SUPERFAMILY 1.75 HMM library and genome assignments server

Superfamily is undergoing a server migration - you are now browsing on the new server. Please contact us if you experience any problems.


Glycosyl hydrolase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Glycosyl hydrolase domain [ 51010]
Superfamily:   Glycosyl hydrolase domain [ 51011] (5)
Families:   alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)
  Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [ 89388] (4)
  Putative alpha-L-fucosidase C-terminal domain [ 101928]
  Putative glucosidase YicI, domain 3 [ 117298]
  Beta-galactosidase LacA, domain 2 [ 117301]


Superfamily statistics
Genomes (2,566) Uniprot 2018_03 genome PDB chains (SCOP 1.75)
Domains 18,524 121,779 154
Proteins 18,260 120,575 152


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004805InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.00000000005571Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.000001116Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.0001201Highly InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)disease of metabolism0.0003497Moderately InformativeDirect
Disease Ontology (DO)lysosomal storage disease0.1057InformativeInherited
Disease Ontology (DO)sphingolipidosis0.000005523Highly InformativeDirect

Document: DO annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of the digestive system0Least InformativeDirect
Phenotypic Abnormality (PA)Abnormality of the cardiovascular system0.01505Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system morphology0.03995Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the head0.4389Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the eye0.6415Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0.7236Least InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the vasculature0.0006758Moderately InformativeDirect
Phenotypic Abnormality (PA)Abnormality of cardiovascular system physiology0.05379Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of higher mental function0.05411Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormality of the abdominal organs0.09489Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal oral cavity morphology0.1074Moderately InformativeInherited
Phenotypic Abnormality (PA)Abnormal eye morphology0.4109Moderately InformativeInherited
Phenotypic Abnormality (PA)Cognitive impairment0.0009403InformativeDirect
Phenotypic Abnormality (PA)Peripheral neuropathy0.01218InformativeInherited
Phenotypic Abnormality (PA)Abnormal cornea morphology0.01392InformativeInherited
Phenotypic Abnormality (PA)Abnormal lip morphology0.12InformativeInherited
Phenotypic Abnormality (PA)Abnormal heart valve physiology0.1306InformativeInherited
Phenotypic Abnormality (PA)Hypertension0.0001312Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal autonomic nervous system physiology0.0001676Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormality of lower lip0.0003328Highly InformativeDirect
Phenotypic Abnormality (PA)Corneal opacity0.0003417Highly InformativeDirect
Phenotypic Abnormality (PA)Paresthesia0.0004413Highly InformativeDirect
Phenotypic Abnormality (PA)Abnormal mitral valve physiology0.0005988Highly InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cardiovascular system phenotype0.02Least InformativeInherited
Mammalian Phenotype (MP)abnormal homeostasis0.5382Least InformativeInherited
Mammalian Phenotype (MP)abnormal heart morphology0.03821Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.19Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal skeleton morphology0.2477Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal behavior1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal heart ventricle morphology0.003789InformativeInherited
Mammalian Phenotype (MP)abnormal voluntary movement0.01526InformativeInherited
Mammalian Phenotype (MP)abnormal glucose homeostasis0.2617InformativeInherited
Mammalian Phenotype (MP)abnormal heart left ventricle size0.000004689Highly InformativeDirect
Mammalian Phenotype (MP)abnormal glycogen homeostasis0.0002308Highly InformativeDirect
Mammalian Phenotype (MP)abnormal heart electrocardiography waveform feature0.0003654Highly InformativeDirect
Mammalian Phenotype (MP)abnormal gait0.0006454Highly InformativeDirect
Mammalian Phenotype (MP)kyphosis0.0009808Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details) Document: WP annotation of SCOP domains

Xenopus Anatomy (XA)

(show details)
XA termFDR (all)SDXA levelAnnotation (direct or inherited)
Xenopus ANatomical entity (XAN)cavitated compound organ0Least InformativeDirect

Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)flower0Least InformativeDirect
Plant ANatomical entity (PAN)collective phyllome structure0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0Least InformativeDirect
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosylases0Moderately InformativeDirect
Enzyme Commission (EC)Isomerases1Moderately InformativeInherited
Enzyme Commission (EC)Hexosyltransferases0InformativeDirect
Enzyme Commission (EC)Intramolecular transferases1InformativeInherited
Enzyme Commission (EC)Beta-galactosidase0.0004097Highly InformativeDirect
Enzyme Commission (EC)Transferring other glycosyl groups1Highly InformativeInherited

Document: EC annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 81 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycosyl hydrolase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 81 hidden Markov models representing the Glycosyl hydrolase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Enzyme Commission (EC) · Disease Ontology (DO) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · Internal database links ]