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alpha-D-mannose-specific plant lectins superfamily

SCOP classification
Root:   SCOP hierarchy in SUPERFAMILY [ 0] (11)
Class:   All beta proteins [ 48724] (174)
Fold:   beta-Prism II [ 51109]
Superfamily:   alpha-D-mannose-specific plant lectins [ 51110]
Families:   alpha-D-mannose-specific plant lectins [ 51111] (3)


Superfamily statistics
Genomes (230) Uniprot 2017_06 genome PDB chains (SCOP 1.75)
Domains 7,737 12,951 13
Proteins 7,013 11,636 12


Functional annotation
General category Metabolism
Detailed category Polysaccharide metabolism and transport

Document:
Function annotation of SCOP domain superfamilies

Gene Ontology (high-coverage)

(show details)
GO term FDR (all) SDFO level Annotation (direct or inherited)
Biological Process (BP) response to stimulus 0.7099 Least Informative Inherited
Biological Process (BP) macromolecule metabolic process 0.7816 Least Informative Inherited
Biological Process (BP) primary metabolic process 1 Least Informative Inherited
Biological Process (BP) organonitrogen compound metabolic process 0.6792 Least Informative Inherited
Biological Process (BP) defense response 0.00003766 Moderately Informative Direct
Biological Process (BP) response to biotic stimulus 0.0005957 Moderately Informative Direct
Biological Process (BP) response to external stimulus 0.04458 Moderately Informative Inherited
Biological Process (BP) multi-organism process 0.06835 Moderately Informative Inherited
Biological Process (BP) cellular protein modification process 0.03329 Moderately Informative Inherited
Biological Process (BP) phosphorylation 0.0003436 Informative Direct
Molecular Function (MF) transferase activity 0 Least Informative Direct
Molecular Function (MF) binding 0.000000000005371 Least Informative Direct
Molecular Function (MF) transferase activity, transferring phosphorus-containing groups 0 Moderately Informative Direct
Molecular Function (MF) kinase activity 0 Informative Direct
Molecular Function (MF) phosphotransferase activity, alcohol group as acceptor 0 Informative Direct
Molecular Function (MF) enzyme binding 0.1134 Informative Inherited
Molecular Function (MF) protein kinase activity 0 Highly Informative Direct

Document: GO annotation of SCOP domains

Enzyme Commission (EC)

(show details)
EC termFDR (all)SDEO levelAnnotation (direct or inherited)
Enzyme Commission (EC)Protein-serine/threonine kinases0Moderately InformativeDirect

Document: EC annotation of SCOP domains

UniProtKB KeyWords (KW)

(show details)
KW termFDR (all)SDKW levelAnnotation (direct or inherited)
Biological processPlant defense0.0000000000005824InformativeDirect
Cellular componentMembrane0Least InformativeDirect
Cellular componentCell membrane0.00003799Moderately InformativeDirect
DomainSignal0Least InformativeDirect
DomainTransmembrane0.000000001679Least InformativeDirect
DomainEGF-like domain0InformativeDirect
Molecular functionNucleotide-binding0.00000007551Least InformativeDirect
Molecular functionLectin0InformativeDirect
Post-translational modificationTransferase0Least InformativeDirect
Post-translational modificationKinase0Moderately InformativeDirect
Post-translational modificationReceptor0Moderately InformativeDirect
Post-translational modificationSerine/threonine-protein kinase0InformativeDirect
Post-translational modificationHemagglutinin0.0000000008672Highly InformativeDirect
Post-translational modificationGlycoprotein0Least InformativeDirect
Post-translational modificationDisulfide bond0Least InformativeDirect

Document: KW annotation of SCOP domains

InterPro annotation
Cross references IPR001480 SSF51110 Protein matches
Abstract Members of this domain are plant lectins. Curculin is a sweet-tasting and taste-modifying protein from the fruits of Curculigo latifolia (Lumbah). The three mannose-binding sites are devoid of mannose-binding activity [PubMed9132060]. Other members of this domain are mannose specific and have diverse functions. The lectin of the saffron crocus (Crocus sativus) (Saffron) specifically interacts with a yeast mannan and is a major corm protein specifically expressed in this organ [PubMed10691656].

The actin-binding and vesicle-associated protein comitin exhibits a mannose-specific lectin activity and may have a role in cell motility. It binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton.


InterPro database


PDBeMotif information about ligands, sequence and structure motifs
Cross references PDB entries
Ligand binding statistics
Nucleic-acid binding statistics
Occurrence of secondary structure elements
Occurrence of small 3D structural motifs

PDBeMotif resource

Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) ]

Internal database links

Browse genome assignments for this superfamily. The SUPERFAMILY hidden Markov model library has been used to carry out SCOP domain assignments to all genomes at the superfamily level.


Alignments of sequences to 11 models in this superfamily are available by clicking on the 'Alignments' icon above. PDB sequences less than 40% identical are shown by default, but any other sequence(s) may be aligned. Select PDB sequences, genome sequences, or paste in or upload your own sequences.


Browse and view proteins in genomes which have different domain combinations including a alpha-D-mannose-specific plant lectins domain.


Examine the distribution of domain superfamilies, or families, across the major taxonomic kingdoms or genomes within a kingdom. This gives an immediate impression of how superfamilies, or families, are restricted to certain kingdoms of life.


Explore domain occurrence network where nodes represent genomes and edges are domain architectures (shared between genomes) containing the superfamily of interest.

There are 11 hidden Markov models representing the alpha-D-mannose-specific plant lectins superfamily. Information on how the models are built, and plots showing hydrophobicity, match emmission probabilities and insertion/deletion probabilities can be inspected.


Jump to [ Top of page · SCOP classification · InterPro annotation · PDBeMotif links · Functional annotation · Gene Ontology (high-coverage) · Enzyme Commission (EC) · UniProtKB KeyWords (KW) · Internal database links ]