SUPERFAMILY 1.75 HMM library and genome assignments server

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Eukaryotic proteases family

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Trypsin-like serine proteases [ 50493]
Superfamily:   Trypsin-like serine proteases [ 50494] (4)
Family:   Eukaryotic proteases [ 50514] (47)


Family statistics
Genomes (146) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 5,996 14,161 207
Proteins 5,844 13,906 207


Enzyme Commission (EC)

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show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0Moderately InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1r0.0003Highly InformativeDirect
Enzyme Commission (EC)Complement subcomponent C1s0.0003Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.1848Least InformativeInherited
Disease Ontology (DO)hematopoietic system disease0.0000377Moderately InformativeDirect
Disease Ontology (DO)integumentary system disease0.02534Moderately InformativeInherited
Disease Ontology (DO)inherited blood coagulation disease0.0006963InformativeDirect
Disease Ontology (DO)endocrine gland cancer0.217InformativeInherited
Disease Ontology (DO)pancreatic ductal adenocarcinoma0.0009129Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0.1076Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the immune system0.1857Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.2498Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of metabolism/homeostasis0.5119Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the genitourinary system0.6465Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the face0.8634Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the musculature1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology1Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of blood and blood-forming tissues0.000001118Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of immune system physiology0.07129Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal cardiovascular system physiology0.08824Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the upper urinary tract0.09185Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the urinary system physiology0.1074Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal circulating metabolite concentration0.1789Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal respiratory system morphology0.1937Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the endocrine system0.209Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.3186Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of digestive system physiology0.3473Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal reproductive system morphology0.582Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal homeostasis0.6376Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal skeletal muscle morphology0.9982Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology1Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of coagulation0.0001601InformativeDirect
Phenotypic Abnormality (PA)Abnormality of complement system0.000186InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the gingiva0.0005956InformativeDirect
Phenotypic Abnormality (PA)Abnormal renal physiology0.006602InformativeInherited
Phenotypic Abnormality (PA)Pain0.03845InformativeInherited
Phenotypic Abnormality (PA)Azotemia0.04833InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the menstrual cycle0.1078InformativeInherited
Phenotypic Abnormality (PA)Internal hemorrhage0.2086InformativeInherited
Phenotypic Abnormality (PA)Anemia0.2406InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the dentition0.569InformativeInherited
Phenotypic Abnormality (PA)Abnormal glucose homeostasis0.5797InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the nose0.6323InformativeInherited
Phenotypic Abnormality (PA)Joint hemorrhage0.000000001822Highly InformativeDirect
Phenotypic Abnormality (PA)Prolonged prothrombin time0.000005455Highly InformativeDirect
Phenotypic Abnormality (PA)Autoimmunity0.00001072Highly InformativeDirect
Phenotypic Abnormality (PA)Intramuscular hematoma0.00001238Highly InformativeDirect
Phenotypic Abnormality (PA)Epistaxis0.0001199Highly InformativeDirect
Phenotypic Abnormality (PA)Menorrhagia0.0002837Highly InformativeDirect
Phenotypic Abnormality (PA)Elevated serum creatinine0.0006194Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the pleura0.0006229Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal urine output0.0008579Highly InformativeDirect
Phenotypic Abnormality (PA)Diabetes mellitus0.456Highly InformativeInherited
Phenotypic Abnormality (PA)Hemolytic anemia1Highly InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.03032Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.5359Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.9665Least InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to infection0.0006604Moderately InformativeDirect
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2975Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.4012Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.4195Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.7881Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal eye morphology0.9985Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.00001574InformativeDirect
Mammalian Phenotype (MP)abnormal innate immunity0.01379InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel physiology0.4736InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.00001745Moderately InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)anatomical cluster0.1074Least InformativeInherited
Xenopus ANatomical entity (XAN)trunk0.3602Least InformativeInherited
Xenopus ANatomical entity (XAN)viscus0.04087Moderately InformativeInherited
Xenopus ANatomical entity (XAN)alimentary system0.05114Moderately InformativeInherited
Xenopus ANatomical entity (XAN)pancreas0.00002993Highly InformativeDirect

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Serine endopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

   
Superfamily level     Family level

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


   
Superfamily level     Family level

Alignments of sequences to 181 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Superfamily level

Browse and view proteins in genomes which have different domain combinations including a Trypsin-like serine proteases domain.


   
Superfamily level     Family level

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Jump to [ Top of page · SCOP classification · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]