Least InformativeInherited
Zebrafish Anatomy (ZA)head0.7392Moderately InformativeInherited
Zebrafish Anatomy (ZA)skeletal system0.005787InformativeInherited
Zebrafish Anatomy (ZA)olfactory region0.0007194Highly InformativeDirect
Zebrafish Anatomy (ZA)fin0.134Highly InformativeInherited
Zebrafish Anatomy (ZA)bone element0.1618Highly InformativeInherited

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)embryo0Least InformativeDirect
Xenopus ANatomical entity (XAN)nervous system0Least InformativeDirect
Xenopus ANatomical entity (XAN)head0Least InformativeDirect
Xenopus ANatomical entity (XAN)tissue0Least InformativeDirect
Xenopus ANatomical entity (XAN)cavitated compound organ0.2994Least InformativeInherited
Xenopus ANatomical entity (XAN)anatomical cluster1Least InformativeInherited
Xenopus ANatomical entity (XAN)embryonic structure0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)sensory system0Moderately InformativeDirect
Xenopus ANatomical entity (XAN)multi-tissue structure0.000002357Moderately InformativeDirect
Xenopus ANatomical entity (XAN)musculoskeletal system0.009515Moderately InformativeInherited
Xenopus ANatomical entity (XAN)ectoderm0.1334Moderately InformativeInherited
Xenopus ANatomical entity (XAN)eye0.000000009445InformativeDirect
Xenopus ANatomical entity (XAN)neural tube0.00000001123InformativeDirect
Xenopus ANatomical entity (XAN)neuroectoderm0.00000001367InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.000003413InformativeDirect
Xenopus ANatomical entity (XAN)pharyngeal region0.000003971InformativeDirect
Xenopus ANatomical entity (XAN)anatomical direction0.00002765InformativeDirect
Xenopus ANatomical entity (XAN)notochord0.00006769InformativeDirect
Xenopus ANatomical entity (XAN)surface structure0.0001158InformativeDirect
Xenopus ANatomical entity (XAN)mesenchyme0.0008234InformativeDirect
Xenopus ANatomical entity (XAN)tail0.005026InformativeInherited
Xenopus ANatomical entity (XAN)peripheral nervous system0.005914InformativeInherited
Xenopus ANatomical entity (XAN)skeletal system0.1633InformativeInherited
Xenopus ANatomical entity (XAN)vestibuloauditory system0.1958InformativeInherited
Xenopus ANatomical entity (XAN)limb0.7164InformativeInherited
Xenopus ANatomical entity (XAN)fin0.0000001732Highly InformativeDirect
Xenopus ANatomical entity (XAN)neurogenic placode0.000003471Highly InformativeDirect
Xenopus ANatomical entity (XAN)cranial neural crest0.000009822Highly InformativeDirect
Xenopus ANatomical entity (XAN)presomitic mesoderm0.00001493Highly InformativeDirect
Xenopus ANatomical entity (XAN)splanchnocranium0.00003863Highly InformativeDirect
Xenopus ANatomical entity (XAN)blastema0.0001301Highly InformativeDirect
Xenopus ANatomical entity (XAN)tail bud0.0004585Highly InformativeDirect
Xenopus ANatomical entity (XAN)ganglion0.0005642Highly InformativeDirect
Xenopus ANatomical entity (XAN)limb bud0.001875Highly InformativeInherited
Xenopus DEvelopment stage (XDE)embryonic stage0.005041Moderately InformativeInherited
Xenopus DEvelopment stage (XDE)tailbud stage0.5932InformativeInherited

Document: XA annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 33 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Cytokine domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Fly Phenotype (FP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Internal database links ]