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Glycosyl hydrolase domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   Glycosyl hydrolase domain [ 51010]
Superfamily:   Glycosyl hydrolase domain [ 51011] (5)
Families:   alpha-Amylases, C-terminal beta-sheet domain [ 51012] (22)
  Composite domain of glycosyl hydrolase families 5, 30, 39 and 51 [ 89388] (4)
  Putative alpha-L-fucosidase C-terminal domain [ 101928]
  Putative glucosidase YicI, domain 3 [ 117298]
  Beta-galactosidase LacA, domain 2 [ 117301]


Superfamily statistics
Genomes (2,566) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 18,524 96,475 154
Proteins 18,260 95,543 152


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) single-organism metabolic process 0 Least Informative Direct
Biological Process (BP) primary metabolic process 0.000001863 Least Informative Direct
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) cellular component organization or biogenesis 1 Least Informative Inherited
Biological Process (BP) multicellular organismal process 1 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 1 Least Informative Inherited
Biological Process (BP) single-organism cellular process 0.7471 Least Informative Inherited
Biological Process (BP) organic substance catabolic process 0 Moderately Informative Direct
Biological Process (BP) carbohydrate metabolic process 0 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0000000000009475 Moderately Informative Direct
Biological Process (BP) generation of precursor metabolites and energy 0.000000000003311 Moderately Informative Direct
Biological Process (BP) single-organism catabolic process 0.0000000008942 Moderately Informative Direct
Biological Process (BP) oxidation-reduction process 0.00007841 Moderately Informative Direct
Biological Process (BP) carbohydrate derivative metabolic process 0.04702 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.9909 Moderately Informative Inherited
Biological Process (BP) lipid metabolic process 1 Moderately Informative Inherited
Biological Process (BP) ion transport 0.6826 Moderately Informative Inherited
Biological Process (BP) cellular macromolecule biosynthetic process 0.2202 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.9847 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.7498 Moderately Informative Inherited
Biological Process (BP) carbohydrate catabolic process 0 Informative Direct
Biological Process (BP) cellular carbohydrate metabolic process 0 Informative Direct
Biological Process (BP) polysaccharide metabolic process 0 Informative Direct
Biological Process (BP) carbohydrate biosynthetic process 0.0000009322 Informative Direct
Biological Process (BP) membrane lipid metabolic process 0.000001368 Informative Direct
Biological Process (BP) liposaccharide metabolic process 0.00001848 Informative Direct
Biological Process (BP) carbohydrate derivative catabolic process 0.00008792 Informative Direct
Biological Process (BP) anion transport 0.06088 Informative Inherited
Biological Process (BP) lipid catabolic process 0.2258 Informative Inherited
Biological Process (BP) monosaccharide metabolic process 0.01483 Informative Inherited
Biological Process (BP) organic acid transport 0.002665 Informative Inherited
Biological Process (BP) energy reserve metabolic process 0 Highly Informative Direct
Biological Process (BP) cellular carbohydrate catabolic process 0 Highly Informative Direct
Biological Process (BP) oligosaccharide catabolic process 0.00000000003965 Highly Informative Direct
Biological Process (BP) polysaccharide catabolic process 0.0000000007489 Highly Informative Direct
Biological Process (BP) cellular polysaccharide biosynthetic process 0.0000004649 Highly Informative Direct
Biological Process (BP) digestion 0.00001173 Highly Informative Direct
Biological Process (BP) cell wall biogenesis 0.00002884 Highly Informative Direct
Biological Process (BP) cell wall macromolecule metabolic process 0.00002982 Highly Informative Direct
Biological Process (BP) amino acid transport 0.00008158 Highly Informative Direct
Molecular Function (MF) hydrolase activity 0 Least Informative Direct
Molecular Function (MF) binding 1 Least Informative Inherited
Molecular Function (MF) transferase activity 1 Least Informative Inherited
Molecular Function (MF) transporter activity 1 Moderately Informative Inherited
Molecular Function (MF) metal ion binding 0.09814 Moderately Informative Inherited
Molecular Function (MF) hydrolase activity, acting on glycosyl bonds 0 Informative Direct
Molecular Function (MF) transferase activity, transferring glycosyl groups 0 Informative Direct
Molecular Function (MF) anion transmembrane transporter activity 0.00964 Informative Inherited
Molecular Function (MF) hydrolase activity, hydrolyzing O-glycosyl compounds 0.00000001059 Highly Informative Direct
Molecular Function (MF) calcium ion binding 0.000004762 Highly Informative Direct
Molecular Function (MF) amino acid transmembrane transporter activity 0.00001075 Highly Informative Direct
Molecular Function (MF) transferase activity, transferring hexosyl groups 0.001619 Highly Informative Inherited
Cellular Component (CC) intracellular organelle part 1 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 0.2561 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.9316 Least Informative Inherited
Cellular Component (CC) vacuole 0.00000000000008179 Moderately Informative Direct
Cellular Component (CC) extracellular region part 0.0002875 Moderately Informative Direct
Cellular Component (CC) vesicle 0.1864 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 1 Moderately Informative Inherited
Cellular Component (CC) extracellular space 0.00001429 Informative Direct
Cellular Component (CC) vacuolar part 0.00002294 Informative Direct
Cellular Component (CC) extracellular organelle 0.0001056 Informative Direct
Cellular Component (CC) external encapsulating structure 0.0004797 Informative Direct
Cellular Component (CC) plastid 0.0005981 Informative Direct
Cellular Component (CC) lytic vacuole 0.001297 Informative Inherited
Cellular Component (CC) vacuolar lumen 0.000001338 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Glycosyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Glycosidases, i.e. enzymes hydrolyzing O- and S-gl0Moderately InformativeDirect
Enzyme Commission (EC)Beta-galactosidase0.0004805InformativeDirect
Enzyme Commission (EC)1,4-alpha-glucan branching enzyme0Highly InformativeDirect
Enzyme Commission (EC)Alpha-glucosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-galactosidase0Highly InformativeDirect
Enzyme Commission (EC)Alpha-amylase0Highly InformativeDirect
Enzyme Commission (EC)Cyclomaltodextrin glucanotransferase0.00000000005571Highly InformativeDirect
Enzyme Commission (EC)Alpha-N-arabinofuranosidase0.000001116Highly InformativeDirect
Enzyme Commission (EC)Pullulanase0.0001201Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processCarbohydrate metabolism0Moderately InformativeDirect
Biological processLipid metabolism1Moderately InformativeInherited
Biological processSphingolipid metabolism0.00000000000357Highly InformativeDirect
Cellular componentSecreted0Moderately InformativeDirect
Cellular componentPlastid1Moderately InformativeInherited
Cellular componentLysosome0InformativeDirect
Cellular componentApoplast0.000002537Highly InformativeDirect
DiseaseGlycogen storage disease0.000000000103InformativeDirect
DomainSignal0Least InformativeDirect
Molecular functionCalcium0Moderately InformativeDirect
Molecular functionChloride0InformativeDirect
Molecular functionLectin0.0009665InformativeDirect
Post-translational modificationHydrolase0Least InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationGlycosidase0InformativeDirect
Post-translational modificationGlycosyltransferase0InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationPyrrolidone carboxylic acid0InformativeDirect
Post-translational modificationSulfation0.0000922InformativeDirect

Document: KW annotation of SCOP domains

Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 55 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a Glycosyl hydrolase domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 55 hidden Markov models representing the Glycosyl hydrolase domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]