SUPERFAMILY 1.75 HMM library and genome assignments server


WW domain superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   WW domain-like [ 51044] (3)
Superfamily:   WW domain [ 51045]
Families:   WW domain [ 51046] (12)


Superfamily statistics
Genomes (496) Uniprot 2014_06 PDB chains (SCOP 1.75)
Domains 15,709 17,116 31
Proteins 10,142 11,090 29


Functional annotation
General category General
Detailed category Protein interaction

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) cellular macromolecule metabolic process 7.996e-14 Least Informative Direct
Biological Process (BP) developmental process 6.16e-07 Least Informative Direct
Biological Process (BP) protein metabolic process 1.167e-06 Least Informative Direct
Biological Process (BP) cellular component organization or biogenesis 1.809e-06 Least Informative Direct
Biological Process (BP) multicellular organismal process 2.748e-05 Least Informative Direct
Biological Process (BP) response to stimulus 0.0007496 Least Informative Direct
Biological Process (BP) single-organism cellular process 0.01151 Least Informative Inherited
Biological Process (BP) localization 0.007607 Least Informative Inherited
Biological Process (BP) regulation of metabolic process 0.6589 Least Informative Inherited
Biological Process (BP) regulation of cellular process 0.7036 Least Informative Inherited
Biological Process (BP) heterocycle metabolic process 0.8541 Least Informative Inherited
Biological Process (BP) cellular aromatic compound metabolic process 0.9168 Least Informative Inherited
Biological Process (BP) organic cyclic compound metabolic process 0.9967 Least Informative Inherited
Biological Process (BP) nitrogen compound metabolic process 1 Least Informative Inherited
Biological Process (BP) regulation of cellular component organization 1.994e-05 Moderately Informative Direct
Biological Process (BP) regulation of localization 3.834e-05 Moderately Informative Direct
Biological Process (BP) regulation of phosphate metabolic process 6.846e-05 Moderately Informative Direct
Biological Process (BP) regulation of signal transduction 0.0001131 Moderately Informative Direct
Biological Process (BP) negative regulation of cellular process 0.00027 Moderately Informative Direct
Biological Process (BP) cellular catabolic process 0.0003928 Moderately Informative Direct
Biological Process (BP) macromolecule localization 0.0007382 Moderately Informative Direct
Biological Process (BP) regulation of developmental process 0.4192 Moderately Informative Inherited
Biological Process (BP) response to endogenous stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular response to chemical stimulus 1 Moderately Informative Inherited
Biological Process (BP) cellular component biogenesis 1 Moderately Informative Inherited
Biological Process (BP) regulation of multicellular organismal process 0.3208 Moderately Informative Inherited
Biological Process (BP) tissue development 0.2161 Moderately Informative Inherited
Biological Process (BP) system process 0.07605 Moderately Informative Inherited
Biological Process (BP) regulation of protein metabolic process 0.6432 Moderately Informative Inherited
Biological Process (BP) positive regulation of metabolic process 0.07618 Moderately Informative Inherited
Biological Process (BP) regulation of cellular biosynthetic process 0.829 Moderately Informative Inherited
Biological Process (BP) regulation of macromolecule biosynthetic process 0.97 Moderately Informative Inherited
Biological Process (BP) regulation of gene expression 1 Moderately Informative Inherited
Biological Process (BP) regulation of nucleobase-containing compound metabolic process 0.6873 Moderately Informative Inherited
Biological Process (BP) organic substance catabolic process 0.003091 Moderately Informative Inherited
Biological Process (BP) organic substance transport 0.2602 Moderately Informative Inherited
Biological Process (BP) signal transduction 0.1939 Moderately Informative Inherited
Biological Process (BP) organ development 1 Moderately Informative Inherited
Biological Process (BP) response to organic substance 1 Moderately Informative Inherited
Biological Process (BP) response to oxygen-containing compound 1 Moderately Informative Inherited
Biological Process (BP) positive regulation of molecular function 0.1701 Moderately Informative Inherited
Biological Process (BP) cellular localization 0.04365 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.003007 Moderately Informative Inherited
Biological Process (BP) positive regulation of cellular process 1 Moderately Informative Inherited
Biological Process (BP) regulation of catalytic activity 0.8224 Moderately Informative Inherited
Biological Process (BP) organelle organization 0.6325 Moderately Informative Inherited
Biological Process (BP) macromolecular complex subunit organization 0.4016 Moderately Informative Inherited
Biological Process (BP) anatomical structure morphogenesis 0.118 Moderately Informative Inherited
Biological Process (BP) regulation of biological quality 1 Moderately Informative Inherited
Biological Process (BP) cell differentiation 0.144 Moderately Informative Inherited
Biological Process (BP) nervous system development 0.06669 Moderately Informative Inherited
Biological Process (BP) RNA metabolic process 0.03885 Moderately Informative Inherited
Biological Process (BP) gene expression 0.06207 Moderately Informative Inherited
Biological Process (BP) protein catabolic process 7.347e-15 Informative Direct
Biological Process (BP) protein modification by small protein conjugation or removal 6.562e-14 Informative Direct
Biological Process (BP) cellular macromolecule catabolic process 8.85e-11 Informative Direct
Biological Process (BP) proteolysis 1.42e-08 Informative Direct
Biological Process (BP) positive regulation of transport 2.944e-07 Informative Direct
Biological Process (BP) negative regulation of cell communication 8.081e-06 Informative Direct
Biological Process (BP) locomotion 9.441e-06 Informative Direct
Biological Process (BP) regulation of vesicle-mediated transport 1.438e-05 Informative Direct
Biological Process (BP) cell projection organization 1.651e-05 Informative Direct
Biological Process (BP) negative regulation of signaling 2.071e-05 Informative Direct
Biological Process (BP) enzyme linked receptor protein signaling pathway 3.311e-05 Informative Direct
Biological Process (BP) positive regulation of hydrolase activity 4.534e-05 Informative Direct
Biological Process (BP) negative regulation of transport 0.0001229 Informative Direct
Biological Process (BP) cytoplasmic transport 0.0002053 Informative Direct
Biological Process (BP) negative regulation of response to stimulus 0.0003679 Informative Direct
Biological Process (BP) blood circulation 0.0008666 Informative Direct
Biological Process (BP) regulation of cellular component biogenesis 0.5233 Informative Inherited
Biological Process (BP) regulation of cellular component movement 0.02562 Informative Inherited
Biological Process (BP) regulation of locomotion 0.08705 Informative Inherited
Biological Process (BP) protein localization to organelle 0.8135 Informative Inherited
Biological Process (BP) cellular membrane organization 0.007871 Informative Inherited
Biological Process (BP) epithelium development 0.06813 Informative Inherited
Biological Process (BP) cellular response to endogenous stimulus 0.1229 Informative Inherited
Biological Process (BP) cellular response to oxygen-containing compound 0.4611 Informative Inherited
Biological Process (BP) protein oligomerization 0.0224 Informative Inherited
Biological Process (BP) regulation of cell development 0.09742 Informative Inherited
Biological Process (BP) regulation of nervous system development 0.1561 Informative Inherited
Biological Process (BP) regulation of anatomical structure morphogenesis 0.4622 Informative Inherited
Biological Process (BP) regulation of growth 0.04905 Informative Inherited
Biological Process (BP) positive regulation of multicellular organismal process 1 Informative Inherited
Biological Process (BP) regulation of intracellular protein kinase cascade 0.6554 Informative Inherited
Biological Process (BP) positive regulation of cellular component organization 0.0024 Informative Inherited
Biological Process (BP) positive regulation of protein metabolic process 0.7089 Informative Inherited
Biological Process (BP) intracellular signal transduction 0.0665 Informative Inherited
Biological Process (BP) response to lipid 0.5052 Informative Inherited
Biological Process (BP) regulation of cell cycle process 1 Informative Inherited
Biological Process (BP) regulation of purine nucleotide metabolic process 0.06353 Informative Inherited
Biological Process (BP) regulation of nucleoside metabolic process 0.327 Informative Inherited
Biological Process (BP) regulation of cellular catabolic process 0.5759 Informative Inherited
Biological Process (BP) posttranscriptional regulation of gene expression 0.4837 Informative Inherited
Biological Process (BP) negative regulation of developmental process 1 Informative Inherited
Biological Process (BP) peptidyl-amino acid modification 1 Informative Inherited
Biological Process (BP) regulation of cell proliferation 0.01106 Informative Inherited
Biological Process (BP) chromosome organization 0.003069 Informative Inherited
Biological Process (BP) organ morphogenesis 0.2293 Informative Inherited
Biological Process (BP) single-organism behavior 0.8853 Informative Inherited
Biological Process (BP) muscle structure development 0.002121 Informative Inherited
Biological Process (BP) cell cycle process 0.004174 Informative Inherited
Biological Process (BP) vesicle-mediated transport 0.9365 Informative Inherited
Biological Process (BP) protein transport 0.002106 Informative Inherited
Biological Process (BP) embryonic organ development 0.4171 Informative Inherited
Biological Process (BP) cardiovascular system development 0.4744 Informative Inherited
Biological Process (BP) tube development 0.2385 Informative Inherited
Biological Process (BP) tissue morphogenesis 0.8023 Informative Inherited
Biological Process (BP) embryonic morphogenesis 0.9284 Informative Inherited
Biological Process (BP) regulation of ion transport 0.01279 Informative Inherited
Biological Process (BP) generation of neurons 0.04494 Informative Inherited
Biological Process (BP) localization of cell 0.001301 Informative Inherited
Biological Process (BP) cellular component movement 0.01056 Informative Inherited
Biological Process (BP) RNA processing 0.0061 Informative Inherited
Biological Process (BP) protein ubiquitination 0 Highly Informative Direct
Biological Process (BP) ubiquitin-dependent protein catabolic process 0 Highly Informative Direct
Biological Process (BP) regulation of transporter activity 4.317e-09 Highly Informative Direct
Biological Process (BP) regulation of transmembrane transport 5.385e-09 Highly Informative Direct
Biological Process (BP) regulation of protein catabolic process 5.394e-09 Highly Informative Direct
Biological Process (BP) regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.044e-08 Highly Informative Direct
Biological Process (BP) negative regulation of cell cycle 2.634e-07 Highly Informative Direct
Biological Process (BP) RNA splicing 4.52e-07 Highly Informative Direct
Biological Process (BP) regulation of protein kinase B signaling cascade 2.778e-06 Highly Informative Direct
Biological Process (BP) extracellular matrix organization 3.801e-06 Highly Informative Direct
Biological Process (BP) regulation of endocytosis 5.504e-06 Highly Informative Direct
Biological Process (BP) mRNA processing 5.971e-06 Highly Informative Direct
Biological Process (BP) establishment of protein localization to organelle 5.978e-06 Highly Informative Direct
Biological Process (BP) negative regulation of cellular component movement 1.116e-05 Highly Informative Direct
Biological Process (BP) negative regulation of locomotion 5.092e-05 Highly Informative Direct
Biological Process (BP) negative regulation of sequence-specific DNA binding transcription factor activity 6.377e-05 Highly Informative Direct
Biological Process (BP) renal system development 0.0002158 Highly Informative Direct
Biological Process (BP) positive regulation of catabolic process 0.0003362 Highly Informative Direct
Biological Process (BP) peptidyl-lysine modification 0.0004365 Highly Informative Direct
Biological Process (BP) regulation of Rho protein signal transduction 0.0006595 Highly Informative Direct
Biological Process (BP) regulation of epithelial cell differentiation 0.0006662 Highly Informative Direct
Biological Process (BP) chemotaxis 0.0007295 Highly Informative Direct
Biological Process (BP) muscle organ development 0.0007315 Highly Informative Direct
Biological Process (BP) regulation of protein stability 0.000861 Highly Informative Direct
Biological Process (BP) regulation of cellular response to growth factor stimulus 0.001334 Highly Informative Inherited
Biological Process (BP) epithelial cell development 0.009129 Highly Informative Inherited
Biological Process (BP) cellular response to growth factor stimulus 0.01404 Highly Informative Inherited
Biological Process (BP) regulation of neuron projection development 0.01154 Highly Informative Inherited
Biological Process (BP) regulation of cell morphogenesis involved in differentiation 0.2052 Highly Informative Inherited
Biological Process (BP) positive regulation of growth 0.1961 Highly Informative Inherited
Biological Process (BP) regulation of cellular response to stress 0.1867 Highly Informative Inherited
Biological Process (BP) regulation of blood pressure 0.002548 Highly Informative Inherited
Biological Process (BP) stem cell development 0.4224 Highly Informative Inherited
Biological Process (BP) regulation of cell division 0.02841 Highly Informative Inherited
Biological Process (BP) positive regulation of GTPase activity 1 Highly Informative Inherited
Biological Process (BP) regulation of Ras GTPase activity 0.01313 Highly Informative Inherited
Biological Process (BP) negative regulation of cell differentiation 1 Highly Informative Inherited
Biological Process (BP) epidermal cell differentiation 0.5073 Highly Informative Inherited
Biological Process (BP) protein methylation 0.002375 Highly Informative Inherited
Biological Process (BP) histone modification 0.01767 Highly Informative Inherited
Biological Process (BP) post-embryonic organ development 0.8663 Highly Informative Inherited
Biological Process (BP) post-embryonic development 0.981 Highly Informative Inherited
Biological Process (BP) learning or memory 0.01288 Highly Informative Inherited
Biological Process (BP) heart morphogenesis 0.00238 Highly Informative Inherited
Biological Process (BP) embryonic organ morphogenesis 0.03907 Highly Informative Inherited
Molecular Function (MF) binding 1.874e-13 Least Informative Direct
Molecular Function (MF) structural molecule activity 7.583e-08 Moderately Informative Direct
Molecular Function (MF) enzyme regulator activity 0.4516 Moderately Informative Inherited
Molecular Function (MF) nucleic acid binding 0.9399 Moderately Informative Inherited
Molecular Function (MF) ligase activity 0 Informative Direct
Molecular Function (MF) enzyme binding 4.446e-05 Informative Direct
Molecular Function (MF) receptor binding 0.007555 Informative Inherited
Molecular Function (MF) amide binding 0.002087 Informative Inherited
Molecular Function (MF) enzyme activator activity 0.001935 Informative Inherited
Molecular Function (MF) GTPase regulator activity 0.01365 Informative Inherited
Molecular Function (MF) DNA binding 1 Informative Inherited
Molecular Function (MF) small conjugating protein ligase activity 0 Highly Informative Direct
Molecular Function (MF) channel regulator activity 2.082e-12 Highly Informative Direct
Molecular Function (MF) transcription factor binding transcription factor activity 1.853e-07 Highly Informative Direct
Molecular Function (MF) protein domain specific binding 9.438e-07 Highly Informative Direct
Molecular Function (MF) peptide binding 2.006e-05 Highly Informative Direct
Molecular Function (MF) GTPase activator activity 0.0001072 Highly Informative Direct
Molecular Function (MF) small GTPase regulator activity 0.08012 Highly Informative Inherited
Molecular Function (MF) protein complex binding 0.001444 Highly Informative Inherited
Molecular Function (MF) transcription regulatory region DNA binding 0.06931 Highly Informative Inherited
Cellular Component (CC) intracellular non-membrane-bounded organelle 0.0008961 Least Informative Direct
Cellular Component (CC) cytoplasmic part 1 Least Informative Inherited
Cellular Component (CC) membrane 0.1645 Least Informative Inherited
Cellular Component (CC) intracellular membrane-bounded organelle 1 Least Informative Inherited
Cellular Component (CC) intracellular organelle part 0.004542 Least Informative Inherited
Cellular Component (CC) protein complex 1 Least Informative Inherited
Cellular Component (CC) cell projection 1.352e-07 Moderately Informative Direct
Cellular Component (CC) ribonucleoprotein complex 1.278e-05 Moderately Informative Direct
Cellular Component (CC) nuclear part 0.0001577 Moderately Informative Direct
Cellular Component (CC) cytoskeleton 0.0004657 Moderately Informative Direct
Cellular Component (CC) intracellular organelle lumen 0.3116 Moderately Informative Inherited
Cellular Component (CC) plasma membrane 0.7461 Moderately Informative Inherited
Cellular Component (CC) cell junction 2.569e-09 Informative Direct
Cellular Component (CC) synapse part 1.864e-05 Informative Direct
Cellular Component (CC) cell leading edge 0.0001389 Informative Direct
Cellular Component (CC) ubiquitin ligase complex 0.0003531 Informative Direct
Cellular Component (CC) nucleoplasm part 0.6709 Informative Inherited
Cellular Component (CC) actin cytoskeleton 0.5111 Informative Inherited
Cellular Component (CC) spliceosomal complex 2.392e-12 Highly Informative Direct
Cellular Component (CC) perinuclear region of cytoplasm 6.92e-07 Highly Informative Direct
Cellular Component (CC) nuclear body 0.0001341 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Transferring one-carbon groups1.4e-12Least InformativeDirect
Enzyme Commission (EC)Isomerases4.689e-05Least InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003595Least InformativeInherited
Enzyme Commission (EC)Methyltransferases5.085e-15Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides; involved in cellular an7.733e-06Moderately InformativeDirect
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.564e-14InformativeDirect

Document: EC annotation of SCOP domains

Mouse Phenotype (MP)

(show details)
MP termFDR (all)SDMP levelAnnotation (direct or inherited)
Mammalian Phenotype (MP)cellular phenotype0.05931Least InformativeInherited
Mammalian Phenotype (MP)cardiovascular system phenotype0.1108Least InformativeInherited
Mammalian Phenotype (MP)muscle phenotype0.1091Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cardiovascular system physiology0.2535Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal cell death0.6552Moderately InformativeInherited
Mammalian Phenotype (MP)abnormal embryogenesis/ development1Moderately InformativeInherited
Mammalian Phenotype (MP)fibrosis0.0001623InformativeDirect
Mammalian Phenotype (MP)increased apoptosis0.2255InformativeInherited
Mammalian Phenotype (MP)abnormal rostral-caudal body axis extension2.341e-05Highly InformativeDirect

Document: MP annotation of SCOP domains

Worm Phenotype (WP)

(show details)
WP termFDR (all)SDWP levelAnnotation (direct or inherited)
Worm Phenotype (WP)organism metabolism processing variant0.004131Least InformativeInherited
Worm Phenotype (WP)organism environmental stimulus response variant0.08902Least InformativeInherited
Worm Phenotype (WP)chemical response variant0.003814Moderately InformativeInherited
Worm Phenotype (WP)drug resistant0.1295InformativeInherited
Worm Phenotype (WP)aldicarb resistant0.0007778Highly InformativeDirect

Document: WP annotation of SCOP domains

Yeast Phenotype (YP)

(show details)
YP termFDR (all)SDYP levelAnnotation (direct or inherited)
Yeast Phenotype (YP)resistance to chemicals0Least InformativeDirect
Yeast Phenotype (YP)metabolism and growth0.3584Least InformativeInherited
Yeast Phenotype (YP)protein/peptide modification0.0005811Highly InformativeDirect

Document: YP annotation of SCOP domains

Fly Anatomy (FA)

(show details) Document: FA annotation of SCOP domains

Xenopus Anatomy (XA)

(show details) Document: XA annotation of SCOP domains

Arabidopsis Plant Ontology (AP)

(show details)
AP termFDR (all)SDAP levelAnnotation (direct or inherited)
Plant ANatomical entity (PAN)guard cell0Least InformativeDirect
Plant structure DEvelopment stage (PDE)E expanded cotyledon stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)F mature embryo stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)C globular stage0Least InformativeDirect
Plant structure DEvelopment stage (PDE)D bilateral stage0Least InformativeDirect

Document: AP annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEC levelAnnotation (direct or inherited)
Enzyme Commission (EC)Hydrolases0.687Least InformativeInherited
Enzyme Commission (EC)Transferring one-carbon groups1.944e-13Moderately InformativeDirect
Enzyme Commission (EC)Isomerases5.648e-05Moderately InformativeDirect
Enzyme Commission (EC)Acting on acid anhydrides0.003687Moderately InformativeInherited
Enzyme Commission (EC)Histone-lysine N-methyltransferase0InformativeDirect
Enzyme Commission (EC)RNA helicase2.329e-08InformativeDirect
Enzyme Commission (EC)Peptidylprolyl isomerase9.006e-14Highly InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processTranscription regulation0Moderately InformativeDirect
Biological processApoptosis1.004e-13Moderately InformativeDirect
Biological processUbl conjugation pathway0InformativeDirect
Biological processNeurogenesis1.045e-09InformativeDirect
Biological processWnt signaling pathway8.169e-08InformativeDirect
Biological processmRNA splicing8.434e-06InformativeDirect
Cellular componentNucleus0Least InformativeDirect
Cellular componentMembrane0.02308Least InformativeInherited
Cellular componentCytoplasm0.02577Least InformativeInherited
Cellular componentCell junction0Moderately InformativeDirect
Cellular componentCytoskeleton2.666e-10Moderately InformativeDirect
Cellular componentCell membrane4.811e-08Moderately InformativeDirect
Cellular componentCell projection0.0007955Moderately InformativeDirect
Cellular componentChromosome1.054e-13InformativeDirect
Cellular componentSpliceosome4.279e-06InformativeDirect
Cellular componentTight junction1.825e-05Highly InformativeDirect
Coding sequence diversityAlternative splicing2.182e-07Least InformativeDirect
DiseaseProto-oncogene0.0001175Moderately InformativeDirect
DomainRepeat0Least InformativeDirect
DomainCoiled coil0Moderately InformativeDirect
DomainSH3 domain6.727e-05InformativeDirect
Molecular functionCalcium0.000341Moderately InformativeDirect
Molecular functionActin-binding1.883e-10InformativeDirect
Molecular functionS-adenosyl-L-methionine0.0002901InformativeDirect
Post-translational modificationTransferase1Least InformativeInherited
Post-translational modificationRepressor2.074e-14Moderately InformativeDirect
Post-translational modificationActivator4.303e-08Moderately InformativeDirect
Post-translational modificationLigase5.545e-08Moderately InformativeDirect
Post-translational modificationIsomerase0.1798Moderately InformativeInherited
Post-translational modificationChromatin regulator1.193e-08InformativeDirect
Post-translational modificationGTPase activation1.193e-08InformativeDirect
Post-translational modificationMethyltransferase5.281e-05InformativeDirect
Post-translational modificationRotamase8.862e-09Highly InformativeDirect
Post-translational modificationPhosphoprotein0Least InformativeDirect
Post-translational modificationUbl conjugation3.74e-07Moderately InformativeDirect

Document: KW annotation of SCOP domains

UniProtKB UniPathway (UP)

(show details)
UP termFDR (all)SDUP levelAnnotation (direct or inherited)
UniPathway (UP)biopolymer metabolism0Least InformativeDirect
UniPathway (UP)protein ubiquitination0Moderately InformativeDirect

Document: UP annotation of SCOP domains

InterPro annotation
Cross references IPR001202 SSF51045 Protein matches
Abstract

Synonym(s): Rsp5 or WWP domain

The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some proteins [PubMed7846762, PubMed7802651, PubMed7828727, PubMed7641887]. The name WW or WWP derives from the presence of two signature tryptophan residues that are spaced 20-23 amino acids apart and are present in most WW domains known to date, as well as that of a conserved Pro. The WW domain binds to proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs [PubMed7644498, PubMed11911877]. It is frequently associated with other domains typical for proteins in signal transduction processes.

A large variety of proteins containing the WW domain are known. These include; dystrophin, a multidomain cytoskeletal protein; utrophin, a dystrophin-like protein of unknown function; vertebrate YAP protein, substrate of an unknown serine kinase; Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system; Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organization; Rattus norvegicus (Rat) FE65, a transcription-factor activator expressed preferentially in liver; Nicotiana tabacum (Common tobacco) DB10 protein and others.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 17 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a WW domain domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 17 hidden Markov models representing the WW domain superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · Mouse Phenotype (MP) · Worm Phenotype (WP) · Yeast Phenotype (YP) · Fly Anatomy (FA) · Xenopus Anatomy (XA) · Arabidopsis Plant Ontology (AP) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · UniProtKB UniPathway (UP) · Internal database links ]