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Hemopexin-like domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   4-bladed beta-propeller [ 50922]
Superfamily:   Hemopexin-like domain [ 50923]
Families:   Hemopexin-like domain [ 50924] (5)

Superfamily statistics
Genomes (191) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 2,387 6,477 11
Proteins 2,259 5,945 10

Functional annotation
General category General
Detailed category Protein interaction

Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Acting on peptide bonds (peptide hydrolases)0Least InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect
Enzyme Commission (EC)Gelatinase B0.000006093Highly InformativeDirect
Enzyme Commission (EC)Gelatinase A0.000006093Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)organ system cancer0.02457Least InformativeInherited
Disease Ontology (DO)nervous system disease0.4567Least InformativeInherited
Disease Ontology (DO)lower respiratory tract disease0.0007287Moderately InformativeDirect
Disease Ontology (DO)artery disease0.001434Moderately InformativeInherited
Disease Ontology (DO)gastrointestinal system disease0.001635Moderately InformativeInherited
Disease Ontology (DO)cell type cancer0.00183Moderately InformativeInherited
Disease Ontology (DO)connective tissue disease0.003557Moderately InformativeInherited
Disease Ontology (DO)disease by infectious agent0.0142Moderately InformativeInherited
Disease Ontology (DO)hypersensitivity reaction type II disease0.0199Moderately InformativeInherited
Disease Ontology (DO)sensory system disease0.1279Moderately InformativeInherited
Disease Ontology (DO)hematologic cancer0.181Moderately InformativeInherited
Disease Ontology (DO)nervous system cancer0.2343Moderately InformativeInherited
Disease Ontology (DO)prostate cancer0.000001075InformativeDirect
Disease Ontology (DO)myopia0.000002421InformativeDirect
Disease Ontology (DO)female reproductive system disease0.000007595InformativeDirect
Disease Ontology (DO)carcinoma0.00004304InformativeDirect
Disease Ontology (DO)intrinsic cardiomyopathy0.00005572InformativeDirect
Disease Ontology (DO)atherosclerosis0.00007221InformativeDirect
Disease Ontology (DO)primary bacterial infectious disease0.0006049InformativeDirect
Disease Ontology (DO)arthritis0.0006951InformativeDirect
Disease Ontology (DO)meningioma0.0007287InformativeDirect
Disease Ontology (DO)myeloid neoplasm0.0008098InformativeDirect
Disease Ontology (DO)rheumatic disease0.001747InformativeInherited
Disease Ontology (DO)connective tissue cancer0.004116InformativeInherited
Disease Ontology (DO)collagen disease0.008731InformativeInherited
Disease Ontology (DO)malignant glioma0.04725InformativeInherited
Disease Ontology (DO)female reproductive organ cancer0.9429InformativeInherited
Disease Ontology (DO)Kawasaki disease0.0000004531Highly InformativeDirect
Disease Ontology (DO)chondrosarcoma0.0000008605Highly InformativeDirect
Disease Ontology (DO)adult astrocytic tumour0.000006869Highly InformativeDirect
Disease Ontology (DO)abdominal aortic aneurysm0.000007201Highly InformativeDirect
Disease Ontology (DO)ovary epithelial cancer0.00001683Highly InformativeDirect
Disease Ontology (DO)salivary gland adenoid cystic carcinoma0.0001366Highly InformativeDirect
Disease Ontology (DO)bronchiectasis0.0001547Highly InformativeDirect
Disease Ontology (DO)integumentary system cancer0.0003572Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of limbs0.1077Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.4315Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of skeletal morphology0.866Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of limb bone morphology0.09121Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal joint morphology0.1063Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of cardiovascular system morphology0.1141Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve morphology0.0606InformativeInherited
Phenotypic Abnormality (PA)Abnormality of long bone morphology0.2003InformativeInherited
Phenotypic Abnormality (PA)Arthropathy0.0000542Highly InformativeDirect
Phenotypic Abnormality (PA)Metaphyseal widening0.0002172Highly InformativeDirect
Phenotypic Abnormality (PA)Arthritis0.0006933Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)immune system phenotype0.03083Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1333Least InformativeInherited
Mammalian Phenotype (MP)neoplasm0.02895Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal inflammatory response0.04699Moderately InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.05362Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal craniofacial morphology0.1136Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal blood vessel morphology0.1175Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.7339Moderately InformativeInherited
Mammalian Phenotype (MP)altered susceptibility to bacterial infection0.00003867InformativeDirect
Mammalian Phenotype (MP)abnormal trabecular bone morphology0.0007042InformativeDirect
Mammalian Phenotype (MP)abnormal viscerocranium morphology0.008127InformativeInherited
Mammalian Phenotype (MP)joint inflammation0.01225InformativeInherited
Mammalian Phenotype (MP)abnormal angiogenesis0.01595InformativeInherited
Mammalian Phenotype (MP)abnormal systemic artery morphology0.0255InformativeInherited
Mammalian Phenotype (MP)altered tumor pathology0.06825InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.2205InformativeInherited
Mammalian Phenotype (MP)decreased angiogenesis0.0001423Highly InformativeDirect
Mammalian Phenotype (MP)decreased tumor growth/size0.0002623Highly InformativeDirect
Mammalian Phenotype (MP)arthritis0.0005263Highly InformativeDirect
Mammalian Phenotype (MP)aneurysm0.0006977Highly InformativeDirect
Mammalian Phenotype (MP)abnormal pulmonary alveolus morphology0.01377Highly InformativeInherited
Mammalian Phenotype (MP)abnormal maxilla morphology0.1865Highly InformativeInherited

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)pericellular component development variant0.0000008118Moderately InformativeDirect
Worm Phenotype (WP)basement membrane remodeling variant0.0000002436InformativeDirect

Document: WP annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details)
ZA termFDR (all)SDZA levelAnnotation (direct or inherited)
Zebrafish Anatomy (ZA)anatomical cluster0Moderately InformativeDirect
Zebrafish Anatomy (ZA)skeletal system0.0003636InformativeDirect

Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)tissue0.3018Least InformativeInherited
Xenopus ANatomical entity (XAN)embryo0.8719Least InformativeInherited
Xenopus ANatomical entity (XAN)notochord0.0001014InformativeDirect
Xenopus ANatomical entity (XAN)mesoderm0.06436InformativeInherited

Document: XA annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Acting on peptide bonds (peptidases)0Moderately InformativeDirect
Enzyme Commission (EC)Metalloendopeptidases0InformativeDirect

Document: EC annotation of SCOP domains

InterPro annotation
Cross references IPR000585 SSF50923 Protein matches

Hemopexin is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [PubMed12042069]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino acid residues connected by a histidine-rich hinge region. Each half is itself formed by the repetition of a basic unit of some 35 to 45 residues. Hemopexin-like domains have been found in two other types of proteins, vitronectin [PubMed9572850], a cell adhesion and spreading factor found in plasma and tissues, and matrixins MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-11, MMP-12, MMP-14, MMP-15 and MMP-16, members of the matrix metalloproteinase family that cleave extracellular matrix constituents [PubMed14619953]. These zinc endopeptidases, which belong to MEROPS peptidase subfamily M10A, have a single hemopexin-like domain in their C-terminal section. It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).

InterPro database

PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.

Alignments of sequences to 9 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.

Browse and view proteins in genomes which have different domain combinations including a Hemopexin-like domain domain.

Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.

Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 9 hidden Markov models representing the Hemopexin-like domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Enzyme Commission (EC) · Internal database links ]