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Lipocalins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Lipocalins [ 50813]
Superfamily:   Lipocalins [ 50814] (9)
Families:   Retinol binding protein-like [ 50815] (21)
  Fatty acid binding protein-like [ 50847] (17)
  Thrombin inhibitor [ 50872]
  Hypothetical protein YodA [ 101863]
  Hypothetical protein YwiB [ 101866]
  Phenolic acid decarboxylase (PAD) [ 141469]
  Dinoflagellate luciferase repeat [ 141472]
  Rv2717c-like [ 141475] (2)
  All1756-like [ 159230]


Superfamily statistics
Genomes (1,876) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,589 31,420 119
Proteins 7,313 30,586 118


Functional annotation
General category Processes_IC
Detailed category Transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-quality)

(show details)
GO termFDR (singleton)FDR (all)SDFO levelAnnotation (direct or inherited)
Biological Process (BP)multicellular organismal process00.00003383Least InformativeDirect
Biological Process (BP)single-organism metabolic process0.0000000010030Least InformativeDirect
Biological Process (BP)response to stimulus0.0002470.1187Least InformativeInherited
Biological Process (BP)single-organism cellular process0.00024460.04333Least InformativeInherited
Biological Process (BP)biosynthetic process11Least InformativeInherited
Biological Process (BP)cellular component organization or biogenesis0.0048460.8986Least InformativeInherited
Biological Process (BP)primary metabolic process0.0095610.3123Least InformativeInherited
Biological Process (BP)biological regulation0.0000000026850.4426Least InformativeInherited
Biological Process (BP)carbohydrate metabolic process0.000094530.0000009617Moderately InformativeDirect
Biological Process (BP)lipid metabolic process00Moderately InformativeDirect
Biological Process (BP)negative regulation of metabolic process0.00000023250.0000009902Moderately InformativeDirect
Biological Process (BP)regulation of cell communication0.0000012640.00007466Moderately InformativeDirect
Biological Process (BP)regulation of signaling0.000017050.00008073Moderately InformativeDirect
Biological Process (BP)monocarboxylic acid metabolic process0.000000000011080.000000000000007296Moderately InformativeDirect
Biological Process (BP)regulation of localization0.0000062160.000001056Moderately InformativeDirect
Biological Process (BP)negative regulation of cellular process0.00000034470.0003268Moderately InformativeDirect
Biological Process (BP)regulation of response to stimulus0.000007750.00006185Moderately InformativeDirect
Biological Process (BP)regulation of multicellular organismal process0.000000017690.00003618Moderately InformativeDirect
Biological Process (BP)response to organic substance0.60691Moderately InformativeInherited
Biological Process (BP)cellular response to chemical stimulus0.54150.5992Moderately InformativeInherited
Biological Process (BP)organelle organization11Moderately InformativeInherited
Biological Process (BP)anatomical structure morphogenesis0.8781Moderately InformativeInherited
Biological Process (BP)regulation of protein metabolic process0.033470.0003744Moderately InformativeInherited
Biological Process (BP)regulation of cellular component organization0.0079350.04713Moderately InformativeInherited
Biological Process (BP)single-organism catabolic process0.90280.7071Moderately InformativeInherited
Biological Process (BP)organic substance catabolic process0.82930.3577Moderately InformativeInherited
Biological Process (BP)cellular catabolic process0.57880.5635Moderately InformativeInherited
Biological Process (BP)positive regulation of metabolic process0.50111Moderately InformativeInherited
Biological Process (BP)regulation of cellular biosynthetic process0.92451Moderately InformativeInherited
Biological Process (BP)regulation of biological quality0.0038590.002011Moderately InformativeInherited
Biological Process (BP)tissue development0.051740.1631Moderately InformativeInherited
Biological Process (BP)response to endogenous stimulus0.28010.6223Moderately InformativeInherited
Biological Process (BP)cell differentiation11Moderately InformativeInherited
Biological Process (BP)ion transport0.63640.9119Moderately InformativeInherited
Biological Process (BP)organic substance transport0.38440.5567Moderately InformativeInherited
Biological Process (BP)cellular response to stress0.00036520.001295Moderately InformativeInherited
Biological Process (BP)positive regulation of cellular process0.38150.9443Moderately InformativeInherited
Biological Process (BP)animal organ development0.018820.284Moderately InformativeInherited
Biological Process (BP)single-organism transport0.18180.02534Moderately InformativeInherited
Biological Process (BP)macromolecule localization0.0046840.1555Moderately InformativeInherited
Biological Process (BP)small molecule biosynthetic process0.082040.02728Moderately InformativeInherited
Biological Process (BP)oxidation-reduction process0.21160.3526Moderately InformativeInherited
Biological Process (BP)generation of precursor metabolites and energy0.00071940.001155Moderately InformativeInherited
Biological Process (BP)defense response0.95460.975Moderately InformativeInherited
Biological Process (BP)response to oxygen-containing compound0.0012070.001166Moderately InformativeInherited
Biological Process (BP)regulation of cytokine production0.000020470.000000003491InformativeDirect
Biological Process (BP)monosaccharide metabolic process0.0000000018390.00000000003InformativeDirect
Biological Process (BP)fatty acid metabolic process0.000085540.0004763InformativeDirect
Biological Process (BP)anion transport0.00092010.0004399InformativeDirect
Biological Process (BP)response to oxidative stress0.00000000049770.000000000000003734InformativeDirect
Biological Process (BP)mitochondrion organization0.0000051730.00002464InformativeDirect
Biological Process (BP)central nervous system development0.00000000010220.000000009057InformativeDirect
Biological Process (BP)behavior0.000000016330.0002948InformativeDirect
Biological Process (BP)response to wounding0.000000026080.000000006111InformativeDirect
Biological Process (BP)negative regulation of cell communication0.0000000000015240.00000000004569InformativeDirect
Biological Process (BP)regulation of hormone levels0.000015620.00000004532InformativeDirect
Biological Process (BP)lipid localization0.000000000000010610.0000000000003173InformativeDirect
Biological Process (BP)organic acid transport0.00078860.00006985InformativeDirect
Biological Process (BP)regulation of lipid metabolic process00InformativeDirect
Biological Process (BP)negative regulation of signaling0.0000000000014020.00000000005242InformativeDirect
Biological Process (BP)regulation of defense response0.00037470.000004169InformativeDirect
Biological Process (BP)regulation of response to external stimulus0.00006560.00000002245InformativeDirect
Biological Process (BP)regulation of protein localization00InformativeDirect
Biological Process (BP)growth0.00000016370.00000505InformativeDirect
Biological Process (BP)regulation of locomotion0.0000029670.0000005177InformativeDirect
Biological Process (BP)regulation of cell proliferation0.0000000000031280.0000000001788InformativeDirect
Biological Process (BP)regulation of cellular component biogenesis0.000000087690.0000004631InformativeDirect
Biological Process (BP)cellular respiration0.0000019630.000003775InformativeDirect
Biological Process (BP)negative regulation of response to stimulus0.0000000010880.000000001772InformativeDirect
Biological Process (BP)negative regulation of transport00InformativeDirect
Biological Process (BP)negative regulation of cellular component organization0.00000029850.0000002698InformativeDirect
Biological Process (BP)negative regulation of multicellular organismal process0.0000014440.00001581InformativeDirect
Biological Process (BP)regulation of cellular component movement0.00000020330.0000001134InformativeDirect
Biological Process (BP)regulation of cellular localization0.000000000012940.000000000007592InformativeDirect
Biological Process (BP)cellular response to lipid0.000028520.00001861InformativeDirect
Biological Process (BP)monocarboxylic acid biosynthetic process0.0000066270.000002021InformativeDirect
Biological Process (BP)regulation of peptide transport00InformativeDirect
Biological Process (BP)cellular component morphogenesis0.0038420.1971InformativeInherited
Biological Process (BP)generation of neurons0.20960.3911InformativeInherited
Biological Process (BP)cell development0.14630.5854InformativeInherited
Biological Process (BP)positive regulation of signal transduction11InformativeInherited
Biological Process (BP)regulation of intracellular signal transduction11InformativeInherited
Biological Process (BP)response to organic cyclic compound0.32340.5834InformativeInherited
Biological Process (BP)regulation of secretion0.61530.5315InformativeInherited
Biological Process (BP)lipid catabolic process0.0076770.007556InformativeInherited
Biological Process (BP)negative regulation of cellular biosynthetic process0.032150.4654InformativeInherited
Biological Process (BP)alcohol metabolic process0.10740.5801InformativeInherited
Biological Process (BP)glycerolipid metabolic process0.17780.8363InformativeInherited
Biological Process (BP)isoprenoid metabolic process0.17220.02923InformativeInherited
Biological Process (BP)negative regulation of cytokine production0.00000000061070.000000000001969Highly InformativeDirect
Biological Process (BP)negative regulation of immune system process0.000000015820.00000000007721Highly InformativeDirect
Biological Process (BP)regulation of leukocyte migration0.00000000000046250Highly InformativeDirect
Biological Process (BP)negative regulation of peptide secretion0.00052630.0002225Highly InformativeDirect
Biological Process (BP)glucose metabolic process00Highly InformativeDirect
Biological Process (BP)energy reserve metabolic process0.00000000000032960.0000000000162Highly InformativeDirect
Biological Process (BP)unsaturated fatty acid biosynthetic process00Highly InformativeDirect
Biological Process (BP)acylglycerol metabolic process0.0001520.000007299Highly InformativeDirect
Biological Process (BP)icosanoid metabolic process00Highly InformativeDirect
Biological Process (BP)aging0.00000000062330Highly InformativeDirect
Biological Process (BP)circadian rhythm0.000000000075970.0000006905Highly InformativeDirect
Biological Process (BP)negative regulation of cell proliferation0.000000000063030.0000000000487Highly InformativeDirect
Biological Process (BP)aerobic respiration0.0000000023290.000000005018Highly InformativeDirect
Biological Process (BP)regulation of cellular carbohydrate metabolic process0.0000084190.000002621Highly InformativeDirect
Biological Process (BP)monocarboxylic acid transport0.000000000031960.00000000005504Highly InformativeDirect
Biological Process (BP)diterpenoid metabolic process0.00000000000033960.0002965Highly InformativeDirect
Biological Process (BP)regeneration0.0000000000018260Highly InformativeDirect
Biological Process (BP)negative regulation of defense response0.000000010650.0000000001236Highly InformativeDirect
Biological Process (BP)negative regulation of response to external stimulus0.00000028060.000000001514Highly InformativeDirect
Biological Process (BP)negative regulation of intracellular transport0.00000000051810.000000002064Highly InformativeDirect
Biological Process (BP)negative regulation of homeostatic process0.000000030510.00000003137Highly InformativeDirect
Biological Process (BP)regulation of intracellular protein transport0.00055310.0008629Highly InformativeDirect
Biological Process (BP)carbohydrate homeostasis0.000041020.0002804Highly InformativeDirect
Biological Process (BP)primary alcohol metabolic process0.0000016270.000000273Highly InformativeDirect
Biological Process (BP)cellular hormone metabolic process0.00000036560.00000006153Highly InformativeDirect
Biological Process (BP)negative regulation of locomotion0.0000000000009160.00000000000003429Highly InformativeDirect
Biological Process (BP)response to drug0.00000000029820.0000000001113Highly InformativeDirect
Biological Process (BP)regulation of circadian rhythm0.000000000058510.00000006191Highly InformativeDirect
Biological Process (BP)regulation of carbohydrate biosynthetic process0.000000000006040.0000000004159Highly InformativeDirect
Biological Process (BP)negative regulation of lipid metabolic process00Highly InformativeDirect
Biological Process (BP)positive regulation of lipid metabolic process0.00000016810.00000000117Highly InformativeDirect
Biological Process (BP)negative regulation of carbohydrate metabolic process0.00000010140.000000004405Highly InformativeDirect
Biological Process (BP)glycerolipid catabolic process0.000000031180.000000004368Highly InformativeDirect
Biological Process (BP)regulation of nucleocytoplasmic transport00Highly InformativeDirect
Biological Process (BP)regulation of smooth muscle cell proliferation0.0000000034530.0000000000000376Highly InformativeDirect
Biological Process (BP)neuron development0.00000047590.0001127Highly InformativeDirect
Biological Process (BP)response to axon injury0.000000000000023470Highly InformativeDirect
Biological Process (BP)multicellular organismal homeostasis0.000058330.00001332Highly InformativeDirect
Biological Process (BP)negative regulation of cellular component movement0.0000000000013750.00000000000002273Highly InformativeDirect
Biological Process (BP)response to glucocorticoid0.00027770.000345Highly InformativeDirect
Biological Process (BP)positive regulation of protein kinase B signaling0.00000000000026680.00000000008622Highly InformativeDirect
Biological Process (BP)plasma membrane bounded cell projection organization0.000000000050560.0003049Highly InformativeDirect
Biological Process (BP)regulation of protein localization to nucleus00Highly InformativeDirect
Biological Process (BP)fatty acid derivative biosynthetic process00Highly InformativeDirect
Biological Process (BP)negative regulation of secretion by cell0.000019210.000002174Highly InformativeDirect
Biological Process (BP)regulation of protein import0.000017270.00005894Highly InformativeDirect
Biological Process (BP)negative regulation of establishment of protein localization00Highly InformativeDirect
Biological Process (BP)regulation of lipid localization0.000036620.000009733Highly InformativeDirect
Biological Process (BP)regulation of hormone secretion0.0018260.0005483Highly InformativeInherited
Biological Process (BP)locomotory behavior0.0039840.003779Highly InformativeInherited
Biological Process (BP)wound healing0.009720.0009213Highly InformativeInherited
Biological Process (BP)inflammatory response0.003520.01131Highly InformativeInherited
Molecular Function (MF)binding00.000003381Least InformativeDirect
Molecular Function (MF)transferase activity11Least InformativeInherited
Molecular Function (MF)isomerase activity0.000000000031590.000000000001337Moderately InformativeDirect
Molecular Function (MF)small molecule binding00Moderately InformativeDirect
Molecular Function (MF)anion binding0.00000000039870.000001958Moderately InformativeDirect
Molecular Function (MF)transporter activity0.0017270.006661Moderately InformativeInherited
Molecular Function (MF)transferase activity, transferring phosphorus-containing groups0.091190.7755Moderately InformativeInherited
Molecular Function (MF)intramolecular oxidoreductase activity00InformativeDirect
Molecular Function (MF)carboxylic acid binding00InformativeDirect
Molecular Function (MF)signal transducer activity0.010880.5436InformativeInherited
Molecular Function (MF)molecular transducer activity0.0057670.4642InformativeInherited
Molecular Function (MF)phosphotransferase activity, alcohol group as acceptor0.0024810.3235InformativeInherited
Molecular Function (MF)kinase activity0.021830.4749InformativeInherited
Molecular Function (MF)lipid transporter activity0.000000000012270.0000000001083Highly InformativeDirect
Molecular Function (MF)steroid binding00Highly InformativeDirect
Molecular Function (MF)odorant binding0.000000000033220Highly InformativeDirect
Molecular Function (MF)isoprenoid binding0.0000014420Highly InformativeDirect
Molecular Function (MF)monocarboxylic acid binding00Highly InformativeDirect
Molecular Function (MF)alcohol binding00Highly InformativeDirect
Molecular Function (MF)protein kinase activity0.000077110.08283Highly InformativeInherited
Molecular Function (MF)transmembrane signaling receptor activity0.00067420.05798Highly InformativeInherited
Cellular Component (CC)cytoplasmic part0.000030760.00002627Least InformativeDirect
Cellular Component (CC)membrane11Least InformativeInherited
Cellular Component (CC)non-membrane-bounded organelle0.38920.8134Least InformativeInherited
Cellular Component (CC)intracellular membrane-bounded organelle0.27180.5541Least InformativeInherited
Cellular Component (CC)ribosome0.00000086960.00000000005732Moderately InformativeDirect
Cellular Component (CC)endomembrane system0.00000000019580.0000002241Moderately InformativeDirect
Cellular Component (CC)cell projection0.00000000056580.000005428Moderately InformativeDirect
Cellular Component (CC)extracellular region part00Moderately InformativeDirect
Cellular Component (CC)cytosolic part0.00000054240.0000000002843Moderately InformativeDirect
Cellular Component (CC)vesicle0.45370.2126Moderately InformativeInherited
Cellular Component (CC)plasma membrane11Moderately InformativeInherited
Cellular Component (CC)extracellular space00InformativeDirect
Cellular Component (CC)cytosolic ribosome0.0000000000065410InformativeDirect
Cellular Component (CC)extracellular organelle0.026040.0006618InformativeInherited
Cellular Component (CC)plasma membrane region0.024670.3895InformativeInherited
Cellular Component (CC)plasma membrane bounded cell projection part11InformativeInherited
Cellular Component (CC)neuron projection0.010290.02108InformativeInherited
Cellular Component (CC)dendrite0.00000000094090.0000001942Highly InformativeDirect
Cellular Component (CC)brush border membrane0.00000019660.0000003474Highly InformativeDirect
Cellular Component (CC)neuronal cell body0.0000020250.00000001112Highly InformativeDirect
Cellular Component (CC)perinuclear region of cytoplasm0.0000000076350.000000005765Highly InformativeDirect
Cellular Component (CC)yolk0.00000000063690.0000000000009233Highly InformativeDirect

Document: GO annotation of SCOP domains

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) multicellular organismal process 0.00003383 Least Informative Direct
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) response to stimulus 0.1187 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.04333 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 0.8986 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.3123 Least Informative Inherited
Biological Process (BP) biological regulation 0.4426 Least Informative Inherited
Biological Process (BP) carbohydrate metabolic process 0.0000009617 Moderately Informative Direct
Biological Process (BP) lipid metabolic process 0 Moderately Informative Direct
Biological Process (BP) negative regulation of metabolic process 0.0000009902 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00007466 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00008073 Moderately Informative Direct
Biological Process (BP) monocarboxylic acid metabolic process 0.000000000000007296 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.000001056 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0003268 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00006185 Moderately Informative Direct
Biological Process (BP) regulation of multicellular organismal process 0.00003618 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.0003744 Moderately Informative Direct
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 0.5992 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.04713 Moderately Informative Inherited
Biological Process (BP) single-organism catabolic process 0.7071 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.3577 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.5635 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.002011 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1631 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 0.6223 Moderately Informative Inherited
Biological Process (BP) cell differentiation 1 Moderately Informative Inherited
Biological Process (BP) generation of precursor metabolites and energy 0.001155 Moderately Informative Inherited
Biological Process (BP) ion transport 0.9119 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.5567 Moderately Informative Inherited
Biological Process (BP) cellular response to stress 0.001295 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.9443 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.284 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.02534 Moderately Informative Inherited
Biological Process (BP) macromolecule localization 0.1555 Moderately Informative Inherited
Biological Process (BP) small molecule biosynthetic process 0.02728 Moderately Informative Inherited
Biological Process (BP) oxidation-reduction process 0.3526 Moderately Informative Inherited
Biological Process (BP) defense response 0.975 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 0.001166 Moderately Informative Inherited
Biological Process (BP) regulation of cytokine production 0.000000003491 Informative Direct
Biological Process (BP) monosaccharide metabolic process 0.00000000003 Informative Direct
Biological Process (BP) fatty acid metabolic process 0.0004763 Informative Direct
Biological Process (BP) anion transport 0.0004399 Informative Direct
Biological Process (BP) response to oxidative stress 0.000000000000003734 Informative Direct
Biological Process (BP) mitochondrion organization 0.00002464 Informative Direct
Biological Process (BP) central nervous system development 0.000000009057 Informative Direct
Biological Process (BP) behavior 0.0002948 Informative Direct
Biological Process (BP) response to wounding 0.000000006111 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00000000004569 Informative Direct
Biological Process (BP) regulation of hormone levels 0.00000004532 Informative Direct
Biological Process (BP) lipid localization 0.0000000000003173 Informative Direct
Biological Process (BP) organic acid transport 0.00006985 Informative Direct
Biological Process (BP) regulation of lipid metabolic process 0 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00000000005242 Informative Direct
Biological Process (BP) regulation of defense response 0.000004169 Informative Direct
Biological Process (BP) regulation of response to external stimulus 0.00000002245 Informative Direct
Biological Process (BP) regulation of protein localization 0 Informative Direct
Biological Process (BP) growth 0.00000505 Informative Direct
Biological Process (BP) regulation of locomotion 0.0000005177 Informative Direct
Biological Process (BP) regulation of cell proliferation 0.0000000001788 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.0000004631 Informative Direct
Biological Process (BP) cellular respiration 0.000003775 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000000001772 Informative Direct
Biological Process (BP) negative regulation of transport 0 Informative Direct
Biological Process (BP) negative regulation of cellular component organization 0.0000002698 Informative Direct
Biological Process (BP) negative regulation of multicellular organismal process 0.00001581 Informative Direct
Biological Process (BP) regulation of cellular component movement 0.0000001134 Informative Direct
Biological Process (BP) regulation of cellular localization 0.000000000007592 Informative Direct
Biological Process (BP) cellular response to lipid 0.00001861 Informative Direct
Biological Process (BP) monocarboxylic acid biosynthetic process 0.000002021 Informative Direct
Biological Process (BP) regulation of peptide transport 0 Informative Direct
Biological Process (BP) cellular component morphogenesis 0.1971 Informative Inherited
Biological Process (BP) generation of neurons 0.3911 Informative Inherited
Biological Process (BP) cell development 0.5854 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 1 Informative Inherited
Biological Process (BP) response to organic cyclic compound 0.5834 Informative Inherited
Biological Process (BP) regulation of secretion 0.5315 Informative Inherited
Biological Process (BP) lipid catabolic process 0.007556 Informative Inherited
Biological Process (BP) negative regulation of cellular biosynthetic process 0.4654 Informative Inherited
Biological Process (BP) isoprenoid metabolic process 0.02923 Informative Inherited
Biological Process (BP) alcohol metabolic process 0.5801 Informative Inherited
Biological Process (BP) glycerolipid metabolic process 0.8363 Informative Inherited
Biological Process (BP) negative regulation of cytokine production 0.000000000001969 Highly Informative Direct
Biological Process (BP) negative regulation of immune system process 0.00000000007721 Highly Informative Direct
Biological Process (BP) regulation of leukocyte migration 0 Highly Informative Direct
Biological Process (BP) negative regulation of peptide secretion 0.0002225 Highly Informative Direct
Biological Process (BP) glucose metabolic process 0 Highly Informative Direct
Biological Process (BP) energy reserve metabolic process 0.0000000000162 Highly Informative Direct
Biological Process (BP) unsaturated fatty acid biosynthetic process 0 Highly Informative Direct
Biological Process (BP) acylglycerol metabolic process 0.000007299 Highly Informative Direct
Biological Process (BP) icosanoid metabolic process 0 Highly Informative Direct
Biological Process (BP) aging 0 Highly Informative Direct
Biological Process (BP) circadian rhythm 0.0000006905 Highly Informative Direct
Biological Process (BP) negative regulation of cell proliferation 0.0000000000487 Highly Informative Direct
Biological Process (BP) aerobic respiration 0.000000005018 Highly Informative Direct
Biological Process (BP) regulation of cellular carbohydrate metabolic process 0.000002621 Highly Informative Direct
Biological Process (BP) monocarboxylic acid transport 0.00000000005504 Highly Informative Direct
Biological Process (BP) diterpenoid metabolic process 0.0002965 Highly Informative Direct
Biological Process (BP) regeneration 0 Highly Informative Direct
Biological Process (BP) negative regulation of defense response 0.0000000001236 Highly Informative Direct
Biological Process (BP) negative regulation of response to external stimulus 0.000000001514 Highly Informative Direct
Biological Process (BP) negative regulation of intracellular transport 0.000000002064 Highly Informative Direct
Biological Process (BP) negative regulation of homeostatic process 0.00000003137 Highly Informative Direct
Biological Process (BP) regulation of intracellular protein transport 0.0008629 Highly Informative Direct
Biological Process (BP) carbohydrate homeostasis 0.0002804 Highly Informative Direct
Biological Process (BP) primary alcohol metabolic process 0.000000273 Highly Informative Direct
Biological Process (BP) cellular hormone metabolic process 0.00000006153 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00000000000003429 Highly Informative Direct
Biological Process (BP) wound healing 0.0009213 Highly Informative Direct
Biological Process (BP) response to drug 0.0000000001113 Highly Informative Direct
Biological Process (BP) regulation of circadian rhythm 0.00000006191 Highly Informative Direct
Biological Process (BP) regulation of carbohydrate biosynthetic process 0.0000000004159 Highly Informative Direct
Biological Process (BP) negative regulation of lipid metabolic process 0 Highly Informative Direct
Biological Process (BP) positive regulation of lipid metabolic process 0.00000000117 Highly Informative Direct
Biological Process (BP) negative regulation of carbohydrate metabolic process 0.000000004405 Highly Informative Direct
Biological Process (BP) glycerolipid catabolic process 0.000000004368 Highly Informative Direct
Biological Process (BP) regulation of nucleocytoplasmic transport 0 Highly Informative Direct
Biological Process (BP) regulation of hormone secretion 0.0005483 Highly Informative Direct
Biological Process (BP) regulation of smooth muscle cell proliferation 0.0000000000000376 Highly Informative Direct
Biological Process (BP) neuron development 0.0001127 Highly Informative Direct
Biological Process (BP) response to axon injury 0 Highly Informative Direct
Biological Process (BP) multicellular organismal homeostasis 0.00001332 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00000000000002273 Highly Informative Direct
Biological Process (BP) response to glucocorticoid 0.000345 Highly Informative Direct
Biological Process (BP) positive regulation of protein kinase B signaling 0.00000000008622 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.0003049 Highly Informative Direct
Biological Process (BP) regulation of protein localization to nucleus 0 Highly Informative Direct
Biological Process (BP) fatty acid derivative biosynthetic process 0 Highly Informative Direct
Biological Process (BP) negative regulation of secretion by cell 0.000002174 Highly Informative Direct
Biological Process (BP) regulation of protein import 0.00005894 Highly Informative Direct
Biological Process (BP) negative regulation of establishment of protein localization 0 Highly Informative Direct
Biological Process (BP) regulation of lipid localization 0.000009733 Highly Informative Direct
Biological Process (BP) locomotory behavior 0.003779 Highly Informative Inherited
Biological Process (BP) inflammatory response 0.01131 Highly Informative Inherited
Molecular Function (MF) binding 0.000003381 Least Informative Direct
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) isomerase activity 0.000000000001337 Moderately Informative Direct
Molecular Function (MF) small molecule binding 0 Moderately Informative Direct
Molecular Function (MF) anion binding 0.000001958 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.7379 Moderately Informative Inherited
Molecular Function (MF) transporter activity 0.006661 Moderately Informative Inherited
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0.7755 Moderately Informative Inherited
Molecular Function (MF) intramolecular oxidoreductase activity 0 Informative Direct
Molecular Function (MF) carboxylic acid binding 0 Informative Direct
Molecular Function (MF) tetrapyrrole binding 0.000001117 Informative Direct
Molecular Function (MF) peptidase regulator activity 0.0001861 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.06784 Informative Inherited
Molecular Function (MF) signal transducer activity 0.5436 Informative Inherited
Molecular Function (MF) molecular transducer activity 0.4642 Informative Inherited
Molecular Function (MF) enzyme inhibitor activity 0.001745 Informative Inherited
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0.3235 Informative Inherited
Molecular Function (MF) kinase activity 0.4749 Informative Inherited
Molecular Function (MF) lipid transporter activity 0.0000000001083 Highly Informative Direct
Molecular Function (MF) steroid binding 0 Highly Informative Direct
Molecular Function (MF) odorant binding 0 Highly Informative Direct
Molecular Function (MF) isoprenoid binding 0 Highly Informative Direct
Molecular Function (MF) heme binding 0.00000003351 Highly Informative Direct
Molecular Function (MF) monocarboxylic acid binding 0 Highly Informative Direct
Molecular Function (MF) alcohol binding 0 Highly Informative Direct
Molecular Function (MF) protein kinase activity 0.08283 Highly Informative Inherited
Molecular Function (MF) transmembrane signaling receptor activity 0.05798 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 0.00002627 Least Informative Direct
Cellular Component (CC) membrane 1 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.8134 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.5541 Least Informative Inherited
Cellular Component (CC) ribosome 0.00000000005732 Moderately Informative Direct
Cellular Component (CC) endomembrane system 0.0000002241 Moderately Informative Direct
Cellular Component (CC) cell projection 0.000005428 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0 Moderately Informative Direct
Cellular Component (CC) cytosolic part 0.0000000002843 Moderately Informative Direct
Cellular Component (CC) vesicle 0.2126 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0 Informative Direct
Cellular Component (CC) cytosolic ribosome 0 Informative Direct
Cellular Component (CC) extracellular organelle 0.0006618 Informative Direct
Cellular Component (CC) plasma membrane region 0.3895 Informative Inherited
Cellular Component (CC) plasma membrane bounded cell projection part 1 Informative Inherited
Cellular Component (CC) neuron projection 0.02108 Informative Inherited
Cellular Component (CC) dendrite 0.0000001942 Highly Informative Direct
Cellular Component (CC) brush border membrane 0.0000003474 Highly Informative Direct
Cellular Component (CC) neuronal cell body 0.00000001112 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000000005765 Highly Informative Direct
Cellular Component (CC) yolk 0.0000000000009233 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Isomerases0.00000000000004383Least InformativeDirect
Enzyme Commission (EC)Intramolecular oxidoreductases0Moderately InformativeDirect
Enzyme Commission (EC)Other intramolecular oxidoreductases0Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTransport0Least InformativeDirect
Biological processImmunity0.003277Moderately InformativeInherited
Biological processLipid metabolism0.3574Moderately InformativeInherited
Biological processSensory transduction0.000000003875InformativeDirect
Biological processInnate immunity0.000004594InformativeDirect
Biological processFatty acid metabolism0.0000521InformativeDirect
Biological processLipid biosynthesis0.05359InformativeInherited
Biological processProstaglandin biosynthesis0Highly InformativeDirect
Biological processAcute phase4.848e-16Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentEndoplasmic reticulum0.00007749Moderately InformativeDirect
Cellular componentGolgi apparatus0.0001777Moderately InformativeDirect
DiseaseAllergen0Moderately InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionZinc1Least InformativeInherited
Molecular functionLipid-binding0Moderately InformativeDirect
Molecular functionChromophore0.0000008829InformativeDirect
Molecular functionZinc transport0.000000003641Highly InformativeDirect
Post-translational modificationProtease inhibitor0.000006309InformativeDirect
Post-translational modificationSerine protease inhibitor0.0000006538Highly InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationAcetylation0.0006547Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011038 SSF50814 Protein matches
Abstract

Calycins form a large protein superfamily that share similar beta-barrel structures. Calycins can be divided into families that include lipocalins, fatty acid binding proteins, triabin, and thrombin inhibitor [PubMed11058743]. Of these families, the lipocalin family is the largest and functionally the most diverse. Lipocalins are extracellular proteins that share several common recognition properties such as ligand binding, receptor binding and the formation of complexes with other macromolecules. Lipocalins include the retinol binding protein, lipocalin allergen, aphrodisin (a sex hormone), alpha-2U-globulin, prostaglandin D synthase, beta-lactoglobulin, bilin-binding protein, and the nitrophorins [PubMed12432930, PubMed11058763, PubMed11058769, PubMed11058756].

This entry represents calycin as well as some other proteins that share a similar calycin beta-barrel structure, including two bacterial hypothetical proteins YodA from Escherichia coli and YwiB from bacillus subtilis. Part of the YodA hypothetical protein has a calycin-like structure [PubMed12909634].

Please be aware that some of the protein hits may be false positives.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 69 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Lipocalins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 69 hidden Markov models representing the Lipocalins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-quality) · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]