SUPERFAMILY 1.75 HMM library and genome assignments server

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Soluble quinoprotein glucose dehydrogenase superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   6-bladed beta-propeller [ 50938] (11)
Superfamily:   Soluble quinoprotein glucose dehydrogenase [ 50952]
Families:   Soluble quinoprotein glucose dehydrogenase [ 50953]


Superfamily statistics
Genomes (1,463) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 3,763 22,434 1
Proteins 3,595 22,269 1


Functional annotation
General category Metabolism
Detailed category Other enzymes

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.5456 Least Informative Inherited
Biological Process (BP) regulation of signaling 0.1005 Moderately Informative Inherited
Biological Process (BP) negative regulation of cellular process 0.1507 Moderately Informative Inherited
Biological Process (BP) regulation of cell communication 0.1511 Moderately Informative Inherited
Biological Process (BP) regulation of response to stimulus 0.25 Moderately Informative Inherited
Biological Process (BP) negative regulation of cell communication 0.001404 Informative Inherited
Biological Process (BP) negative regulation of response to stimulus 0.004082 Informative Inherited
Biological Process (BP) negative regulation of signaling 0.0014 Informative Inherited
Cellular Component (CC) membrane 0.04025 Least Informative Inherited
Cellular Component (CC) plasma membrane 0.001986 Moderately Informative Inherited

Document: GO annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Cellular componentSecreted0.00000001634Moderately InformativeDirect
Cellular componentCell junction0.0000003614Moderately InformativeDirect
Cellular componentSynapse0.000000002441InformativeDirect
Cellular componentSynaptosome0.00000000000008049Highly InformativeDirect
DomainSignal0.0003323Least InformativeDirect
DomainRepeat0.0005966Least InformativeDirect
DomainWD repeat0.0000004356InformativeDirect
DomainEGF-like domain0.0000005522InformativeDirect
Post-translational modificationGlycoprotein0.000000006192Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR011041 SSF50952 Protein matches
Abstract

Quinoproteins form a class of dehydrogenases distinct from the NAD(P)- and flavin-dependent enzymes, using one of four different quinone cofactors for the oxidation of a variety of compounds. Soluble glucose dehydrogenase (s-GDH) from the bacterium Acinetobacter calcoaceticus is a quinoprotein that requires the cofactor pyrroloquinoline quinone (PQQ) to catalyse the oxidation of glucose to gluconolactone [PubMed10518528]. s-GDH has six 4-stranded beta-sheets in a beta-propeller fold.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 1 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Soluble quinoprotein glucose dehydrogenase domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 1 hidden Markov models representing the Soluble quinoprotein glucose dehydrogenase superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · UniProtKB KeyWords (KW) · Internal database links ]