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WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (505) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 16,207 40,078 31
Proteins 10,466 25,683 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) biological regulation 0.0000000000676 Least Informative Direct
Biological Process (BP) macromolecule metabolic process 0.00000001751 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000001934 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.0001294 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.6691 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.002775 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.1089 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.5622 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.6069 Least Informative Inherited
Biological Process (BP) response to stimulus 0.5164 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.7744 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.6944 Least Informative Inherited
Biological Process (BP) cell differentiation 0.000000003325 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.00000004367 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.0000004435 Moderately Informative Direct
Biological Process (BP) cellular protein modification process 0.00000993 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00001182 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00002872 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00005933 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00009767 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0002622 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.0002667 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0003296 Moderately Informative Direct
Biological Process (BP) regulation of cellular biosynthetic process 0.6048 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.3464 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.9327 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.008875 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002205 Moderately Informative Inherited
Biological Process (BP) tissue development 0.006484 Moderately Informative Inherited
Biological Process (BP) animal organ development 0.6863 Moderately Informative Inherited
Biological Process (BP) single-organism transport 0.5116 Moderately Informative Inherited
Biological Process (BP) cell communication 0.005422 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.4386 Moderately Informative Inherited
Biological Process (BP) protein complex biogenesis 0.002776 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2996 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3884 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.282 Moderately Informative Inherited
Biological Process (BP) cellular catabolic process 0.003854 Moderately Informative Inherited
Biological Process (BP) nitrogen compound transport 0.0376 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1799 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.8049 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.01836 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) organelle organization 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.03197 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) single organism signaling 0.002077 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.02098 Moderately Informative Inherited
Biological Process (BP) regulation of cell cycle 0.0000001482 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000002621 Informative Direct
Biological Process (BP) negative regulation of signaling 0.000001371 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.000005477 Informative Direct
Biological Process (BP) positive regulation of transport 0.00003971 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.00005349 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.00007175 Informative Direct
Biological Process (BP) cell cycle process 0.00007608 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00008182 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0003984 Informative Direct
Biological Process (BP) proteolysis 0.0007226 Informative Direct
Biological Process (BP) regulation of ion transport 0.2662 Informative Inherited
Biological Process (BP) regulation of transmembrane transport 0.05593 Informative Inherited
Biological Process (BP) regulation of system process 0.1281 Informative Inherited
Biological Process (BP) cell development 0.004668 Informative Inherited
Biological Process (BP) epithelium development 0.01695 Informative Inherited
Biological Process (BP) protein oligomerization 0.09155 Informative Inherited
Biological Process (BP) behavior 0.05876 Informative Inherited
Biological Process (BP) system process 0.499 Informative Inherited
Biological Process (BP) regulation of growth 0.009183 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.006065 Informative Inherited
Biological Process (BP) organelle assembly 0.03895 Informative Inherited
Biological Process (BP) supramolecular fiber organization 0.09442 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.2072 Informative Inherited
Biological Process (BP) actin cytoskeleton organization 0.6772 Informative Inherited
Biological Process (BP) anatomical structure formation involved in morphogenesis 1 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.0291 Informative Inherited
Biological Process (BP) protein localization to organelle 0.7679 Informative Inherited
Biological Process (BP) protein transport 0.002482 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1383 Informative Inherited
Biological Process (BP) regulation of catabolic process 0.001368 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.06321 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5714 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6606 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.06326 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03916 Informative Inherited
Biological Process (BP) intracellular transport 0.2108 Informative Inherited
Biological Process (BP) single-organism cellular localization 0.01358 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.06854 Informative Inherited
Biological Process (BP) regulation of locomotion 0.06712 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9679 Informative Inherited
Biological Process (BP) chromosome organization 0.05538 Informative Inherited
Biological Process (BP) post-embryonic development 0.9861 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.5262 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.03068 Informative Inherited
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) modification-dependent macromolecule catabolic process 0 Highly Informative Direct
Biological Process (BP) cellular protein catabolic process 0.00000000336 Highly Informative Direct
Biological Process (BP) mRNA processing 0.00000001022 Highly Informative Direct
Biological Process (BP) kidney development 0.0000003229 Highly Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.0000004217 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000004816 Highly Informative Direct
Biological Process (BP) RNA splicing 0.0000007398 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.000001843 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000007328 Highly Informative Direct
Biological Process (BP) plasma membrane bounded cell projection organization 0.00001232 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00002755 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00003233 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.00008784 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0002082 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0006249 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.0008658 Highly Informative Direct
Biological Process (BP) epithelial cell differentiation 0.01543 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.2171 Highly Informative Inherited
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.001765 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.003991 Highly Informative Inherited
Biological Process (BP) nervous system process 0.9386 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.004235 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1074 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.08051 Highly Informative Inherited
Biological Process (BP) actomyosin structure organization 0.02492 Highly Informative Inherited
Biological Process (BP) cellular component assembly involved in morphogenesis 0.06071 Highly Informative Inherited
Biological Process (BP) striated muscle cell development 0.2252 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.005882 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.0905 Highly Informative Inherited
Biological Process (BP) histone modification 0.003007 Highly Informative Inherited
Biological Process (BP) protein alkylation 0.01609 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.0236 Highly Informative Inherited
Biological Process (BP) post-embryonic animal morphogenesis 0.09242 Highly Informative Inherited
Biological Process (BP) appendage development 0.3753 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1554 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.5717 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Molecular Function (MF) binding 0.000000003196 Least Informative Direct
Molecular Function (MF) transferase activity 0.003187 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.00000001006 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.001304 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.00006155 Informative Direct
Molecular Function (MF) macromolecular complex binding 0.0001703 Informative Direct
Molecular Function (MF) receptor binding 0.0007214 Informative Direct
Molecular Function (MF) amide binding 0.01786 Informative Inherited
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.00000004915 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.000000088 Highly Informative Direct
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00006353 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0007745 Highly Informative Direct
Cellular Component (CC) membrane 0.4405 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.3871 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.2174 Least Informative Inherited
Cellular Component (CC) protein complex 0.5872 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) cell projection 0.00002032 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.00003804 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.000106 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0001876 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.2862 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.005867 Moderately Informative Inherited
Cellular Component (CC) plasma membrane protein complex 0.000000000002704 Informative Direct
Cellular Component (CC) cytoplasmic region 0.0002419 Informative Direct
Cellular Component (CC) nucleoplasm part 0.08539 Informative Inherited
Cellular Component (CC) spliceosomal complex 0.000001512 Highly Informative Direct
Cellular Component (CC) nuclear body 0.000001685 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000002519 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.001218 Highly Informative Inherited
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000014Least InformativeDirect
Enzyme Commission (EC)Isomerases0.00004689Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000005085Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000007733Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009564InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis0.0000000000002368Moderately InformativeDirect
Biological processDifferentiation0.000002352Moderately InformativeDirect
Biological processmRNA processing0.00000000000002914InformativeDirect
Biological processNeurogenesis0.000000003628InformativeDirect
Biological processWnt signaling pathway0.0000001151InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentCytoplasm0.01805Least InformativeInherited
Cellular componentMembrane0.02131Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton0.00000000001388Moderately InformativeDirect
Cellular componentCell membrane0.000000014Moderately InformativeDirect
Cellular componentCell projection0.00001238Moderately InformativeDirect
Cellular componentChromosome0.0000000000005971InformativeDirect
Cellular componentSpliceosome0.00000707InformativeDirect
Cellular componentTight junction0.00005589Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000003005Least InformativeDirect
DiseaseProto-oncogene0.0002233Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.0000846InformativeDirect
Molecular functionCalcium0.0001716Moderately InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0004293InformativeDirect
Post-translational modificationTransferase0.009661Least InformativeInherited
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.000000000505Moderately InformativeDirect
Post-translational modificationIsomerase0.2057Moderately InformativeInherited
Post-translational modificationActin-binding0.00000000001965InformativeDirect
Post-translational modificationChromatin regulator0.000000001617InformativeDirect
Post-translational modificationGTPase activation0.00000002579InformativeDirect
Post-translational modificationMethyltransferase0.0009721InformativeDirect
Post-translational modificationRotamase0.00000001097Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000000003771Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.0006039Moderately InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]