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PH domain-like superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   PH domain-like barrel [ 50728] (2)
Superfamily:   PH domain-like [ 50729] (13)
Families:   Pleckstrin-homology domain (PH domain) [ 50730] (47)
  Phosphotyrosine-binding domain (PTB) [ 50755] (12)
  Ran-binding domain [ 50764] (4)
  Enabled/VASP homology 1 domain (EVH1 domain) [ 50767] (6)
  Dcp1 [ 101836]
  Third domain of FERM [ 50776] (8)
  PreBEACH PH-like domain [ 82146] (2)
  GRAM domain [ 101839]
  TFIIH domain [ 110272] (2)
  SSRP1-like [ 141436]
  Necap1 N-terminal domain-like [ 141439]
  VPS36 N-terminal domain-like [ 141442]
  BPHL domain [ 159216] (2)


Superfamily statistics
Genomes (922) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 75,120 226,141 146
Proteins 66,982 203,244 145


Functional annotation
General category Regulation
Detailed category Signal transduction

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on ester bonds0Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides1Least InformativeInherited
Enzyme Commission (EC)Phosphoric diester hydrolases0Moderately InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.05493Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as accep1Moderately InformativeInherited
Enzyme Commission (EC)Glycosyltransferases0.02837Moderately InformativeInherited
Enzyme Commission (EC)Phosphoinositide phospholipase C0InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.00000004532InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase0Highly InformativeDirect
Enzyme Commission (EC)Acting on GTP; involved in cellular and subcellula0.00000000000001873Highly InformativeDirect
Enzyme Commission (EC)Protein kinase C0.000003652Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)muscle tissue disease0.8863InformativeInherited

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.6096Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.7532Least InformativeInherited
Phenotypic Abnormality (PA)Abnormal nervous system electrophysiology0.01652InformativeInherited

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)nervous system phenotype0.1546Least InformativeInherited
Mammalian Phenotype (MP)hematopoietic system phenotype0.3012Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.4449Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood coagulation0.1397InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology1InformativeInherited
Mammalian Phenotype (MP)abnormal brain pia mater morphology0.00001073Highly InformativeDirect
Mammalian Phenotype (MP)abnormal respiratory epithelium morphology0.9303Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)cell physiology variant0.0000000001094Least InformativeDirect
Worm Phenotype (WP)organ system morphology variant0.000000001954Least InformativeDirect
Worm Phenotype (WP)cell morphology variant0.000000004186Least InformativeDirect
Worm Phenotype (WP)cell development variant0.000007577Least InformativeDirect
Worm Phenotype (WP)organism metabolism processing variant0.0001107Least InformativeDirect
Worm Phenotype (WP)organism behavior variant0.0001652Least InformativeDirect
Worm Phenotype (WP)organism environmental stimulus response variant0.01518Least InformativeInherited
Worm Phenotype (WP)endocytic transport variant0.00000002511Moderately InformativeDirect
Worm Phenotype (WP)apoptosis variant0.0000002632Moderately InformativeDirect
Worm Phenotype (WP)protein expression variant0.000001283Moderately InformativeDirect
Worm Phenotype (WP)organism segment morphology variant0.000004652Moderately InformativeDirect
Worm Phenotype (WP)body region morphology variant0.000005033Moderately InformativeDirect
Worm Phenotype (WP)organism stress response variant0.005304Moderately InformativeInherited
Worm Phenotype (WP)metabolic pathway variant0.005975Moderately InformativeInherited
Worm Phenotype (WP)movement variant0.0112Moderately InformativeInherited
Worm Phenotype (WP)neuron development variant0.08967Moderately InformativeInherited
Worm Phenotype (WP)drug response variant0.2108Moderately InformativeInherited
Worm Phenotype (WP)nervous system morphology variant0.334Moderately InformativeInherited
Worm Phenotype (WP)germ cell morphology variant0.8485Moderately InformativeInherited
Worm Phenotype (WP)cell homeostasis metabolism variant0.8573Moderately InformativeInherited
Worm Phenotype (WP)cell organization biogenesis variant0.8965Moderately InformativeInherited
Worm Phenotype (WP)muscle cell physiology variant0.000000000009172InformativeDirect
Worm Phenotype (WP)coelomic system physiology variant0.000000009957InformativeDirect
Worm Phenotype (WP)brood size variant0.000002028InformativeDirect
Worm Phenotype (WP)mitochondria morphology variant0.000002028InformativeDirect
Worm Phenotype (WP)body bend variant0.00003635InformativeDirect
Worm Phenotype (WP)axon outgrowth variant0.00005957InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.00008826InformativeDirect
Worm Phenotype (WP)cell component localization variant0.0004331InformativeDirect
Worm Phenotype (WP)organism pathogen response variant0.0005802InformativeDirect
Worm Phenotype (WP)level of protein expression variant0.0007146InformativeDirect
Worm Phenotype (WP)tail morphology variant0.01084InformativeInherited
Worm Phenotype (WP)organism osmotic stress response variant0.01888InformativeInherited
Worm Phenotype (WP)defecation variant0.03384InformativeInherited
Worm Phenotype (WP)cell stress response variant0.08282InformativeInherited
Worm Phenotype (WP)neuron morphology variant0.1513InformativeInherited
Worm Phenotype (WP)forward locomotion variant0.2731InformativeInherited
Worm Phenotype (WP)cytoskeleton organization biogenesis variant0.4564InformativeInherited
Worm Phenotype (WP)cell number increased0.4827InformativeInherited
Worm Phenotype (WP)protein modification variant0.5733InformativeInherited
Worm Phenotype (WP)oocyte morphology variant0.761InformativeInherited
Worm Phenotype (WP)endocytic transport defect1InformativeInherited
Worm Phenotype (WP)gonad sheath contractions variant0.000000008015Highly InformativeDirect
Worm Phenotype (WP)cellular osmotic stress response variant0.000000351Highly InformativeDirect
Worm Phenotype (WP)growth rate variant0.00000389Highly InformativeDirect
Worm Phenotype (WP)ovulation variant0.000009669Highly InformativeDirect
Worm Phenotype (WP)pathogen resistance increased0.00004329Highly InformativeDirect
Worm Phenotype (WP)response to injury variant0.0001117Highly InformativeDirect
Worm Phenotype (WP)endomitotic oocytes0.0001407Highly InformativeDirect
Worm Phenotype (WP)actin organization biogenesis variant0.0001695Highly InformativeDirect
Worm Phenotype (WP)extra excretory cells0.0002153Highly InformativeDirect
Worm Phenotype (WP)protein phosphorylation variant0.0004088Highly InformativeDirect
Worm Phenotype (WP)coelomocyte endocytosis defective0.000546Highly InformativeDirect
Worm Phenotype (WP)defecation contraction variant0.0006019Highly InformativeDirect
Worm Phenotype (WP)forward locomotion decreased0.0006468Highly InformativeDirect
Worm Phenotype (WP)drug induced gene expression variant0.0009227Highly InformativeDirect
Worm Phenotype (WP)membrane trafficking variant0.001287Highly InformativeInherited

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)morphology0.02795Moderately InformativeInherited
Yeast Phenotype (YP)subcellular morphology0.3789InformativeInherited

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details)
FA termFDR (all)SDFA levelAnnotation (direct or inherited)
Fly Anatomy (FA)organ system subdivision0.01653Least InformativeInherited
Fly Anatomy (FA)multi-tissue structure0.08276Least InformativeInherited
Fly Anatomy (FA)embryo0.1778Moderately InformativeInherited
Fly Anatomy (FA)presumptive embryonic/larval system0.05646InformativeInherited
Fly Anatomy (FA)gut section0.5295InformativeInherited
Fly Anatomy (FA)embryonic foregut0.0005364Highly InformativeDirect

Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)nervous system0.07515Least InformativeInherited
Xenopus ANatomical entity (XAN)cavitated compound organ0.2774Least InformativeInherited
Xenopus ANatomical entity (XAN)head0.4383Least InformativeInherited
Xenopus ANatomical entity (XAN)brain0.0002482Moderately InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)sporangium0.0003839Least InformativeDirect
Plant ANatomical entity (PAN)whole plant0.03634Least InformativeInherited
Plant ANatomical entity (PAN)microsporophyll0.6566Least InformativeInherited
Plant ANatomical entity (PAN)pollen0.0003383Moderately InformativeDirect
Plant ANatomical entity (PAN)pollen tube cell0.00001548InformativeDirect
Plant structure DEvelopment stage (PDE)pollen development stage0.00004521Moderately InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring phosphorus-containing groups0Least InformativeDirect
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect
Enzyme Commission (EC)Phosphoric monoester hydrolases0.000007383Moderately InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0.04169Moderately InformativeInherited
Enzyme Commission (EC)Phosphotransferases with an alcohol group as acceptor1Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides1Moderately InformativeInherited
Enzyme Commission (EC)Protein-tyrosine kinases0InformativeDirect
Enzyme Commission (EC)Phosphoric diester hydrolases0InformativeDirect
Enzyme Commission (EC)Hexosyltransferases0.0000000000003104InformativeDirect
Enzyme Commission (EC)Protein-tyrosine-phosphatase0.0002048InformativeDirect
Enzyme Commission (EC)Diacylglycerol kinase (ATP)0Highly InformativeDirect
Enzyme Commission (EC)Non-specific protein-tyrosine kinase0Highly InformativeDirect
Enzyme Commission (EC)Phosphoinositide phospholipase C0Highly InformativeDirect

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 129 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a PH domain-like domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 129 hidden Markov models representing the PH domain-like superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]