SUPERFAMILY 1.75 HMM library and genome assignments server

WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (497) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,861 17,116 31
Proteins 10,249 11,090 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 0.0000000000000883 Least Informative Direct
Biological Process (BP) developmental process 0.000001114 Least Informative Direct
Biological Process (BP) protein metabolic process 0.000001313 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 0.000004446 Least Informative Direct
Biological Process (BP) multicellular organismal process 0.00002335 Least Informative Direct
Biological Process (BP) response to stimulus 0.0007468 Least Informative Direct
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) biosynthetic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.8245 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.5518 Least Informative Inherited
Biological Process (BP) positive regulation of biological process 0.5689 Least Informative Inherited
Biological Process (BP) single-organism metabolic process 1 Least Informative Inherited
Biological Process (BP) localization 0.01184 Least Informative Inherited
Biological Process (BP) single-organism cellular process 1 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 1 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9223 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.86 Least Informative Inherited
Biological Process (BP) regulation of localization 0.00002739 Moderately Informative Direct
Biological Process (BP) regulation of cellular component organization 0.00006271 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0001517 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0003395 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0003521 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.0006071 Moderately Informative Direct
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.3937 Moderately Informative Inherited
Biological Process (BP) regulation of developmental process 0.4186 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 0.5896 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.4905 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.8039 Moderately Informative Inherited
Biological Process (BP) cellular nitrogen compound biosynthetic process 0.1258 Moderately Informative Inherited
Biological Process (BP) heterocycle biosynthetic process 0.1937 Moderately Informative Inherited
Biological Process (BP) aromatic compound biosynthetic process 0.1943 Moderately Informative Inherited
Biological Process (BP) organic cyclic compound biosynthetic process 0.4196 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.5014 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.06436 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 0.9781 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.06539 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.976 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.1717 Moderately Informative Inherited
Biological Process (BP) tissue development 0.1954 Moderately Informative Inherited
Biological Process (BP) regulation of phosphorus metabolic process 0.02128 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.002839 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.01345 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1584 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.86 Moderately Informative Inherited
Biological Process (BP) single-organism organelle organization 0.02017 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.002901 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.09832 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1922 Moderately Informative Inherited
Biological Process (BP) response to external stimulus 1 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.1835 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.07174 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.04137 Moderately Informative Inherited
Biological Process (BP) gene expression 0.09479 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 0.000000000000009016 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 0.00000000000006627 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 0.000000000114 Informative Direct
Biological Process (BP) proteolysis 0.00000001301 Informative Direct
Biological Process (BP) single-organism cellular localization 0.00000005383 Informative Direct
Biological Process (BP) regulation of apoptotic process 0.00000006393 Informative Direct
Biological Process (BP) cell projection organization 0.0000002728 Informative Direct
Biological Process (BP) positive regulation of transport 0.000001475 Informative Direct
Biological Process (BP) cell cycle process 0.000008473 Informative Direct
Biological Process (BP) locomotion 0.000009328 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 0.00001869 Informative Direct
Biological Process (BP) negative regulation of cell communication 0.00002631 Informative Direct
Biological Process (BP) regulation of cell development 0.00002859 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 0.00003252 Informative Direct
Biological Process (BP) negative regulation of signaling 0.00005013 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 0.00005474 Informative Direct
Biological Process (BP) negative regulation of transport 0.0001209 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0004394 Informative Direct
Biological Process (BP) cellular component movement 0.0006747 Informative Direct
Biological Process (BP) blood circulation 0.0008789 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.000968 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.5681 Informative Inherited
Biological Process (BP) regulation of locomotion 0.08813 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02516 Informative Inherited
Biological Process (BP) positive regulation of developmental process 0.487 Informative Inherited
Biological Process (BP) response to lipid 0.5109 Informative Inherited
Biological Process (BP) response to acid chemical 0.608 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4659 Informative Inherited
Biological Process (BP) protein oligomerization 0.01197 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1692 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4295 Informative Inherited
Biological Process (BP) anatomical structure homeostasis 0.0101 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 0.9847 Informative Inherited
Biological Process (BP) regulation of growth 0.04083 Informative Inherited
Biological Process (BP) regulation of MAPK cascade 1 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.007458 Informative Inherited
Biological Process (BP) single-organism intracellular transport 0.0221 Informative Inherited
Biological Process (BP) single-organism membrane organization 0.009574 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.1192 Informative Inherited
Biological Process (BP) positive regulation of phosphate metabolic process 0.3048 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) positive regulation of catabolic process 0.002178 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.07214 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.3891 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.6783 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.295 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) epithelium development 0.02769 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) chromosome organization 0.00183 Informative Inherited
Biological Process (BP) localization of cell 0.001027 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01056 Informative Inherited
Biological Process (BP) regulation of ion transport 0.02023 Informative Inherited
Biological Process (BP) single-organism behavior 0.3934 Informative Inherited
Biological Process (BP) neurological system process 1 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9414 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8055 Informative Inherited
Biological Process (BP) protein transport 0.1005 Informative Inherited
Biological Process (BP) embryonic organ development 0.3584 Informative Inherited
Biological Process (BP) organ morphogenesis 0.1593 Informative Inherited
Biological Process (BP) tube development 0.3713 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.6839 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.83 Informative Inherited
Biological Process (BP) generation of neurons 0.04599 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4619 Informative Inherited
Biological Process (BP) RNA processing 0.003243 Informative Inherited
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.00000004751 Highly Informative Direct
Biological Process (BP) histone modification 0.00000008079 Highly Informative Direct
Biological Process (BP) RNA splicing 0.000000464 Highly Informative Direct
Biological Process (BP) positive regulation of transmembrane transport 0.00000166 Highly Informative Direct
Biological Process (BP) positive regulation of transporter activity 0.000001752 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 0.000003385 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 0.000003694 Highly Informative Direct
Biological Process (BP) mRNA processing 0.000006059 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 0.00001082 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 0.00003537 Highly Informative Direct
Biological Process (BP) kidney development 0.00003625 Highly Informative Direct
Biological Process (BP) mesenchyme development 0.0001265 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000215 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0004065 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.000654 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0007154 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0007285 Highly Informative Direct
Biological Process (BP) epithelial cell development 0.0009765 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001304 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01487 Highly Informative Inherited
Biological Process (BP) cellular response to acid chemical 0.0561 Highly Informative Inherited
Biological Process (BP) negative regulation of intracellular signal transduction 0.01012 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.0119 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.5499 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.2925 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1997 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.003575 Highly Informative Inherited
Biological Process (BP) protein localization to membrane 0.01035 Highly Informative Inherited
Biological Process (BP) stem cell development 0.3084 Highly Informative Inherited
Biological Process (BP) regulation of ion transmembrane transport 0.001743 Highly Informative Inherited
Biological Process (BP) regulation of transmembrane transporter activity 0.004044 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.01321 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) epidermis development 0.3853 Highly Informative Inherited
Biological Process (BP) protein methylation 0.002813 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.8111 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.9983 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01367 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.002342 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.0382 Highly Informative Inherited
Molecular Function (MF) binding 0.0000000000003308 Least Informative Direct
Molecular Function (MF) transferase activity 0.0004246 Least Informative Direct
Molecular Function (MF) structural molecule activity 0.00000008054 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.2297 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.8948 Moderately Informative Inherited
Molecular Function (MF) enzyme binding 0.00005418 Informative Direct
Molecular Function (MF) amide binding 0.002099 Informative Inherited
Molecular Function (MF) receptor binding 0.007916 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.002199 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) protein complex binding 0.03833 Informative Inherited
Molecular Function (MF) ubiquitin-protein transferase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 0.000000000002719 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 0.0000001826 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 0.00000109 Highly Informative Direct
Molecular Function (MF) peptide binding 0.00002052 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.001925 Highly Informative Inherited
Molecular Function (MF) small GTPase regulator activity 0.0799 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.07575 Highly Informative Inherited
Molecular Function (MF) sequence-specific DNA binding 0.7388 Highly Informative Inherited
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.023 Least Informative Inherited
Cellular Component (CC) membrane 0.1654 Least Informative Inherited
Cellular Component (CC) non-membrane-bounded organelle 0.001309 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) ribonucleoprotein complex 0.00001337 Moderately Informative Direct
Cellular Component (CC) cell projection 0.0003203 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0004141 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.000427 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.2931 Moderately Informative Inherited
Cellular Component (CC) plasma membrane part 0.9512 Moderately Informative Inherited
Cellular Component (CC) transferase complex 0.05976 Moderately Informative Inherited
Cellular Component (CC) synapse 0.000000000000003071 Informative Direct
Cellular Component (CC) cell junction 0.000000002421 Informative Direct
Cellular Component (CC) cell leading edge 0.0001355 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0005427 Informative Direct
Cellular Component (CC) nucleoplasm part 0.6486 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.4451 Informative Inherited
Cellular Component (CC) spliceosomal complex 0.000000000001181 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 0.0000007272 Highly Informative Direct
Cellular Component (CC) nuclear body 0.000003929 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000014Least InformativeDirect
Enzyme Commission (EC)Isomerases0.00004689Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases0.000000000000005085Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an0.000007733Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009564InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.05931Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1108Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)fibrosis0.0001623InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.2255InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension0.00002341Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.004131Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08902Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.003814Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.1295InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0007778Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.3584Least InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.0005811Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.687Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups0.0000000000001944Moderately InformativeDirect
Enzyme Commission (EC)Isomerases0.00005648Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003687Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase0.00000002329InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase0.00000000000009006Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis0.0000000000001004Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis0.000000001045InformativeDirect
Biological processWnt signaling pathway0.00000008169InformativeDirect
Biological processmRNA splicing0.000008434InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.02308Least InformativeInherited
Cellular componentCytoplasm0.02577Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton0.0000000002666Moderately InformativeDirect
Cellular componentCell membrane0.00000004811Moderately InformativeDirect
Cellular componentCell projection0.0007955Moderately InformativeDirect
Cellular componentChromosome0.0000000000001054InformativeDirect
Cellular componentSpliceosome0.000004279InformativeDirect
Cellular componentTight junction0.00001825Highly InformativeDirect
Coding sequence diversityAlternative splicing0.0000002182Least InformativeDirect
DiseaseProto-oncogene0.0001175Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain0.00006727InformativeDirect
Molecular functionCalcium0.000341Moderately InformativeDirect
Molecular functionActin-binding0.0000000001883InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0002901InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationRepressor0.00000000000002074Moderately InformativeDirect
Post-translational modificationActivator0.00000004303Moderately InformativeDirect
Post-translational modificationLigase0.00000005545Moderately InformativeDirect
Post-translational modificationIsomerase0.1798Moderately InformativeInherited
Post-translational modificationChromatin regulator0.00000001193InformativeDirect
Post-translational modificationGTPase activation0.00000001193InformativeDirect
Post-translational modificationMethyltransferase0.00005281InformativeDirect
Post-translational modificationRotamase0.000000008862Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation0.000000374Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]