SUPERFAMILY 1.75 HMM library and genome assignments server


WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (485) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,066 17,116 31
Proteins 9,744 11,090 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 4.724e-14 Least Informative Direct
Biological Process (BP) developmental process 2.278e-07 Least Informative Direct
Biological Process (BP) protein metabolic process 2.202e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 1.119e-05 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.132e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.0002332 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01179 Least Informative Inherited
Biological Process (BP) localization 0.01527 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6491 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.6508 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8285 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.8946 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9751 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 8.926e-06 Moderately Informative Direct
Biological Process (BP) regulation of localization 1.598e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 3.806e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 6.394e-05 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 8.049e-05 Moderately Informative Direct
Biological Process (BP) single-organism developmental process 0.0003998 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0005941 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0006301 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.3375 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 0.9638 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.2451 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2772 Moderately Informative Inherited
Biological Process (BP) homeostatic process 1 Moderately Informative Inherited
Biological Process (BP) system process 0.07182 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6853 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.144 Moderately Informative Inherited
Biological Process (BP) regulation of biosynthetic process 1 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.769 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.004524 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2344 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1663 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1775 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06356 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.001488 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.7954 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6273 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.2739 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.1153 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.06399 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1532 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03303 Moderately Informative Inherited
Biological Process (BP) gene expression 0.05318 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 2.099e-14 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 4.724e-14 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 2.847e-10 Informative Direct
Biological Process (BP) proteolysis 2.371e-08 Informative Direct
Biological Process (BP) regulation of apoptotic process 2.87e-08 Informative Direct
Biological Process (BP) positive regulation of transport 1.282e-07 Informative Direct
Biological Process (BP) negative regulation of cell communication 5.765e-06 Informative Direct
Biological Process (BP) negative regulation of signaling 1.494e-05 Informative Direct
Biological Process (BP) cell projection organization 1.676e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 2.525e-05 Informative Direct
Biological Process (BP) locomotion 4.393e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 5.637e-05 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002035 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0002422 Informative Direct
Biological Process (BP) protein complex assembly 0.0006447 Informative Direct
Biological Process (BP) blood circulation 0.0007422 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.4588 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02273 Informative Inherited
Biological Process (BP) regulation of locomotion 0.07601 Informative Inherited
Biological Process (BP) cellular component morphogenesis 0.06686 Informative Inherited
Biological Process (BP) generation of neurons 0.04571 Informative Inherited
Biological Process (BP) cellular component movement 0.03541 Informative Inherited
Biological Process (BP) protein localization to organelle 0.9133 Informative Inherited
Biological Process (BP) cellular membrane organization 0.007242 Informative Inherited
Biological Process (BP) epithelium development 0.04668 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.09664 Informative Inherited
Biological Process (BP) regulation of cell development 0.0941 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1574 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.484 Informative Inherited
Biological Process (BP) regulation of growth 0.03916 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6131 Informative Inherited
Biological Process (BP) regulation of response to stress 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.001449 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.08265 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.05709 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.303 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.6734 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4371 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 0.9998 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01561 Informative Inherited
Biological Process (BP) chromosome organization 0.003177 Informative Inherited
Biological Process (BP) organ morphogenesis 0.3257 Informative Inherited
Biological Process (BP) single-organism behavior 0.8797 Informative Inherited
Biological Process (BP) muscle structure development 0.001884 Informative Inherited
Biological Process (BP) cell cycle process 0.004788 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9023 Informative Inherited
Biological Process (BP) protein transport 0.001675 Informative Inherited
Biological Process (BP) embryonic organ development 0.4214 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4824 Informative Inherited
Biological Process (BP) tube development 0.2475 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.7984 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9284 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01209 Informative Inherited
Biological Process (BP) localization of cell 0.004307 Informative Inherited
Biological Process (BP) RNA processing 0.00566 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 3.633e-09 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.096e-09 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 2.264e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 2.814e-07 Highly Informative Direct
Biological Process (BP) RNA splicing 4.067e-07 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 1.788e-06 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.31e-06 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 3.314e-06 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 5.222e-06 Highly Informative Direct
Biological Process (BP) mRNA processing 6.474e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.239e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 5.449e-05 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.695e-05 Highly Informative Direct
Biological Process (BP) regulation of Rho GTPase activity 0.0002102 Highly Informative Direct
Biological Process (BP) renal system development 0.0002258 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0003878 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.000459 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0005445 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0006474 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0006737 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.0009028 Highly Informative Direct
Biological Process (BP) cell projection morphogenesis 0.003706 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.00107 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.006603 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.001548 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01259 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.213 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1858 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1469 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.002845 Highly Informative Inherited
Biological Process (BP) stem cell development 0.3438 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.02622 Highly Informative Inherited
Biological Process (BP) positive regulation of Ras GTPase activity 0.02497 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.5115 Highly Informative Inherited
Biological Process (BP) protein methylation 0.002349 Highly Informative Inherited
Biological Process (BP) histone modification 0.01629 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.8715 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.9703 Highly Informative Inherited
Biological Process (BP) learning or memory 0.009912 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.001487 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.03031 Highly Informative Inherited
Molecular Function (MF) binding 3.981e-12 Least Informative Direct
Molecular Function (MF) structural molecule activity 7.435e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.4467 Moderately Informative Inherited
Molecular Function (MF) ligase activity, forming carbon-nitrogen bonds 2.583e-06 Informative Direct
Molecular Function (MF) enzyme binding 1.506e-05 Informative Direct
Molecular Function (MF) receptor binding 0.005851 Informative Inherited
Molecular Function (MF) amide binding 0.0018 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.001519 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.01173 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 2.405e-12 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 6.54e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 1.604e-05 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0001029 Highly Informative Direct
Molecular Function (MF) protein binding transcription factor activity 0.0001172 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.07587 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.001066 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0005934 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.08101 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.003815 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 6.453e-08 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1.11e-05 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0001342 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0003945 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.3418 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.5718 Moderately Informative Inherited
Cellular Component (CC) synapse part 7.84e-06 Informative Direct
Cellular Component (CC) cell leading edge 0.0001221 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0003085 Informative Direct
Cellular Component (CC) cell-cell junction 1 Informative Inherited
Cellular Component (CC) nucleoplasm part 0.6462 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.4899 Informative Inherited
Cellular Component (CC) spliceosomal complex 2.031e-12 Highly Informative Direct
Cellular Component (CC) apical junction complex 4.721e-09 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 3.919e-07 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0001361 Highly Informative Direct
Cellular Component (CC) actin filament 0.000149 Highly Informative Direct
Cellular Component (CC) adherens junction 0.0007621 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups1.4e-12Least InformativeDirect
Enzyme Commission (EC)Isomerases4.689e-05Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases5.085e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an7.733e-06Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.564e-14InformativeDirect

Document: EC annotation of SCOP domains

Disease Ontology (DO)

(show details)
DO termFDR (all)SDDO levelAnnotation (direct or inherited)
Disease Ontology (DO)nervous system disease0.1937Least InformativeInherited
Disease Ontology (DO)neuromuscular disease0.007566InformativeInherited

Document: DO annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.0512Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1077Least InformativeInherited
Mammalian Phenotype (MP)respiratory system phenotype0.03507Moderately InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1054Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2455Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6579Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal lung morphology0.08767InformativeInherited
Mammalian Phenotype (MP)increased apoptosis0.2389InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension2.367e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.004131Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08902Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.003814Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.1295InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0007778Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.354Least InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.0005359Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.6821Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups2.01e-13Moderately InformativeDirect
Enzyme Commission (EC)Isomerases5.679e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003713Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase2.254e-08InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.228e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis1.012e-13Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis1.018e-09InformativeDirect
Biological processWnt signaling pathway8.251e-08InformativeDirect
Biological processmRNA splicing0.0002253InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.02195Least InformativeInherited
Cellular componentCytoplasm0.02636Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton2.604e-10Moderately InformativeDirect
Cellular componentCell membrane4.043e-08Moderately InformativeDirect
Cellular componentCell projection0.0007721Moderately InformativeDirect
Cellular componentChromosome1.067e-13InformativeDirect
Cellular componentSpliceosome4.331e-06InformativeDirect
Cellular componentTight junction1.84e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing2.122e-07Least InformativeDirect
DiseaseProto-oncogene0.0001202Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain6.906e-05InformativeDirect
Molecular functionCalcium0.0003101Moderately InformativeDirect
Molecular functionActin-binding1.868e-10InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0002924InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationRepressor1.644e-14Moderately InformativeDirect
Post-translational modificationActivator4.299e-08Moderately InformativeDirect
Post-translational modificationLigase5.607e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.1805Moderately InformativeInherited
Post-translational modificationChromatin regulator1.121e-08InformativeDirect
Post-translational modificationGTPase activation1.328e-08InformativeDirect
Post-translational modificationMethyltransferase5.301e-05InformativeDirect
Post-translational modificationRotamase8.988e-09Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation2.931e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Disease Ontology (DO) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]