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WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (498) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,866 17,116 31
Proteins 10,257 11,090 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) macromolecule metabolic process 0.00000002184 Least Informative Direct
Biological Process (BP) biological regulation 0.000000000003458 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.0002428 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.9308 Least Informative Inherited
Biological Process (BP) response to stimulus 0.3947 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.7425 Least Informative Inherited
Biological Process (BP) cellular nitrogen compound metabolic process 0.9749 Least Informative Inherited
Biological Process (BP) primary metabolic process 0.002674 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.7707 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.704 Least Informative Inherited
Biological Process (BP) cellular protein modification process 0.00000000000001068 Moderately Informative Direct
Biological Process (BP) cell communication 0.00009999 Moderately Informative Direct
Biological Process (BP) regulation of cell communication 0.000000006841 Moderately Informative Direct
Biological Process (BP) regulation of signaling 0.00000004392 Moderately Informative Direct
Biological Process (BP) signaling 0.00007373 Moderately Informative Direct
Biological Process (BP) regulation of localization 0.0004958 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.00001013 Moderately Informative Direct
Biological Process (BP) macromolecular complex subunit organization 0.0006778 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0009276 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00000144 Moderately Informative Direct
Biological Process (BP) regulation of response to stimulus 0.00007121 Moderately Informative Direct
Biological Process (BP) cellular developmental process 0.000007296 Moderately Informative Direct
Biological Process (BP) regulation of protein metabolic process 0.00008355 Moderately Informative Direct
Biological Process (BP) regulation of molecular function 0.0001139 Moderately Informative Direct
Biological Process (BP) regulation of biosynthetic process 0.7362 Moderately Informative Inherited
Biological Process (BP) regulation of nitrogen compound metabolic process 0.8437 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.002203 Moderately Informative Inherited
Biological Process (BP) system development 0.02522 Moderately Informative Inherited
Biological Process (BP) cellular component assembly 0.3694 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.3302 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5489 Moderately Informative Inherited
Biological Process (BP) regulation of cellular component organization 0.002824 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.006809 Moderately Informative Inherited
Biological Process (BP) regulation of cellular metabolic process 0.2006 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.07351 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.4986 Moderately Informative Inherited
Biological Process (BP) response to abiotic stimulus 0.642 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 1 Moderately Informative Inherited
Biological Process (BP) gene expression 0.09639 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.07205 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.05107 Moderately Informative Inherited
Biological Process (BP) protein targeting 0.000002953 Informative Direct
Biological Process (BP) regulation of catabolic process 0.0009391 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00005376 Informative Direct
Biological Process (BP) cell cycle process 0.00003453 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00002441 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.0003908 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.0000003221 Informative Direct
Biological Process (BP) single-organism membrane organization 0.00008984 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003442 Informative Direct
Biological Process (BP) positive regulation of transport 0.0002516 Informative Direct
Biological Process (BP) positive regulation of cellular component organization 0.0008071 Informative Direct
Biological Process (BP) regulation of hydrolase activity 0.00009051 Informative Direct
Biological Process (BP) regulation of cell cycle 0.000001862 Informative Direct
Biological Process (BP) regulation of transmembrane transport 0.02801 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8451 Informative Inherited
Biological Process (BP) cell development 0.003753 Informative Inherited
Biological Process (BP) positive regulation of catalytic activity 0.03843 Informative Inherited
Biological Process (BP) protein oligomerization 0.0339 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.05554 Informative Inherited
Biological Process (BP) regulation of growth 0.01038 Informative Inherited
Biological Process (BP) regulation of intracellular signal transduction 0.02137 Informative Inherited
Biological Process (BP) regulation of phosphorylation 1 Informative Inherited
Biological Process (BP) negative regulation of transport 0.1559 Informative Inherited
Biological Process (BP) regulation of locomotion 0.04937 Informative Inherited
Biological Process (BP) epithelium development 0.005833 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.5628 Informative Inherited
Biological Process (BP) positive regulation of cellular protein metabolic process 0.06238 Informative Inherited
Biological Process (BP) regulation of protein modification process 0.04473 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.6545 Informative Inherited
Biological Process (BP) positive regulation of signal transduction 1 Informative Inherited
Biological Process (BP) movement of cell or subcellular component 0.03907 Informative Inherited
Biological Process (BP) actin filament-based process 0.01013 Informative Inherited
Biological Process (BP) proteolysis 0.001953 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9887 Informative Inherited
Biological Process (BP) response to radiation 0.02735 Informative Inherited
Biological Process (BP) post-embryonic development 1 Informative Inherited
Biological Process (BP) animal organ morphogenesis 0.3613 Informative Inherited
Biological Process (BP) system process 0.2791 Informative Inherited
Biological Process (BP) behavior 0.07324 Informative Inherited
Biological Process (BP) cell surface receptor signaling pathway 0.01832 Informative Inherited
Biological Process (BP) regulation of ion transport 0.1887 Informative Inherited
Biological Process (BP) RNA splicing 0.000005715 Highly Informative Direct
Biological Process (BP) mRNA metabolic process 0.0001917 Highly Informative Direct
Biological Process (BP) endosomal transport 0.0000002558 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0005622 Highly Informative Direct
Biological Process (BP) modification-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) cell projection organization 0.0004266 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0001083 Highly Informative Direct
Biological Process (BP) protein modification by small protein conjugation 0 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00003577 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 0.0004502 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00003099 Highly Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.000005434 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0000009983 Highly Informative Direct
Biological Process (BP) regulation of cation transmembrane transport 0.0000008837 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001699 Highly Informative Inherited
Biological Process (BP) epithelial cell differentiation 0.002681 Highly Informative Inherited
Biological Process (BP) negative regulation of mitotic cell cycle 0.1427 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.007344 Highly Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.00263 Highly Informative Inherited
Biological Process (BP) regulation of developmental growth 0.1514 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1599 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.01426 Highly Informative Inherited
Biological Process (BP) establishment or maintenance of cell polarity 0.04785 Highly Informative Inherited
Biological Process (BP) histone modification 0.008635 Highly Informative Inherited
Biological Process (BP) macromolecule methylation 0.01667 Highly Informative Inherited
Biological Process (BP) morphogenesis of an epithelium 1 Highly Informative Inherited
Biological Process (BP) metamorphosis 0.3323 Highly Informative Inherited
Biological Process (BP) tube morphogenesis 0.6025 Highly Informative Inherited
Biological Process (BP) instar larval or pupal morphogenesis 0.5826 Highly Informative Inherited
Biological Process (BP) appendage development 0.5511 Highly Informative Inherited
Biological Process (BP) single-organism behavior 0.1318 Highly Informative Inherited
Biological Process (BP) muscle structure development 0.001253 Highly Informative Inherited
Molecular Function (MF) binding 0.000000001177 Least Informative Direct
Molecular Function (MF) transferase activity 0.00291 Least Informative Inherited
Molecular Function (MF) structural molecule activity 0.000000001157 Moderately Informative Direct
Molecular Function (MF) protein binding 0.00000000003113 Moderately Informative Direct
Molecular Function (MF) molecular function regulator 0.001892 Moderately Informative Inherited
Molecular Function (MF) receptor binding 0.0009494 Informative Direct
Molecular Function (MF) enzyme activator activity 0.0007478 Informative Direct
Molecular Function (MF) enzyme binding 0.00002311 Informative Direct
Molecular Function (MF) amide binding 0.009709 Informative Inherited
Molecular Function (MF) macromolecular complex binding 0.02448 Informative Inherited
Molecular Function (MF) transcription factor activity, transcription factor binding 0.00003242 Highly Informative Direct
Molecular Function (MF) G-protein coupled receptor binding 0.00000002321 Highly Informative Direct
Molecular Function (MF) ubiquitin-like protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) peptide binding 0.0003044 Highly Informative Direct
Cellular Component (CC) membrane 0.2855 Least Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 0.1883 Least Informative Inherited
Cellular Component (CC) protein complex 0.6377 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.7217 Least Informative Inherited
Cellular Component (CC) cytoskeleton 0.0001044 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0005849 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0003379 Moderately Informative Direct
Cellular Component (CC) membrane protein complex 0.0006297 Moderately Informative Direct
Cellular Component (CC) plasma membrane 0.3173 Moderately Informative Inherited
Cellular Component (CC) intracellular organelle lumen 0.01564 Moderately Informative Inherited
Cellular Component (CC) cell junction 0.0000000000007614 Informative Direct
Cellular Component (CC) cell projection part 0.0009891 Informative Direct
Cellular Component (CC) synapse 0 Informative Direct
Cellular Component (CC) plasma membrane protein complex 0.000000005244 Informative Direct
Cellular Component (CC) nucleoplasm part 0.7845 Informative Inherited
Cellular Component (CC) spliceosomal complex 0.00001722 Highly Informative Direct
Cellular Component (CC) small nuclear ribonucleoprotein complex 0.0009659 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.000001316 Highly Informative Direct
Cellular Component (CC) cell-cell junction 1 Highly Informative Inherited
Cellular Component (CC) anchoring junction 0.9731 Highly Informative Inherited

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000014Least InformativeDirect
Enzyme Commission (EC)Isomerases0.00004689Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000005085Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000007733Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009564InformativeDirect

Document: EC annotation of SCOP domains

Human Phenotype (HP)

(show details)
HP termFDR (all)SDHP levelAnnotation (direct or inherited)
Phenotypic Abnormality (PA)Abnormality of nervous system physiology0Least InformativeDirect

Document: HP annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.1497Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1543Least InformativeInherited
Mammalian Phenotype (MP)abnormal muscle physiology0.01754Moderately InformativeInherited
Mammalian Phenotype (MP)liver/biliary system phenotype0.2162Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal gland morphology0.3218Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.3909Moderately InformativeInherited
Mammalian Phenotype (MP)embryo phenotype0.6316Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6682Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal muscle morphology0.8737Moderately InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.268InformativeInherited
Mammalian Phenotype (MP)abnormal embryo development0.3648InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension0.0001647Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism environmental stimulus response variant0.05863Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.04865Moderately InformativeInherited
Worm Phenotype (WP)maintenance of gene silencing variant0.0003017InformativeDirect
Worm Phenotype (WP)aldicarb response variant0.002445InformativeInherited
Worm Phenotype (WP)drug resistant0.125InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0009299Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Zebrafish Anatomy (ZA)

(show details) Document: ZA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases1Least InformativeInherited
Enzyme Commission (EC)Acyltransferases0Moderately InformativeDirect
Enzyme Commission (EC)Transferring one-carbon groups0.01419Moderately InformativeInherited
Enzyme Commission (EC)Isomerases0.02472Moderately InformativeInherited
Enzyme Commission (EC)Acting on acid anhydrides0.1592Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Aminoacyltransferases0InformativeDirect
Enzyme Commission (EC)RNA helicase0.000006487InformativeDirect
Enzyme Commission (EC)HECT-type E3 ubiquitin transferase0Highly InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.0000000002907Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processUbl conjugation pathway0Moderately InformativeDirect
Biological processApoptosis0.0000000000002099Moderately InformativeDirect
Biological processDifferentiation0.000001775Moderately InformativeDirect
Biological processmRNA processing0.00000000000002362InformativeDirect
Biological processNeurogenesis0.000000002973InformativeDirect
Biological processWnt signaling pathway0.0000001132InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.01814Least InformativeInherited
Cellular componentCytoplasm0.02496Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton0.000000007696Moderately InformativeDirect
Cellular componentCell membrane0.00000001732Moderately InformativeDirect
Cellular componentCell projection0.00003443Moderately InformativeDirect
Cellular componentChromosome0.0000000000002855InformativeDirect
Cellular componentSpliceosome0.000006483InformativeDirect
Cellular componentTight junction0.00004409Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000003738Least InformativeDirect
DiseaseProto-oncogene0.0001576Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.00007946InformativeDirect
Molecular functionCalcium0.0005318Moderately InformativeDirect
Molecular functionActin-binding0.0000000002963InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0003715InformativeDirect
Post-translational modificationRepressor0Moderately InformativeDirect
Post-translational modificationActivator0.0000000003935Moderately InformativeDirect
Post-translational modificationIsomerase0.2057Moderately InformativeInherited
Post-translational modificationChromatin regulator0.00000001756InformativeDirect
Post-translational modificationGTPase activation0.00000002396InformativeDirect
Post-translational modificationRotamase0.00000001066Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.00000000000008101Moderately InformativeDirect
Post-translational modificationIsopeptide bond0.000001827Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Human Phenotype (HP) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Zebrafish Anatomy (ZA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]